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    • 4. 发明申请
    • NOVEL GAMMA-SECRETASE INHIBITOR
    • 新型GAMMA-SECRETASE抑制剂
    • US20110071224A1
    • 2011-03-24
    • US12672326
    • 2008-07-01
    • Atsuhiro AbeHideaki ShimizuSeigo SawadaHiroshi Kodaira
    • Atsuhiro AbeHideaki ShimizuSeigo SawadaHiroshi Kodaira
    • A61K31/198C07C229/28A61P25/28
    • C07K5/0207A61K38/00
    • It is intended to provide a novel compound that has an excellent γ-secretase inhibitory effect and specifically inhibits Aβ production.The present invention provides a compound of the following formula (1) or a pharmaceutically acceptable salt thereof: wherein R1 represents a linear or branched alkyl group having 1 to 4 carbon atoms or a phenyl group; R2 represents a linear or branched alkyl group having 1 to 4 carbon atoms which may be substituted by one or more phenyl or halogenophenyl groups; R3 represents a linear or branched alkyl group having 1 to 4 carbon atoms which may be substituted by one or more hydroxyl groups; R4 represents a linear or branched alkyl group having 1 to 4 carbon atoms; and the symbol “*” represents a chiral center.
    • 本发明提供具有优异的γ-分泌酶抑制效果并特异性抑制A&bgr的新型化合物。 生产。 本发明提供下式(1)的化合物或其药学上可接受的盐:其中R1表示具有1-4个碳原子的直链或支链烷基或苯基; R2表示可被一个或多个苯基或卤代苯基取代的具有1至4个碳原子的直链或支链烷基; R3表示可以被一个或多个羟基取代的具有1至4个碳原子的直链或支链烷基; R4代表具有1-4个碳原子的直链或支链烷基; 符号“*”表示手性中心。