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    • 1. 发明申请
    • Nucleic acid nanostructure and method of manufacturing the same
    • 核酸纳米结构及其制造方法
    • US20070275394A1
    • 2007-11-29
    • US11634437
    • 2006-12-06
    • Dong ShinMoon JungSe ParkHyeon PyoChang Choi
    • Dong ShinMoon JungSe ParkHyeon PyoChang Choi
    • C12Q1/68C12M3/00
    • C12Q1/6825B82B1/001C12Q2565/133C12Q2563/137
    • Provided are a nucleic acid nanostructure including: a substrate; a nucleic acid quadruplex immobilized on the substrate to be vertical with respect to the substrate; a metal ion present in a unit lattice of the nucleic acid quadruplex, the unit lattice being made up of eight nucleobases; and a nanoparticle bound to an end of the nucleic acid quadruplex, and a method of manufacturing the same. According to the method, a nucleic acid nanostructure having an array of nanoparticles can be manufactured. The nucleic acid nanostructure can be applied as a sensor nanostructure for sensors such as gas sensors, chemical sensors, and biosensors. In particular, a nucleic acid nanostructure in which metal nanoparticles, e.g., gold or silver, are introduced can be useful as a device having local surface plasmon characteristics.
    • 提供的核酸纳米结构包括:底物; 固定在所述基板上的相对于所述基板垂直的核酸四重链; 存在于核酸四联体的单位晶格中的金属离子,单位晶格由八个核碱基组成; 和结合到核酸四链体末端的纳米颗粒及其制造方法。 根据该方法,可以制造具有纳米颗粒阵列的核酸纳米结构。 核酸纳米结构可用作传感器的传感器纳米结构,如气体传感器,化学传感器和生物传感器。 特别地,其中引入金属纳米颗粒例如金或银的核酸纳米结构可用作具有局部表面等离子体特征的器件。