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    • 4. 发明申请
    • PROCESS FOR PRODUCTION OF PHOSPHINE DERIVATIVE FROM PHOSPHINE OXIDE DERIVATIVE
    • 从氧化膦衍生物生产磷酸衍生物的方法
    • US20110065961A1
    • 2011-03-17
    • US12991931
    • 2009-05-14
    • Hideo TanakaManabu KuroboshiTomotake YanoMasakatsu HoshinoHiromu Kawakubo
    • Hideo TanakaManabu KuroboshiTomotake YanoMasakatsu HoshinoHiromu Kawakubo
    • C07F9/50
    • C25B3/04C07F9/5022C07F9/509C07F9/65515Y02P20/582
    • Disclosed is a process for producing a phosphine derivative from a phosphine oxide derivative, which comprises the following steps: (I) mixing a phosphine oxide derivative represented by formula (1) with a chlorinating agent in a polar organic solvent to cause the reaction between these components; and (II-1) adding a salt of a metal having an ionization tendency equal to or lower than that of aluminum to the reaction mixture and carrying out the reductive reaction in the presence of aluminum or (II-2) subjecting the reaction mixture to electrolytic reduction, thereby producing a phosphine derivative represented by formula (2). ArnR3-nP═O (1) ArnR3-nP (2) In formulae (1) and (2), Ar represents an aryl group such as a phenyl group, a phenyl group having a substituent, a heteroaromatic ring group, and a heteroaromatic ring group having a substituent; R represents an aliphatic hydrocarbon group or an aliphatic hydrocarbon group having a substituent; and n represents an integer of 0 to 3.
    • 公开了一种由氧化膦衍生物制备膦衍生物的方法,其包括以下步骤:(I)将式(1)表示的氧化膦衍生物与氯化剂在极性有机溶剂中混合,引起它们之间的反应 组件; 和(II-1)将具有等于或低于铝的电离倾向的金属的盐加入到反应混合物中并在铝的存在下进行还原反应或(II-2)使反应混合物 电解还原,从而制得由式(2)表示的膦衍生物。 ArnR3-nP=O(1)ArnR3-nP(2)式(1)和(2)中,Ar表示苯基,具有取代基的苯基,杂芳环,杂芳基等芳基 具有取代基的环基; R表示脂肪族烃基或具有取代基的脂族烃基; n表示0〜3的整数。