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1. 发明授权

US08114872B2 Triazolyl aminopyrimidine compounds 失效
标题翻译：三唑基氨基嘧啶化合物
公开(公告)号：US08114872B2
公开(公告)日：2012-02-14
申请号：US12596957
申请日：2008-05-07
申请人： Joyce Z. Crich , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang , James Robert Henry , Hong Hu , Sachin Govindlal Maniar
发明人： Joyce Z. Crich , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang , James Robert Henry , Hong Hu , Sachin Govindlal Maniar
IPC分类号： C07D409/14 , A61K31/506
CPC分类号： C07D409/14
摘要： The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.
摘要翻译：本发明提供可用于治疗癌症的三唑基氨基嘧啶化合物。

2. 发明申请

US20100087431A1 TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS 失效
公开(公告)号：US20100087431A1
公开(公告)日：2010-04-08
申请号：US12598926
申请日：2008-05-07
申请人： Harold Burns Brooks , Joyce Z. Crich , James Robert Henry , Hong Hu , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang
发明人： Harold Burns Brooks , Joyce Z. Crich , James Robert Henry , Hong Hu , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang
IPC分类号： A61K31/506 , C07D409/14 , C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号： C07D409/14
摘要： The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.

3. 发明授权

US07405299B2 Compounds as pharmaceutical agents 失效
标题翻译：化合物作为药剂
公开(公告)号：US07405299B2
公开(公告)日：2008-07-29
申请号：US10535381
申请日：2003-11-24
申请人： Douglas Wade Beight , Timothy Paul Burkholder , Todd Vincent Decollo , Alexander Glenn Godfrey , Charles Raymond Heap , Chi-Hsin Richard King , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Yan Wang , Clive Gideon Diefenbacher , Thomas Albert Engler , Sushant Malhotra , Sreenivasa Reedy Mundla
发明人： Douglas Wade Beight , Timothy Paul Burkholder , Todd Vincent Decollo , Alexander Glenn Godfrey , Charles Raymond Heap , Chi-Hsin Richard King , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Yan Wang , Clive Gideon Diefenbacher , Thomas Albert Engler , Sushant Malhotra , Sreenivasa Reedy Mundla
IPC分类号： C07D241/36 , C07D217/00 , C07D401/00
CPC分类号： C07D487/04
摘要： The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.
摘要翻译：本发明涉及式（Ia）化合物及其药学上可接受的盐及其作为TGF-β信号转导抑制剂的用途，其用于通过施用所述化合物治疗有需要的患者中的癌症和其它疾病。

4. 发明授权

US07368445B2 Fused pyrazole derivatives as TGF-β signal transduction inhibitors for the treatment of fibrosis and neoplasms 失效
标题翻译：融合的吡唑衍生物作为TGF-β信号转导抑制剂用于治疗纤维化和肿瘤
公开(公告)号：US07368445B2
公开(公告)日：2008-05-06
申请号：US10597979
申请日：2005-02-16
申请人： Hong-Yu Li , William Thomas McMillen , Yan Wang
发明人： Hong-Yu Li , William Thomas McMillen , Yan Wang
IPC分类号： C07D487/04 , A61K31/517
CPC分类号： C07D413/14 , C07D401/14 , C07D487/04
摘要： The disclosed invention is directed to compounds of the formula: Formula (I) and methods of using these compounds.
摘要翻译：所公开的发明涉及下式的化合物：式（I）和使用这些化合物的方法。

5. 发明申请

US20060058295A1 Novel compounds as pharmaceutical agents 失效
标题翻译：新型化合物作为药剂
公开(公告)号：US20060058295A1
公开(公告)日：2006-03-16
申请号：US10535381
申请日：2003-11-24
申请人： Douglas Beight , Timothy Burkholder , Todd Decollo , Alexander Godfrey , Charles Heap , Chi-Hsin King , Hong-Yu Li , William McMillen , Jason Sawyer , Yan Wang , Clive Diefenbacher , Thomas Engler , Sushant Malhotra , Sreenivasa Mundla
发明人： Douglas Beight , Timothy Burkholder , Todd Decollo , Alexander Godfrey , Charles Heap , Chi-Hsin King , Hong-Yu Li , William McMillen , Jason Sawyer , Yan Wang , Clive Diefenbacher , Thomas Engler , Sushant Malhotra , Sreenivasa Mundla
IPC分类号： A61K31/5377 , A61K31/519 , A61K31/4745 , C07D471/02
CPC分类号： C07D487/04
摘要： The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.
摘要翻译：本发明涉及式（Ia）化合物及其药学上可接受的盐及其作为TGF-β信号转导抑制剂的用途，其用于通过施用所述化合物治疗有需要的患者中的癌症和其它疾病。

6. 发明授权

US08268869B2 Vinyl indazolyl compounds 有权
标题翻译：乙烯基吲唑基化合物
公开(公告)号：US08268869B2
公开(公告)日：2012-09-18
申请号：US12773186
申请日：2010-05-04
申请人： Daohong Chen , Hong-Yu Li , Genshi Zhao
发明人： Daohong Chen , Hong-Yu Li , Genshi Zhao
IPC分类号： C07D401/14 , A61K31/4439
CPC分类号： C07D401/14 , A61K31/4439
摘要： The present invention provides vinyl indazolyl compounds useful in the treatment of cancer.
摘要翻译：本发明提供了可用于治疗癌症的乙烯基吲唑基化合物。

7. 发明授权

US08201746B2 On-chip antenna and a method of fabricating the same 失效
标题翻译：片上天线及其制造方法
公开(公告)号：US08201746B2
公开(公告)日：2012-06-19
申请号：US12161958
申请日：2007-01-24
申请人： Li Hui Guo , Hong Yu Li , Min Tang
发明人： Li Hui Guo , Hong Yu Li , Min Tang
IPC分类号： G06K19/06
CPC分类号： G06K19/07749 , G06K19/07775 , G06K19/07779 , Y10T29/49016
摘要： An on-chip antenna fabricated on a chip for wireless communication is disclosed. The on-chip antenna includes a first dielectric layer arranged on a surface of the chip of the radio frequency identification tag, a grounded shielding layer arranged on the first dielectric layer, a second dielectric layer arranged on the grounded shielding layer, and a planar antenna arranged on the second dielectric layer above the grounded shielding layer. A radio frequency identification tag with an on-chip antenna and a method of fabricating an on-chip antenna on a chip for wireless communication are also disclosed.
摘要翻译：公开了一种制造在用于无线通信的芯片上的片上天线。片上天线包括布置在射频识别标签的芯片的表面上的第一介电层，布置在第一介电层上的接地屏蔽层，布置在接地屏蔽层上的第二介电层和平面天线布置在接地屏蔽层上方的第二电介质层上。还公开了一种具有片上天线的射频识别标签和用于无线通信的芯片上制造片上天线的方法。

8. 发明授权

US08063035B2 Triazolyl aminopyrimidine compounds 失效
标题翻译：三唑基氨基嘧啶化合物
公开(公告)号：US08063035B2
公开(公告)日：2011-11-22
申请号：US12598926
申请日：2008-05-07
申请人： Joyce Z. Crich , James Robert Henry , Hong Hu , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang
发明人： Joyce Z. Crich , James Robert Henry , Hong Hu , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang
IPC分类号： A61K31/381 , C07D333/16 , C07D409/14
CPC分类号： C07D409/14
摘要： The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.
摘要翻译：本发明提供可用于治疗癌症的三唑基氨基嘧啶化合物。

9. 发明申请

US20100081641A1 IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER 失效
标题翻译：用于治疗癌症的咪达唑仑胺氨基嘧啶化合物
公开(公告)号：US20100081641A1
公开(公告)日：2010-04-01
申请号：US12516251
申请日：2007-12-11
申请人： Harold Burns Brooks , Joyce Z. Crich , James Robert Henry , Hong-Yu Li , Jason Scott Sawyer , Yan Wang
发明人： Harold Burns Brooks , Joyce Z. Crich , James Robert Henry , Hong-Yu Li , Jason Scott Sawyer , Yan Wang
IPC分类号： A61K31/397 , C07D403/14 , A61K31/506 , C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号： C07D409/14
摘要： The present invention provides novel imidazolidinonyl aminopyrimidine compounds believed to have clinical use for treatment of cancer through inhibiting Plk1. Formula I wherein: R1 is aminomethyl, (C1-C3 alkyl)aminomethyl, di(C1-C2 alkyl)aminomethyl, N-ethyl-N-methyl-aminomethyl, 1-aminoethyl, 1-((C1-C2 alkyl)amino)-ethyl, 3,3,3-trifluoro-propylaminomethyl, ethynyl, 2-hydroxy-ethoxy, 2-hydroxyethylaminomethyl, 2-cyanoethylaminomethyl, mopholin-4-ylmethyl, methoxymethoxymethyl, cyclopropyl, 1-azetidinylmethyl, 1-pyrrolidinylmethyl, or 1,3-dioxolan-2-yl; R2 is hydrogen or halo; R3 is hydrogen or halo; provided that at least one of R2 and R3 is hydrogen; R4 is hydrogen, methyl, or halo; and is a single bond that is either present or absent, or pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了被认为具有通过抑制Plk1治疗癌症的临床用途的新型咪唑烷基氨基嘧啶化合物。式（I）其中：R1是氨基甲基，（C1-C3烷基）氨基甲基，二（C1-C2烷基）氨基甲基，N-乙基-N-甲基 - 氨基甲基，1-氨基乙基，1-（（C1-C2烷基）乙基，3,3,3-三氟 - 丙基氨基甲基，乙炔基，2-羟基 - 乙氧基，2-羟乙基氨基甲基，2-氰基乙基氨基甲基，吗啉-4-基甲基，甲氧基甲氧基甲基，环丙基，1-氮杂环丁基甲基，1-吡咯烷基甲基， 3-二氧戊环-2-基; R2为氢或卤素; R3是氢或卤素; R2和R3中的至少一个是氢; R4是氢，甲基或卤素; 并且是存在或不存在的单键或其药学上可接受的盐。

10. 发明授权

US08063212B2 Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer 失效
标题翻译：咪唑烷酰氨基嘧啶化合物治疗癌症
公开(公告)号：US08063212B2
公开(公告)日：2011-11-22
申请号：US12516251
申请日：2007-12-11
申请人： Harold Burns Brooks , Joyce Z. Crich , James Robert Henry , Hong-Yu Li , Jason Scott Sawyer , Yan Wang
发明人： Harold Burns Brooks , Joyce Z. Crich , James Robert Henry , Hong-Yu Li , Jason Scott Sawyer , Yan Wang
IPC分类号： C07D401/00
CPC分类号： C07D409/14
摘要： The present invention provides novel imidazolidinonyl aminopyrimidine compounds believed to have clinical use for treatment of cancer through inhibiting Plk1. Formula I wherein: R1 is aminomethyl, (C1-C3 alkyl)aminomethyl, di(C1-C2 alkyl)aminomethyl, N-ethyl-N-methyl-aminomethyl, 1-aminoethyl, 1-((C1-C2 alkyl)amino)-ethyl, 3,3,3-trifluoro-propylaminomethyl, ethynyl, 2-hydroxy-ethoxy, 2-hydroxyethylaminomethyl, 2-cyanoethylaminomethyl, morpholin-4-ylmethyl, methoxymethoxymethyl, cyclopropyl, 1-azetidinylmethyl, 1-pyrrolidinylmethyl, or 1,3-dioxolan-2-yl; R2 is hydrogen or halo; R3 is hydrogen or halo; provided that at least one of R2 and R3 is hydrogen; R4 is hydrogen, methyl, or halo; and is a single bond that is either present or absent, or pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了被认为具有通过抑制Plk1治疗癌症的临床用途的新型咪唑烷基氨基嘧啶化合物。式（I）其中：R1是氨基甲基，（C1-C3烷基）氨基甲基，二（C1-C2烷基）氨基甲基，N-乙基-N-甲基 - 氨基甲基，1-氨基乙基，1-（（C1-C2烷基）氨基）乙基，3,3,3-三氟 - 丙氨基甲基，乙炔基，2-羟基 - 乙氧基，2-羟乙基氨基甲基，2-氰乙基氨基甲基，吗啉-4-基甲基，甲氧基甲氧基甲基，环丙基，1-氮杂环丁基甲基，1-吡咯烷基甲基， 3-二氧戊环-2-基; R2是氢或卤素; R3是氢或卤素; R2和R3中的至少一个是氢; R4是氢，甲基或卤素; 并且是存在或不存在的单键或其药学上可接受的盐。

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