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1. 发明申请

US20120029169A1 METHODS AND COMPOSITIONS COMPRISING TAU OLIGOMERS 有权
标题翻译：包含TAU OLIGOMERS的方法和组合物
公开(公告)号：US20120029169A1
公开(公告)日：2012-02-02
申请号：US13060143
申请日：2009-08-21
申请人： James G. Moe , Eliot J. Davidowitz
发明人： James G. Moe , Eliot J. Davidowitz
IPC分类号： C07K14/435
CPC分类号： C07K14/47 , A61K38/1709 , G01N2500/00 , G01N2800/2821
摘要： Tau protein has a causative role in Alzheimer's disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed tauopathies. The primary function of tau protein is to facilitate assembly and maintenance of microtubules in neuronal axons. In the disease process tau protein becomes modified, loses its affinity to microtubules and accumulates in the cell body where it forms aggregates. The large neurofibrillary tangles formed from tau protein assembled into filaments were thought to be the pathological structure of tau. However, more recent work indicates that smaller, soluble oligomeric forms of tau are best associated with neuron loss and memory impairment. Here, novel compositions of tau oligomers and novel mechanisms for tau oligomer nucleation, extension and termination are taught. Methods for producing and purifying these structures for the development of small molecule and immunotherapeutics as well as antibodies for biomarkers of neurodegenerative diseases are taught.
摘要翻译： Tau蛋白在阿尔茨海默病和多种其他神经退行性疾病中起着重要的作用，其表现为组织病理学统称为tau蛋白病。 tau蛋白的主要功能是促进神经元轴突中微管的组装和维持。在疾病过程中，tau蛋白被修饰，丧失其对微管的亲和力，并在细胞体积聚，形成聚集体。由tau蛋白形成的大的神经原纤维缠结组织成长丝被认为是tau的病理结构。然而，最近的工作表明，较小的可溶性寡聚体形式的tau最好与神经元损失和记忆障碍有关。在这里，教导了tau寡聚体的新型组合物和用于tau低聚物成核，延伸和终止的新机制。制备和纯化用于开发小分子和免疫治疗剂的这些结构的方法以及用于神经变性疾病的生物标志物的抗体。

2. 发明授权

US07955965B2 Nanophotovoltaic devices 有权
标题翻译：纳米光伏器件
公开(公告)号：US07955965B2
公开(公告)日：2011-06-07
申请号：US12851893
申请日：2010-08-06
申请人： Steven J. Wojtczuk , James G. Moe , Roger G. Little
发明人： Steven J. Wojtczuk , James G. Moe , Roger G. Little
IPC分类号： H01L21/44
CPC分类号： H01L31/07 , B82Y30/00 , H01L31/035281 , H01L31/18 , Y02E10/50
摘要： The present invention provides nanophotovoltaic devices having sizes in a range of about 50 nm to about 5 microns, and method of their fabrication. In some embodiments, the nanophotovoltaic device includes a semiconductor core, e.g., formed of silicon, sandwiched between two metallic layers, one of which forms a Schottky barrier junction with the semiconductor core and the other forms an ohmic contact therewith. In other embodiment, the nanophotovoltaic device includes a semiconductor core comprising a p-n junction that is sandwiched between two metallic layers forming ohmic contacts with the core.
摘要翻译：本发明提供尺寸在约50nm至约5微米范围内的纳米光伏器件及其制造方法。在一些实施例中，纳米光伏器件包括夹在两个金属层之间的例如由硅形成的半导体芯，其中一个与半导体芯形成肖特基势垒结，另一个与其形成欧姆接触。在另一个实施例中，纳米光伏器件包括半导体芯，该半导体芯包括夹在与芯之间形成欧姆接触的两个金属层之间的p-n结。

3. 发明申请

US20100297803A1 NANOPHOTOVOLTAIC DEVICES 有权
标题翻译： NANOPHOTOVOLTAIC设备
公开(公告)号：US20100297803A1
公开(公告)日：2010-11-25
申请号：US12851893
申请日：2010-08-06
申请人： Steven J. Wojtczuk , James G. Moe , Roger G. Little
发明人： Steven J. Wojtczuk , James G. Moe , Roger G. Little
IPC分类号： H01L31/18 , H01L21/78
CPC分类号： H01L31/07 , B82Y30/00 , H01L31/035281 , H01L31/18 , Y02E10/50
摘要： The present invention provides nanophotovoltaic devices having sizes in a range of about 50 nm to about 5microns, and method of their fabrication. In some embodiments, the nanophotovoltaic device includes a semiconductor core, e.g., formed of silicon, sandwiched between two metallic layers, one of which forms a Schottky barrier junction with the semiconductor core and the other forms an ohmic contact therewith. In other embodiment, the nanophotovoltaic device includes a semiconductor core comprising a p-n junction that is sandwiched between two metallic layers forming ohmic contacts with the core.
摘要翻译：本发明提供尺寸在约50nm至约5微米范围内的纳米光伏器件及其制造方法。在一些实施例中，纳米光伏器件包括夹在两个金属层之间的例如由硅形成的半导体芯，其中一个与半导体芯形成肖特基势垒结，另一个与其形成欧姆接触。在另一个实施例中，纳米光伏器件包括半导体芯，该半导体芯包括夹在与芯之间形成欧姆接触的两个金属层之间的p-n结。

4. 发明授权

US09506051B2 Tau protease compositions and methods of use 有权
标题翻译： Tau蛋白酶组合物和使用方法
公开(公告)号：US09506051B2
公开(公告)日：2016-11-29
申请号：US14119154
申请日：2012-05-18
申请人： James G. Moe , Eliot J. Davidowitz , Patricia Lopez
发明人： James G. Moe , Eliot J. Davidowitz , Patricia Lopez
IPC分类号： C12N9/64 , C12Q1/37 , G01N33/68 , A61K38/00 , A61K38/48 , A61K39/395 , C07K16/40 , G01N33/573
CPC分类号： C12N9/6424 , A61K38/00 , A61K38/482 , A61K39/3955 , C07K16/40 , C12Q1/37 , G01N33/573 , G01N33/6896 , G01N2800/2821
摘要： Disclosed are mammalian tau proteases, as well as proteolytically-active fragments, variants, and mutants thereof. Also disclosed are polynucleotides and recombinant expression vectors that encode these polypeptides, as well as methods for producing such proteins in selected recombinant host cells, and for using the compositions in a variety of diagnostic and analytical assays.
摘要翻译：公开了哺乳动物tau蛋白酶，以及蛋白水解活性片段，变体和突变体。还公开了编码这些多肽的多核苷酸和重组表达载体，以及在选择的重组宿主细胞中产生此类蛋白质的方法，以及在各种诊断和分析测定中使用该组合物。

5. 发明申请

US20150266947A1 ANTIBODY BASED REAGENTS THAT SPECIFICALLY RECOGNIZE TOXIC OLIGOMERIC FORMS OF TAU 有权
标题翻译：特异性识别TAO毒性低分子形式的基于抗体的试剂
公开(公告)号：US20150266947A1
公开(公告)日：2015-09-24
申请号：US14434742
申请日：2013-10-15
申请人： Michael SIERKS , James G. MOE , Eliot DAVIDOWITZ , Huilai TIAN , ARIZONA BOARD OF AGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF
发明人： Michael Sierks , Huilai Tian , James G. Moe , Eliot Davidowitz
IPC分类号： C07K16/18 , G01N33/68 , C07K16/00 , C12N15/10
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/005 , C07K2317/21 , C07K2317/30 , C07K2317/62 , C07K2317/622 , C07K2317/76 , C12N15/1037 , G01N33/6896 , G01N2333/47 , G01N2333/4703 , G01N2800/28 , G01N2800/2814 , G01N2800/2821 , G01N2800/7047
摘要： The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomelic tau, fibrillar tau or non-disease associated forms of tau.
摘要翻译：本发明涉及特异性识别寡聚tau但不结合单体tau，纤维状tau或非疾病相关形式的tau的抗体，抗体片段和结合剂。

6. 发明申请

US20090224216A1 Surface-Activation of Semiconductor Nanostructures for Biological Applications 有权
标题翻译：用于生物应用的半导体纳米结构的表面活化
公开(公告)号：US20090224216A1
公开(公告)日：2009-09-10
申请号：US12430464
申请日：2009-04-27
申请人： Nader M. Kalkhoran , James G. Moe , Kurt J. Linden , Marisa Sambito
发明人： Nader M. Kalkhoran , James G. Moe , Kurt J. Linden , Marisa Sambito
IPC分类号： G02F1/01 , C23F1/00
CPC分类号： G01N21/6489 , B82Y10/00 , Y10S438/96 , Y10S977/773 , Y10S977/774 , Y10S977/786 , Y10S977/888
摘要： The present invention provides means and methods for producing surface-activated semiconductor nanoparticles suitable for in vitro and in vivo applications that can fluoresce in response to light excitation. Semiconductor nanostructures can be produced by generating a porous layer in semiconductor substrate comprising a network of nanostructures. Prior or subsequent to cleavage from the substrate, the nanostructures can be activated by an activation means such as exposing their surfaces to a plasma, oxidation or ion implantation. In some embodiments, the surface activation renders the nanostructures more hydrophilic, thereby facilitating functionalization of the nanoparticles for either in vitro or in vivo use.
摘要翻译：本发明提供了用于生产表面活化的半导体纳米颗粒的方法和方法，所述表面活化的半导体纳米颗粒适于体外和体内应用，其可响应于光激发而发荧光可以通过在包括纳米结构网络的半导体衬底中产生多孔层来制造半导体纳米结构。在从衬底切割之前或之后，纳米结构可以通过激活手段来激活，例如将其表面暴露于等离子体，氧化或离子注入。在一些实施方案中，表面活化使得纳米结构更亲水，从而促进纳米颗粒的体外或体内使用的官能化。

7. 发明申请

US20090165852A1 NANOPHOTOVOLTAIC DEVICES 有权
标题翻译： NANOPHOTOVOLTAIC设备
公开(公告)号：US20090165852A1
公开(公告)日：2009-07-02
申请号：US12388895
申请日：2009-02-19
申请人： Steven J. Wojtczuk , James G. Moe , Roger G. Little
发明人： Steven J. Wojtczuk , James G. Moe , Roger G. Little
IPC分类号： H01L31/0224 , H01L31/0216 , H01L31/06 , H01L31/028
CPC分类号： H01L31/07 , B82Y30/00 , H01L31/035281 , H01L31/18 , Y02E10/50
摘要： The present invention provides nanophotovoltaic devices having sizes in a range of about 50 nm to about 5 microns, and method of their fabrication. In some embodiments, the nanophotovoltaic device includes a semiconductor core, e.g., formed of silicon, sandwiched between two metallic layers, one of which forms a Schottky barrier junction with the semiconductor core and the other forms an ohmic contact therewith. In other embodiment, the nanophotovoltaic device includes a semiconductor core comprising a p-n junction that is sandwiched between two metallic layers forming ohmic contacts with the core.
摘要翻译：本发明提供尺寸在约50nm至约5微米范围内的纳米光伏器件及其制造方法。在一些实施例中，纳米光伏器件包括夹在两个金属层之间的例如由硅形成的半导体芯，其中一个与半导体芯形成肖特基势垒结，另一个与其形成欧姆接触。在另一个实施例中，纳米光伏器件包括半导体芯，该半导体芯包括夹在与芯之间形成欧姆接触的两个金属层之间的p-n结。

8. 发明授权

US07524776B2 Surface-activation of semiconductor nanostructures for biological applications 有权
标题翻译：用于生物应用的半导体纳米结构的表面活化
公开(公告)号：US07524776B2
公开(公告)日：2009-04-28
申请号：US11002851
申请日：2004-11-30
申请人： Nader M. Kalkhoran , James G. Moe , Kurt J. Linden , Marisa Sambito
发明人： Nader M. Kalkhoran , James G. Moe , Kurt J. Linden , Marisa Sambito
IPC分类号： H01L21/3065
CPC分类号： G01N21/6489 , B82Y10/00 , Y10S438/96 , Y10S977/773 , Y10S977/774 , Y10S977/786 , Y10S977/888
摘要： Means and methods for producing surface-activated semiconductor nanoparticles suitable for in vitro and in vivo applications that can fluoresce in response to light excitation. Semiconductor nanostructures can be produced by generating a porous layer in semiconductor substrate comprising a network of nanostructures. Prior or subsequent to cleavage from the substrate, the nanostructures can be activated by an activation means such as exposing their surfaces to a plasma, oxidation or ion implantation. In some embodiments, the surface activation renders the nanostructures more hydrophilic, thereby facilitating functionalization of the nanoparticles for either in vitro or in vivo use.
摘要翻译：用于生产表面活化的半导体纳米颗粒的方法和方法，其适于体外和体内应用，其可以响应于光激发而发荧光。可以通过在包括纳米结构网络的半导体衬底中产生多孔层来制造半导体纳米结构。在从衬底切割之前或之后，纳米结构可以通过激活手段来激活，例如将其表面暴露于等离子体，氧化或离子注入。在一些实施方案中，表面活化使得纳米结构更亲水，从而促进纳米颗粒的体外或体内使用的官能化。

9. 发明申请

US20080240985A1 Nucleic Acid Assays 审中-公开
标题翻译：核酸测定
公开(公告)号：US20080240985A1
公开(公告)日：2008-10-02
申请号：US11780164
申请日：2007-07-19
申请人： Luigi Catanzariti , Bryan W. Kluttz , Marcela Vera-Garcia , J. Lawrence Burg , James G. Moe , Geoff A. McKinley
发明人： Luigi Catanzariti , Bryan W. Kluttz , Marcela Vera-Garcia , J. Lawrence Burg , James G. Moe , Geoff A. McKinley
IPC分类号： B01J19/00
CPC分类号： G01N35/026 , C12Q1/6834 , C12Q1/6846 , C12Q2600/166 , Y10T436/143333 , C12Q2537/125 , C12Q2527/125 , C12Q2565/629 , C12Q2565/519 , C12Q2545/101
摘要： The present invention relates to the detection of specific nucleic acid sequences, either by a process of amplification of specific nucleic acid sequences or not. More particularly the invention provides for improved compositions and methods for reducing the chance for contamination from manipulation of reagents, internal controls for amplification, and the use of automated apparatus for the automated detection of one, or more than one amplified nucleic acid sequences.
摘要翻译：本发明涉及通过扩增特异性核酸序列的方法来检测特异性核酸序列。更具体地，本发明提供了改进的组合物和方法，用于降低操纵试剂的污染机会，用于扩增的内部对照，以及使用用于自动检测一个或多于一个扩增的核酸序列的自动化装置。

10. 发明授权

US07309588B2 Nucleic acid assays 有权
标题翻译：核酸测定
公开(公告)号：US07309588B2
公开(公告)日：2007-12-18
申请号：US09901181
申请日：2001-07-09
申请人： J. Lawrence Burg , Bryan W. Kluttz , Luigi Catanzariti , Marcela Vera-Garcia , James G. Moe , Geoff A. McKinley
发明人： J. Lawrence Burg , Bryan W. Kluttz , Luigi Catanzariti , Marcela Vera-Garcia , James G. Moe , Geoff A. McKinley
IPC分类号： C19P19/24 , C12Q1/68
CPC分类号： G01N35/026 , C12Q1/6834 , C12Q1/6846 , C12Q2600/166 , Y10T436/143333 , C12Q2537/125 , C12Q2527/125 , C12Q2565/629 , C12Q2565/519 , C12Q2545/101
摘要： The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplification and detection of one or more specific nucleic acid sequences, the use of internal controls, reduced potential for contamination caused by the manual manipulation of reagents, and improved reagent compositions to better control assay performance and provide for further protection against contamination.
摘要翻译：本发明涉及在扩增过程之后或直接没有扩增的情况下检测特异性核酸序列。特别地，本发明提供了扩增和检测过程的自动化，一个或多个特定核酸序列的扩增和检测，内部对照的使用，手动操作试剂引起的污染降低的潜力和改进的试剂组合物以更好地控制测定性能并进一步防止污染。

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