专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06892097B2 Method of preparing neural tissue of the brain for subsequent electrical stimulation 失效
标题翻译：制备脑的神经组织用于随后的电刺激的方法
公开(公告)号：US06892097B2
公开(公告)日：2005-05-10
申请号：US10393204
申请日：2003-03-20
申请人： Jan Holsheimer
发明人： Jan Holsheimer
IPC分类号： A61N1/36
CPC分类号： A61N1/3604
摘要： Methods are disclosed of preparing neural tissue of the brain for subsequent electrical stimulation. For example, first, second and third electrodes may be placed in close proximity to tissue of a patient's brain. A hyperpolarizing electrical pre-pulse may be applied to the tissue through the first electrode wherein the tissue is more susceptible to subsequent electric stimulation, or a depolarizing electrical pre-pulse may be applied to the tissue through the first electrode wherein the tissue is less susceptible to subsequent electric stimulation. Other exemplary embodiments are also disclosed.
摘要翻译：公开了制备脑的神经组织用于随后的电刺激的方法。例如，第一，第二和第三电极可以放置在紧邻患者大脑的组织的位置。超极化电预脉冲可以通过第一电极施加到组织，其中组织更易于随后的电刺激，或者可以通过第一电极将组织的去极化电预脉冲施加到组织，其中组织较不敏感到随后的电刺激。还公开了其它示例性实施例。

2. 发明授权

US10537741B2 System and method for choosing electrodes in an implanted stimulator device 有权
公开(公告)号：US10537741B2
公开(公告)日：2020-01-21
申请号：US11295168
申请日：2005-12-05
申请人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
发明人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
IPC分类号： A61N1/36
摘要： A method of selecting a subset of electrodes in a stimulator device implanted in a patient for further clinical evaluation is disclosed. The method comprises measuring at least first and second measurement for each of the plurality of electrodes that are indicative of the ability of the electrode if activated to provide useful therapy to the patient in which the stimulator device is implanted A weight is then determined for each of the measurements. The weight is then applied to each electrode measurement, which measurement may be normalized, and the weighted measurements for each electrode are preferably summed to arrive at a value which itself is indicative of a particular electrode's ability to provide useful therapy to the patient. These values can then be used to determine a subset of the electrodes useful for further clinical evaluation in the patient, which improved the accuracy and speeding determining appropriate patient therapy.

3. 发明授权

US5643330A Multichannel apparatus for epidural spinal cord stimulation 失效
标题翻译：用于硬膜外脊髓刺激的多通道装置
公开(公告)号：US5643330A
公开(公告)日：1997-07-01
申请号：US599832
申请日：1996-02-12
申请人： Jan Holsheimer , Johannes J. Struijk
发明人： Jan Holsheimer , Johannes J. Struijk
IPC分类号： A61N1/32 , A61N1/04 , A61N1/05 , A61N1/34
CPC分类号： A61N1/0551 , A61N1/36071 , A61N1/0553
摘要： Apparatus for multi-channel transverse epidural spinal cord stimulation uses a multi-channel pulse generator driving a plurality of electrodes mounted near the distal end of a lead. These electrodes are mounted in one or more lines, generally perpendicular to the lead axis, and have a planar surface along one surface of the lead. The lead is implanted adjacent to spinal cord dura mater with the electrodes transverse and facing the spinal cord. Pulses generated by the pulse generator for each channel are not simultaneous but are selectively offset in time and may be of equal or varying amplitude and of equal or varying duration. When the pulses given by the stimulator channels are offset in time and have sufficient amplitude and duration, overlapping areas of stimulation of the spinal area can be obtained. In the overlapping areas of stimulation, the frequency of stimulation is double the frequency of the pulses given by the each stimulator channel separately. Changes in pulse duration and magnitude permit shifting the electrical stimulation field and the resulting paresthesia pattern after installation to accommodate improper lead placement or postoperative dislocation and to minimize unwanted motor responses.
摘要翻译：用于多通道横向硬膜外脊髓刺激的装置使用多通道脉冲发生器驱动安装在铅的远端附近的多个电极。这些电极安装在大致垂直于引线轴线的一条或多条线上，并且沿引线的一个表面具有平坦表面。铅被植入邻近脊髓硬膜，电极横向并面向脊髓。由脉冲发生器为每个通道产生的脉冲不是同时的，而是在时间上有选择地偏移，并且可以是相等或变化的幅度以及相等或不同的持续时间。当由刺激器通道给出的脉冲在时间上偏移并且具有足够的幅度和持续时间时，可以获得脊髓区域的重叠刺激区域。在刺激的重叠区域中，刺激频率分别是由每个刺激器通道给出的脉冲的频率的两倍。脉冲持续时间和幅度的变化允许在安装之后移动电刺激场和由此产生的感觉异常模式，以适应不适当的引线放置或术后脱位并且使不需要的运动反应最小化。

4. 发明授权

US08494640B2 System and method for increasing relative intensity between cathodes and anodes of neurostimulation system 有权
标题翻译：增加阴极和神经刺激系统阳极之间的相对强度的系统和方法
公开(公告)号：US08494640B2
公开(公告)日：2013-07-23
申请号：US12508407
申请日：2009-07-23
申请人： David K. L. Peterson , Kerry Bradley , Jan Holsheimer
发明人： David K. L. Peterson , Kerry Bradley , Jan Holsheimer
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/3605 , A61N1/36157
摘要： A method and neurostimulation system for providing therapy to a patient is provided. A plurality of electrodes is placed adjacent to tissue of the patient. The electrodes include first and second electrodes, with the first electrode having a first tissue contacting surface area and the second electrode having a second tissue contact surface area greater than the first tissue contacting surface area. Anodic electrical current is simultaneously sourced from one of the first and second electrodes to the tissue and while cathodic electrical current is sunk from the tissue to another of the first and second electrodes to provide the therapy to the patient.
摘要翻译：提供了一种用于向患者提供治疗的方法和神经刺激系统。多个电极邻近患者的组织放置。电极包括第一和第二电极，第一电极具有第一组织接触表面区域，第二电极具有大于第一组织接触表面积的第二组织接触表面积。阳极电流同时从第一和第二电极之一提供到组织，同时阴极电流从组织下沉到另一个第一和第二电极，以向患者提供治疗。

5. 发明申请

US20100023097A1 SYSTEM AND METHOD FOR INCREASING RELATIVE INTENSITY BETWEEN CATHODES AND ANODES OF NEUROSTIMULATION SYSTEM 有权
标题翻译：阴茎和神经系统阳极相对强度的增加系统与方法
公开(公告)号：US20100023097A1
公开(公告)日：2010-01-28
申请号：US12508407
申请日：2009-07-23
申请人： David K.L. Peterson , Kerry Bradley , Jan Holsheimer
发明人： David K.L. Peterson , Kerry Bradley , Jan Holsheimer
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/3605 , A61N1/36157
摘要： A method and neurostimulation system for providing therapy to a patient is provided. A plurality of electrodes is placed adjacent to tissue of the patient. The electrodes include first and second electrodes, with the first electrode having a first tissue contacting surface area and the second electrode having a second tissue contact surface area greater than the first tissue contacting surface area. Anodic electrical current is simultaneously sourced from one of the first and second electrodes to the tissue and while cathodic electrical current is sunk from the tissue to another of the first and second electrodes to provide the therapy to the patient.
摘要翻译：提供了一种用于向患者提供治疗的方法和神经刺激系统。多个电极邻近患者的组织放置。电极包括第一和第二电极，第一电极具有第一组织接触表面区域，第二电极具有大于第一组织接触表面积的第二组织接触表面积。阳极电流同时从第一和第二电极之一提供到组织，同时阴极电流从组织下沉到另一个第一和第二电极，以向患者提供治疗。

6. 发明授权

US06675046B2 Selective dorsal column stimulation in SCS, using conditioning pulses 有权
公开(公告)号：US06675046B2
公开(公告)日：2004-01-06
申请号：US10140387
申请日：2002-05-07
申请人： Jan Holsheimer
发明人： Jan Holsheimer
IPC分类号： A61N136
CPC分类号： A61N1/3604
摘要： A system and method is described for preferentially stimulating dorsal column fibers while avoiding stimulation of dorsal root fibers. The invention applies hyperpolarizing pre-pulses and depolarizing pre-pulses to neural tissue, such as spinal cord tissue, through a lead placed over the spinal cord having the electrodes arranged on a line approximately transverse to the axis of the spine. To increase the threshold needed to stimulate dorsal root fibers, the anodal pulse given by each lateral contact of the electrodes has to be preceded by a depolarizing pre-pulse and simultaneously, the central electrode contact gives a hyperpolarizing pre-pulse, thereby reducing the stimulation threshold for the dorsal column fibers to subsequent depolarizing pulses.

7. 发明申请

US20060195159A1 System and method for choosing electrodes in an implanted stimulator device 审中-公开
标题翻译：用于在植入的刺激器装置中选择电极的系统和方法
公开(公告)号：US20060195159A1
公开(公告)日：2006-08-31
申请号：US11295168
申请日：2005-12-05
申请人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
发明人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
IPC分类号： A61N1/18
CPC分类号： A61N1/36135 , A61N1/36132 , A61N1/36185
摘要： A method of selecting of subset of electrodes in a stimulator device implanted in a patient for further clinical evaluation is disclosed. In one embodiment, the method comprises measuring at least first and second measurement for each of the plurality of electrodes that are indicative of the ability of the electrode if activated to provide useful therapy to the patient in which the stimulator device is implanted, such as electrode impedance, field potential, and nerve response. The measurements can be objective such as those measurements just mentioned, or can comprise subjective measurements which are quantified in response to qualitative feedback from the patient. A weight is then determined for each of the measurements, which may be a predetermined weight or determined on the basis of the variance of the measurement between the electrodes. The weight is then applied to each electrode measurement, which measurement may be normalized, and the weighted measurements for each electrode are preferably summed to arrive at a value which itself is indicative of a particular electrode's ability to provide useful therapy to the patient. These values can then be used to determine a subset of the electrodes useful for further clinical evaluation in the patient, which improved the accuracy and speeding determining appropriate patient therapy.
摘要翻译：公开了一种在植入患者中的刺激器装置中选择电极子集的方法，用于进一步的临床评价。在一个实施例中，该方法包括测量多个电极中的每个电极的至少第一和第二测量，其指示如果被激活的电极的能力为其中植入刺激器装置的患者提供有用的治疗，例如电极阻抗，场电位和神经反应。测量可以是客观的，例如刚刚提到的那些测量，或者可以包括根据来自患者的定性反馈量化的主观测量。然后为每个测量确定权重，其可以是预定权重，或者基于电极之间的测量方差来确定。然后将重量施加到每个电极测量，该测量可以被归一化，并且优选地将每个电极的加权测量相加以得到其本身指示特定电极向患者提供有用治疗的能力的值。然后可以使用这些值来确定用于患者进一步临床评估的电极子集，这提高了准确性并加快了确定适当的患者治疗。

8. 发明授权

US06850802B2 Selective brain stimulation using conditioning pulses 失效
标题翻译：选择性脑刺激使用调理脉冲
公开(公告)号：US06850802B2
公开(公告)日：2005-02-01
申请号：US10393026
申请日：2003-03-20
申请人： Jan Holsheimer
发明人： Jan Holsheimer
IPC分类号： A61N1/36
CPC分类号： A61N1/3604
摘要： Methods of electrically stimulating neural tissue of the brain are disclosed. A first electrode is placed in close proximity with tissue of a patient's brain (e.g., in the brain, or on or near the surface of the brain). A hyperpolariziag electrical pre-pulse is applied to the tissue through the first electrode wherein the tissue is more susceptible to subsequent electric stimulation. A subsequent depolarizing electrical pulse is applied to the tissue through the first electrode wherein an action potential is generated in the tissue.
摘要翻译：公开了电刺激脑组织的方法。将第一电极放置在患者大脑的组织（例如，在脑中，或在脑的表面上或附近）附近。超极化电气预脉冲通过第一电极施加到组织，其中组织对随后的电刺激更敏感。随后的去极化电脉冲通过第一电极施加到组织，其中在组织中产生动作电位。

9. 发明授权

US06421566B1 Selective dorsal column stimulation in SCS, using conditioning pulses 有权
公开(公告)号：US06421566B1
公开(公告)日：2002-07-16
申请号：US09591752
申请日：2000-06-12
申请人： Jan Holsheimer
发明人： Jan Holsheimer
IPC分类号： A61N136
CPC分类号： A61N1/3604
摘要： A system and method is described for preferentially stimulating dorsal column fibers while avoiding stimulation of dorsal root fibers. The invention applies hyperpolarizing pre-pulses and depolarizing pre-pulses to neural tissue, such as spinal cord tissue, through a lead placed over the spinal cord having the electrodes arranged on a line approximately transverse to the axis of the spine. To increase the threshold needed to stimulate dorsal root fibers, the anodal pulse given by each lateral contact of the electrodes has to be preceded by a depolarizing pre-pulse and simultaneously, the central electrode contact gives a hyperpolarizing pre-pulse, thereby reducing the stimulation threshold for the dorsal column fibers to subsequent depolarizing pulses.

10. 发明授权

US5501703A Multichannel apparatus for epidural spinal cord stimulator 失效
标题翻译：用于硬膜外脊髓刺激器的多通道装置
公开(公告)号：US5501703A
公开(公告)日：1996-03-26
申请号：US185616
申请日：1994-01-24
申请人： Jan Holsheimer , Johannes J. Struijk
发明人： Jan Holsheimer , Johannes J. Struijk
IPC分类号： A61N1/32 , A61N1/04 , A61N1/05 , A61N1/34
CPC分类号： A61N1/0551 , A61N1/36071 , A61N1/0553
摘要： Apparatus for multi-channel transverse epidural spinal cord stimulation uses a multi-channel pulse generator driving a plurality of electrodes mounted near the distal end of a lead. These electrodes are mounted in one or more lines, generally perpendicular to the lead axis, and have a planar surface along one surface of the lead. The lead is implanted adjacent to spinal cord dura mater with the electrodes transverse and facing the spinal cord. Pulses generated by the pulse generator for each channel are normally simultaneous, of equal amplitude and of equal duration, however the pulse generator is arranged such that pulses for each channel can selectably alternate in time, can selectably be of unequal amplitude, or both. The changes in pulse timing and magnitude permit shifting the electrical stimulation field and the resulting paresthesia pattern after installation to accommodate improper lead placement or postoperative dislocation and to minimize unwanted motor responses.
摘要翻译：用于多通道横向硬膜外脊髓刺激的装置使用多通道脉冲发生器驱动安装在铅的远端附近的多个电极。这些电极安装在大致垂直于引线轴线的一条或多条线上，并且沿引线的一个表面具有平坦表面。铅被植入邻近脊髓硬膜，电极横向并面向脊髓。由脉冲发生器为每个通道产生的脉冲通常是同步的，幅度相等且持续时间相等，然而脉冲发生器被布置成使得每个通道的脉冲可以可选择地在时间上交替，可以选择地具有不等的幅度，或者两者。脉冲定时和幅度的变化允许在安装后移动电刺激场和所得的感觉异常模式，以适应不适当的引线放置或术后位错并且最小化不需要的运动反应。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式