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1. 发明授权

US09001513B2 Semiconductor switch insulation protection device and power supply assembly 有权
标题翻译：半导体开关绝缘保护装置和电源组件
公开(公告)号：US09001513B2
公开(公告)日：2015-04-07
申请号：US13584995
申请日：2012-08-14
申请人： Lifeng Pan , Hongming Li
发明人： Lifeng Pan , Hongming Li
IPC分类号： H05K7/20 , H01L23/40 , H01L23/473
CPC分类号： H01L23/4006 , H01L2023/4087 , H01L2924/0002 , H01L2924/00
摘要： A semiconductor switch insulation protection device and a power supply assembly. Said semiconductor switch protection device comprises a semiconductor switch having a metal component, an insulation component, and a pin installed at a bottom plane of said insulation component, and an insulation protection cover having a body with a second hole and a side belt. A front surface of said metal component is installed on a back surface of said insulation component. A metal portion, with a first hole and having a first height, is extended above an upper plane of said insulation component. Said second hole and said side belt are extended toward a back surface of said body, respectively, to form a hole column having a second height and a sidewall having a third height. Said metal portion is disposed in a groove formed by said back surface of said body, hole column and sidewall.
摘要翻译：半导体开关绝缘保护装置和电源组件。所述半导体开关保护装置包括具有金属部件，绝缘部件和安装在所述绝缘部件的底平面处的销的半导体开关，以及具有带有第二孔和侧带的主体的绝缘保护盖。所述金属部件的前表面安装在所述绝缘部件的后表面上。具有第一孔并且具有第一高度的金属部分在所述绝缘部件的上平面的上方延伸。所述第二孔和所述侧带分别延伸到所述主体的后表面，以形成具有第二高度的孔柱和具有第三高度的侧壁。所述金属部分设置在由所述主体的后表面，孔柱和侧壁形成的凹槽中。

2. 发明授权

US08791262B2 Asymmetric friedel-crafts alkylations catalyzed by bifunctional cinchona alkaloids 有权
标题翻译：不对称Friedel-Crafts由双功能金雀草生物碱催化的烷基化
公开(公告)号：US08791262B2
公开(公告)日：2014-07-29
申请号：US12095843
申请日：2006-12-01
申请人： Li Deng , Hongming Li
发明人： Li Deng , Hongming Li
IPC分类号： C07D453/04
CPC分类号： C07D209/18
摘要： In certain embodiments, the present invention relates to methods for asymmetric Friedel-Crafts alkylation catalyzed by bifunctional cinchona alkaloids. In certain embodiments, the catalyst is a 6′-OH cinchona alkaloid. In certain embodiments, the electrophile is an α-ketoester or aldehyde. In certain embodiments, the nucleophile is an aromatic heterocycle. In certain embodiments, the nucleophile is an aromatic N-containing heterocycle. In certain embodiments, the nucleophile is an indole. In certain embodiments, the methods of the invention are relatively insensitive to concentration, temperature, air and moisture.
摘要翻译：在某些实施方案中，本发明涉及由双功能甜菜碱生物碱催化的不对称Friedel-Crafts烷基化方法。在某些实施方案中，催化剂是6'-OH cinchona生物碱。在某些实施方案中，亲电试剂是α-酮酯或醛。在某些实施方案中，亲核试剂是芳族杂环。在某些实施方案中，亲核试剂是芳香族含氮杂环。在某些实施方案中，亲核试剂是吲哚。在某些实施方案中，本发明的方法对浓度，温度，空气和水分相对不敏感。

3. 发明申请

US20130182931A1 METHOD FOR BRAIN TUMOR SEGMENTATION IN MULTI-PARAMETRIC IMAGE BASED ON STATISTICAL INFORMATION AND MULTI-SCALE STRUTURE INFORMATION 有权
标题翻译：基于统计信息和多尺度信息信息的多参数图像中脑肿瘤分期的方法
公开(公告)号：US20130182931A1
公开(公告)日：2013-07-18
申请号：US13806493
申请日：2011-12-21
申请人： Yong Fan , Hongming Li
发明人： Yong Fan , Hongming Li
IPC分类号： G06T7/00
CPC分类号： G06T7/0081 , G06T7/11 , G06T7/143 , G06T2207/10088 , G06T2207/20076 , G06T2207/20081 , G06T2207/30016 , G06T2207/30096 , Y10S128/922
摘要： A method for brain tumor segmentation in multi-parametric 3D magnetic resonance (MR) images, comprising: determining, for each voxel in the multi-parametric 3D MR image sequence, a probability that the voxel is part of brain tumor; extracting multi-scale structure information of the image; generating multi-scale tumor probability map based on initial tumor probability at voxel level and multi-scale structure information; determining salient tumor region based on multi-scale tumor probability map; obtaining robust initial tumor and non-tumor label based on tumor probability map at voxel level and salient tumor region; and generating a segmented brain tumor image using graph based label information propagation. The present invention is capable of achieving statistical reliable, spatially compact, and robust tumor label initialization, which is helpful to the accurate and reliable tumor segmentation. And the label information propagation framework could partially alleviate the performance degradation caused by image inconsistency between images to be segmented and training images.
摘要翻译：一种用于多参数三维磁共振（MR）图像中的脑肿瘤分割的方法，包括：针对多参数3D MR图像序列中的每个体素，确定体素是脑肿瘤一部分的概率; 提取图像的多尺度结构信息; 根据体素水平的初始肿瘤概率和多尺度结构信息生成多尺度肿瘤概率图; 基于多尺度肿瘤概率图确定显着肿瘤区域; 基于体素水平和显着肿瘤区域的肿瘤概率图获得稳健的初始肿瘤和非肿瘤标志物; 并使用基于图的标签信息传播产生分割的脑肿瘤图像。本发明能够实现统计可靠，空间紧凑，鲁棒的肿瘤标签初始化，有助于准确可靠的肿瘤分割。标签信息传播框架可以部分缓解由要分割的图像与训练图像之间的图像不一致引起的性能下降。

4. 发明申请

US20060014956A1 Asymmetric Michael and Aldol additions using bifunctional cinchona-alkaloid-based catalysts 有权
标题翻译：使用双功能金雀子 - 生物碱类催化剂的不对称Michael和Aldol添加剂
公开(公告)号：US20060014956A1
公开(公告)日：2006-01-19
申请号：US11140574
申请日：2005-05-27
申请人： Li Deng , Hongming Li
发明人： Li Deng , Hongming Li
IPC分类号： C07F7/02 , C07D453/04
CPC分类号： C07D453/04 , B01J31/0237 , B01J31/0244 , C07B2200/07 , C07C205/45 , C07C205/51 , C07C205/53 , C07C205/55 , C07C205/56 , C07C231/18 , C07C253/30 , C07C281/02 , C07C315/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C317/44 , C07C317/46 , C07C317/50 , C07C233/87 , C07C255/19 , C07C255/41
摘要： One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the invention relates to a method of preparing a derivatized quinine-based or quinidine-based catalyst comprising 1) reacting quinine or quinidine with base and a compound that has a suitable leaving group, and 2) converting the ring methoxy group to a hydroxy group. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral ketone, comprising the step of: reacting a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral ketone with a nucleophile in the presence of a catalyst; thereby producing a chiral, non-racemic compound; wherein said catalyst is a derivatized quinine or quinidine. Another aspect of the present invention relates to a method of kinetic resolution, comprising the step of: reacting racemic chiral alkene with a nucleophile in the presence of a derivatized quinine or quinidine.
摘要翻译：本发明的一个方面涉及基于奎宁和奎尼丁的催化剂。本发明的另一方面涉及一种制备衍生的基于奎宁或奎尼丁的催化剂的方法，其包括：1）将奎宁或奎尼丁与碱和具有合适离去基团的化合物反应，和2）将环甲氧基转化为羟基。本发明的另一方面涉及从前手电子缺乏烯烃或偶氮化合物或前手性醛或前手性酮制备手性非外消旋化合物的方法，其包括以下步骤：使前手电子缺乏烯烃或偶氮化合物或前手性醛或前手性酮与亲核试剂在催化剂存在下反应; 从而产生手性，非外消旋化合物; 其中所述催化剂是衍生的奎宁或奎尼丁。本发明的另一方面涉及一种动力学拆分方法，其包括以下步骤：在衍生的奎宁或奎尼丁存在下使外消旋手性烯与亲核试剂反应。

5. 发明申请

US20160251375A1 METHODS AND INTERMEDIATES FOR PREPARING MACROLACTAMS 有权
标题翻译：用于制备微波炉的方法和中间件
公开(公告)号：US20160251375A1
公开(公告)日：2016-09-01
申请号：US15029876
申请日：2014-10-14
申请人： Feng XU , Richard DESMOND , Guy R. HUMPHREY , Hongming LI , Ji QI , Rebecca T. RUCK , Zhiguo Jake SONG , Tao WANG , Yong-Li ZHONG , Jeonghan PARK , Laura Marie ARTINO , Richard John VARSOLONA , MERCK SHARP & DOHME CORP.
发明人： Feng XU , Richard DESMOND , Guy R. HUMPHREY , Hongming LI , Ji QI , Rebecca T. RUCK , Zhiguo Jake SONG , Tao WANG , Yong-Li ZHONG , Jeonghan PARK , Laura Marie ARTINO , Richard John VARSOLONA
IPC分类号： C07D498/16 , C07C231/12 , C07C45/00 , C07C45/63 , C07C271/34 , C07C29/58 , C07C269/04 , C07D403/12 , C07K5/12 , C07C29/36 , C07C27/20
CPC分类号： C07D498/16 , C07C27/20 , C07C29/36 , C07C29/58 , C07C45/00 , C07C45/63 , C07C69/14 , C07C69/63 , C07C231/12 , C07C269/04 , C07C271/34 , C07C2601/02 , C07D403/12 , C07K5/06034 , C07K5/0808 , C07K5/126 , C07C233/58
摘要： The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.
摘要翻译：本发明包括可用作制备大内酰胺的中间体的化合物，制备中间体的方法和制备大新戊酰胺的方法。本文描述的方法和中间体的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。 HCV NS3抑制化合物具有治疗和研究应用。

6. 发明授权

US09129382B2 Method and system for brain tumor segmentation in multi-parameter 3D MR images via robust statistic information propagation 有权
标题翻译：通过鲁棒统计信息传播，在多参数三维MR图像中进行脑肿瘤分割的方法和系统
公开(公告)号：US09129382B2
公开(公告)日：2015-09-08
申请号：US13000255
申请日：2010-06-25
申请人： Yong Fan , Hongming Li
发明人： Yong Fan , Hongming Li
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0081 , G06T7/11 , G06T7/143 , G06T7/162 , G06T2207/10088 , G06T2207/20081 , G06T2207/30016 , G06T2207/30096
摘要： A method for brain tumor segmentation in multi-parametric 3D MR images. The method comprises: pre-processing an input multi-parametric 3D MR image; classifying each voxel in the pre-processed multi-parametric 3D MR image, determining the probability that the voxel is part of a brain tumor, and obtaining an initial label information for the image segmentation based on the classification probability; constructing a graph based representation for the pre-processed image to be segmented; and generating the segmented brain tumor image using the initial label information and graph based representation. This method tries to exploit the local and global consistency of the image to be segmented for the tumor segmentation and can alleviate partially the performance degradation caused by the inter-subject image variability and insufficient statistical information from training.
摘要翻译：一种多参数三维MR图像中脑肿瘤分割的方法。该方法包括：对输入的多参数3D MR图像进行预处理; 对预处理的多参数3D MR图像中的每个体素进行分类，确定体素是脑肿瘤一部分的可能性，并且基于分类概率获得用于图像分割的初始标签信息; 构建要分割的预处理图像的基于图形的表示; 并使用初始标签信息和基于图形的表示来产生分割的脑肿瘤图像。该方法试图利用分割图像的局部和全局一致性进行肿瘤分割，并可以部分减轻受试者图像变异性引起的性能下降和培训不足的统计信息。

7. 发明授权

US08908948B2 Method for brain tumor segmentation in multi-parametric image based on statistical information and multi-scale structure information 有权
标题翻译：基于统计信息和多尺度结构信息的多参数图像脑肿瘤分割方法
公开(公告)号：US08908948B2
公开(公告)日：2014-12-09
申请号：US13806493
申请日：2011-12-21
申请人： Yong Fan , Hongming Li
发明人： Yong Fan , Hongming Li
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0081 , G06T7/11 , G06T7/143 , G06T2207/10088 , G06T2207/20076 , G06T2207/20081 , G06T2207/30016 , G06T2207/30096 , Y10S128/922
摘要： A method for brain tumor segmentation in multi-parametric 3D magnetic resonance (MR) images, comprising: determining, for each voxel in the multi-parametric 3D MR image sequence, a probability that the voxel is part of brain tumor; extracting multi-scale structure information of the image; generating multi-scale tumor probability map based on initial tumor probability at voxel level and multi-scale structure information; determining salient tumor region based on multi-scale tumor probability map; obtaining robust initial tumor and non-tumor label based on tumor probability map at voxel level and salient tumor region; and generating a segmented brain tumor image using graph based label information propagation. The present invention is capable of achieving statistical reliable, spatially compact, and robust tumor label initialization, which is helpful to the accurate and reliable tumor segmentation. And the label information propagation framework could partially alleviate the performance degradation caused by image inconsistency between images to be segmented and training images.
摘要翻译：一种用于多参数三维磁共振（MR）图像中的脑肿瘤分割的方法，包括：针对多参数3D MR图像序列中的每个体素，确定体素是脑肿瘤一部分的概率; 提取图像的多尺度结构信息; 根据体素水平的初始肿瘤概率和多尺度结构信息生成多尺度肿瘤概率图; 基于多尺度肿瘤概率图确定显着肿瘤区域; 基于体素水平和显着肿瘤区域的肿瘤概率图获得稳健的初始肿瘤和非肿瘤标志物; 并使用基于图的标签信息传播产生分割的脑肿瘤图像。本发明能够实现统计可靠，空间紧凑，鲁棒的肿瘤标签初始化，有助于准确可靠的肿瘤分割。标签信息传播框架可以部分缓解由要分割的图像与训练图像之间的图像不一致引起的性能下降。

8. 发明授权

US08765955B2 Asymmetric aldol additions using bifunctional cinchona-alkaloid-based catalysts 有权
标题翻译：使用双功能胡萝卜素 - 生物碱类催化剂的不对称醛醇醛添加剂
公开(公告)号：US08765955B2
公开(公告)日：2014-07-01
申请号：US11442667
申请日：2006-05-26
申请人： Li Deng , Hongming Li
发明人： Li Deng , Hongming Li
IPC分类号： C07D453/04
CPC分类号： C07D453/04
摘要： One aspect of the present invention relates to asymmetric catalytic nitroaldol (Henry) reactions with ketones as the electrophilic component. In one embodiment, the present invention relates to asymmetric nitroaldol reactions with α-keto esters catalyzed by a new C6′-OH cinchona alkaloid catalyst. In certain embodiments, this reaction is operationally simple and affords high enantioselectivity as well as good to excellent yield for an exceptionally broad range of α-keto esters.
摘要翻译：本发明的一个方面涉及与酮作为亲电子组分的不对称催化硝基醛（Henry）反应。在一个实施方案中，本发明涉及与新的C6'-OH cinchona生物碱催化剂催化的α-酮酯的不对称硝基醛反应。在某些实施方案中，该反应在操作上是简单的，并且对于特别宽范围的α-酮酯而言具有高的对映选择性以及良好至极好的收率。

9. 发明授权

US08164518B2 Method and system for a GNSS receiver with self-assisted ephemeris extensions 有权
标题翻译：具有自助星历延长的GNSS接收机的方法和系统
公开(公告)号：US08164518B2
公开(公告)日：2012-04-24
申请号：US12487763
申请日：2009-06-19
申请人： Frank van Diggelen , Hongming Li
发明人： Frank van Diggelen , Hongming Li
IPC分类号： G01S19/27
CPC分类号： G01S19/27
摘要： A GNSS enabled mobile device receives GNSS signals from visible GNSS satellites. Broadcast ephemeris is extracted from the received GNSS signals for generating ephemeris extension (future ephemeris) in the next several days for each of the visible GNSS satellites. The GNSS enabled mobile device uses the generated future ephemeris to determine a position fix even without fresh broadcast ephemeris completely received from the visible GNSS satellites. The generation of future ephemeris is scheduled according to the age of available ephemeris extensions and/or the time of visibility. Available ephemeris such as extracted broadcast ephemeris are integrated into an orbit model using the multi-step numerical integration methods and propagated to generate future ephemeris. The generated future ephemeris is reformatted into a desired orbit model and/or format of the GNSS enabled mobile device. A curve fitting polynomial of generated future ephemeris is stored instead of actual generated future ephemeris to conserve storage space.
摘要翻译：支持GNSS的移动设备从可见的GNSS卫星接收GNSS信号。从接收到的GNSS信号中提取广播星历，用于在接下来的几天内为每个可见的GNSS卫星产生星历延长（未来星历）。即使没有从可见的GNSS卫星完全接收到新的广播星历，GNSS启用的移动设备也使用所生成的未来星历来确定位置锁定。根据可用的星历延长的时代和/或可见度的时间安排未来星历的生成。提取的广播星历中的可用星历表使用多步数值积分方法集成到轨道模型中，并被传播以产生未来的星历。所生成的未来星历将重新格式化为支持GNSS的移动设备的所需轨道模型和/或格式。存储生成的未来星历的曲线拟合多项式，而不是实际生成的未来星历，以节省存储空间。

10. 发明授权

US07312335B2 Asymmetric Michael and Aldol additions using bifunctional cinchona-alkaloid-based catalysts 有权
标题翻译：使用双功能金雀子 - 生物碱类催化剂的不对称Michael和Aldol添加剂
公开(公告)号：US07312335B2
公开(公告)日：2007-12-25
申请号：US11140574
申请日：2005-05-27
申请人： Li Deng , Hongming Li
发明人： Li Deng , Hongming Li
IPC分类号： C07D453/02 , C07D453/04
CPC分类号： C07D453/04 , B01J31/0237 , B01J31/0244 , C07B2200/07 , C07C205/45 , C07C205/51 , C07C205/53 , C07C205/55 , C07C205/56 , C07C231/18 , C07C253/30 , C07C281/02 , C07C315/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C317/44 , C07C317/46 , C07C317/50 , C07C233/87 , C07C255/19 , C07C255/41
摘要： One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the invention relates to a method of preparing a derivatized quinine-based or quinidine-based catalyst comprising 1) reacting quinine or quinidine with base and a compound that has a suitable leaving group, and 2) converting the ring methoxy group to a hydroxy group. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral ketone, comprising the step of: reacting a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral ketone with a nucleophile in the presence of a catalyst; thereby producing a chiral, non-racemic compound; wherein said catalyst is a derivatized quinine or quinidine. Another aspect of the present invention relates to a method of kinetic resolution, comprising the step of: reacting racemic chiral alkene with a nucleophile in the presence of a derivatized quinine or quinidine.
摘要翻译：本发明的一个方面涉及基于奎宁和奎尼丁的催化剂。本发明的另一方面涉及一种制备衍生的基于奎宁或奎尼丁的催化剂的方法，其包括：1）将奎宁或奎尼丁与碱和具有合适离去基团的化合物反应，和2）将环甲氧基转化为羟基。本发明的另一方面涉及从前手电子缺乏烯烃或偶氮化合物或前手性醛或前手性酮制备手性非外消旋化合物的方法，其包括以下步骤：使前手电子缺乏烯烃或偶氮化合物或前手性醛或前手性酮与亲核试剂在催化剂存在下反应; 从而产生手性，非外消旋化合物; 其中所述催化剂是衍生的奎宁或奎尼丁。本发明的另一方面涉及一种动力学拆分方法，其包括以下步骤：在衍生的奎宁或奎尼丁存在下使外消旋手性烯与亲核试剂反应。

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