专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4729876A Blood analysis system 失效
标题翻译：血液分析系统
公开(公告)号：US4729876A
公开(公告)日：1988-03-08
申请号：US931894
申请日：1986-11-17
申请人： James W. Hennessy , Henry R. Angel , William J. Casey, Jr. , Samuel P. Baron
发明人： James W. Hennessy , Henry R. Angel , William J. Casey, Jr. , Samuel P. Baron
IPC分类号： G01N1/00 , G01N15/12 , B01L11/00
CPC分类号： G01N35/1097 , G01N15/1209
摘要： A blood analyzer is provided with means to automatically pierce the sealed closure of a vacuum container or to aspirate through an aspirator tip blood samples to be analyzed. The samples are drawn serially through a repositionable valve structure, preferably of rotary form, and having three members in layers with aligned ports in one position to receive the blood that is drawn through the valve by a syringe type aspirator. Another position of the valve connects diluent supplies providing measured amounts of diluent to wash out the bores of the middle member of the valve containing amounts of blood measured by the size of the bores. In the case of the red blood cell measurement, where the bore is extremely small, a larger by-pass port is provided in parallel with the sample containing bore to allow more rapid flow simultaneously through both.Blood analysis is performed by separate conventional cell counter arrangements for each of the red and white counts. A novel configuration involves a bore through a block generally tangential to a bore which engages a cylindrical chamber in the sidewall of which is a jewel orifice. A foil electrode is used in the tangential passage and a larger tapered electrode with the smaller end near the orifice in the cylindrical output chamber. A discontinuity in the form of an air bubble in a passage feeding the counter apparatus enables the position of the bubble to be sensed at one place to turn on the counter and in another place in the passage to turn off the counter.The three-layer valve structure has various special indexing features and cleaning features, and the intake devices have features associated with cleaning as well.
摘要翻译：血液分析仪具有自动穿透真空容器的密封封闭件或通过抽吸器尖端吸取要分析的血样的装置。样品通过优选旋转形式的可重新定位的阀结构串联绘制，并且具有三个部件，其中对齐的端口处于一个位置，以接收通过注射器型抽吸器抽吸通过该阀的血液。阀的另一位置连接稀释剂供应源，提供测量量的稀释剂以冲洗含有由孔尺寸测量的血量的阀的中间构件的孔。在红细胞测量的情况下，其中孔非常小，与样品容纳孔平行地设置较大的旁路端口，以允许通过两者同时更快速地流动。通过用于红色和白色计数中的每一个的单独的常规细胞计数器装置进行血液分析。一种新颖的构造包括穿过大致与孔相切的块的孔，孔与其侧壁中的圆柱形室相接合，该圆柱形腔是宝石孔。在切向通道中使用箔电极，在圆柱形输出室中使用较大的锥形电极，较小的端部靠近孔口。通过供给对置装置的通道中的气泡形式的不连续性使得能够在一个地方感测气泡的位置以打开计数器并且在通道中的另一位置关闭计数器。三层阀结构具有各种特殊的分度特征和清洁特征，进气装置也具有清洗功能。

2. 发明授权

US4042808A Particle count correction 失效
标题翻译：粒子数校正
公开(公告)号：US4042808A
公开(公告)日：1977-08-16
申请号：US603586
申请日：1975-08-11
申请人： James W. Hennessy , Henry R. Angel , Bernard O. Bachenheimer
发明人： James W. Hennessy , Henry R. Angel , Bernard O. Bachenheimer
IPC分类号： G01N15/12 , G06M11/00 , H03K21/00
CPC分类号： H03K21/00 , G01N15/1227 , G06M11/00
摘要： A method and apparatus for correcting the output count of an electronic particle counting system in which additional correction pulses are added to the pulses generated by the electronic counting system as a result of detecting particles flowing through an orifice. The correction pulses are added in accordance with a curve which is generated by statistical computation determined by the size of the orifice and the character of the particles being detected therein and their quantity per unit volume. The improved apparatus comprises the addition of a second counter chain to the system which includes digital counters having outputs at various frequencies which are dividends of the frequency of the input pulses. The various-frequency outputs are combined through logic circuitry to generate individual correction pulses at frequencies such that when the pulses are added to the detected pulses, the total of the pulses corresponds to the actual number of particles flowing through the orifice.
摘要翻译：一种用于校正电子粒子计数系统的输出计数的方法和装置，其中附加的校正脉冲被附加到由电子计数系统产生的脉冲中，作为检测流过孔的粒子的结果。校正脉冲根据通过由孔的尺寸和被检测的颗粒的特性及其每单位体积的量确定的统计计算产生的曲线相加。改进的装置包括向系统添加第二反向链，该系统包括具有各种频率的输出的数字计数器，这些输出是输入脉冲的频率的除数。各种频率输出通过逻辑电路组合以在频率处产生单独的校正脉冲，使得当脉冲被添加到检测到的脉冲时，脉冲的总数对应于流过孔的实际颗粒数。

3. 发明授权

US4706207A Count accuracy control means for a blood analyses system 失效
标题翻译：用于血液分析系统的计数精度控制装置
公开(公告)号：US4706207A
公开(公告)日：1987-11-10
申请号：US748003
申请日：1985-06-24
申请人： James W. Hennessy , Henry R. Angel , Richard A. Carlson
发明人： James W. Hennessy , Henry R. Angel , Richard A. Carlson
IPC分类号： G01N33/49 , G01N1/00 , G01N15/12 , G01N35/00 , G01N33/48 , G06M11/04
CPC分类号： G01N35/1097 , G01N15/12 , G01N2035/00306 , G01N2035/00316
摘要： An apparatus for making blood counts is provided with computer and instrument control to optimize performance of the apparatus. Means for counting blood cells such as platelets, white blood and red blood cells enables a plot of the number of particles counted in each of the adjacent bands or channels inclusive within a selected range of particle size so that a plot of count against particle size may be made. The computer enables analyses of plots thus obtained by system algorithms in order to correct errors of various types which may occur in the plot. For example, by calculating the logarithms of the counts of particles and of mean particle size for each particle size channel, a further plot of log count against log of blood particle size of generally symmetrical bell shape may be generated. The computer further calculates change of logarithm (.DELTA. log) of counts in adjacent channels. A straight line of fixed slope is then plotted representing the change of logarithm counts against the logarithm of blood particle size, giving more weight to those points near the peak. The calculation steps are reversed using the points on the straight line for ultimately calculating counts in the various channels from .DELTA. log and taking the anti-log of the log particle size to regenerate a new curve showing more accurately distribution of the selected blood particles against particle size.
摘要翻译：提供血液计数的装置具有计算机和仪器控制以优化装置的性能。用于计数诸如血小板，白血球和红细胞之类的血液细胞的方法能够在所选择的粒径范围内计算每个相邻条带或通道中的每个相邻条带中计数的颗粒数的图，使得计数与粒径的比例可以做成计算机能够对由系统算法获得的图进行分析，以纠正图中可能发生的各种类型的错误。例如，通过计算每个粒子通道的粒子计数和平均粒度的对数，可以产生对数计数与大致对称钟形状的血液粒子大小对数的另一个曲线图。计算机进一步计算相邻信道中计数的对数（DELTA log）的变化。然后绘制一条固定斜率的直线，表示对数计数与血液粒径对数的变化，给予靠近峰值的点更多的重量。计算步骤使用直线上的点反转，最终从DELTA对数计算各种通道中的计数，并采用对数粒子的反对数来重新生成显示更准确地分配所选血液颗粒对颗粒的新曲线尺寸。

4. 发明授权

US4296373A Hematology cell counting apparatus incorporating multiple transducers for sequential operation 失效
标题翻译：包含多个换能器的血液细胞计数装置用于顺序操作
公开(公告)号：US4296373A
公开(公告)日：1981-10-20
申请号：US57045
申请日：1979-07-12
申请人： Henry R. Angel , James W. Hennessy
发明人： Henry R. Angel , James W. Hennessy
IPC分类号： G01N15/12 , G01N27/00
CPC分类号： G01N15/12 , G01N15/1245
摘要： In particle counting apparatus such as a hematology parameter measurement apparatus for performing multiple measurements on one blood sample, first and second impedance transducers, each including inner and outer electrodes, are provided for selective hydraulic connection to a probe head including one set of pressure ports and a further inner electrode. The first and second transducers are respectively immersed in first and second dilutions of the sample. Measurements on each dilution are made in a conventional manner. The inner electrodes are connected in parallel as are the outer electrodes so that small liquid passageways may be provided between the transducers and the probe head while maintaining a low impedance in the liquid path. Means are provided for selecting the sequence of operations and are provided to increase the throughput of samples for which multiple measurements are made.
摘要翻译：在用于对一个血液样本进行多次测量的血液学参数测量装置的颗粒计数装置中，设置有包括内部和外部电极的第一和第二阻抗换能器，用于与包括一组压力端口的探头的选择性液压连接，另一个内部电极。第一和第二换能器分别浸入样品的第一和第二稀释液中。以常规方式进行每种稀释度的测量。内部电极与外部电极并联连接，使得可以在换能器和探针头之间提供小的液体通道，同时在液体路径中保持低阻抗。提供了用于选择操作序列的手段，并且被提供以增加进行多次测量的样本的吞吐量。

5. 发明授权

US4167038A Calculated parameter generation in a hematology parameter measurement apparatus 失效
标题翻译：血液参数测量仪器中计算参数的产生
公开(公告)号：US4167038A
公开(公告)日：1979-09-04
申请号：US842508
申请日：1977-10-17
申请人： James W. Hennessy
发明人： James W. Hennessy
IPC分类号： G01N15/12 , G01N27/00 , G06F15/42
CPC分类号： G01N15/1227
摘要： In a hematology parameter measuring apparatus, signals indicative of measured parameters are obtained and loaded into first digital registers. Calculated parameter values are generated through use of the values stored in the digital registers. A first parameter value is circulated from a register into a digital divider through a digital data line to set a divisor in the divider. A control circuit circulates a value from another register to the divider for utilization as a signal indicative of a dividend. The output of the divider is coupled to a result register to store a value indicative of the calculated parameter. In this manner, calculated parameter values are obtained, and the first registers retain values indicative of the measured parameter values. The control means may selectively couple signals to a display from any of the registers or to a printing unit.
摘要翻译：在血液学参数测量装置中，获得指示测量参数的信号并加载到第一数字寄存器中。通过使用数字寄存器中存储的值生成计算的参数值。第一个参数值通过数字数据线从寄存器循环到数字分频器，以设置分频器中的除数。控制电路将值从另一寄存器循环到分频器，以用作表示分红的信号。分频器的输出耦合到结果寄存器以存储指示计算参数的值。以这种方式，获得计算的参数值，并且第一寄存器保持指示所测量的参数值的值。控制装置可以选择性地将信号从任何寄存器或打印单元耦合到显示器。

6. 发明授权

US3973189A Hematology system 失效
标题翻译：血液系统
公开(公告)号：US3973189A
公开(公告)日：1976-08-03
申请号：US544643
申请日：1975-01-27
申请人： Henry R. Angel , Arthur R. Oefinger , James W. Hennessy
发明人： Henry R. Angel , Arthur R. Oefinger , James W. Hennessy
IPC分类号： G01N15/12 , G01N27/00
CPC分类号： G01N15/12
摘要： A system for counting electrical pulses representing red and white blood cells and for determining hematocrit, mean corpuscular volume and hemoglobin in association with the blood cell counts. The system includes a blood cell transducer through which a blood sample is caused to flow and operative to produce electrical pulses in response to the passage of cells through a metering aperture. Red and white blood cell counts are electronically accumulated during respective analytical runs and logic circuitry is provided for determining, during a red blood cell counting run, mean corpuscular volume and hematocrit. The system can also include correction circuitry to correct for the coincident passage of cells through the metering aperture.
摘要翻译：用于计数表示红细胞和白细胞的电脉冲并用于与血细胞计数相关的红细胞比容，平均红细胞体积和血红蛋白的计数系统。该系统包括血细胞转换器，血液样本通过该血细胞转换器流动并且可操作以响应于细胞通过计量孔而产生电脉冲。红色和白细胞计数在各自的分析运行期间被电子累积，并提供逻辑电路用于在红细胞计数运行期间确定平均红细胞体积和血细胞比容。该系统还可以包括校正电路，以校正细胞通过计量孔的重合通道。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式