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1. 发明授权

US09357937B2 System and method for determining stroke volume of an individual 有权
标题翻译：用于确定个体的搏动量的系统和方法
公开(公告)号：US09357937B2
公开(公告)日：2016-06-07
申请号：US13605626
申请日：2012-09-06
申请人： James Nicholas Watson , Paul Stanley Addison
发明人： James Nicholas Watson , Paul Stanley Addison
IPC分类号： A61B5/0265 , A61B5/0285 , A61B5/029 , A61B5/0295
CPC分类号： A61B5/0265 , A61B5/0285 , A61B5/029 , A61B5/0295
摘要： A system for determining stroke volume of an individual. The system includes a skew-determining module that is configured to calculate a first derivative of photoplethysmogram (PPG) signals of the individual. The first derivative forms a derivative waveform. The skew-determining module is configured to determine a skew metric of the first derivative, wherein the skew metric is indicative of a morphology of at least one pulse wave detected from blood flow of the individual in the derivative waveform. The system also includes an analysis module that is configured to determine a stroke volume of the individual. The stroke volume is a function of the skew metric of the first derivative.
摘要翻译：一种用于确定个体的搏动量的系统。该系统包括偏差确定模块，其被配置为计算个体的光谱体积描记图（PPG）信号的一阶导数。一阶导数形成导数波形。偏移确定模块被配置为确定一阶导数的偏斜量度，其中偏斜度量指示从导数波形中个体的血流检测到的至少一个脉搏波的形态。该系统还包括分析模块，该分析模块被配置为确定个人的冲程体积。行程体积是一阶导数的偏差度量的函数。

2. 发明授权

US09066691B2 Using a continuous wavelet transform to generate a reference signal 有权
标题翻译：使用连续小波变换产生参考信号
公开(公告)号：US09066691B2
公开(公告)日：2015-06-30
申请号：US12245425
申请日：2008-10-03
申请人： Paul Stanley Addison , James Nicholas Watson
发明人： Paul Stanley Addison , James Nicholas Watson
IPC分类号： A61B5/1455 , A61B5/00 , G06K9/64
CPC分类号： A61B5/726 , A61B5/14551 , A61B5/7203
摘要： According to embodiments, systems and methods for generating reference signals are provided. A signal may be transformed using a continuous wavelet transform. Regions of interest may be selected from a transform or the resulting scalogram that may be used to generate a reference signal to use in filtering the signal or other signals. Cross-correlation techniques may be used to cancel noise components or isolate non-noise components from the signal. A physiological parameter may then be determined from the filtered signal or isolated components in the signal.
摘要翻译：根据实施例，提供了用于产生参考信号的系统和方法。可以使用连续小波变换来变换信号。感兴趣区域可以从可用于生成用于滤波信号或其他信号的参考信号的变换或生成的标尺中选择。可以使用互相关技术来消除噪声分量或从信号中隔离非噪声分量。然后可以从经滤波的信号或信号中的隔离分量确定生理参数。

3. 发明授权

US09060745B2 System and method for detecting fluid responsiveness of a patient 有权
标题翻译：用于检测患者的液体反应性的系统和方法
公开(公告)号：US09060745B2
公开(公告)日：2015-06-23
申请号：US13591455
申请日：2012-08-22
申请人： Mark Su , James Nicholas Watson , Paul Stanley Addison
发明人： Mark Su , James Nicholas Watson , Paul Stanley Addison
IPC分类号： A61B5/00 , A61B5/024 , A61B5/0245 , A61B5/026 , A61B5/1455 , A61B5/1495 , A61B6/00 , A61B8/06 , A61B5/0432 , A61B5/05
CPC分类号： A61B5/14552 , A61B5/0059 , A61B5/02007 , A61B5/0205 , A61B5/02416 , A61B5/0245 , A61B5/026 , A61B5/0261 , A61B5/0295 , A61B5/0432 , A61B5/0507 , A61B5/1495 , A61B5/4839 , A61B5/486 , A61B5/6826 , A61B5/7214 , A61B5/7225 , A61B5/7278 , A61B5/742 , A61B6/507 , A61B8/06
摘要： A system is configured to determine a fluid responsiveness index of a patient from a physiological signal. The system may include a sensor configured to be secured to an anatomical portion of the patient, and a monitor operatively connected to the sensor. The sensor is configured to sense a physiological characteristic of the patient. The monitor is configured to receive a physiological signal from the sensor. The monitor may include an index-determining module configured to determine the fluid responsiveness index through formation of a ratio of one or both of amplitude or frequency modulation of the physiological signal to baseline modulation of the physiological signal.
摘要翻译：系统被配置为从生理信号确定患者的流体反应性指数。系统可以包括被配置为固定到患者的解剖部分的传感器，以及可操作地连接到传感器的监视器。传感器被配置为感测患者的生理特征。监视器被配置成从传感器接收生理信号。监视器可以包括索引确定模块，其被配置为通过形成生理信号的幅度或频率调制与生理信号的基线调制之间的一个或两个的比率来确定流体响应性指数。

4. 发明授权

US08696585B2 Detecting a probe-off event in a measurement system 有权
标题翻译：检测测量系统中的探测事件
公开(公告)号：US08696585B2
公开(公告)日：2014-04-15
申请号：US12242894
申请日：2008-09-30
申请人： Paul Stanley Addison , James Nicholas Watson
发明人： Paul Stanley Addison , James Nicholas Watson
IPC分类号： A61B5/02 , A61B8/14
CPC分类号： G06K9/527 , A61B5/14551 , A61B5/6843 , A61B5/726
摘要： According to embodiments, techniques for detecting probe-off events are disclosed. A sensor or probe may be used to obtain a plethysmograph or photoplethysmograph (PPG) signal from a subject. A wavelet transform of the signal may be performed and a scalogram may be generated based at least in part on the wavelet transform. One or more characteristics of the scalogram may be determined. The determined characteristics may include, for example, an energy decrease, a broadscale high-energy cone, a regular, repeated high-scale pattern, a low-scale information pattern; and a pulse band. The absence or presence of these and other characteristics, along with information about the characteristics, may be analyzed to detect a probe-off event. A confidence indicator may be calculated in connection with probe-off event detections and alarms may be generated when probe-off events occur.
摘要翻译：根据实施例，公开了用于检测探测事件的技术。可以使用传感器或探针来获得来自受试者的体积描记器或光电体积描记器（PPG）信号。可以执行信号的小波变换，并且可以至少部分地基于小波变换来生成缩放图。可以确定缩放图的一个或多个特征。确定的特性可以包括例如能量减少，大尺度高能量锥，规则的，重复的高比例图案，低比例的信息图案; 和脉冲带。可以分析这些和其他特征的缺失或存在以及关于特征的信息以检测探测事件。可以结合探测事件检测计算置信指标，并且可以在发生探测事件时生成报警。

5. 发明申请

US20140073962A1 SYSTEM AND METHOD FOR DETERMINING STROKE VOLUME OF A PATIENT 有权
标题翻译：用于确定患者体重的系统和方法
公开(公告)号：US20140073962A1
公开(公告)日：2014-03-13
申请号：US13609566
申请日：2012-09-11
申请人： Paul Stanley Addison , James Nicholas Watson
发明人： Paul Stanley Addison , James Nicholas Watson
IPC分类号： A61B6/00
CPC分类号： A61B5/029 , A61B5/024 , A61B5/02416 , A61B5/02427 , A61B5/0261 , A61B5/14551 , A61B5/742 , A61B8/02
摘要： A PPG system for determining a stroke volume of a patient includes a PPG sensor configured to be secured to an anatomical portion of the patient. The PPG sensor is configured to sense a physiological characteristic of the patient. The PPG system may include a monitor operatively connected to the PPG sensor. The monitor receives a PPG signal from the PPG sensor. The monitor includes a pulse trending module determining a slope transit time of an upslope of a primary peak of the PPG signal. The pulse trending module determines a stroke volume of the patient as a function of the slope transit time.
摘要翻译：用于确定患者的行程体积的PPG系统包括被配置为固定到患者的解剖部分上的PPG传感器。 PPG传感器被配置为感测患者的生理特征。 PPG系统可以包括可操作地连接到PPG传感器的监视器。监视器从PPG传感器接收PPG信号。监视器包括确定PPG信号的主峰的上坡的斜率通过时间的脉冲趋势模块。脉冲趋势模块根据斜率通过时间确定患者的搏动量。

6. 发明申请

US20140066732A1 SYSTEM AND METHOD FOR DETERMINING CARDIAC OUTPUT 审中-公开
标题翻译：用于确定心脏输出的系统和方法
公开(公告)号：US20140066732A1
公开(公告)日：2014-03-06
申请号：US13597501
申请日：2012-08-29
申请人： Paul Stanley Addison , James Nicholas Watson
发明人： Paul Stanley Addison , James Nicholas Watson
IPC分类号： A61B5/0205 , A61B5/021 , A61B6/00
CPC分类号： A61B5/029 , A61B5/021 , A61B5/1455
摘要： A system is configured to determine cardiac output of a patient. The system may include a first sub-system configured to detect a first physiological signal, and a second sub-system configured to detect a second physiological signal that differs from the first physiological signal. The first and second sub-systems may be separate and distinct from one another. The system may also include a cardiac output determination module that is configured to determine the cardiac output based, at least in part, on the first and second physiological signals.
摘要翻译：系统被配置为确定患者的心输出量。该系统可以包括配置成检测第一生理信号的第一子系统，以及配置成检测不同于第一生理信号的第二生理信号的第二子系统。第一和第二子系统可以是分离的并且彼此不同。该系统还可以包括心输出确定模块，其被配置为至少部分地基于第一和第二生理信号来确定心输出量。

7. 发明申请

US20140058229A1 SYSTEM AND METHOD FOR DETECTING FLUID RESPONSIVENESS OF A PATIENT 有权
标题翻译：用于检测患者的流体反应的系统和方法
公开(公告)号：US20140058229A1
公开(公告)日：2014-02-27
申请号：US13591455
申请日：2012-08-22
申请人： Mark Su , James Nicholas Watson , Paul Stanley Addison
发明人： Mark Su , James Nicholas Watson , Paul Stanley Addison
IPC分类号： A61B6/00 , A61B5/1455
CPC分类号： A61B5/14552 , A61B5/0059 , A61B5/02007 , A61B5/0205 , A61B5/02416 , A61B5/0245 , A61B5/026 , A61B5/0261 , A61B5/0295 , A61B5/0432 , A61B5/0507 , A61B5/1495 , A61B5/4839 , A61B5/486 , A61B5/6826 , A61B5/7214 , A61B5/7225 , A61B5/7278 , A61B5/742 , A61B6/507 , A61B8/06
摘要： A system is configured to determine a fluid responsiveness index of a patient from a physiological signal. The system may include a sensor configured to be secured to an anatomical portion of the patient, and a monitor operatively connected to the sensor. The sensor is configured to sense a physiological characteristic of the patient. The monitor is configured to receive a physiological signal from the sensor. The monitor may include an index-determining module configured to determine the fluid responsiveness index through formation of a ratio of one or both of amplitude or frequency modulation of the physiological signal to baseline modulation of the physiological signal.
摘要翻译：系统被配置为从生理信号确定患者的流体反应性指数。系统可以包括被配置为固定到患者的解剖部分的传感器，以及可操作地连接到传感器的监视器。传感器被配置为感测患者的生理特征。监视器被配置为从传感器接收生理信号。监视器可以包括索引确定模块，其被配置为通过形成生理信号的幅度或频率调制与生理信号的基线调制之间的一个或两个的比率来确定流体响应性指数。

8. 发明授权

US08433524B2 Low perfusion signal processing systems and methods 有权
标题翻译：低灌注信号处理系统和方法
公开(公告)号：US08433524B2
公开(公告)日：2013-04-30
申请号：US13215349
申请日：2011-08-23
申请人： James Nicholas Watson , Paul Stanley Addison , Edward M McKenna
发明人： James Nicholas Watson , Paul Stanley Addison , Edward M McKenna
IPC分类号： G06F19/10
CPC分类号： G06F19/10 , A61B5/0261 , A61B5/1455 , A61B5/726 , G01N33/48
摘要： In some embodiments, systems and methods for identifying a low perfusion condition are provided by transforming a signal using a wavelet transform to generate a scalogram. A pulse band and adjacent marker regions in the scalogram are identified. Characteristics of the marker regions are used to detect the existence of a lower perfusion condition. If such a condition is detected, an event may be triggered, such as an alert or notification.
摘要翻译：在一些实施例中，用于识别低灌注条件的系统和方法通过使用小波变换变换信号以产生缩放图来提供。识别出标尺中的脉冲带和相邻的标记区域。标记区域的特征用于检测较低灌注条件的存在。如果检测到这种情况，则可能触发事件，例如警报或通知。

9. 发明申请

US20130046185A1 METHOD OF ANALYZING AND PROCESSING SIGNALS 有权
公开(公告)号：US20130046185A1
公开(公告)日：2013-02-21
申请号：US13590111
申请日：2012-08-20
申请人： Paul Stanley Addison , James Nicholas Watson
发明人： Paul Stanley Addison , James Nicholas Watson
IPC分类号： A61B6/00 , A61B5/08
CPC分类号： A61B5/726 , A61B5/0002 , A61B5/0082 , A61B5/02416 , A61B5/02438 , A61B5/0816 , A61B5/14551 , A61B5/14552 , A61B5/4818 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B5/6896 , A61B5/7207 , A61B5/7214 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B2503/06 , G01N21/3151 , G06F19/00
摘要： A physiological measurement system is disclosed which can take a pulse oximetry signal such as a photoplethysmogram from a patient and then analyse the signal to measure physiological parameters including respiration, pulse, oxygen saturation and movement. The system comprises a pulse oximeter which includes a light emitting device and a photodetector attachable to a subject to obtain a pulse oximetry signal; analogue to digital converter means arranged to convert said pulse oximetry signal into a digital pulse oximetry signal; signal processing means suitable to receive said digital pulse oximetry signal and arranged to decompose that signal by wavelet transform means; feature extraction means arranged to derive physiological information from the decomposed signal; an analyser component arranged to collect information from the feature extraction means; and data output means arranged in communication with the analyser component.

10. 发明申请

US20120278001A1 Signal Procesing Systems and Methods Using Basis Functions and Wavelet Transforms 审中-公开
公开(公告)号：US20120278001A1
公开(公告)日：2012-11-01
申请号：US13547012
申请日：2012-07-11
申请人： James Nicholas Watson , Paul Stanley Addison
发明人： James Nicholas Watson , Paul Stanley Addison
IPC分类号： G06F19/00
CPC分类号： A61B5/00 , A61B5/14551 , A61B5/7203 , A61B5/726 , G06K9/00516
摘要： According to embodiments, systems and methods are provided that use continuous wavelet transforms and basis functions to provide an optimized system for the determination of physiological information. In an embodiment, the basis functions may be used to refine an area of interest in the signal in frequency or in time, and the continuous wavelet transform may be used to identify a maxima ridge in the scalogram at scales with characteristic frequencies proximal to the frequency or frequencies of interest. In another embodiment, a wavelet transform may be used to identify regions of a signal with the morphology of interest while basis functions may be used to focus on these regions to determine or filter information of interest. In yet another embodiment, basis functions and continuous wavelet transforms may be used concurrently and their results combined to form optimized information or a confidence metric for determined physiological information.

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