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    • 5. 发明申请
    • Porous Drug Delivery Devices and Related Methods
    • 多种药物输送装置及相关方法
    • US20090214601A1
    • 2009-08-27
    • US12238641
    • 2008-09-26
    • Ralph A. ChappaJames H. ArpsSteven J. Keough
    • Ralph A. ChappaJames H. ArpsSteven J. Keough
    • A61K9/00A61K47/02A61K31/7036
    • A61K9/0024A61K9/167A61K9/5026A61K9/5031A61K9/5073A61K9/5084A61K31/7036
    • The invention relates to porous drug delivery devices and related methods. In an embodiment, the invention includes an active agent delivery system including a reservoir body defining a plurality of interconnected pores, an active agent disposed within the interconnected pores, and a first polymeric layer disposed over the reservoir body. In an embodiment, the invention includes an implantable medical device including a porous substrate defining a plurality of interconnected pores, an active agent disposed within the interconnected pores, and a first polymeric layer disposed over the reservoir body. In an embodiment, the invention includes a method of making an active agent delivery system including forming a porous reservoir body, inserting an active agent within the porous reservoir body, and applying a polymeric layer over the porous reservoir body. Other embodiments are also included herein.
    • 本发明涉及多孔药物输送装置及相关方法。 在一个实施方案中,本发明包括活性剂递送系统,其包括限定多个互连孔的贮存器主体,布置在互连孔内的活性剂和设置在贮存器主体上的第一聚合物层。 在一个实施方案中,本发明包括可植入医疗装置,其包括限定多个互连孔的多孔基质,设置在互连孔内的活性剂,以及设置在贮存器主体上方的第一聚合物层。 在一个实施方案中,本发明包括制备活性剂递送系统的方法,包括形成多孔储存器体,将活性剂插入多孔储存器体内,以及在多孔储存器体上施加聚合物层。 本文还包括其它实施例。