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1. 发明授权

US5858392A Supported polyionic hydrogels 失效
标题翻译：负载型聚离子水凝胶
公开(公告)号：US5858392A
公开(公告)日：1999-01-12
申请号：US806218
申请日：1997-02-26
申请人： Severian Dumitriu , Hilda Guttmann , Itzhak Kahane
发明人： Severian Dumitriu , Hilda Guttmann , Itzhak Kahane
IPC分类号： A61L15/60 , A61K9/70 , C12N5/00 , C12N11/10 , C12N11/12
CPC分类号： A61L15/60 , C12N2533/70 , C12N2533/72 , Y10S530/813 , Y10S530/814
摘要： A supported polyionic hydrogel is prepared by impregnating a support matel with a solution of anionic polysaccharide and a solution of cationic polysaccharide where the anionic polysaccharide and cationic polysaccharide react with each other to form a polyionic hydrogel impregnated in the support material. The hydrogel may be dried such as by lyophilization. Preferably, the anionic polysaccharide is xanthan, dicarboxystarch or dicarboxycellulose and the cationic polysaccharide is chitosan. Especially preferred is a polyionic hydrogel formed from xanthan and chitosan. A paper material or a textile material can be used as the support material. A dry supported polyionic hydrogel can be formed as a bandage without active material incorporated therein. The supported polyionic hydrogel may be formed containing a biologically active material by having the active material in either polysaccharide solution or in another solution impregnated into the support material. The biologically active materials can be enzymes, antibody-producing cells or water-soluble drugs such as the antimicrobial agent, chlorohexidine.
摘要翻译：通过用阴离子多糖溶液和阳离子多糖溶液浸渍载体材料制备负载的聚离子水凝胶，其中阴离子多糖和阳离子多糖彼此反应以形成浸渍在载体材料中的聚离子水凝胶。水凝胶可以干燥，例如通过冻干。优选地，阴离子多糖是黄原胶，二羧甲基纤维素或二羧基纤维素，阳离子多糖是壳聚糖。特别优选的是由黄原胶和壳聚糖形成的聚离子水凝胶。可以使用纸材料或纺织材料作为支撑材料。干燥的负载型聚离子水凝胶可以形成为绷带而不含有活性材料。支撑的聚离子水凝胶可以通过使活性物质在多糖溶液中或在浸渍到载体材料中的另一种溶液中形成而含有生物活性物质。生物活性物质可以是酶，抗体产生细胞或水溶性药物如抗微生物剂，氯己定。

2. 发明授权

US5648252A Supported polyionic hydrogels containing biologically active material 失效
标题翻译：含有生物活性物质的负载聚离子水凝胶
公开(公告)号：US5648252A
公开(公告)日：1997-07-15
申请号：US409264
申请日：1995-03-22
申请人： Severian Dumitriu , Itzhak Kahane , Hilda Guttmann
发明人： Severian Dumitriu , Itzhak Kahane , Hilda Guttmann
IPC分类号： A61L15/60 , C12N5/00 , C12N11/02 , C12N11/04 , C12N11/12 , C12N11/10 , G01N33/544
CPC分类号： C12N11/04 , A61L15/60 , C12N11/02 , C12N5/0068 , C12N2533/70 , C12N2533/72 , Y10S530/813 , Y10S530/814
摘要： A supported polyionic hydrogel containing biologically active material is epared by impregnating into a porous support material a solution of anionic polysaccharide, a solution of cationic polysaccharide and a biologically active material. The anionic polysaccharide and the cationic polysaccharide react with each other to form a hydrogel containing the biologically active material. The hydrogel may be dried such as by lyophilization. The biologically active material can be in either polysaccharide solution or in another solution impregnated into the porous support material. A paper material or a textile material may be used as the porous support material. Preferably, the anionic polysaccharide is xanthan, dicarboxystarch or dicarboxycellulose and the cationic polysaccharide is chitosan. Especially preferred is a hydrogel formed from xanthan and chitosan. Biologically active materials in the hydrogel can be enzymes, antibody-producing cells or water-soluble drugs such as the antimicrobial agent, chlorohexidine.
摘要翻译：通过将阴离子多糖，阳离子多糖溶液和生物活性物质的溶液浸渍到多孔载体材料中制备含有生物活性材料的负载型聚离子水凝胶。阴离子多糖和阳离子多糖彼此反应形成含有生物活性物质的水凝胶。水凝胶可以干燥，例如通过冻干。生物活性物质可以是多糖溶液或浸渍在多孔载体材料中的另一种溶液中。可以使用纸材料或纺织材料作为多孔载体材料。优选地，阴离子多糖是黄原胶，二羧甲基纤维素或二羧基纤维素，阳离子多糖是壳聚糖。特别优选由黄原胶和壳聚糖形成的水凝胶。水凝胶中的生物活性物质可以是酶，抗体产生细胞或水溶性药物如抗微生物剂，氯己定。

3. 发明授权

US4066387A Method of improving the sorption capacity of polymers 失效
标题翻译：提高聚合物吸附能力的方法
公开(公告)号：US4066387A
公开(公告)日：1978-01-03
申请号：US661926
申请日：1976-02-27
申请人： Menachem Lewin , Hilda Guttmann
发明人： Menachem Lewin , Hilda Guttmann
IPC分类号： B01D67/00 , B01J20/22 , B29C71/00 , C08J7/00 , C08J7/12 , C08J7/14 , C08J9/06 , C08J9/12 , D06M11/09 , D06P5/22 , D06P5/00 , B05D3/04
CPC分类号： B01D67/003 , B01D67/0023 , B01J20/22 , C08J7/12 , C08J7/126 , C08J9/06 , C08J9/12 , D06M11/09 , D06P5/22 , B01D2323/08 , B01D2323/12 , B01D2325/38 , C08J2323/06 , Y10S521/905 , Y10S8/922
摘要： A method of improving the sorption capacity of a substantially hydrophobic, thermoplastic polymer, which comprises introducing into the polymer a halogen by contacting the polymer with a solution containing the halogen under conditions which avoid chemical reaction of the halogen with the polymer, separating the free halogen-containing polymer from the solution, and contacting the polymer with a reagent which pervades the polymer and reacts with the free halogen contained therein so as to produce a gas as one of the reaction products. The product polymers have increased sorption capacity and improved dyeability and are capable of sorbing and retaining useful substances such as medicaments, pesticides and perfumes.

4. 发明授权

US5707736A Products having anti-microbial activity 失效
标题翻译：产品具有抗微生物活性
公开(公告)号：US5707736A
公开(公告)日：1998-01-13
申请号：US461852
申请日：1995-06-05
申请人： David Levy , Hilda Guttmann , Itzhak Kahane
发明人： David Levy , Hilda Guttmann , Itzhak Kahane
IPC分类号： A01N25/34 , A01N33/12 , A01N47/44 , A61L15/46 , D06M13/432 , D06M13/463 , D06M13/47 , D06M13/477 , D06M16/00 , D02G3/00
CPC分类号： D06M16/00 , A01N25/34 , A01N33/12 , A01N47/44 , A61L15/46 , D06M13/432 , D06M13/463 , D06M13/47 , D06M13/477 , A61L2300/206 , A61L2300/404 , A61L2300/602 , Y10S428/907 , Y10T428/2913 , Y10T428/2927 , Y10T428/2933 , Y10T428/2965 , Y10T428/2967 , Y10T428/2969 , Y10T442/20 , Y10T442/2525 , Y10T442/2762 , Y10T442/2861 , Y10T442/2869
摘要： The invention provides a dry, disposable, polymeric product having sustained-release anti-microbial activity, the product consisting essentially of a polymeric material selected from the group consisting of fibers, fabrics, sheets, films and other stable woven, non-woven and knitted materials prepared from natural, man-made and synthetic polymers and an amine salt anti-microbial agent, the anti-microbial agent being incorporated in the polymeric material without an intermediary adhesive, carrier or linking agent and being releasable therefrom in anti-microbially effective amounts for a period of at least three days upon the product being brought into contact with a moist surface.
摘要翻译：本发明提供了一种具有缓释抗微生物活性的干燥，一次性聚合产品，该产品基本上由选自纤维，织物，片材，薄膜和其它稳定的织造，无纺布和针织物的聚合材料组成由天然，人造和合成聚合物制备的材料和胺盐抗微生物剂，抗微生物剂并入聚合物材料中，不含中间粘合剂，载体或连接剂，并可以以抗微生物有效量从其中释放使产品与潮湿的表面接触至少三天的时间。

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