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1. 发明申请

US20070111219A1 Label integrity verification of chemical array data 审中-公开
标题翻译：化学阵列数据的标签完整性验证
公开(公告)号：US20070111219A1
公开(公告)日：2007-05-17
申请号：US11283453
申请日：2005-11-17
申请人： James Minor
发明人： James Minor
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G01N33/582
摘要： Methods, systems and computer readable media for checking label integrity of labeled biopolymers in a sample assayed by chemical array analysis. A sample is divided into equal aliquots. At least first and second labels are incorporated into biopolymers contained in first and second aliquots of the equal aliquots, respectively. The labels are added to the aliquots in amounts expected to incorporate into the biopolymers of the respective aliquots to produce signals of proportional quantity when read from probes on a chemical array designed to couple with biopolymers of the aliquots. The aliquots are then combined into a single, multi-labeled sample having at least first-labeled biopolymers and second-labeled biopolymers. The multi-labeled sample is hybridized with probes on a chemical array. Signal values are read from the probes on the chemical array bound to labeled biopolymers from the multi-labeled sample. Comparisons are made between signal values from probes bound to biopolymer having the first label incorporated therein (first-labeled signal values) and signal values from the same probes bound to biopolymers having the second label incorporated therein (second-labeled signal values), respectively, from which it is determined that label integrity is of acceptable quality if divergence between the first-labeled signal values and the second-labeled signal values is less than a predetermined threshold value.
摘要翻译：用于检查通过化学阵列分析测定的样品中标记的生物聚合物的标记完整性的方法，系统和计算机可读介质。样品分成等份。至少第一和第二标签分别并入等份的第一等份和第二等分试样中的生物聚合物中。将标签以预期掺入各等分试样的生物聚合物的量加入到等分试样中，以便在设计成与等分试样的生物聚合物偶联的化学阵列上从探针读取时产生比例量的信号。然后将等分试样合并成具有至少第一标记生物聚合物和第二标记的生物聚合物的单个多标记样品。多标记样品与化学阵列上的探针杂交。从与多标记样品的标记生物聚合物结合的化学阵列上的探针读取信号值。比较来自与其中结合有第一标记（第一标记信号值）的生物聚合物结合的探针的信号值和来自与其中结合有第二标记（第二标记信号值）的生物聚合物结合的相同探针的信号值，如果第一标记信号值和第二标记信号值之间的偏差小于预定阈值，则确定标签完整性是可接受的质量。

2. 发明申请

US20050078860A1 Feature quantitation methods and system 有权
标题翻译：特征定量方法和系统
公开(公告)号：US20050078860A1
公开(公告)日：2005-04-14
申请号：US10685135
申请日：2003-10-14
申请人： James Minor
发明人： James Minor
IPC分类号： C12Q1/68 , G01N21/64 , G06F19/00 , G06K9/00
CPC分类号： G06T7/0012 , C12Q1/6837 , G06F19/20 , G06K9/00 , G06T7/11 , G06T2207/10056 , G06T2207/10064 , G06T2207/30072
摘要： Methods, systems and recordable media for accurately reading and identifying high quality signals from a microarray feature. Signals may be identified and used regardless of their geographic/geometric locations and patterns within the feature zone. High quality signals may be read, identified and outputted from a microarray feature in a geometrically independent manner, such that the best quality signals are identified and useable, regardless of the locations or patterns in the region from which the best quality signals are outputted.
摘要翻译：用于从微阵列特征准确读取和识别高质量信号的方法，系统和可记录介质。可以识别和使用信号，而不管其特征区域内的地理/几何位置和图案如何。可以以几何独立的方式从微阵列特征读取，识别和输出高质量信号，使得可以识别和使用最佳质量信号，而不管输出最佳质量信号的区域中的位置或图案。

3. 发明申请

US20050143933A1 Analyzing and correcting biological assay data using a signal allocation model 审中-公开
标题翻译：使用信号分配模型分析和校正生物测定数据
公开(公告)号：US20050143933A1
公开(公告)日：2005-06-30
申请号：US10167119
申请日：2002-06-10
申请人： James Minor
发明人： James Minor
IPC分类号： G01N33/48 , G01N33/50 , G06F20060101 , G06F19/20 , H03F1/26 , H04B15/00 , G06F19/00
CPC分类号： G16B25/00
摘要： Data from a biological assay are analyzed and corrected to deconvolve and estimate the expression of a target material using the measured signals from a target probe and on or more homologous probes. The expressions of target and non-target material in a biological sample are allocated to the measured signals of multiple probes. The SIAM is used to correct the biological assay data to obtain more accurate results for the true expression.
摘要翻译：使用来自靶探针和或多个同源探针的测量信号，分析和校正来自生物测定的数据以对其进行去卷积和估计靶材料的表达。生物样本中的靶标和非目标物质的表达被分配给多个探针的测量信号。 SIAM用于校正生物测定数据，以获得更准确的真实表达结果。

4. 发明授权

US06740410B2 Electrostatic dissipating polymeric multi-layer article or laminate 失效
标题翻译：静电消散聚合物多层制品或层压板
公开(公告)号：US06740410B2
公开(公告)日：2004-05-25
申请号：US10126794
申请日：2002-04-19
申请人： Timothy Edward Fahey , James Minor Ludlow, III , Kyung J. Kim
发明人： Timothy Edward Fahey , James Minor Ludlow, III , Kyung J. Kim
IPC分类号： B32B2736
CPC分类号： B32B27/08 , B32B7/12 , B32B27/286 , B32B27/304 , B32B27/308 , B32B27/34 , B32B27/36 , B32B37/153 , B32B2262/106 , B32B2264/108 , B32B2307/202 , B32B2307/21 , B32B2307/738 , B32B2325/00 , B32B2327/06 , B32B2333/08 , B32B2367/00 , B32B2375/00 , B32B2377/00 , Y10T428/24942 , Y10T428/2495 , Y10T428/31504
摘要： The present invention relates to a thermoplastic, multi-layer, electrostatic discharging, laminate comprised of at least one outer layer that is permanent static dissipative and non-contaminating, and a core or base layer that is conductive. The outer layer has a surface resistivity of from about 1.0×105 to about 1.0×1012 Ohm/sq, and the core layer has a surface resistivity of from about 1.0×101 to about 1.0×1011 Ohm/sq.
摘要翻译：本发明涉及一种热塑性多层静电放电层压板，其包括至少一个永久静电耗散和不污染的外层，以及导电的芯层或基层。外层具有约1.0×10 5至约1.0×10 10欧姆/平方的表面电阻率，并且芯层的表面电阻率为约1.0×10 -1至约1.0×10 10欧姆 / sq。

5. 发明授权

US1123458A Automobile-top. 失效
公开(公告)号：US1123458A
公开(公告)日：1915-01-05
申请号：US1913759519
申请日：1913-04-07
申请人： WORKMAN JAMES MINOR
发明人： WORKMAN JAMES MINOR
IPC分类号： B60J7/12
CPC分类号： B60J7/126

6. 发明申请

US20070136035A1 Methods and system for predicting multi-variable outcomes 审中-公开
标题翻译：预测多变量结果的方法和系统
公开(公告)号：US20070136035A1
公开(公告)日：2007-06-14
申请号：US11700480
申请日：2007-01-30
申请人： James Minor , Mika Illouz
发明人： James Minor , Mika Illouz
IPC分类号： G06F17/10
CPC分类号： G16B40/00 , G16B50/00 , G16H50/50 , Y02A90/26
摘要： Systems methods and recordable media for predicting multi-variable outcomes based on multi-variable inputs. Additionally, the models described can be used to predict the multi-variable inputs themselves, based on the multi-variable inputs, providing a smoothing function, acting as a noise filter. Both multi-variable inputs and multi-variable outputs may be simultaneously predicted, based upon the multi-variable inputs. The models find a critical subset of data points, or “tent poles” to optimally model all outcome variables simultaneously to leverage communalities among outcomes.
摘要翻译：基于多变数输入预测多变量结果的系统方法和可记录媒体。此外，所描述的模型可以用于基于多变量输入来预测多变量输入本身，提供作为噪声滤波器的平滑功能。可以基于多变量输入来同时预测多变量输入和多变量输出。这些模型找到数据点的关键子集，或者“帐篷极点”，以同时优化所有结果变量的模型，以利用结果之间的共同体。

7. 发明申请

US20050227221A1 Methods and systems for evaluating and for comparing methods of testing tissue samples 审中-公开
标题翻译：用于评估和比较组织样本测试方法的方法和系统
公开(公告)号：US20050227221A1
公开(公告)日：2005-10-13
申请号：US10821829
申请日：2004-04-09
申请人： James Minor
发明人： James Minor
IPC分类号： C12Q1/00 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G01N33/5005 , G01N33/5008 , G01N33/5023 , G16B25/00
摘要： Using contextual response profiles to group genes into “equivalent” classes to infer biological functionality. Comparing such classes from different contexts (conditions) to identify genes that change functionality. Also, methods, systems and computer readable media to separate gene expression signatures and distinguish differential gene expression specific to pure tissue in a heterogeneous tissue sample. Further, methods, systems and computer readable media for validating or calibrating a plotted curve of sorted p-values is provided. Still further, methods, systems and computer readable media are provided for distinguishing differentially expressed genes based on plotting expression levels and replicates derived from one or more genes in a first sample against corresponding expression levels and replicated derived from one or more genes in a second sample.
摘要翻译：使用上下文响应简档将基因分组为“等效”类以推断生物功能。比较不同上下文（条件）的类别来识别改变功能的基因。而且，分离基因表达特征的方法，系统和计算机可读介质，并且在异质组织样品中区分特异于纯组织的差异基因表达。此外，提供了用于验证或校准分类p值的绘图曲线的方法，系统和计算机可读介质。此外，提供了方法，系统和计算机可读介质，用于基于绘制表达水平和从第一样品中的一个或多个基因衍生的相对于相应表达水平的拷贝来区别差异表达的基因，并从第二个样品中的一个或多个基因。

8. 发明申请

US20070292013A1 Feature quantitation methods and system 审中-公开
标题翻译：特征定量方法和系统
公开(公告)号：US20070292013A1
公开(公告)日：2007-12-20
申请号：US11895091
申请日：2007-08-22
申请人： James Minor
发明人： James Minor
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , C12Q1/6837 , G06K9/00 , G06T7/11 , G06T2207/10056 , G06T2207/10064 , G06T2207/30072 , G16B25/00
摘要： Methods, systems and recordable media for accurately reading and identifying high quality signals from a microarray feature. Signals may be identified and used regardless of their geographic/geometric locations and patterns within the feature zone. High quality signals may be read, identified and outputted from a microarray feature in a geometrically independent manner, such that the best quality signals are identified and useable, regardless of the locations or patterns in the region from which the best quality signals are outputted.
摘要翻译：用于从微阵列特征准确读取和识别高质量信号的方法，系统和可记录介质。可以识别和使用信号，而不管其特征区域内的地理/几何位置和图案如何。可以以几何独立的方式从微阵列特征读取，识别和输出高质量信号，使得可以识别和使用最佳质量信号，而不管输出最佳质量信号的区域中的位置或图案。

9. 发明申请

US20070111218A1 Label integrity verification of chemical array data 审中-公开
标题翻译：化学阵列数据的标签完整性验证
公开(公告)号：US20070111218A1
公开(公告)日：2007-05-17
申请号：US11282527
申请日：2005-11-17
申请人： Diane Ilsley , James Minor
发明人： Diane Ilsley , James Minor
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G01N33/582 , C12Q1/6837 , G01N33/58 , C12Q2565/102 , C12Q2545/101
摘要： Methods, systems and computer readable media for checking label integrity of labeled biopolymers in a single sample assayed by chemical array analysis. At least first and second labels are incorporated into biopolymers in the single sample to produce a multi-labeled, single sample. The multi-labeled, single sample is hybridized with probes on a chemical array, and signal values are read from probes on the chemical array bound to a set of biopolymer sequences labeled with the at least first and second labels. First-labeled signal values from a probe, having the first label incorporated therein, are compared with second-labeled signal values from the probe bound to biopolymer having the second label incorporated therein. The reading signal values and comparing steps are repeated for at least one additional probe on the chemical microarray bound to a set of different biopolymer sequences labeled with the at t least first and second labels, and label integrity is determined to be of acceptable quality if divergence between the first-labeled signal values read from the probes and the second-labeled signal values read from the same probes is less than a predetermined threshold value.
摘要翻译：用于通过化学阵列分析测定的单个样品中标记的生物聚合物的标签完整性的方法，系统和计算机可读介质。至少第一和第二标签被并入单个样品中的生物聚合物中以产生多标记的单个样品。多标记的单个样品与化学阵列上的探针杂交，并且从与至少第一和第二标记标记的一组生物聚合物序列结合的化学阵列上的探针读取信号值。将具有掺入其中的第一标记的探针的第一标记信号值与来自结合到其中结合有第二标签的生物聚合物的探针的第二标记信号值进行比较。对于与至少第一和第二标签标记的一组不同生物聚合物序列结合的化学微阵列上的至少一个附加探针重复阅读信号值和比较步骤，并且如果发散发生，标签完整性被确定为具有可接受的质量在从探针读取的第一标记信号值和从相同探针读取的第二标记信号值之间小于预定阈值。

10. 发明申请

US20060149503A1 Methods and systems for fast least squares optimization for analysis of variance with covariants 审中-公开
标题翻译：用于快速最小二乘优化的方法和系统，用于与协变量进行方差分析
公开(公告)号：US20060149503A1
公开(公告)日：2006-07-06
申请号：US11026484
申请日：2004-12-30
申请人： James Minor
发明人： James Minor
IPC分类号： G06F17/18
CPC分类号： G06F17/18
摘要： Methods, systems and computer readable media for fast linear regression for modeling effects of multiple variables on uni-variable or multi-variable outputs. The techniques are particularly advantageous for large data matrices representing nominal and/or ordinal variables in conjunction with one or more scalar variables. Because nominal variables tend to produce very large, yet very sparse matrices, techniques for condensing such matrices and implementing such condensed matrices in performance of linear regression calculations are also provided.
摘要翻译：用于快速线性回归的方法，系统和计算机可读介质，用于建模多变量对单变量或多变量输出的影响。这些技术对于表示与一个或多个标量变量相关的名义和/或顺序变量的大数据矩阵特别有利。因为标称变量倾向于产生非常大但非常稀疏的矩阵，所以还提供了在线性回归计算的表现中冷凝这种矩阵和实现这样的缩合矩阵的技术。

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