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1. 发明申请

US20130196881A1 SUGAR CHAIN ARRAY 有权
标题翻译：糖链阵列
公开(公告)号：US20130196881A1
公开(公告)日：2013-08-01
申请号：US13812787
申请日：2011-07-29
申请人： Shin-Ichiro Nishimura , Takahiko Matsushita , Hideyuki Shimaoka , Wataru Takada , Kohta Igarashi , Midori Abe , Hiroki Abe , Masao Fukushima
发明人： Shin-Ichiro Nishimura , Takahiko Matsushita , Hideyuki Shimaoka , Wataru Takada , Kohta Igarashi , Midori Abe , Hiroki Abe , Masao Fukushima
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N33/54393 , G01N33/569 , G01N33/66 , G01N2333/42
摘要： A sugar chain array containing a sugar chain immobilized thereon for detecting binding between an analyte and a sugar chain, and a sugar chain array having the sugar chain immobilized thereon that is capable of inhibiting non-specific adsorption and binding of an analyte without having to coat the array with an adsorption inhibitor. A specific sugar chain is immobilized on the array, and is useful for detecting binding between the sugar chain and an analyte, such as a pathogen of an infectious disease or an excretion thereof. In addition, in the array, when a base material is coated with a polymeric compound having a unit having a primary amino group, a unit for maintaining hydrophilicity, and a unit having a hydrophobic group, the sugar chain is immobilized efficiently and non-specific adsorption and binding of the analyte can be effectively inhibited.
摘要翻译：含有固定在其上用于检测分析物和糖链之间的结合的糖链的糖链阵列和其上固定有糖链的糖链阵列，其能够抑制分析物的非特异性吸附和结合而不必涂覆该阵列带有吸附抑制剂。特定的糖链固定在阵列上，并且可用于检测糖链和分析物之间的结合，例如感染性疾病的病原体或其排泄物。此外，在阵列中，当用具有伯氨基单元的聚合化合物，保持亲水性的单元和具有疏水基团的单元涂覆基材时，糖链被有效且非特异性地固定可以有效地抑制分析物的吸附和结合。

2. 发明申请

US20130123470A1 METHOD FOR PREPARING SUGAR CHAINS FROM ANTIBODIES 审中-公开
标题翻译：从抗体制备糖链的方法
公开(公告)号：US20130123470A1
公开(公告)日：2013-05-16
申请号：US13812760
申请日：2011-07-29
申请人： Hideyuki Shimaoka , Midori Abe
发明人： Hideyuki Shimaoka , Midori Abe
IPC分类号： C07K1/14
CPC分类号： C07K1/14 , C07K16/00 , C07K16/065 , C07K2317/41 , G01N2030/8836
摘要： A method allowing easy and quick preparation of sugar chains of antibodies is provided. Sugar chains are cut off from the antibodies in a state where the antibodies are kept being bonded to an absorbing materials, such as the Protein A or the Protein G. Then, the cut off sugar chains are captured to sugar-chain-capturing solid-phase carriers having a functional group that forms a stable bonding with the sugar chains by reacting specifically with the aldehyde groups of the sugar chains. Then, the captured sugar chains are re-released. Sugar chain samples suitable for mass spectrometry, chromatography, or electrophoresis can be prepared easily and quickly by the present method.
摘要翻译：提供了允许容易且快速地制备抗体糖链的方法。在抗体保持与吸收材料例如蛋白A或蛋白G结合的状态下，从抗体中切断糖链。然后将切断的糖链捕获到糖链捕获固相 - 具有通过与糖链的醛基特异性反应与糖链形成稳定键合的官能团的相载体。然后，捕获的糖链被重新释放。可以通过本方法容易且快速地制备适合于质谱，色谱或电泳的糖链样品。

3. 发明申请

US20130109043A1 METHOD FOR INSPECTING GASTROENTEROLOGICAL CANCER BY UTILIZING N-LINKED SUGAR CHAIN 有权
标题翻译：利用N链糖链检测胃肠癌的方法
公开(公告)号：US20130109043A1
公开(公告)日：2013-05-02
申请号：US13639724
申请日：2011-04-06
申请人： Shoji Natsugoe , Yasuto Uchikado , Teruto Hashiguchi , Hiroyuki Shinchi , Kosei Maemura , Yuko Mataki , Norichika Moriwaki , Masaru Sekijima , Hideyuki Shimaoka , Midori Abe , Masao Fukushima , Kota Igarashi , Hiroki Abe , Taichi Aihara
发明人： Shoji Natsugoe , Yasuto Uchikado , Teruto Hashiguchi , Hiroyuki Shinchi , Kosei Maemura , Yuko Mataki , Norichika Moriwaki , Masaru Sekijima , Hideyuki Shimaoka , Midori Abe , Masao Fukushima , Kota Igarashi , Hiroki Abe , Taichi Aihara
IPC分类号： G01N33/50
CPC分类号： G01N33/50 , G01N33/57446 , G01N33/66 , Y10T436/14 , Y10T436/142222 , Y10T436/143333
摘要： As a result of collecting blood from pancreatic cancer patients, esophageal cancer patients, and stomach cancer patients, and conducting mass spectrometry on N-linked sugar chains in the plasmas, sugar chains whose abundances are significantly different from those of healthy subjects have been successfully identified from the blood samples of the cancer patients.
摘要翻译：通过从胰腺癌患者，食管癌患者和胃癌患者中收集血液，并对等离子体中的N-连接糖链进行质谱分析，已经成功鉴定了其丰度与健康受试者的丰度显着不同的糖链来自癌症患者的血液样本。

4. 发明授权

US07985874B2 Polymer particle 失效
标题翻译：聚合物颗粒
公开(公告)号：US07985874B2
公开(公告)日：2011-07-26
申请号：US10594182
申请日：2005-03-18
申请人： Shinichiro Nishimura , Hideyuki Shimaoka
发明人： Shinichiro Nishimura , Hideyuki Shimaoka
IPC分类号： C01B21/14
CPC分类号： G01N33/543 , G01N2400/00
摘要： A support comprising functional groups supported therein that specifically react with an aldehyde group of a sugar chain, and a polymer particle and a glycochip to which the support is applied, and uses thereof.
摘要翻译：其中包含与糖链的醛基特异性反应的官能团的载体，以及应用了载体的聚合物颗粒和糖芯片及其用途。

5. 发明申请

US20090068752A1 Method for Preparing Analysis Sample, Analysis Sample and Sugar Chain Capture Agent 失效
标题翻译：分析样品，分析样品和糖链捕获剂的制备方法
公开(公告)号：US20090068752A1
公开(公告)日：2009-03-12
申请号：US12224953
申请日：2007-03-13
申请人： Hideyuki Shimaoka , Hiromitsu Kuramoto , Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Jun-ichi Furukawa
发明人： Hideyuki Shimaoka , Hiromitsu Kuramoto , Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Jun-ichi Furukawa
IPC分类号： G01N33/50 , C07K2/00
CPC分类号： C07K1/22 , C07B2200/05 , C07B2200/11 , C07C323/60 , C07K5/0806 , Y10T436/143333 , Y10T436/17 , Y10T436/18 , Y10T436/182 , Y10T436/25 , Y10T436/25125
摘要： A method for preparing an analysis sample which involves the sugar chain capture step comprising a reaction of capturing a sugar chain and/or a sugar derivative from a biological sample by using a sugar chain capture agent and the excision step comprising excising a compound containing a moiety capturing the sugar chain and/or the sugar derivative from the sugar chain capture agent after the completion of the sugar chain capture reaction and releasing the compound.
摘要翻译：一种制备包含糖链捕获步骤的分析样品的方法，其包括通过使用糖链捕获剂从生物样品捕获糖链和/或糖衍生物的反应，并且所述切除步骤包括切除含有部分的化合物在糖链捕获反应完成后从糖链捕获剂捕获糖链和/或糖衍生物并释放该化合物。

6. 发明申请

US20130316932A1 GLYCOPEPTIDE ARRAY 审中-公开
标题翻译：糖蛋白阵列
公开(公告)号：US20130316932A1
公开(公告)日：2013-11-28
申请号：US13989023
申请日：2011-11-22
申请人： Shin-Ichiro Nishimura , Takahiko Matsushita , Hideyuki Shimaoka , Wataru Takada , Kohta Igarashi , Midori Abe , Hiroki Abe , Masao Fukushima
发明人： Shin-Ichiro Nishimura , Takahiko Matsushita , Hideyuki Shimaoka , Wataru Takada , Kohta Igarashi , Midori Abe , Hiroki Abe , Masao Fukushima
IPC分类号： G01N33/68
CPC分类号： G01N33/6845 , G01N33/54353 , G01N33/54393 , G01N33/6842
摘要： The present invention provides: a glycopeptide array which is useful for the detection of the binding between a substance to be detected and a glycopeptide; and an array which can inhibit the non-specific adsorption or binding of a substance to be detected without the need of coating any adsorption-inhibiting agent and which has the glycopeptide immobilized thereon. In the present invention, it was found that a glycopeptide that has a molecule having a carbonyl group bound to a peptide moiety thereof can be immobilized on a substrate that is coated with a polymer compound containing a unit having a primary amino group with high efficiency through the carbonyl group. Particularly, it was found by the present inventors that a glycopeptide can be immobilized on a substrate with high efficiency and the non-specific adsorption or binding of a substance to be detected can be inhibited effectively when a substrate that is coated with a polymer compound containing a unit having a primary amino group, a unit for retaining hydrophilicity and a unit having a hydrophobic group is used as the substrate for the glycopeptide.
摘要翻译：本发明提供：糖肽阵列，其可用于检测待检测物质与糖肽之间的结合; 以及可以抑制待检测物质的非特异性吸附或结合而不需要涂覆任何吸附抑制剂并且其上固定有糖肽的阵列。在本发明中，发现具有与其肽部分结合的具有羰基的分子的糖肽可以固定在具有高分子量的高分子化合物的基材上，所述高分子化合物通过羰基。特别是本发明人发现，可以高效率地将糖肽固定在基材上，并且当涂布有含高分子化合物的基材时，能够有效地抑制待检测物质的非特异性吸附或结合使用具有伯氨基的单元，用于保持亲水性的单元和具有疏水基团的单元作为糖肽的底物。

7. 发明申请

US20130071938A1 METHOD FOR ANALYZING SUGAR CHAIN BY MASS SPECTROMETRY 审中-公开
标题翻译：通过质谱分析糖链的方法
公开(公告)号：US20130071938A1
公开(公告)日：2013-03-21
申请号：US13634683
申请日：2011-03-17
申请人： Hideyuki Shimaoka , Midori Abe , Kohta Igarashi
发明人： Hideyuki Shimaoka , Midori Abe , Kohta Igarashi
IPC分类号： G01N33/50
CPC分类号： G01N33/50 , G01N1/405 , G01N2400/00 , H01J49/00 , Y10T436/143333
摘要： It has been found out that it is possible to increase the ionization efficiency of a sample sugar chain by methylating hydroxyl groups of the sugar chain before MALDI-TOF MS measurement. This enables quantitative and structural analyses on the sample sugar chain with high accuracy.
摘要翻译：已经发现，可以在MALDI-TOF MS测量之前通过甲基化糖链的羟基来提高样品糖链的电离效率。这样可以高精度地对样品糖链进行定量和结构分析。

8. 发明申请

US20110089033A1 METHOD OF PREPARING SUGAR CHAIN SAMPLE, SUGAR CHAIN SAMPLE, AND METHOD OF ANALYZING SUGAR CHAIN 审中-公开
标题翻译：制备糖链样品，糖链样品的方法和分析糖链的方法
公开(公告)号：US20110089033A1
公开(公告)日：2011-04-21
申请号：US12997081
申请日：2009-06-10
申请人： Hideyuki Shimaoka , Midori Abe
发明人： Hideyuki Shimaoka , Midori Abe
IPC分类号： C07H1/06 , C07H5/06 , G01N30/02 , H01J49/26 , G01N27/447
CPC分类号： G01N30/88 , B01D15/305 , B01D15/322 , G01N27/447 , G01N30/34 , G01N30/7233 , G01N33/66 , G01N2030/381 , G01N2030/8836
摘要： A method of preparing a sugar chain sample, for reducing unreacted labeling reagent in a sample solution containing a labeled sugar chain, includes (process 1) a process of bringing the sample solution containing the labeled sugar chain into contact with monolithic silica, so as to allow the monolithic silica to adsorb a sugar chain component; (process 2) a process of washing the monolithic silica with a washing liquid; and (process 3) a process of bringing the monolithic silica into contact with an eluant, so as to elute the adsorbed sugar chain.
摘要翻译：制备用于在含有标记糖链的样品溶液中还原未反应的标记试剂的糖链样品的方法包括（方法1）使含有标记的糖链的样品溶液与整体二氧化硅接触的方法，以便允许整体二氧化硅吸附糖链组分; （方法2）用洗涤液洗涤整体二氧化硅的方法; 和（方法3）使整体二氧化硅与洗脱剂接触的过程，以洗脱吸附的糖链。

9. 发明申请

US20080254998A1 Polymer Particle 失效
标题翻译：聚合物颗粒
公开(公告)号：US20080254998A1
公开(公告)日：2008-10-16
申请号：US10594182
申请日：2005-03-18
申请人： Shinichiro Nishimura , Hideyuki Shimaoka
发明人： Shinichiro Nishimura , Hideyuki Shimaoka
IPC分类号： C40B40/14 , C40B40/00 , C40B30/04 , C40B30/06 , C07H1/06
CPC分类号： G01N33/543 , G01N2400/00
摘要： A support comprising functional groups supported therein that specifically react with an aldehyde group of a sugar chain, and a polymer particle and a glycochip to which the support is applied, and uses thereof.
摘要翻译：其中包含与糖链的醛基特异性反应的官能团的载体，以及应用了载体的聚合物颗粒和糖芯片及其用途。

10. 发明申请

US20080097061A1 Oxylamino Group-Containing Compound and Polymer 有权
标题翻译：含氧基氨基的化合物和聚合物
公开(公告)号：US20080097061A1
公开(公告)日：2008-04-24
申请号：US11660985
申请日：2005-07-07
申请人： Shinichiro Nishimura , Hideyuki Shimaoka
发明人： Shinichiro Nishimura , Hideyuki Shimaoka
IPC分类号： C08F20/04 , C07C49/203 , C07C69/52 , C07D207/46 , C07D233/02
CPC分类号： C08F220/60 , C07C291/04 , C08F222/1006
摘要： An oxylamino group-containing compound represented by the following formula: R1—B-A-B—R2, wherein R1 represents a polymerizable group, R2 represents an oxylamino group-containing group or an oxylamino derivative-containing group, B represents an ester linkage or an amide linkage, and A represents an optionally substituted alkylene group having 2 to 12 carbon atoms.
摘要翻译：由下式表示的含氧基氨基的化合物：<？in-line-formula description =“In-line formula”end =“lead”？> R 1 -BABR < / SUP>，<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R 1表示可聚合基团R 2 表示含有氧基氨基的基团或含氧基氨基衍生物的基团，B表示酯键或酰胺键，A表示任选取代的碳原子数2〜12的亚烷基。

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