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1. 发明授权

US08980573B2 Method for providing diagnosis of cancer using seprase as a marker 有权
标题翻译：使用seprase作为标记提供癌症诊断的方法
公开(公告)号：US08980573B2
公开(公告)日：2015-03-17
申请号：US12791946
申请日：2010-06-02
申请人： Wolfgang Rollinger , Johann Karl , Jarema Peter Kochan , Markus Roessler , Michael Tacke
发明人： Wolfgang Rollinger , Johann Karl , Jarema Peter Kochan , Markus Roessler , Michael Tacke
IPC分类号： C12Q1/37 , G01N33/574
CPC分类号： G01N33/57423 , G01N33/57407 , G01N33/57419 , G01N33/57473 , G01N2333/96411
摘要： The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the human fibroblast activation protein (FAP/seprase) as a universal marker of different cancer types. Seprase aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g., of non-small cell lung carcinoma (NSCLC) or colorectal cancer (CRC), but also likely of other specific types of cancer. Such specific cancer types are, e.g., esophagus, head and neck cancer, stomach cancer, bile duct cancer, pancreas cancer, kidney cancer, cervix cancer, ovary cancer, breast cancer, bladder cancer, endometrium cancer or prostate cancer. Furthermore, it especially relates to a method for assessing cancer from a liquid sample, derived from an individual by measuring seprase in said sample. Measurement of seprase can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.
摘要翻译：本发明涉及一种协助癌症评估的方法。它公开了使用人成纤维细胞活化蛋白（FAP / seprase）作为不同癌症类型的通用标记物。 Seprase有助于评估肺或肺癌（LC）或结肠癌，例如非小细胞肺癌（NSCLC）或结肠直肠癌（CRC），但也可能是其他特定类型的癌症。这些特定的癌症类型是例如食管，头颈癌，胃癌，胆管癌，胰腺癌，肾癌，子宫颈癌，卵巢癌，乳腺癌，膀胱癌，子宫内膜癌或前列腺癌。此外，它特别涉及通过测量所述样品中的seprase从源自个体的液体样品中评估癌症的方法。 seprase的测量可以例如用于癌症的早期检测或用于进行手术的患者的监视。

2. 发明授权

US06602983B1 Polypeptide and DNA sequence corresponding to human receptor with high affinity for IgE 失效
标题翻译：多肽和DNA序列对应于人类受体，对IgE具有高亲和力
公开(公告)号：US06602983B1
公开(公告)日：2003-08-05
申请号：US08310902
申请日：1994-09-22
申请人： Jean Pierre Kinet , Jarema Peter Kochan
发明人： Jean Pierre Kinet , Jarema Peter Kochan
IPC分类号： C07K14705
CPC分类号： C07K14/70535
摘要： A Polypeptide and DNA Sequence corresponding to the human receptor high affinity receptor for IgE as well as replicable microbial expression vehicles, transformed microorganisms, and cultures of microbial cells which produce this polypeptide.
摘要翻译：对应于IgE的人受体高亲和力受体以及产生该多肽的可复制的微生物表达载体，转化的微生物和微生物细胞的培养物的多肽和DNA序列。

3. 发明授权

US5639660A Polypeptide and DNA sequence corresponding to the human receptor with high affinity for IgE 失效
标题翻译：多肽和对应于人类受体的DNA序列与IgE具有高亲和力
公开(公告)号：US5639660A
公开(公告)日：1997-06-17
申请号：US160457
申请日：1988-02-24
申请人： Jean Pierre Kinet , Jarema Peter Kochan
发明人： Jean Pierre Kinet , Jarema Peter Kochan
IPC分类号： C07K14/735 , C12N15/12 , C12N1/21 , C12N5/10
CPC分类号： C07K14/70535
摘要： A Polypeptide and DNA Sequence corresponding to the human receptor high affinity receptor for IgE as well as replicable microbial expression vehicles, transformed microorganisms, and cultures of microbial cells which produce this polypeptide.
摘要翻译：对应于IgE的人受体高亲和力受体以及产生该多肽的可复制的微生物表达载体，转化的微生物和微生物细胞的培养物的多肽和DNA序列。

4. 发明申请

US20090123943A1 Characterization and Identification of Unique Human Adiponectin Isoforms and Antibodies 失效
标题翻译：独特的人脂连蛋白异构体和抗体的表征和鉴定
公开(公告)号：US20090123943A1
公开(公告)日：2009-05-14
申请号：US11968295
申请日：2008-01-02
申请人： Charles Roger Burghardt , Jarema Peter Kochan , Erik Roy Rasmussen
发明人： Charles Roger Burghardt , Jarema Peter Kochan , Erik Roy Rasmussen
IPC分类号： G01N33/53 , C07K16/18
CPC分类号： C07K16/26 , G01N2800/042
摘要： The invention pertains to methods for measuring different forms of human adiponectin that are present in human plasma/serum, and more specifically methods are based on an ELISA assay that utilizes different monoclonal antibodies directed against adiponectin, in combination with different polyclonal antibodies directed against different domains of human adiponectin. The invention also provides unique isoforms of adiponectin and antibodies thereto, including polyclonal and monoclonal antibodies.
摘要翻译：本发明涉及用于测量存在于人血浆/血清中的不同形式的人类脂联素的方法，更具体地说，方法是基于使用针对脂联素的不同单克隆抗体与针对不同结构域的不同多克隆抗体的ELISA测定法的人脂连蛋白。本发明还提供脂联素及其抗体的独特同种型，包括多克隆和单克隆抗体。

5. 发明授权

US08026345B2 Characterization and identification of unique human adiponectin isoforms and antibodies 失效
标题翻译：独特的人类脂联素同种型和抗体的鉴定和鉴定
公开(公告)号：US08026345B2
公开(公告)日：2011-09-27
申请号：US11968295
申请日：2008-01-02
申请人： Charles Roger Burghardt , Jarema Peter Kochan , Erik Roy Rasmussen
发明人： Charles Roger Burghardt , Jarema Peter Kochan , Erik Roy Rasmussen
IPC分类号： C07K16/00 , A61K39/00 , A61K39/395
CPC分类号： C07K16/26 , G01N2800/042
摘要： The invention pertains to methods for measuring different forms of human adiponectin that are present in human plasma/serum, and more specifically methods are based on an ELISA assay that utilizes different monoclonal antibodies directed against adiponectin, in combination with different polyclonal antibodies directed against different domains of human adiponectin. The invention also provides unique isoforms of adiponectin and antibodies thereto, including polyclonal and monoclonal antibodies.
摘要翻译：本发明涉及用于测量存在于人血浆/血清中的不同形式的人类脂联素的方法，更具体地说，方法是基于使用针对脂联素的不同单克隆抗体与针对不同结构域的不同多克隆抗体的ELISA测定法的人脂连蛋白。本发明还提供脂联素及其抗体的独特同种型，包括多克隆和单克隆抗体。

6. 发明申请

US20100240081A1 SEPRASE AS A MARKER FOR CANCER 有权
标题翻译： SEPRASE作为癌症的标记
公开(公告)号：US20100240081A1
公开(公告)日：2010-09-23
申请号：US12791946
申请日：2010-06-02
申请人： Wolfgang Rollinger , Johann Karl , Jarema Peter Kochan , Markus Roessler , Michael Tacke
发明人： Wolfgang Rollinger , Johann Karl , Jarema Peter Kochan , Markus Roessler , Michael Tacke
IPC分类号： C12Q1/48 , C12Q1/37
CPC分类号： G01N33/57423 , G01N33/57407 , G01N33/57419 , G01N33/57473 , G01N2333/96411
摘要： The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the human fibroblast activation protein (FAP/seprase) as a universal marker of different cancer types. Seprase aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g., of non-small cell lung carcinoma (NSCLC) or colorectal cancer (CRC), but also likely of other specific types of cancer. Such specific cancer types are, e.g., esophagus, head and neck cancer, stomach cancer, bile duct cancer, pancreas cancer, kidney cancer, cervix cancer, ovary cancer, breast cancer, bladder cancer, endometrium cancer or prostate cancer. Furthermore, it especially relates to a method for assessing cancer from a liquid sample, derived from an individual by measuring seprase in said sample. Measurement of seprase can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.
摘要翻译：本发明涉及一种协助癌症评估的方法。它公开了使用人成纤维细胞活化蛋白（FAP / seprase）作为不同癌症类型的通用标记物。 Seprase有助于评估肺或肺癌（LC）或结肠癌，例如非小细胞肺癌（NSCLC）或结肠直肠癌（CRC），但也可能是其他特定类型的癌症。这些特定的癌症类型是例如食管，头颈癌，胃癌，胆管癌，胰腺癌，肾癌，子宫颈癌，卵巢癌，乳腺癌，膀胱癌，子宫内膜癌或前列腺癌。此外，它特别涉及通过测量所述样品中的seprase从源自个体的液体样品中评估癌症的方法。 seprase的测量可以例如用于癌症的早期检测或用于进行手术的患者的监视。

7. 发明申请

US20090075312A1 ASSESSING COLORECTAL CANCER BY MEASURING OSTEOPONTIN AND CARCINOEMBRYONIC ANTIGEN 审中-公开
标题翻译：通过测量OSTEOPONTIN和CARCINOEMBRYONIC ANTIGEN评估色素性癌
公开(公告)号：US20090075312A1
公开(公告)日：2009-03-19
申请号：US12141278
申请日：2008-06-18
申请人： Norbert Wild , Veit Peter Grunert , Johann Karl , Jarema Peter Kochan , Peter Stegmueller , Michael Tacke
发明人： Norbert Wild , Veit Peter Grunert , Johann Karl , Jarema Peter Kochan , Peter Stegmueller , Michael Tacke
IPC分类号： C12Q1/48 , G01N33/00
CPC分类号： G01N33/57419 , G01N2333/52 , G01N2333/70503
摘要： The present invention relates to a method aiding in the assessment of colorectal cancer (=CRC). It discloses the use of a marker combination comprising osteopontin and carcinoembryonic antigen in the assessment of colorectal cancer. Furthermore, it especially relates to a method for assessing colorectal cancer from a liquid sample, derived from an individual by measuring at least the markers osteopontin and carcinoembryonic antigen in said sample. The marker combination comprising osteopontin and carcinoembryonic antigen can, e.g., be used in the early detection of colorectal cancer or in the surveillance of patients who undergo therapy, e.g., surgery.
摘要翻译：本发明涉及一种协助评估结肠直肠癌（= CRC）的方法。它公开了在评估结肠直肠癌中使用包含骨桥蛋白和癌胚抗原的标记物组合。此外，它特别涉及通过至少测量所述样品中的骨桥蛋白和癌胚抗原来评估来自个体的来自液体样品的结肠直肠癌的方法。包括骨桥蛋白和癌胚抗原的标记物组合可以例如用于结肠直肠癌的早期检测或用于进行例如手术治疗的患者的监视。

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