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1. 发明授权

US09302430B2 Method and device for a spatially resolved introduction of an intensity pattern comprising electro-magnetic radiation into a photosensitive substance as well as applications thereof 有权
标题翻译：用于空间分辨地引入包含电磁辐射到感光物质中的强度图案的方法和装置及其应用
公开(公告)号：US09302430B2
公开(公告)日：2016-04-05
申请号：US13405616
申请日：2012-02-27
申请人： Michael Thiel , Holger Fischer
发明人： Michael Thiel , Holger Fischer
IPC分类号： B44C1/22 , B29C67/00 , G03F7/004
CPC分类号： B29C67/0066 , B29C64/135 , G03F7/0045
摘要： A method for the spatially resolved introduction of an intensity pattern of electro-magnetic radiation by at least one optic display system into a photosensitive substance having properties which can be changed by photon exposure. These properties include a first, liquid and at least one second state, with the electro-magnetic radiation being conducted via the optic display system into the photosensitive substance and here being projected on predetermined spatial coordinates, in order to create at or in an area of these spatial coordinates a change of the properties of the substance. A surface of an objective lens of the optic display system, through which the electro-magnetic radiation 4 is emitted, is immersed in the liquid photosensitive substance 2. A corresponding device is provided, and the device and method can be used for the creation of micro or nano-scaled structures.
摘要翻译：一种用于通过至少一个光学显示系统将电磁辐射的强度图案空间分辨地引入具有可以通过光子曝光改变的性质的光敏物质的方法。这些性质包括第一，液体和至少一个第二状态，其中电磁辐射通过光学显示系统传导到感光物质中，并且这里被投影到预定的空间坐标上，以便在这些空间坐标是物质性质的变化。将光电显示系统的物镜透过电磁辐射4发射的表面浸入液体光敏物质2中。提供相应的装置，该装置和方法可用于创建微尺度或纳米级结构。

2. 发明申请

US20120309109A1 METHOD FOR DETERMINING THE BINDING CONSTANT OF HIGH AFFINITY COMPOUNDS 有权
标题翻译：用于确定高亲和性化合物的结合常数的方法
公开(公告)号：US20120309109A1
公开(公告)日：2012-12-06
申请号：US13578848
申请日：2011-02-22
申请人： Frauke Assmus , Holger Fischer
发明人： Frauke Assmus , Holger Fischer
IPC分类号： G01N33/53
CPC分类号： G01N33/566 , B01D61/243 , B01D61/28 , B01L3/50255 , B01L2300/0618 , B01L2300/0829 , B01L2300/0858 , G01N33/5302 , G01N33/68
摘要： The invention relates to a method for determining the binding constant of a compound of interest to proteins comprising the following steps: a) adding the high affinity compound to a two-chamber system, wherein the two chambers are separated by a semipermeable membrane, which is permeable for the compound of interest, and determining the amount of the high affinity compound of interest in one of the chambers after the distribution equilibrium has been reached, b) adding a sink compound to one of the chambers whereby the sink compound can not permeate the membrane, and determining the distribution coefficient of the compound of interest to the sink compound after the distribution equilibrium has been reached, c) adding an unspecific protein to the other chamber, whereby the unspecific protein can not permeate the membrane, and determining the distribution coefficient of the compound of interest to the unspecific protein in presence of a sink compound after the distribution equilibrium has been reached, and d) determining the binding constant of the test compound with the distribution coefficient of steps b) and c).
摘要翻译：本发明涉及一种测定感兴趣的化合物与蛋白质的结合常数的方法，包括以下步骤：a）将高亲和性化合物加入到两室系统中，其中两个室由半透膜隔开，其为半透膜可渗透感兴趣的化合物，并且在达到分配平衡之后确定其中一个室中的高亲和力化合物的量，b）向其中一个室加入沉淀化合物，由此沉淀化合物不能渗透到膜，并且在达到分配平衡之后确定目的化合物对沉淀化合物的分布系数，c）向另一个室添加非特异性蛋白质，由此非特异性蛋白质不能渗透到膜中，并且确定分布系数的分配平衡h之后的沉淀化合物存在下的非特异性蛋白质的目标化合物以及d）用步骤b）和c）的分布系数确定测试化合物的结合常数。

3. 发明申请

US20080191547A1 Pressure Fluid Reservoir, Reservoir Unit, and Method For Producing a Pressure Fluid Reservoir 审中-公开
标题翻译：压力流体储层，储层单元和压力流体储集层的生产方法
公开(公告)号：US20080191547A1
公开(公告)日：2008-08-14
申请号：US11909753
申请日：2006-02-21
申请人： Andreas Weh , Alexander Bareiss , Nathan McCormick , Holger Fischer
发明人： Andreas Weh , Alexander Bareiss , Nathan McCormick , Holger Fischer
IPC分类号： B60T17/06
CPC分类号： F15B1/04 , B60T8/368 , B60T8/4275 , F15B2201/21 , F15B2201/312 , F15B2201/61
摘要： A pressure fluid reservoir for a traction-controlled vehicle brake system; a reservoir unit including a plurality of pressure fluid reservoirs; and a method for producing a pressure fluid reservoir are disclosed. The pressure fluid reservoir with its structural size unchanged, has a larger installation space for a restoring element cooperating with a reservoir piston and at the same time can be produced economically. To that end, as the reservoir piston, a component reshaped in non-metal-cutting fashion from a sheet-metal material is proposed, on whose circumference an encompassing receptacle for a piston seal is integrally formed, likewise in non-metal-cutting fashion. The reservoir piston can be produced by deep drawing; the receptacle for the piston seal can be produced by roller-burnishing. Both method steps can be performed economically in one combined operation.
摘要翻译：用于牵引力控制的车辆制动系统的压力容器; 包括多个压力流体储存器的储存器单元; 并公开了一种用于生产压力流体储存器的方法。其结构尺寸不变的压力贮液器具有较大的安装空间，用于与贮存器活塞配合的恢复元件，同时可以经济地生产。为此，作为储存器活塞，提出了以非金属切割方式从金属板材料重新成形的部件，其圆周上用于活塞密封件的封闭容器一体地形成，同样以非金属切割方式。储层活塞可以通过深拉制作; 用于活塞密封的容器可以通过滚筒抛光来生产。两种方法步骤可以在一个组合操作中经济地执行。

4. 发明授权

US08778617B2 Method for determining the binding constant of high affinity compounds 有权
标题翻译：测定高亲和力化合物结合常数的方法
公开(公告)号：US08778617B2
公开(公告)日：2014-07-15
申请号：US13578848
申请日：2011-02-22
申请人： Frauke Assmus , Holger Fischer
发明人： Frauke Assmus , Holger Fischer
IPC分类号： G01N33/53 , B01D61/00 , B01D53/22
CPC分类号： G01N33/566 , B01D61/243 , B01D61/28 , B01L3/50255 , B01L2300/0618 , B01L2300/0829 , B01L2300/0858 , G01N33/5302 , G01N33/68
摘要： The invention relates to a method for determining the binding constant of a compound of interest to proteins comprising the following steps: a) adding the high affinity compound to a two-chamber system, wherein the two chambers are separated by a semipermeable membrane, which is permeable for the compound of interest, and determining the amount of the high affinity compound of interest in one of the chambers after the distribution equilibrium has been reached, b) adding a sink compound to one of the chambers whereby the sink compound can not permeate the membrane, and determining the distribution coefficient of the compound of interest to the sink compound after the distribution equilibrium has been reached, c) adding an unspecific protein to the other chamber, whereby the unspecific protein can not permeate the membrane, and determining the distribution coefficient of the compound of interest to the unspecific protein in presence of a sink compound after the distribution equilibrium has been reached, and d) determining the binding constant of the test compound with the distribution coefficient of steps b) and c).
摘要翻译：本发明涉及一种测定感兴趣的化合物与蛋白质的结合常数的方法，包括以下步骤：a）将高亲和性化合物加入到两室系统中，其中两个室由半透膜隔开，其为半透膜可渗透感兴趣的化合物，并且在达到分配平衡之后确定其中一个室中的高亲和力化合物的量，b）向其中一个室加入沉淀化合物，由此沉淀化合物不能渗透到膜，并且在达到分配平衡之后确定目的化合物对沉淀化合物的分布系数，c）向另一个室添加非特异性蛋白质，由此非特异性蛋白质不能渗透到膜中，并且确定分布系数的分配平衡h之后的沉淀化合物存在下的非特异性蛋白质的目标化合物以及d）用步骤b）和c）的分布系数确定测试化合物的结合常数。

5. 发明授权

US07778781B2 Automated generation of multi-dimensional structure activity and structure property relationships 有权
标题翻译：自动生成多维结构活动和结构属性关系
公开(公告)号：US07778781B2
公开(公告)日：2010-08-17
申请号：US12214941
申请日：2008-06-24
申请人： Holger Fischer , Manfred Kansy
发明人： Holger Fischer , Manfred Kansy
IPC分类号： G06F19/00
CPC分类号： G06F19/704 , G06F19/707 , G06F19/708 , Y10S707/99943
摘要： The present invention relates to automated generation of multi-dimensional structure activity and structure property relationships.
摘要翻译：本发明涉及自动生成多维结构活性和结构性质关系。

6. 发明申请

US20080270040A1 Automated generation of multi-dimensional structure activity and structure property relationships 有权
标题翻译：自动生成多维结构活动和结构属性关系
公开(公告)号：US20080270040A1
公开(公告)日：2008-10-30
申请号：US12214941
申请日：2008-06-24
申请人： Holger Fischer , Manfred Kansy
发明人： Holger Fischer , Manfred Kansy
IPC分类号： G06F19/00
CPC分类号： G06F19/704 , G06F19/707 , G06F19/708 , Y10S707/99943
摘要： The present invention relates to automated generation of multi-dimensional structure activity and structure property relationships.
摘要翻译：本发明涉及自动生成多维结构活性和结构性质关系。

7. 发明授权

US07400982B2 Automated generation of multi-dimensional structure activity and structure property relationships 有权
公开(公告)号：US07400982B2
公开(公告)日：2008-07-15
申请号：US11495227
申请日：2006-07-28
申请人： Holger Fischer , Manfred Kansy
发明人： Holger Fischer , Manfred Kansy
IPC分类号： G06F19/00
CPC分类号： G06F19/704 , G06F19/707 , G06F19/708 , Y10S707/99943
摘要： The present invention relates to automated generation of multi-dimensional structure activity and structure property relationships.

8. 发明授权

US09835151B2 Hydraulic device, in particular low-pressure accumulator with a closure element 有权
公开(公告)号：US09835151B2
公开(公告)日：2017-12-05
申请号：US13994752
申请日：2011-10-18
申请人： Franz Berger , Andreas Weh , Holger Fischer , Bernd Lutz
发明人： Franz Berger , Andreas Weh , Holger Fischer , Bernd Lutz
IPC分类号： F04B53/16 , B23K20/10 , B60T8/36 , F04B1/04 , F15B1/04
CPC分类号： F04B53/16 , B23K20/106 , B60T8/368 , F04B1/0404 , F04B1/0421 , F15B1/04 , F15B2201/21 , F15B2201/31 , F15B2201/4056 , F15B2201/605
摘要： A hydraulic device includes a housing and a closure element arranged thereon. The closure element is connected to the housing by torsional welding.

9. 发明授权

US07527975B2 Determination of high lipophilicity values 有权
标题翻译：高亲脂性值的测定
公开(公告)号：US07527975B2
公开(公告)日：2009-05-05
申请号：US11375903
申请日：2006-03-15
申请人： Holger Fischer , Manfred Kansy , Bjoern Wagner
发明人： Holger Fischer , Manfred Kansy , Bjoern Wagner
IPC分类号： G01N33/92
CPC分类号： G01N33/92
摘要： The present invention relates to a novel method for determining the lipophilicity of a compound of interest comprising a) providing a layer, b) impregnating said layer with a solvent A, c) applying a dissolved compound of interest on the impregnated layer, d) adding a solvent B, e) removing the solvent B after the distribution equilibrium has been reached, and f) determining the quantity of the compound of interest in at least one of the solvent phases.
摘要翻译：本发明涉及一种用于测定感兴趣的化合物的亲油性的新方法，其包括a）提供一层，b）用溶剂A浸渍所述层，c）将所需的溶解化合物施加到浸渍层上，d）将溶剂B，e）在达到分配平衡之后除去溶剂B，以及f）确定至少一个溶剂相中的目标化合物的量。

10. 发明申请

US20070027632A1 Automated generation of multi-dimensional structure activity and structure property relationships 有权
标题翻译：自动生成多维结构活动和结构属性关系
公开(公告)号：US20070027632A1
公开(公告)日：2007-02-01
申请号：US11495227
申请日：2006-07-28
申请人： Holger Fischer , Manfred Kansy
发明人： Holger Fischer , Manfred Kansy
IPC分类号： G01N33/48
CPC分类号： G06F19/704 , G06F19/707 , G06F19/708 , Y10S707/99943
摘要： The present invention relates to automated generation of multi-dimensional structure activity and structure property relationships.
摘要翻译：本发明涉及自动生成多维结构活性和结构性质关系。

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