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1. 发明授权

US09084976B2 Spray-drying apparatus and methods of using the same 有权
标题翻译：喷雾干燥装置及其使用方法
公开(公告)号：US09084976B2
公开(公告)日：2015-07-21
申请号：US13820494
申请日：2011-09-01
申请人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
发明人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
IPC分类号： B01J2/04 , B01D1/20
CPC分类号： B01D1/18 , B01D1/20 , B01J2/04
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
摘要翻译：喷雾干燥设备包括干燥室，其具有第一端，第二端和在第一和第二端之间延伸的至少一个侧壁，以限定具有中心轴线的干燥室的内部。喷嘴可以位于干燥室的第一端处，并且被配置成雾化液体并且以相对于中心轴线的最大喷射图形角度将雾化的液体喷射到干燥室的内部。可以提供加热装置以在引入干燥室之前加热液体。

2. 发明授权

US09446287B2 Sensor-based athletic activity measurements 有权
标题翻译：基于传感器的运动活动测量
公开(公告)号：US09446287B2
公开(公告)日：2016-09-20
申请号：US13175216
申请日：2011-07-01
申请人： Aaron B. Weast , James M. Mullin
发明人： Aaron B. Weast , James M. Mullin
IPC分类号： G01C22/00 , H03F1/26 , A63B24/00 , A61B5/11 , A61B5/00
CPC分类号： A63B24/0062 , A61B5/1036 , A61B5/112 , A61B5/1123 , A61B5/486 , A61B5/6807 , A61B5/7257 , A61B2503/10 , A63B2024/0065 , A63B2220/20 , A63B2220/836 , A63B2230/75
摘要： Determining pace or speed based on sensor data may include determining an amount of contact time a user's foot has with a workout surface such as the ground. Contact time may be determined by identifying samples in the sensor data that correspond to various events such as a heelstrike, a toe-off and a subsequent heelstrike. In one example, these events may be identified by determining a sequence of three sample values (e.g., a triplet) that exceeds corresponding thresholds. The validity of an identified triplet (e.g., heelstrike, toe-off and heelstrike) may be confirmed by determining whether a difference between a last event sample and a middle event sample is greater than a difference between the middle event sample and an initial event sample. Once confirmed, a contact time may be determined from the triplet. A linear or non-linear relationship may then be applied to the contact time to determine a speed or pace.
摘要翻译：基于传感器数据确定速度或速度可以包括确定用户的脚具有诸如地面的锻炼表面的接触时间量。接触时间可以通过识别传感器数据中对应于各种事件的样品来确定，诸如脚跟，脚趾和随后的脚后跟。在一个示例中，可以通过确定超过相应阈值的三个样本值（例如，三元组）的序列来识别这些事件。可以通过确定最后事件样本和中间事件样本之间的差异是否大于中间事件样本和初始事件样本之间的差异来确认识别的三元组（例如，脚跟，脚趾和脚跟）的有效性。一旦确认，可以从三元组确定接触时间。然后可以将线性或非线性关系应用于接触时间以确定速度或速度。

3. 发明授权

US06872517B2 Early diagnosis of cancerous and precancerous conditions by leakage of signature peptides and carbohydrates into the bloodstream 失效
标题翻译：通过将签名肽和碳水化合物泄漏到血液中来早期诊断癌症和癌前病症
公开(公告)号：US06872517B2
公开(公告)日：2005-03-29
申请号：US09853427
申请日：2001-05-10
申请人： James M. Mullin , James Thornton
发明人： James M. Mullin , James Thornton
IPC分类号： C12Q1/37 , C12Q1/40 , G01N33/574 , C12P15/00 , C12Q1/00 , C12Q1/58 , C12Q1/62 , G01N33/53
CPC分类号： G01N33/57488 , C12Q1/37 , C12Q1/40
摘要： The present invention involves the early diagnosis of cancerous or precancerous conditions in the gastrointestinal tract by detection of a backleak of signature proteins or carbohydrates in a biological sample obtained from the gastrointestinal tract.
摘要翻译：本发明涉及通过检测从胃肠道获得的生物样品中的特征蛋白或碳水化合物的回漏来早期诊断胃肠道中的癌症或癌前病症。

4. 发明申请

US20130190903A1 Action Detection and Activity Classification 有权
公开(公告)号：US20130190903A1
公开(公告)日：2013-07-25
申请号：US13401592
申请日：2012-02-21
申请人： Santosh Balakrishnan , Jordan M. Rice , Steven H. Walker , Adam S. Carroll , Corey C. Dow-Hygelund , Aaron K. Goodwin , James M. Mullin , Tye L. Rattenbury , Joshua M. Rooke-Ley , John M. Schmitt
发明人： Santosh Balakrishnan , Jordan M. Rice , Steven H. Walker , Adam S. Carroll , Corey C. Dow-Hygelund , Aaron K. Goodwin , James M. Mullin , Tye L. Rattenbury , Joshua M. Rooke-Ley , John M. Schmitt
IPC分类号： G06F19/00
CPC分类号： A63B24/0062 , A41D1/002 , A43B3/0005 , A61B5/0002 , A61B5/0004 , A61B5/0022 , A61B5/0059 , A61B5/0077 , A61B5/01 , A61B5/02438 , A61B5/1112 , A61B5/1118 , A61B5/1123 , A61B5/486 , A61B5/6807 , A61B5/681 , A61B5/7246 , A61B5/7257 , A61B5/7264 , A61B5/7282 , A61B5/742 , A61B5/7475 , A61B2503/10 , A61B2562/0219 , A61B2562/0252 , A61B2562/029 , A61B2562/08 , A63B24/0003 , A63B24/0075 , A63B71/06 , A63B2024/0065 , G06F19/00 , G06F19/3418 , G06F19/3481 , G09B5/00 , G09B5/02 , G09B5/125 , G09B19/003 , G09B19/0038 , G16H20/30 , G16H20/40 , G16H40/67
摘要： Activities, actions and events during user performance of physical activity may be detected using various algorithms and templates. Templates may include an arrangement of one or more states that may identify particular event types and timing between events. Templates may be specific to a particular type of activity (e.g., types of sports, drills, events, etc.), user, terrain, time of day and the like.

5. 发明申请

US20130165371A1 SPRAY-DRYING APPARATUS AND METHODS OF USING THE SAME 有权
公开(公告)号：US20130165371A1
公开(公告)日：2013-06-27
申请号：US13820494
申请日：2011-09-01
申请人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
发明人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
IPC分类号： B01D1/20
CPC分类号： B01D1/18 , B01D1/20 , B01J2/04
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.

6. 发明申请

US20110046079A1 Use of Proton Pump Inhibitors as Drug Delivery Adjuvants 审中-公开
标题翻译：使用质子泵抑制剂作为药物递送佐剂
公开(公告)号：US20110046079A1
公开(公告)日：2011-02-24
申请号：US12863230
申请日：2009-01-16
申请人： James M. Mullin , Giancarlo Mercogliano , James J. Thornton
发明人： James M. Mullin , Giancarlo Mercogliano , James J. Thornton
IPC分类号： A61K31/704 , A61K31/4439 , A61P9/04 , A61P9/06 , A61P25/08
CPC分类号： A61K31/44 , A61K31/4439 , A61K45/06 , A61K2300/00
摘要： Compositions and methods for drug delivery are disclosed.
摘要翻译：公开了用于药物递送的组合物和方法。

7. 发明授权

US09352207B2 Action detection and activity classification 有权
标题翻译：行动检测和活动分类
公开(公告)号：US09352207B2
公开(公告)日：2016-05-31
申请号：US13401592
申请日：2012-02-21
申请人： Santoshkumar Balakrishnan , Jordan M. Rice , Steven H. Walker , Adam S. Carroll , Corey C. Dow-Hygelund , Aaron K. Goodwin , James M. Mullin , Tye L. Rattenbury , Joshua M. Rooke-Ley , John M. Schmitt
发明人： Santoshkumar Balakrishnan , Jordan M. Rice , Steven H. Walker , Adam S. Carroll , Corey C. Dow-Hygelund , Aaron K. Goodwin , James M. Mullin , Tye L. Rattenbury , Joshua M. Rooke-Ley , John M. Schmitt
IPC分类号： A63F13/00 , A63B71/06 , A63B24/00 , A61B5/00 , A61B5/11 , G06F19/00 , G09B19/00
CPC分类号： A63B24/0062 , A41D1/002 , A43B3/0005 , A61B5/0002 , A61B5/0004 , A61B5/0022 , A61B5/0059 , A61B5/0077 , A61B5/01 , A61B5/02438 , A61B5/1112 , A61B5/1118 , A61B5/1123 , A61B5/486 , A61B5/6807 , A61B5/681 , A61B5/7246 , A61B5/7257 , A61B5/7264 , A61B5/7282 , A61B5/742 , A61B5/7475 , A61B2503/10 , A61B2562/0219 , A61B2562/0252 , A61B2562/029 , A61B2562/08 , A63B24/0003 , A63B24/0075 , A63B71/06 , A63B2024/0065 , G06F19/00 , G06F19/3418 , G06F19/3481 , G09B5/00 , G09B5/02 , G09B5/125 , G09B19/003 , G09B19/0038 , G16H20/30 , G16H20/40 , G16H40/67
摘要： Activities, actions and events during user performance of physical activity may be detected using various algorithms and templates. Templates may include an arrangement of one or more states that may identify particular event types and timing between events. Templates may be specific to a particular type of activity (e.g., types of sports, drills, events, etc.), user, terrain, time of day and the like.
摘要翻译：使用各种算法和模板可以检测用户体能活动期间的活动，动作和事件。模板可以包括可识别特定事件类型和事件之间的时间的一个或多个状态的布置。模板可以特定于特定类型的活动（例如，运动，演习，事件等的类型），用户，地形，时间等。

8. 发明申请

US20130153157A1 SPRAY-DRYING APPARATUS AND METHODS OF USING THE SAME 有权
公开(公告)号：US20130153157A1
公开(公告)日：2013-06-20
申请号：US13820483
申请日：2011-09-01
申请人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard
发明人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard
IPC分类号： B01D1/20
CPC分类号： B01D1/20 , A61K9/16 , A61K9/1682 , A61K31/137 , A61K38/22 , A61K38/28 , B01D1/18 , B01J2/04
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A ratio of the length between the first end and second end to a maximum width between opposing internal surfaces of the interior of the drying chamber can be at least 5 to 1.

9. 发明授权

US09339516B2 Compositions and methods for the prevention of esophageal cancer 有权
标题翻译：预防食管癌的组成和方法
公开(公告)号：US09339516B2
公开(公告)日：2016-05-17
申请号：US14114236
申请日：2012-05-07
申请人： James M. Mullin , Jonathan Raines
发明人： James M. Mullin , Jonathan Raines
IPC分类号： A61K33/30 , A61K31/315 , A61K9/20
CPC分类号： A61K33/30 , A61K31/315
摘要： Methods of inhibiting Barrett's esophagus and/or adenocarcinoma in a subject are provided. In a particular embodiment, the method comprises administering at least one composition comprising at least one zinc compound and at least one pharmaceutically acceptable carrier to the esophagus of the subject. The zinc may be a pharmaceutically acceptable salt of zinc, such as zinc gluconate. The zinc may be administered, for example, orally, topically, or by an implantable medical device. In a particular embodiment, the methods further comprise administering at least one analgesic, anesthetic, or other therapeutic agent or therapy for the treatment of Barrett's esophagus. The method may further comprise monitoring the progression of Barrett's esophagus in the subject.
摘要翻译：提供了抑制受试者中Barrett食管和/或腺癌的方法。在一个具体实施方案中，所述方法包括向受试者的食道施用至少一种包含至少一种锌化合物和至少一种药学上可接受的载体的组合物。锌可以是药学上可接受的锌盐，例如葡萄糖酸锌。锌可以例如口服，局部施用或通过可植入医疗装置施用。在一个具体实施方案中，所述方法还包括施用至少一种止痛剂，麻醉剂或其它治疗剂或治疗用于治疗巴雷特氏食管。该方法还可以包括监测受试者中Barrett食管的进展。

10. 发明授权

US09084944B2 Spray-drying apparatus and methods of using the same 有权
标题翻译：喷雾干燥装置及其使用方法
公开(公告)号：US09084944B2
公开(公告)日：2015-07-21
申请号：US13820483
申请日：2011-09-01
申请人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard
发明人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard
IPC分类号： B01J2/04 , B01D1/20
CPC分类号： B01D1/20 , A61K9/16 , A61K9/1682 , A61K31/137 , A61K38/22 , A61K38/28 , B01D1/18 , B01J2/04
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A ratio of the length between the first end and second end to a maximum width between opposing internal surfaces of the interior of the drying chamber can be at least 5 to 1.
摘要翻译：喷雾干燥设备包括干燥室，其具有第一端，第二端和在第一和第二端之间延伸的至少一个侧壁，以限定具有中心轴线的干燥室的内部。喷嘴可以位于干燥室的第一端处，并且被配置成雾化液体并且以相对于中心轴线的最大喷射图形角度将雾化的液体喷射到干燥室的内部。第一端部和第二端部之间的长度与干燥室内部的相对的内表面之间的最大宽度的比率可以为至少5比1。

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