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1. 发明授权

US08030315B2 DPP-IV inhibitor including beta-amino group, preparation method thereof and pharmaceutical composition containing the same for preventing and treating diabetes or obesity 有权
标题翻译： DPP-IV抑制剂包括β-氨基，其制备方法和含有其的药物组合物用于预防和治疗糖尿病或肥胖症
公开(公告)号：US08030315B2
公开(公告)日：2011-10-04
申请号：US12596281
申请日：2008-04-18
申请人： Heung Jae Kim , Woo Young Kwak , Chang Yell Shin , Hadong Kim , Jong Pil Min , Kyung Jin Park , Jae Young Lee , Song-Hyen Choi , Tae Hyun Yoon , Hae-Sun Kim , Ji Myun Jang , Mi-Kyung Kim , Moon-Ho Son , Soon Hoe Kim , Moohi Yoo
发明人： Heung Jae Kim , Woo Young Kwak , Chang Yell Shin , Hadong Kim , Jong Pil Min , Kyung Jin Park , Jae Young Lee , Song-Hyen Choi , Tae Hyun Yoon , Hae-Sun Kim , Ji Myun Jang , Mi-Kyung Kim , Moon-Ho Son , Soon Hoe Kim , Moohi Yoo
IPC分类号： A61K31/4965 , C07D241/04
CPC分类号： C07D241/08
摘要： The present invention provides a novel heterocyclic compound containing a beta-amino group, a method for preparing the same, and a pharmaceutical composition comprising the same heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient. The heterocyclic compound of the present invention exhibits excellent DPP-IV inhibitory activity and bioavailability and therefore can be useful for the prophylaxis or treatment of DPP-IV-related diseases such as diabetes or obesity.
摘要翻译：本发明提供了含有β-氨基的新型杂环化合物，其制备方法以及含有相同杂环化合物或其药学上可接受的盐作为有效成分的药物组合物。本发明的杂环化合物显示优异的DPP-IV抑制活性和生物利用度，因此可用于预防或治疗DPP-IV相关疾病如糖尿病或肥胖症。

2. 发明申请

US20130072459A1 PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR THE TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE AND THE METHOD FOR PREVENTION OR TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE USING THE SAME 审中-公开
标题翻译：用于预防或治疗非酒精性脂肪肝疾病的药物组合物及使用该方法预防或治疗非酒精性脂肪肝病
公开(公告)号：US20130072459A1
公开(公告)日：2013-03-21
申请号：US13636670
申请日：2011-03-23
申请人： Gook-Jun An , Eun-Kyoung Yang , Eun-Jung Cho , Yu-Na Chae , Song-Hyen Choi , Ha-Dong Kim , Chang-Yell Shin , Mi-Kyung Kim , Woo-Young Kwak , Heung-Jae Kim , Moon-Ho Son , Soon-Hoe Kim
发明人： Gook-Jun An , Eun-Kyoung Yang , Eun-Jung Cho , Yu-Na Chae , Song-Hyen Choi , Ha-Dong Kim , Chang-Yell Shin , Mi-Kyung Kim , Woo-Young Kwak , Heung-Jae Kim , Moon-Ho Son , Soon-Hoe Kim
IPC分类号： A61K31/675 , A61K31/4965 , A61K31/522 , A61P1/16 , A61P3/06 , A61P3/10 , A61P3/04 , A61K31/4985 , A61K31/40
CPC分类号： A61K31/495 , A61K31/4985
摘要： The present invention provides a pharmaceutical composition for the prevention and treatment of a non-alcoholic fatty liver disease (NAFLD), containing an active ingredient selected from the group consisting of Compound 1 represented by formula 1, sitagliptin, vildagliptin, linagliptin or a pharmaceutically acceptable salt thereof. Further, the present invention provides a method for the prevention or treatment of a non-alcoholic fatty liver disease, including administering an effective amount of an active ingredient selected from the group consisting of Compound 1 represented by formula 1, sitagliptin, vildagliptin, linagliptin or a pharmaceutically acceptable salt thereof to a mammal including a human in need thereof. Further, the present invention provides use of Compound 1 represented by formula 1, sitagliptin, vildagliptin, linagliptin or a pharmaceutically acceptable salt thereof, for manufacturing a pharmaceutical composition for the prevention or treatment of a non-alcoholic fatty liver disease.
摘要翻译：本发明提供了一种用于预防和治疗非酒精性脂肪肝疾病（NAFLD）的药物组合物，其含有选自由式1表示的化合物1，西格列汀，维格列汀，利格列汀或其药学上可接受的组的盐。此外，本发明提供了一种预防或治疗非酒精性脂肪性肝病的方法，包括给予有效量的选自由式1表示的化合物1，西格列汀，维格列汀，利格列汀或其药学上可接受的盐包括需要其的人的哺乳动物。此外，本发明提供了用于制备用于预防或治疗非酒精性脂肪肝疾病的药物组合物的式1化合物1，西他列汀，维格列汀，利格列汀或其药学上可接受的盐的用途。

3. 发明申请

US20060132075A1 Startup control method of brushless DC motor 有权
标题翻译：无刷直流电机启动控制方法
公开(公告)号：US20060132075A1
公开(公告)日：2006-06-22
申请号：US11183956
申请日：2005-07-19
申请人： Kwang Lee , Dae Kim , Sang Lee , Hyen Choi
发明人： Kwang Lee , Dae Kim , Sang Lee , Hyen Choi
IPC分类号： H02P7/06
CPC分类号： H02P6/20 , H02P6/182
摘要： A startup control method of a BLDC motor is disclosed. The method can control the BLDC motor to prevent the generation of a transient current such that the vibration of the BLDC motor can be reduced at the startup stage and perform a stable conversion into a senseless operation mode such that the startup failure rate of the BLDC motor can be reduced. The startup control method includes commutating a current applied to stator windings according to a rotor position. The method of operating the BLDC motor includes a rotor position that is forcibly aligned and so that phase commutation is performed, a back-electromotive force (back- emf) is detected from a lead voltage of a phase of a voltage which is not applied thereto after performing phase commutation and a determination is performed as to whether the detected back-emf is in a rising interval. The lead voltage of the phase of the voltage which is not applied thereto is integrated, such that if the back-emf is in a rising interval and if an instance that the integration result is greater than a predetermined value a phase commutation time point is setand conversion into a senseless operation mode is performed if the back-emf detected from the lead voltage is in a stable interval, based on a frequency of the voltage applied to the stator winding.
摘要翻译：公开了一种BLDC电机的启动控制方法。该方法可以控制BLDC电机，以防止产生瞬态电流，从而可以在启动阶段减小BLDC电机的振动，并执行稳定转换为无意义运行模式，使得BLDC电机的启动故障率可以减少启动控制方法包括根据转子位置对应用于定子绕组的电流进行换向。操作BLDC电动机的方法包括被强制对准的转子位置，从而进行相位换向，从未施加到其上的电压的相位的引线电压检测反向电动势（反电动势）在执行相位换向之后，执行关于所检测的反电动势是否处于上升间隔的确定。未对其施加的电压的相位的引导电压被积分，使得如果反电动势处于上升间隔，并且如果积分结果大于预定值的情况，则设置相位换向时间点，基于施加到定子绕组的电压的频率，如果从引线电压检测到的反电动势处于稳定的间隔，则执行转换为无意义操作模式。

4. 发明授权

US08440669B2 Pharmaceutical composition for prevention and treatment of diabetes or obesity comprising a compound that inhibits activity of dipeptidyl peptidase-IV, and other antidiabetic or antiobesity agents as active ingredients 有权
标题翻译：用于预防和治疗糖尿病或肥胖症的药物组合物，其包含抑制二肽基肽酶-IV的活性的化合物和其它抗糖尿病或抗肥胖剂作为活性成分
公开(公告)号：US08440669B2
公开(公告)日：2013-05-14
申请号：US13124150
申请日：2009-10-16
申请人： Chang Yell Shin , Song-Hyen Choi , Yu Na Chae , Eun Kyoung Yang , Gook Jun Ahn , Moon-Ho Son , Heung Jae Kim , Woo Young Kwak , Jong Pil Min , Tae Hyun Yoon , Soon Hoe Kim , Moohi Yoo
发明人： Chang Yell Shin , Song-Hyen Choi , Yu Na Chae , Eun Kyoung Yang , Gook Jun Ahn , Moon-Ho Son , Heung Jae Kim , Woo Young Kwak , Jong Pil Min , Tae Hyun Yoon , Soon Hoe Kim , Moohi Yoo
IPC分类号： A01N43/60 , A61K31/50 , A61K31/497
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/145 , A61K9/2059 , A61K31/155 , A61K31/4439 , A61K31/495 , A61K31/5377 , A61K31/64 , A61K31/7028 , A61K47/02 , Y02P20/582 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetes or obesity comprising as active ingredients a compound which inhibits the activity of dipeptidyl peptidase-IV (DPP-IV), a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof, and one or more other antidiabetic or antiobesity agents. The pharmaceutical composition exhibits excellent glucose tolerance and may be useful in the prevention and treatment of diabetes, obesity, and the like by effectively inhibiting blood glucose levels and reducing fat mass.
摘要翻译：本发明涉及用于预防和治疗糖尿病或肥胖症的药物组合物，其包含抑制二肽基肽酶-IV（DPP-IV）的活性的化合物，其药学上可接受的盐，其水合物或其一种或多种其它抗糖尿病或抗肥胖剂。药物组合物表现出优异的葡萄糖耐量，可有效抑制血糖水平和降低脂肪量，可用于预防和治疗糖尿病，肥胖症等。

5. 发明申请

US20110201624A1 Pharmaceutical Composition for Prevention and Treatment of Diabetes or Obesity Comprising a Compound that Inhibits Activity of Dipeptidyl Peptidase-IV, and other Antidiabetic or Antiobesity Agents as Active Ingredients 有权
标题翻译：用于预防和治疗糖尿病或肥胖症的药物组合物，其包含抑制二肽基肽酶-IV和其它抗糖尿病或抗肥胖剂作为活性成分的活性的化合物
公开(公告)号：US20110201624A1
公开(公告)日：2011-08-18
申请号：US13124150
申请日：2009-10-16
申请人： Chang Yell Shin , Song-Hyen Choi , Yu Na Chae , Eun Kyoung Yang , Gook Jun Ahn , Moon-Ho Son , Heung Jae Kim , Woo Young Kwak , Jong Pil Min , Tae Hyun Yoon , Soon Hoe Kim , Moohi Yoo
发明人： Chang Yell Shin , Song-Hyen Choi , Yu Na Chae , Eun Kyoung Yang , Gook Jun Ahn , Moon-Ho Son , Heung Jae Kim , Woo Young Kwak , Jong Pil Min , Tae Hyun Yoon , Soon Hoe Kim , Moohi Yoo
IPC分类号： A61K31/4965 , A61P3/04 , A61P3/10
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/145 , A61K9/2059 , A61K31/155 , A61K31/4439 , A61K31/495 , A61K31/5377 , A61K31/64 , A61K31/7028 , A61K47/02 , Y02P20/582 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetes or obesity comprising as active ingredients a compound which inhibits the activity of dipeptidyl peptidase-IV (DPP-IV), a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof, and one or more other antidiabetic or antiobesity agents. The pharmaceutical composition exhibits excellent glucose tolerance and may be useful in the prevention and treatment of diabetes, obesity, and the like by effectively inhibiting blood glucose levels and reducing fat mass.
摘要翻译：本发明涉及用于预防和治疗糖尿病或肥胖症的药物组合物，其包含抑制二肽基肽酶-IV（DPP-IV）的活性的化合物，其药学上可接受的盐，其水合物或其一种或多种其它抗糖尿病或抗肥胖剂。药物组合物表现出优异的葡萄糖耐量，可有效抑制血糖水平和降低脂肪量，可用于预防和治疗糖尿病，肥胖症等。

6. 发明申请

US20100120790A1 DPP-IV INHIBITOR INCLUDING BETA-AMINO GROUP, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING AND TREATING DIABETES OR OBESITY 有权
标题翻译： DPP-IV抑制剂，其包括氨基甲酰胺组，其制备方法和含有该组合物的预防和治疗糖尿病或肥胖的药物组合物
公开(公告)号：US20100120790A1
公开(公告)日：2010-05-13
申请号：US12596281
申请日：2008-04-18
申请人： Heung Jae Kim , Woo Young Kwak , Chang Yell Shin , Hadong Kim , Jong Pil Min , Kyung Jin Park , Jae Young Lee , Song-Hyen Choi , Tae Hyun Yoon , Hae-Sun Kim , Ji Myung Jang , Mi-Kyung Kim , Moon-Ho Son , Soon Hoe Kim , Moohi Yoo
发明人： Heung Jae Kim , Woo Young Kwak , Chang Yell Shin , Hadong Kim , Jong Pil Min , Kyung Jin Park , Jae Young Lee , Song-Hyen Choi , Tae Hyun Yoon , Hae-Sun Kim , Ji Myung Jang , Mi-Kyung Kim , Moon-Ho Son , Soon Hoe Kim , Moohi Yoo
IPC分类号： A61K31/495 , C07D241/04 , A61P3/10 , A61P3/04
CPC分类号： C07D241/08
摘要： The present invention provides a novel heterocyclic compound containing a beta-amino group, a method for preparing the same, and a pharmaceutical composition comprising the same heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient. The heterocyclic compound of the present invention exhibits excellent DPP-IV inhibitory activity and bioavailability and therefore can be useful for the prophylaxis or treatment of DPP-IV-related diseases such as diabetes or obesity.
摘要翻译：本发明提供了含有β-氨基的新型杂环化合物，其制备方法以及含有相同杂环化合物或其药学上可接受的盐作为有效成分的药物组合物。本发明的杂环化合物显示优异的DPP-IV抑制活性和生物利用度，因此可用于预防或治疗DPP-IV相关疾病如糖尿病或肥胖症。

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