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1. 发明申请

US20120276169A1 POLYMER NANOPARTICLE INJECTION FORMULATION COMPOSITION CONTAINING RAPAMYCIN WITH IMPROVED WATER SOLUBILITY, PREPARATION METHOD THEREOF, AND ANTICANCER COMPOSITION FOR COMBINED USE WITH RADIOTHERAPY 审中-公开
标题翻译：具有改善水溶性的含有RAPAMYCIN的聚合物纳米颗粒注射制剂组合物，其制备方法和用于与放射治疗组合使用的反应物组合物
公开(公告)号：US20120276169A1
公开(公告)日：2012-11-01
申请号：US13519914
申请日：2010-12-29
申请人： Hye Won Kang , Min Hyo Seo , Sa Won Lee , Bong Oh Kim , Eun Kyung Choi , Seong Yun Jeong , Ha Na Woo
发明人： Hye Won Kang , Min Hyo Seo , Sa Won Lee , Bong Oh Kim , Eun Kyung Choi , Seong Yun Jeong , Ha Na Woo
IPC分类号： A61K31/436 , A61P35/00 , A61K9/00 , B82Y5/00
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/127 , A61K31/436
摘要： The present invention relates to a polymer nanoparticle injection formulation composition containing rapamycin with improved water solubility, and more specifically, to an injection formulation composition containing rapamycin wherein water solubility is improved by solubilizing rapamycin having low water solubility with polymer nanoparticles, a preparation method thereof, and an anticancer composition for a combined use with radiotherapy.
摘要翻译：本发明涉及包含具有改善的水溶性的雷帕霉素的聚合物纳米颗粒注射制剂组合物，更具体地涉及含有雷帕霉素的注射制剂组合物，其中通过溶解聚合物纳米颗粒具有低水溶性的雷帕霉素来改善水溶性，其制备方法，和用于与放射疗法组合使用的抗癌组合物。

2. 发明授权

US09720864B2 Flexible server system 有权
公开(公告)号：US09720864B2
公开(公告)日：2017-08-01
申请号：US14456138
申请日：2014-08-11
申请人： Bum-Jun Kim , Woo-Seok Chang , Hye-Won Kang , Em-Hwan Kim , Kwang-Hyun La , Su-Hwan Park , Jang-Won Lee
发明人： Bum-Jun Kim , Woo-Seok Chang , Hye-Won Kang , Em-Hwan Kim , Kwang-Hyun La , Su-Hwan Park , Jang-Won Lee
IPC分类号： G06F13/00 , G06F13/40
CPC分类号： G06F13/4022
摘要： A flexible server system includes an embedded processor, one or more processor boards, one or more storage boards, and a switch including a plurality of ports. The embedded processor, the one or more processor boards, and the one or more storage boards are connected to a corresponding one of the plurality of ports. The embedded processor, the one or more processor boards, the one or more storage boards, and the switch each include a peripheral component interconnect express (PCIe) interface. The one or more processor boards and the one or more storage boards are connected to the switch through connectors where each of the corresponding connectors have a same size. The embedded processor controls the switch to route a packet from one of the plurality of ports to another one of the plurality of ports.

3. 发明申请

US20110224151A1 Polymeric Micelle Composition for Treatment of Resistant Cancer and Preparation Method of the Same 审中-公开
标题翻译：用于治疗耐药性的聚合物胶束组合物及其制备方法
公开(公告)号：US20110224151A1
公开(公告)日：2011-09-15
申请号：US13130259
申请日：2009-11-23
申请人： Hye-Won Kang , Min Hyo Seo , Bong Oh Kim
发明人： Hye-Won Kang , Min Hyo Seo , Bong Oh Kim
IPC分类号： A61K38/13 , A61P35/00 , B01J13/02
CPC分类号： A61K31/335 , A61K9/1075
摘要： Disclosed are a polymer micelle composition for treatment of resistant cancer cells that contains an amphiphilic double block copolymer and taxane and a P-glycoprotein inhibitor of cyclosporin as its active ingredients, and a method of preparing the same. Said polymer micelle composition for treatment of cancer resistant cells is accumulated in cancer tissue at high concentrations, and has the advantages that it exhibits superior anti-cancer effects for the cancer cells that have exhibited resistance due to over-expression of P-glycoprotein by the taxane anticancer agent in said cancer tissue, and does not cause hypersensitive reactions due to the use of a solubilizer.
摘要翻译：公开了一种用于治疗含有两亲性双嵌段共聚物和紫杉烷和环孢菌素P-糖蛋白抑制剂作为其活性成分的抗性癌细胞的聚合物胶束组合物及其制备方法。用于治疗耐癌细胞的所述聚合物胶束组合物以高浓度积聚在癌组织中，并且具有对由于P-糖蛋白过度表达而显示出抗性的癌细胞具有优异的抗癌作用的优点所述癌组织中的紫杉烷抗癌剂，并且由于使用增溶剂而不引起过敏反应。

4. 发明申请

US20150143018A1 FLEXIBLE SERVER SYSTEM 有权
标题翻译：灵活的服务器系统
公开(公告)号：US20150143018A1
公开(公告)日：2015-05-21
申请号：US14456138
申请日：2014-08-11
申请人： Bum-Jun KIM , Woo-Seok CHANG , Hye-Won KANG , Em-Hwan KIM , Kwang-Hyun LA , Su-Hwan PARK , Jang-Won LEE
发明人： Bum-Jun KIM , Woo-Seok CHANG , Hye-Won KANG , Em-Hwan KIM , Kwang-Hyun LA , Su-Hwan PARK , Jang-Won LEE
IPC分类号： G06F13/40
CPC分类号： G06F13/4022
摘要： A flexible server system includes an embedded processor, one or more processor boards, one or more storage boards, and a switch including a plurality of ports. The embedded processor, the one or more processor boards, and the one or more storage boards are connected to a corresponding one of the plurality of ports. The embedded processor, the one or more processor boards, the one or more storage boards, and the switch each include a peripheral component interconnect express (PCIe) interface. The one or more processor boards and the one or more storage boards are connected to the switch through connectors where each of the corresponding connectors have a same size. The embedded processor controls the switch to route a packet from one of the plurality of ports to another one of the plurality of ports.
摘要翻译：灵活的服务器系统包括嵌入式处理器，一个或多个处理器板，一个或多个存储板以及包括多个端口的开关。嵌入式处理器，一个或多个处理器板和一个或多个存储板连接到多个端口中的相应一个端口。嵌入式处理器，一个或多个处理器板，一个或多个存储板和开关各自包括外围组件互连快速（PCIe）接口。一个或多个处理器板和一个或多个存储板通过连接器连接到开关，其中每个相应的连接器具有相同的尺寸。嵌入式处理器控制交换机将分组从多个端口中的一个端口路由到多个端口中的另一个。

5. 发明申请

US20100008998A1 SUBMICRON NANOPARTICLE OF POORLY WATER SOLUBLE CAMPTOTHECIN DERIVATIVES AND PROCESS FOR PREPARATION THEREOF 审中-公开
标题翻译：不溶性水溶性衍生物的亚硝酸盐及其制备方法
公开(公告)号：US20100008998A1
公开(公告)日：2010-01-14
申请号：US12442819
申请日：2007-09-20
申请人： Hye Won Kang , Eun Young Yim , Min Hyo Seo
发明人： Hye Won Kang , Eun Young Yim , Min Hyo Seo
IPC分类号： A61K31/4745 , A61P35/00 , A61K9/14
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/19
摘要： The present invention relates to a nanoparticle composition comprising a camptothecin derivative, solid polyethyleneglycol and an anti-associative agent, and the process for preparing the same. Specifically, the present invention provides a composition comprising a nanoparticle of the camptothecin derivative, which is prepared by solid-dispersing the poorly water soluble camptothecin derivative in polyethyleneglycol and dissolving the solid dispersions in an aqueous solution containing an anti-associative agent. The composition of the present invention stabilizes the camptothecin derivative lactone form in body fluid for effective anticancer activity.
摘要翻译：本发明涉及包含喜树碱衍生物，固体聚乙二醇和抗结合剂的纳米颗粒组合物及其制备方法。具体地说，本发明提供包含喜树碱衍生物的纳米颗粒的组合物，其通过将难溶于水的喜树碱衍生物固体分散在聚乙二醇中并将固体分散体溶解在含有抗关联剂的水溶液中制备。本发明的组合物稳定了体液中的喜树碱衍生物内酯形式，有效的抗癌活性。

6. 发明申请

US20070254905A1 Pharmaceutical Formulation for Increasing Solubility of 10-Hydroxycamptothecin Compounds in Non-Aqueous Polar Solvents 审中-公开
标题翻译：增加10-羟基喜树碱化合物在非极性极性溶剂中的溶解度的药物制剂
公开(公告)号：US20070254905A1
公开(公告)日：2007-11-01
申请号：US11666511
申请日：2005-11-04
申请人： Min-Hyo Seo , Hye-Won Kang
发明人： Min-Hyo Seo , Hye-Won Kang
IPC分类号： A61K31/437 , C07D471/12
CPC分类号： A61K47/18 , A61K31/475
摘要： The present invention relates to a pharmaceutical formulation for increasing the solubility of a 10-hydroxycamptothecin compound in non-aqueous polar solvent, comprising a 10-hydroxycamptothecin compound and an amine compound whose pKa value is 7.4 or more. By using the formulation according to the present invention, the solubility of the 10-hydroxycamptothecin compound for non-aqueous polar solvent is increased, while maintaining the active lactone form of 10-hydroxycamptothecin.
摘要翻译：本发明涉及一种用于增加10-羟基喜树碱化合物在非水极性溶剂中的溶解度的药物制剂，其包含10-羟基喜树碱化合物和其pK值为7.4以上的胺化合物。通过使用根据本发明的制剂，在保持10-羟基喜树碱的活性内酯形式的同时，增加10-羟基喜树碱化合物对非水极性溶剂的溶解度。

7. 发明申请

US20080260850A1 Delivery System For Bioactive Agents on the Basis of a Polymeric Drug Carrier Comprising an Amphiphilic Block Polymer and a Polylacticacid Derivative 审中-公开
标题翻译：基于包含两亲性嵌段聚合物和聚乳酸衍生物的聚合物药物载体的生物活性剂的递送系统
公开(公告)号：US20080260850A1
公开(公告)日：2008-10-23
申请号：US11568313
申请日：2005-05-06
申请人： Yil-Woong Yi , Sa-Won Lee , Jeong-Il Yu , Dong-Hoon Chang , Min-Hyo Seo , Hye-Won Kang , Jae-Hong Kim
发明人： Yil-Woong Yi , Sa-Won Lee , Jeong-Il Yu , Dong-Hoon Chang , Min-Hyo Seo , Hye-Won Kang , Jae-Hong Kim
IPC分类号： A61K9/14 , A61K47/30 , A61K38/02 , A61K38/16 , A61K31/7052 , A61P43/00
CPC分类号： C08G63/912 , A61K9/0019 , A61K9/1075 , A61K9/19 , A61K9/5153 , A61K47/34 , C08G2261/126 , C08L53/00 , C08L67/00 , C08L67/04 , C08L87/005 , C08L101/06 , C08L2666/02
摘要： Delivery system for bioactive agents on the basis of a polymeric drug carrier formed from compositions comprising an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block having a terminal hydroxyl group substituted with a tocopherol or cholesterol group, and a polylactic acide derivative wherein one end of the polylactic acid is covalently bound to at least one carboxyl group. The carboxyl group of the polylactic acid derivative may be fixed with a di- or trivalent metal ion, which is obtained by adding the di- or trivalent metal ion to the polymeric composition.
摘要翻译：基于由包含亲水嵌段的两亲性嵌段共聚物和具有被生育酚或胆固醇基取代的末端羟基的疏水嵌段的组合物形成的聚合物药物载体的递送系统和聚乳酸酰胺衍生物，其中一端的聚乳酸与至少一个羧基共价结合。聚乳酸衍生物的羧基可以通过将二价或三价金属离子加入到聚合物组合物中而获得的二价或三价金属离子固定。

8. 发明申请

US20070183488A1 TTR offset control apparatus and method in asymmetric digital subscriber line 审中-公开
标题翻译：非对称数字用户线路中的TTR偏移控制装置和方法
公开(公告)号：US20070183488A1
公开(公告)日：2007-08-09
申请号：US11641891
申请日：2006-12-20
申请人： Hye-Won Kang
发明人： Hye-Won Kang
IPC分类号： H04B1/38 , H04L7/00
CPC分类号： H04M11/062 , H04L7/0079 , H04L25/085 , H04L27/2601
摘要： The present invention relates to an apparatus and method for TCM Timing Reference (TTR) offset control in an Asymmetric Digital Subscriber Line (ADSL), the apparatus and method controlling TTR offset in order to remove Near End Crosstalk (NEXT) or Far End Crosstalk (FEXT) noise which would otherwise take place in services due to matching between an Asymmetric Digital Subscriber Line (ADSL) and a Time-Compression Multiplexing Integrated Service Digital Network (TCM-ISDN). The offset control method includes the steps of: synchronizing first and second clocks with each other, the first and second clocks being synchronized with a TTRc clock which is a reference clock for entering the ADSL equipment; dividing the synchronized second clock into a predetermined magnitude of a third clock; classifying the TTRc clock into high and low clocks by using the divided third clock and counting the high and low clocks, respectively; and compensating the counted high and low clocks according to a preset offset adjustment value so as to produce a compensated fourth clock, and providing the fourth clock, together with the first and second clocks, to the ADSL equipment.
摘要翻译：本发明涉及一种用于非对称数字用户线路（ADSL）中的TCM定时参考（TTR）偏移控制的装置和方法，该装置和方法控制TTR偏移，以便去除近端串扰（NEXT）或远端串扰 FEXT）由于非对称数字用户线路（ADSL）和时间压缩复合综合业务数字网络（TCM-ISDN）之间的匹配而在业务中发生的噪声。偏移控制方法包括以下步骤：使第一和第二时钟彼此同步，第一和第二时钟与作为用于进入ADSL设备的参考时钟的TTRc时钟同步; 将所述同步的第二时钟划分为第三时钟的预定大小; 通过使用分频的第三个时钟分别将TTRc时钟分为高低时钟，并分别对高低时钟进行计数; 以及根据预置的偏移调整值补偿所计数的高和低时钟，以产生经补偿的第四时钟，并且将第四时钟与第一和第二时钟一起提供给ADSL设备。

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