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    • 1. 发明授权
    • Veneer roughness detection
    • 单板粗糙度检测
    • US07777897B1
    • 2010-08-17
    • US11900285
    • 2007-09-10
    • James Sheridan Gibbons
    • James Sheridan Gibbons
    • G01B11/30
    • G01B11/303
    • A sample surface such as a surface of a wood veneer sheet is illuminated by a dual color light system and electronically scanned with a color line scan camera. The light system provides red and green light fluxes that are incident to a veneer surface from different directions, and corresponding line images associated with the red and green light fluxes are processed by rescaling, linear to log conversion, edge filtering, and/or thresholding to provide binary surface maps associated with veneer surface roughness.
    • 样品表面如木皮单板的表面被双色光系统照亮并用彩色线扫描照相机电子扫描。 光系统提供从不同方向入射到单板表面的红色和绿色光束,并且通过重新缩放,线性对数转换,边缘滤波和/或阈值处理来处理与红色和绿色光通量相关联的对应线形图像 提供与单板表面粗糙度相关的二进制表面贴图。
    • 5. 发明授权
    • Assembly and screening of highly complex and fully human antibody repertoire in yeast
    • 组装和筛选酵母中高度复杂和完全的人体抗体谱
    • US06610472B1
    • 2003-08-26
    • US09703399
    • 2000-10-31
    • Li ZhuShaobing Benjamin HuaJames SheridanYu-Huei Lin
    • Li ZhuShaobing Benjamin HuaJames SheridanYu-Huei Lin
    • G01N3353
    • C40B30/04C07K16/00C07K2317/21C07K2317/55C12Q1/6897G01N33/6845C12Q2565/201
    • Compositions, methods, and kits are provided for efficiently generating and screening a library of highly diverse protein complexes for their ability to bind to other proteins or oligonucleotide sequences. In one aspect of the invention, a library of expression vectors is provided for expressing the library of protein complexes. The library comprises a first nucleotide sequence encoding a first polypeptide subunit; and a second nucleotide sequence encoding a second polypeptide subunit. The first and second nucleotide sequences each independently varies within the library of expression vectors. In addition, the first and second polypeptide subunit are expressed as separate proteins which self-assemble to form a protein complex, such as a double-chain antibody fragment (dcFv or Fab) and a fully assembled antibody, in cells into which the library of expression vectors are introduced. The library of expression vectors can be efficiently generated in yeast cells through homologous recombination; and the encoded proteins complexes with high binding affinity to their target molecule can be selected by high throughput screening in vivo or in vitro.
    • 提供了组合物,方法和试剂盒,用于有效地产生和筛选高度多样化的蛋白质复合物的文库以获得与其它蛋白质或寡核苷酸序列结合的能力。 在本发明的一个方面,提供表达载体文库用于表达蛋白质复合物的文库。 该文库包含编码第一多肽亚基的第一核苷酸序列; 和编码第二多肽亚基的第二核苷酸序列。 第一和第二核苷酸序列各自独立地在表达载体的文库内变化。 此外,第一和第二多肽亚基表达为分离的蛋白,其自组装形成蛋白复合物,例如双链抗体片段(dcFv或Fab)和完全组装的抗体,其中文库 引入表达载体。 表达载体文库可以通过同源重组在酵母细胞中有效产生; 并且可以通过体内或体外的高通量筛选来选择对其靶分子具有高结合亲和力的编码蛋白复合物。
    • 7. 发明申请
    • EXPANDABLE REFRIGERATION SYSTEM FOR VEHICLES
    • 用于车辆的可扩展制冷系统
    • US20160089953A1
    • 2016-03-31
    • US14850182
    • 2015-09-10
    • James SheridanJennifer Sheridan
    • James SheridanJennifer Sheridan
    • B60H1/00
    • B60H1/00542B60H1/00478B60N3/104B65D5/36F25B21/02F25D3/08
    • An expandable refrigeration system for vehicles includes a generally rigid frame member having a plurality of walls that define a first hollow interior space. An expandable cooler body that includes a plurality of expandable wall sections is connected to the rigid frame member. The expandable body section is positioned within the first hollow interior space when the system is collapsed, and extends outward therefrom when the system is in the expanded configuration. A refrigeration unit is secured to the rigid frame member and controls a temperature of the expandable body section. A transitional wall member selectively operates as a lid for the cooler body and to secure the cooler body within the frame member.
    • 用于车辆的可膨胀制冷系统包括具有限定第一中空内部空间的多个壁的大致刚性的框架构件。 包括多个可膨胀壁部分的可膨胀冷却器主体连接到刚性框架构件。 当系统折叠时,可膨胀体部分定位在第一中空内部空间内,并且当系统处于膨胀构型时从其向外延伸。 制冷单元被固定到刚性框架构件并且控制可膨胀体部分的温度。 过渡壁构件选择性地作为冷却器主体的盖子操作并将冷却器本体固定在框架构件内。
    • 8. 发明申请
    • Rainstopper - The Sunroof Shield
    • Rainstopper - 天窗
    • US20100326609A1
    • 2010-12-30
    • US12386159
    • 2009-04-14
    • Thomas James Sheridan
    • Thomas James Sheridan
    • B60J10/04
    • B60J11/04
    • The problem with sunroofs on vehicles, is that they sometimes leak, as mine does. I tried various forms of quick fixes, besides having it fixed correctly and more expensively. One day, after the tin foil I used blew off (it actually sticks when the roof is wet) I began thinking what could possibly exist that was durable and would ‘stick’ to the roof. This is when I thought up my idea of the The Rainstopper-Sunroof Shield.Using a flexible magnetic sheet, I was able to fabricate a shape that would cover the seal zone of the sunroof. Then with the help of the magnetic properties of the sheet, the roof now had a covering that would stick in place and help prevent major leaks during a windy rainstorm & downpour.The specific improvement of this device is the new application for the use of the flexible magnetic sheets. Currently, they are used primarily for sign making/business advertising purposes.
    • 车上天窗的问题是,它们有时像我的那样泄漏。 我尝试了各种形式的快速修复,除了正确和更昂贵地修复。 有一天,在我使用的锡箔被吹掉之后(当屋顶是湿的时候,它实际上是粘在一起的),我开始想到可能存在的可能是耐用的并且会“贴在屋顶上”。 这是当我想到了“Rainstopper-Sunroof Shield”的想法。 使用柔性磁性片,我能够制造一种能覆盖天窗密封区的形状。 然后在片材的磁性能的帮助下,屋顶现在有一个覆盖物将粘在适当位置,有助于防止在大风暴雨暴雨期间发生大的泄漏。 该设备的具体改进是使用柔性磁性片的新应用。 目前,它们主要用于签字/商业广告用途。