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    • 2. 发明申请
    • Dye composition and method for detection of demineralized lesions in teeth
    • 染色组合物和牙齿脱矿质病变检测方法
    • US20050058602A1
    • 2005-03-17
    • US10894553
    • 2004-07-20
    • Nivedita RamjiJamesina Fitzgerald
    • Nivedita RamjiJamesina Fitzgerald
    • A61K8/46A61K8/49A61K49/00A61Q11/00A61K7/16A61K7/18
    • A61Q11/00A61K8/466A61K8/492A61K8/498A61K49/0063A61K2800/43A61K2800/88
    • The present invention relates to an oral care dye composition for detection of demineralization lesions comprising: a first phase (or first composition) comprising from about 0.1% to about 10% by weight of the composition of a blue dye and mixtures thereof; a second phase (or second composition) comprising from about 0.1% to about 10% by weight of the composition of a red dye or a yellow dye or mixtures thereof; a safe and effective amount of a solvent wherein the dye is soluble in the solvent; and optionally a safe and effective amount of a flavor; wherein the composition is effective for detection of demineralized lesions. The present invention further relates to method of visually highlighting demineralization lesions, in tooth surfaces, or a method of detecting the mineralization health of teeth, wherein the above dye composition is applied to the oral cavity or to the teeth, of a human or animal subject, in need thereof. In one embodiment a first dye composition and a second dye composition are applied, sequentially, to a human or animal subject's oral cavity or teeth, in need thereof, wherein after the dye compositions are applied, the teeth are visually observed to assess demineralized lesions stained by the dyes.
    • 本发明涉及一种用于检测脱矿质损伤的口腔护理染料组合物,其包含:第一相(或第一组合物),其包含组合物的约0.1重量%至约10重量%的蓝色染料及其混合物; 第二相(或第二组合物),其包含按组合物重量计约0.1%至约10%的红色染料或黄色染料或其混合物; 安全有效量的溶剂,其中染料可溶于溶剂中; 和任选地安全有效量的风味剂; 其中所述组合物对于去除软化病变的检测是有效的。 本发明还涉及在视觉上突出牙齿表面的脱矿质损伤的方法或检测牙齿的矿化健康的方法,其中将上述染料组合物施用于人或动物受试者的口腔或牙齿 ,需要它。 在一个实施方案中,将第一染料组合物和第二染料组合物依次施用于需要其的人或动物受试者的口腔或牙齿,其中在施用染料组合物后,目视观察牙齿以评估染色的软化病变 由染料。