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1. 发明申请

US20130104697A1 Method of Fabricating Indium-111 Radioactive Isotope 有权
标题翻译：制备铟-111放射性同位素的方法
公开(公告)号：US20130104697A1
公开(公告)日：2013-05-02
申请号：US13352550
申请日：2012-01-18
申请人： Wuu-Jyh Lin , Chien-Hsin Lu , Jenn-Tzong Chen , Sun-Rong Hwang , Ying-Chieh Wang
发明人： Wuu-Jyh Lin , Chien-Hsin Lu , Jenn-Tzong Chen , Sun-Rong Hwang , Ying-Chieh Wang
IPC分类号： C22B58/00
CPC分类号： C22B58/00 , G21G1/001 , G21G2001/0057
摘要： The present invention provides a method for fabricating an indium(In)-111 radioactive isotope. A target of cadmium(Cd)-112 is processed through steps of dissolving with heat, absorbing, washing, desorbing and drying for obtaining the In-111 radioactive isotope. Thus, chemical separation is coordinated with the target for fabricating the In-111 radioactive isotope with high efficiency and low cost for production procedure.
摘要翻译：本发明提供一种制造铟（In）-111放射性同位素的方法。通过加热，吸收，洗涤，解吸和干燥的步骤来处理镉（Cd）-112的靶子，以获得In-111放射性同位素。因此，化学分离与用于制造In-111放射性同位素的靶相配合，生产过程效率高，成本低。

2. 发明申请

US20110077430A1 Method and precursor for production of no-carrier-added N-(4-[18F] fluorobutyl)-Ethacrynic amide 审中-公开
标题翻译：制备无载体加入的N-（4- [18 F]氟丁基） - 乙酰胺的方法和前体
公开(公告)号：US20110077430A1
公开(公告)日：2011-03-31
申请号：US12569910
申请日：2009-09-30
申请人： Chung-Shan Yu , Li-Wu Chiang , Hao-Lien Huang , Yu-Hsuan Ku , Chia-Jung Chen , Shao Wei Chen , Yean-Hung Tu , Mao-Hsung Chang , Jenn-Tzong Chen , Wuu-Jyn Lin
发明人： Chung-Shan Yu , Li-Wu Chiang , Hao-Lien Huang , Yu-Hsuan Ku , Chia-Jung Chen , Shao Wei Chen , Yean-Hung Tu , Mao-Hsung Chang , Jenn-Tzong Chen , Wuu-Jyn Lin
IPC分类号： C07C233/17
CPC分类号： C07C233/13 , C07C233/18 , C07C309/73 , Y02P20/55 , Y02P20/582
摘要： The present invention is related to a precursor for no-carrier-added fluorine-18 labeled ethacrynic acid, N-(4-[18F]fluorobutyl)-Ethacrynic amide([18F]FBuEA) and the preparation method for HPLC non-radioactive standards. Its chemical structure is shown in the following: In the precursor, R1 represents a protective group for the amide functional group; R2 represents leaving group; or R1 represents carboxyl group, R2 represents p-tosyloxy, methane sulfonyloxy group or trifluoromethane sulfonyloxy group or bromine (Br). For the HPLC non-radioactive standards, R1 represents a protective group for the amide functional group and hydrogen, R2 represents fluorine.
摘要翻译：本发明涉及无载体添加的氟-18标记的乙酰丙酸，N-（4- [18 F]氟丁基） - 乙酰胺（[18F] FBuEA）的前体）和HPLC非放射性标准品的制备方法。其化学结构如下：在前体中，R1表示酰胺官能团的保护基; R2表示离去基团; 或R 1表示羧基，R 2表示对甲苯磺酰氧基，甲磺酰氧基或三氟甲磺酰氧基或溴（Br）。对于HPLC非放射性标准品，R1表示酰胺官能团和氢的保护基，R2表示氟。

3. 发明申请

US20100320136A1 Device for Separating out Radioisotope Thallium-201 有权
标题翻译：用于分离放射性同位素铊-201的装置
公开(公告)号：US20100320136A1
公开(公告)日：2010-12-23
申请号：US12621979
申请日：2009-11-19
申请人： Wuu-Jyh Lin , Jenn-Tzong Chen , Sun-Rong Huang , Ying-Ming Tsai , Jainn-Hsin Lu
发明人： Wuu-Jyh Lin , Jenn-Tzong Chen , Sun-Rong Huang , Ying-Ming Tsai , Jainn-Hsin Lu
IPC分类号： B01D15/36 , B01D63/00 , B01D1/00 , C01G15/00
CPC分类号： C01G15/00 , B01D61/14 , B01D61/145 , B01D61/147 , B01D61/16 , B01D2311/04 , B01D2311/16 , B01D2311/2623 , B01D2311/2673 , C01P2006/88
摘要： Disclosed is a device for separating radioisotope thallium-201. The device includes an evaporation unit for a solution vial, a first glass vial connected to a first valve and a second valve, an ion exchange column connected to a third valve, a second glass vial connected to a fourth valve and a fifth valve, a collection vial for receiving solution from the fifth valve, a product vial with a membrane filter and a vacuum unit connected to the first valve, the fourth valve and a sixth valve. This device can separate out high-concentration thallium-201 solution from which radioisotope thallium-201 can be obtained.
摘要翻译：公开了一种用于分离放射性同位素铊-201的装置。该装置包括用于溶液小瓶的蒸发单元，连接到第一阀和第二阀的第一玻璃小瓶，连接到第三阀的离子交换柱，连接到第四阀和第五阀的第二玻璃小瓶，用于从第五阀接收溶液的收集瓶，具有膜过滤器的产品小瓶和连接到第一阀，第四阀和第六阀的真空单元。该装置可以分离出可从其获得放射性同位素铊-201的高浓度铊-201溶液。

4. 发明申请

US20100243082A1 Liquid isotope delivery system 审中-公开
标题翻译：液体同位素输送系统
公开(公告)号：US20100243082A1
公开(公告)日：2010-09-30
申请号：US11980743
申请日：2007-10-31
申请人： Wuu-Jyh Lin , Mao-Hsung Chang , Kuo-Yuan Chu , Dow-chi Chen , Ping-Yen Huang , Jenn-Tzong Chen , Ting-shien Duh
发明人： Wuu-Jyh Lin , Mao-Hsung Chang , Kuo-Yuan Chu , Dow-chi Chen , Ping-Yen Huang , Jenn-Tzong Chen , Ting-shien Duh
IPC分类号： F16K15/00
CPC分类号： B01J4/008 , Y10T137/7838
摘要： A liquid isotope delivery system includes a pressure-controlling unit, an input unit, a target chamber, a proton-radiating unit and a storage unit. The pressure-controlling unit includes a first regulating valve, a second regulating valve connected to the first regulating valve and a third regulating valve connected to the first regulating valve. The input unit is connected to the second regulating valve. The target chamber is connected to the third regulating valve and the input unit. The proton-radiating unit is located near the target chamber. The storage unit is connected to the target chamber.
摘要翻译：液体同位素输送系统包括压力控制单元，输入单元，目标室，质子辐射单元和存储单元。压力控制单元包括第一调节阀，连接到第一调节阀的第二调节阀和连接到第一调节阀的第三调节阀。输入单元连接到第二调节阀。目标腔室连接到第三调节阀和输入单元。质子辐射单元位于目标室附近。存储单元连接到目标室。

5. 发明申请

US20080063571A1 Separation device of radioisotope T1-201 有权
标题翻译：放射性同位素T1-201分离装置
公开(公告)号：US20080063571A1
公开(公告)日：2008-03-13
申请号：US11518411
申请日：2006-09-11
申请人： Wuu-Jyh Lin , Ting-Shien Duh , Ying-Ming Tsai , Sun-Rong Huang , Chien-Hsin Lu , Mao-Hsung Chang , Jenn-Tzong Chen
发明人： Wuu-Jyh Lin , Ting-Shien Duh , Ying-Ming Tsai , Sun-Rong Huang , Chien-Hsin Lu , Mao-Hsung Chang , Jenn-Tzong Chen
IPC分类号： B01L11/00
CPC分类号： G21G4/08
摘要： A device to rapidly obtain a solution of Pb(lead)-201 from a solution of a solid target material of Tl(thallium)-203. The solution of Pb-201 is then processed through a degeneration and an ion exchange to obtain in Tl-201 radioisotope.
摘要翻译：从Tl（铊）-203的固体靶材的溶液中快速获得Pb（铅）-201溶液的装置。然后通过退化和离子交换处理Pb-201的溶液，以获得Tl-201放射性同位素。

6. 发明授权

US06345958B1 Pressure adjusting device for engine cooling system 失效
标题翻译：发动机冷却系统调压装置
公开(公告)号：US06345958B1
公开(公告)日：2002-02-12
申请号：US09854896
申请日：2001-05-11
申请人： Jenn-Tzong Chen
发明人： Jenn-Tzong Chen
IPC分类号： F04B4900
CPC分类号： F04B33/00 , F01P11/00 , F01P11/0209 , F01P11/0214 , F01P2070/00
摘要： A pressure adjusting device has a pumping device, a connector device, and a connection pipe connected to the pumping device and the connector device. The pumping device has a hollow cylinder, a plunger device inserted through the hollow cylinder, a cover covering the hollow cylinder, a check valve and a non-return valve inserted in the cover, and an inhale joint and an exhale joint connected to the cover. The connector device has a stepped post, a threaded rod inserted through the stepped post, a handle bar disposed on the stepped post, and a button disposed on the handle bar and receiving the threaded rod. The threaded rod has a head portion inserted in the connection pipe.
摘要翻译：压力调节装置具有泵送装置，连接器装置和连接到泵送装置和连接器装置的连接管。泵送装置具有中空筒体，插入穿过中空圆柱体的柱塞装置，覆盖中空圆筒的盖子，插入盖子中的止回阀和止回阀以及连接到盖子的吸气接头和呼气接头。连接器装置具有阶梯状柱，穿过阶梯柱的螺杆，设置在阶梯柱上的把手和设置在把手上并接收螺纹杆的按钮。螺纹杆具有插入连接管中的头部。

7. 发明授权

US07678248B2 Circulated cooled target 有权
标题翻译：循环冷却目标
公开(公告)号：US07678248B2
公开(公告)日：2010-03-16
申请号：US11500936
申请日：2006-08-09
申请人： Wuu-Jyh Lin , Mao-Hsung Chang , Ping-Yen Huang , Jenn-Tzong Chen , Ting-Shien Duh , Dow-Che Chen , Kuo-Yuan Chu
发明人： Wuu-Jyh Lin , Mao-Hsung Chang , Ping-Yen Huang , Jenn-Tzong Chen , Ting-Shien Duh , Dow-Che Chen , Kuo-Yuan Chu
IPC分类号： C23C14/00
CPC分类号： H01J37/3497 , H01J37/3435
摘要： A liquid and a gas is constantly filled into a target chamber of a target. Then the liquid and the gas flow around the chamber and are flown out. By doing so, the target is effectively cooled down.
摘要翻译：液体和气体不断地被填充到目标的靶室中。然后液体和气体流过室并流出。通过这样做，目标被有效地冷却下来。

8. 发明申请

US20090211917A1 RADIOISOTOPE T1-201 PRODUCTION PROCESS 有权
标题翻译：放射科技T1-201生产工艺
公开(公告)号：US20090211917A1
公开(公告)日：2009-08-27
申请号：US11500931
申请日：2006-08-09
申请人： Wuu-Jyh Lin , Ting-Shien Duh , Ying-Ming Tsai , Sun-Rong Huang , Chien-Hsin Lu , Mao-Hsung Chang , Jenn-Tzong Chen
发明人： Wuu-Jyh Lin , Ting-Shien Duh , Ying-Ming Tsai , Sun-Rong Huang , Chien-Hsin Lu , Mao-Hsung Chang , Jenn-Tzong Chen
IPC分类号： C25B1/24
CPC分类号： G21G1/10 , G21G1/001 , G21G2001/0078
摘要： A radioisotope Tl-201 is produced. The process includes electroplating, irradiating, dissolving precipitating, ion exchanging, decaying and filtering. The Tl-201 obtained is a liquid having a high purity.
摘要翻译：生产放射性同位素Tl-201。该方法包括电镀，照射，溶解沉淀，离子交换，腐蚀和过滤。得到的T1-201是纯度高的液体。

9. 外观设计

USD412482S Vehicle-attached bicycle rack 失效
公开(公告)号：USD412482S
公开(公告)日：1999-08-03
申请号：US96840
申请日：1998-11-20
申请人： Jenn Tzong Chen
设计人： Jenn Tzong Chen

10. 发明申请

US20220227728A1 Microtubule-associated protein Tau imaging compounds for Alzheimer's disease and precursors thereof 有权
公开(公告)号：US20220227728A1
公开(公告)日：2022-07-21
申请号：US17152344
申请日：2021-01-19
申请人： MING-HSIN LI , KAI-HUNG CHENG , SHENG-NAN LO , SHIH-WEI LO , YUAN-RUEI HUANG , JENN-TZONG CHEN
发明人： MING-HSIN LI , KAI-HUNG CHENG , SHENG-NAN LO , SHIH-WEI LO , YUAN-RUEI HUANG , JENN-TZONG CHEN
IPC分类号： C07D401/04 , A61K51/04
摘要： The present invention discloses a series of nuclear medicine tracers that are combined with brain microtubule-associated protein Tau targeting compounds to produce a group of compounds of nuclear medicine that can be utilized for imaging of microtubule-associated protein Tau. When the positrons released by the decay encounter the electrons of the cells in the sample, utilizing the positron decay characteristics of fluorine-18 or iodine-124 isotope to generate mutual destruction reactions, a pair of opposite gamma rays is formed which are imaged by positron emission tomography. The compounds can be applied for the in vivo detection of microtubule-associated protein Tau deposits in the brain. The invention provides a strategy for diagnosis of Alzheimer's disease and a method to measure the efficacy of therapeutic drugs targeting microtubule-associated protein Tau.

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