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1. 发明授权

US08211436B2 Anticancer vaccine and diagnostic methods and reagents 有权
标题翻译：抗癌疫苗及诊断方法及试剂
公开(公告)号：US08211436B2
公开(公告)日：2012-07-03
申请号：US12698822
申请日：2010-02-02
申请人： Olivera J. Finn , Henry Kao , Donald F. Hunt , Jarrod A. Marto
发明人： Olivera J. Finn , Henry Kao , Donald F. Hunt , Jarrod A. Marto
IPC分类号： A61K39/00 , A61K35/12
CPC分类号： G01N33/57484 , A61K39/00 , A61K39/0011 , A61K2039/5158 , C07K14/4738
摘要： The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the patient. The invention further provides a method of identifying tumor antigens.
摘要翻译：本发明提供了一种针对恶性肿瘤接种患者的方法，包括将包含细胞周期蛋白全部或免疫原性片段的蛋白质或肽引入患者体内。本发明还提供了鉴定肿瘤抗原的方法。

2. 发明申请

US20120184042A1 Electron Transfer Dissociation for Biopolymer Sequence Analysis 有权
标题翻译：电子传递解离生物聚合物序列分析
公开(公告)号：US20120184042A1
公开(公告)日：2012-07-19
申请号：US13422812
申请日：2012-03-16
申请人： Donald F. HUNT , Joshua J. COON , John Edward Philip SYKA , Jarrod A. MARTO
发明人： Donald F. HUNT , Joshua J. COON , John Edward Philip SYKA , Jarrod A. MARTO
IPC分类号： G01N27/62
CPC分类号： H01J49/423 , G01N33/6848 , H01J49/0072 , Y10T436/212 , Y10T436/24
摘要： The present invention relates to a new method for fragmenting ions in a mass spectrometer through the use of electron transfer dissociation, and for performing sequence analysis of peptides and proteins by mass spectrometry. In the case of peptides, the invention promotes fragmentation along the peptide backbone and makes it possible to deduce the amino acid sequence of the sample, including modified amino acid residues, through the use of an RF field device.
摘要翻译：本发明涉及通过使用电子转移离解在质谱仪中分离离子的新方法，以及通过质谱法进行肽和蛋白质的序列分析。在肽的情况下，本发明促进沿肽主链的断裂，并且可以通过使用RF场设备来推断样品的氨基酸序列，包括修饰的氨基酸残基。

3. 发明授权

US09678083B2 Protected amine labels and use in detecting analytes 有权
公开(公告)号：US09678083B2
公开(公告)日：2017-06-13
申请号：US13501940
申请日：2010-10-14
申请人： Jarrod A. Marto , Scott B. Ficarro , Manor Askenazi
发明人： Jarrod A. Marto , Scott B. Ficarro , Manor Askenazi
IPC分类号： C07D295/24 , C40B40/04 , G01N27/62 , G01N33/68 , C07D207/40 , C07D207/404 , C07D249/18 , C07D253/08 , C07D471/04
CPC分类号： G01N33/6848 , C07D207/40 , C07D207/404 , C07D249/18 , C07D253/08 , C07D471/04 , G01N2458/15 , G01N2560/00 , Y10T436/145555
摘要： The invention is directed towards novel amino acid based compounds, which may be isotopically enriched, and methods of use of such compounds for characterizing one or more molecules of a sample by mass spectrometry, the method comprising: (a) reacting the one or more molecules with the compound; and (b) characterizing the one or more molecules by mass spectrometry.

4. 发明申请

US20120258886A1 PROTECTED AMINE LABELS AND USE IN DETECTING ANALYTES 有权
标题翻译：保护胺标签和用于检测分析
公开(公告)号：US20120258886A1
公开(公告)日：2012-10-11
申请号：US13501940
申请日：2010-10-14
申请人： Jarrod A. Marto , Scott B. Ficarro , Manor Askenazi
发明人： Jarrod A. Marto , Scott B. Ficarro , Manor Askenazi
IPC分类号： C07D295/24 , C40B40/04 , G01N27/62
CPC分类号： G01N33/6848 , C07D207/40 , C07D207/404 , C07D249/18 , C07D253/08 , C07D471/04 , G01N2458/15 , G01N2560/00 , Y10T436/145555
摘要： The invention is directed towards novel amino acid based compounds, which may be isotopically enriched, and methods of use of such compounds for characterising one or more molecules of a sample by mass spectrometry, the method comprising: (a) reacting the one or more molecules with the compound; and (b) characterising the one or more molecules by mass spectrometry.
摘要翻译：本发明涉及可以同位素富集的新型氨基酸基化合物，以及通过质谱法来表征样品的一种或多种分子的方法，该方法包括：（a）使一种或多种分子与化合物; 和（b）通过质谱鉴定所述一种或多种分子。

5. 发明申请

US20100297158A1 ANTICANCER VACCINE AND DIAGNOSTIC METHODS AND REAGENTS 有权
标题翻译： ANTICANCER VACCINE和诊断方法和试剂
公开(公告)号：US20100297158A1
公开(公告)日：2010-11-25
申请号：US12698822
申请日：2010-02-02
申请人： Olivera J. Finn , Henry Kao , Donald Hunt , Jarrod A. Marto
发明人： Olivera J. Finn , Henry Kao , Donald Hunt , Jarrod A. Marto
IPC分类号： A61K39/00 , C12Q1/02 , A61P37/04
CPC分类号： G01N33/57484 , A61K39/00 , A61K39/0011 , A61K2039/5158 , C07K14/4738
摘要： The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the patient. The invention further provides a method of identifying tumor antigens.
摘要翻译：本发明提供了一种针对恶性肿瘤接种患者的方法，包括将包含细胞周期蛋白全部或免疫原性片段的蛋白质或肽引入患者体内。本发明还提供了鉴定肿瘤抗原的方法。

6. 发明授权

US09110071B2 Chromatographic columns with integrated electrospray emitters 有权
标题翻译：带集成电喷射器的色谱柱
公开(公告)号：US09110071B2
公开(公告)日：2015-08-18
申请号：US12601607
申请日：2008-05-27
申请人： Jarrod A. Marto
发明人： Jarrod A. Marto
IPC分类号： G01N30/60 , G01N30/72
CPC分类号： G01N30/6004 , G01N30/7266 , G01N2030/6013
摘要： A method of fabricating a chromatographic column and columns produced by such a method are disclosed. The method includes: (a) obtaining a tube comprising two open ends and a lumen with a diameter of 75 microns or less extending between the two open ends; (b) depositing a liquid silicate composition into the tube lumen at a first open end of the tube; (c) forming a porous ceramic material from the composition in the tube lumen at a location near the first open end such that a space is formed between the ceramic material and the open end that is substantially free of the ceramic material; and (d) forming a tapered emitter having an orifice diameter of less than 3 microns at the first open end.
摘要翻译：公开了制造色谱柱的方法和通过这种方法生产的色谱柱。该方法包括：（a）获得包括两个开口端和在两个开口端之间延伸的直径为75微米或更小的内腔的管; （b）在所述管的第一开口端将液体硅酸盐组合物沉积到所述管腔中; （c）在靠近第一开口端的位置处从管腔中的组合物形成多孔陶瓷材料，使得在陶瓷材料和基本上不含陶瓷材料的开口端之间形成空间; 和（d）在第一开口端形成孔径小于3微米的锥形发射器。

7. 发明申请

US20100193683A1 CHROMATOGRAPHIC COLUMNS WITH INTEGRATED ELECTROSPRAY EMITTERS 有权
标题翻译：具有集成电沉积发射体的色谱柱
公开(公告)号：US20100193683A1
公开(公告)日：2010-08-05
申请号：US12601607
申请日：2008-05-27
申请人： Jarrod A. Marto
发明人： Jarrod A. Marto
IPC分类号： B01D59/44 , B29C44/32 , B01D15/08 , H01J49/04
CPC分类号： G01N30/6004 , G01N30/7266 , G01N2030/6013
摘要： A method of fabricating a chromatographic column and columns produced by such a method are disclosed. The method includes: (a) obtaining a tube comprising two open ends and a lumen with a diameter of 75 microns or less extending between the two open ends; (b) depositing a liquid silicate composition into the tube lumen at a first open end of the tube; (c) forming a porous ceramic material from the composition in the tube lumen at a location near the first open end such that a space is formed between the ceramic material and the open end that is substantially free of the ceramic material; and (d) forming a tapered emitter having an orifice diameter of less than 3 microns at the first open end.
摘要翻译：公开了制造色谱柱的方法和通过这种方法生产的色谱柱。该方法包括：（a）获得包括两个开口端和在两个开口端之间延伸的直径为75微米或更小的内腔的管; （b）在所述管的第一开口端将液体硅酸盐组合物沉积到所述管腔中; （c）在靠近第一开口端的位置处从管腔中的组合物形成多孔陶瓷材料，使得在陶瓷材料和基本上不含陶瓷材料的开口端之间形成空间; 和（d）在第一开口端形成孔径小于3微米的锥形发射器。

8. 发明授权

US07704507B2 Anticancer vaccine and diagnostic methods and reagents 有权
标题翻译：抗癌疫苗及诊断方法及试剂
公开(公告)号：US07704507B2
公开(公告)日：2010-04-27
申请号：US11366196
申请日：2006-03-02
申请人： Olivera J. Finn , Henry Kao , Donald F. Hunt , Jarrod A. Marto
发明人： Olivera J. Finn , Henry Kao , Donald F. Hunt , Jarrod A. Marto
IPC分类号： A61K39/00 , A61K38/00
CPC分类号： G01N33/57484 , A61K39/00 , A61K39/0011 , A61K2039/5158 , C07K14/4738
摘要： The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the patient. The invention further provides a method of identifying tumor antigens.
摘要翻译：本发明提供了一种针对恶性肿瘤接种患者的方法，包括将包含细胞周期蛋白全部或免疫原性片段的蛋白质或肽引入患者体内。本发明还提供了鉴定肿瘤抗原的方法。

9. 发明授权

US07534622B2 Electron transfer dissociation for biopolymer sequence mass spectrometric analysis 有权
标题翻译：电子转移解离生物聚合物序列质谱分析
公开(公告)号：US07534622B2
公开(公告)日：2009-05-19
申请号：US11079147
申请日：2005-03-14
申请人： Donald F. Hunt , Joshua J. Coon , John Edward Philip Syka , Jarrod A. Marto
发明人： Donald F. Hunt , Joshua J. Coon , John Edward Philip Syka , Jarrod A. Marto
IPC分类号： G01N24/00
CPC分类号： H01J49/423 , G01N33/6848 , H01J49/0072 , Y10T436/212 , Y10T436/24
摘要： The present invention relates to a new method for fragmenting ions in a mass spectrometer through the use of electron transfer dissociation, and for performing sequence analysis of peptides and proteins by mass spectrometry. In the case of peptides, the invention promotes fragmentation along the peptide backbone and makes it possible to deduce the amino acid sequence of the sample, including modified amino acid residues, through the use of an RF field device.
摘要翻译：本发明涉及通过使用电子转移离解在质谱仪中分离离子的新方法，以及通过质谱法进行肽和蛋白质的序列分析。在肽的情况下，本发明促进沿肽主链的断裂，并且可以通过使用RF场设备来推断样品的氨基酸序列，包括修饰的氨基酸残基。

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