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1. 发明授权

US09041901B2 Liquid recovery apparatus, exposure apparatus, exposure method, and device manufacturing method 有权
公开(公告)号：US09041901B2
公开(公告)日：2015-05-26
申请号：US12318574
申请日：2008-12-31
申请人： Hideaki Hara , Hiroaki Takaiwa , Dai Arai
发明人： Hideaki Hara , Hiroaki Takaiwa , Dai Arai
IPC分类号： G03B27/52 , G03F7/20
CPC分类号： G03F7/70341 , G03F7/2041 , G03F7/70533 , G03F7/70866 , G03F7/70933 , G03F7/70991
摘要： A lithographic projection apparatus includes a substrate table by which a substrate is held, a projection system via which a patterned beam is projected onto the substrate to expose the substrate through liquid, and a liquid supply system. The liquid supply system includes a supply flow path, and supplies the liquid via the supply flow path during the exposure. The liquid supply system also includes a device by which the supply flow path is connected with a vacuum system to prevent liquid in the supply flow path from leaking.

2. 发明申请

US20120040994A1 THERAPEUTIC AGENT FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND PROSTAGLANDIN 审中-公开
标题翻译：包含Rho激酶抑制剂和前列腺素的GLAUCOMA治疗药物
公开(公告)号：US20120040994A1
公开(公告)日：2012-02-16
申请号：US13280684
申请日：2011-10-25
申请人： Tadashi NAKAJIMA , Takeshi MATSUGI , Hideaki HARA
发明人： Tadashi NAKAJIMA , Takeshi MATSUGI , Hideaki HARA
IPC分类号： A61K31/497 , A61P27/06 , A61K31/437
CPC分类号： A61K45/06 , A61K9/0048 , A61K31/437 , A61K31/4409 , A61K31/4725 , A61K31/5377 , A61K31/553 , A61K31/5575 , A61K2300/00
摘要： A therapeutic composition for treating glaucoma or for reducing intraocular pressure containing a combination of pharmaceutically effective amounts of drugs including (i) a Rho kinase inhibitor selected from the group consisting of (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide and 1-(5-isoquinolinesulfonyl)-homopiperazine, or a salt thereof and (ii) a prostaglandin which is latanoprost or a salt of latanoprost, and (iii) optionally a pharmaceutically acceptable carrier. A therapeutic composition for treating glaucoma or for reducing intraocular pressure containing a combination of pharmaceutically effective amounts of drugs comprising (i) a Rho kinase which is (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide or a slat thereof and (ii) a prostaglandin which is isopropyl unoprostone or a salt thereof, and (iii) optionally a pharmaceutically acceptable carrier.
摘要翻译：一种用于治疗青光眼或降低眼内压的治疗组合物，其包含药学有效量的药物的组合，包括（i）选自（R） - （+）-N-（1H-吡咯并[2 ，3-b]吡啶-4-基）-4-（1-氨基乙基）苯甲酰胺和1-（5-异喹啉磺酰基） - 高哌嗪或其盐和（ii）前列腺素，其为拉坦前列素或拉坦前列素盐，和（iii）任选的药学上可接受的载体。一种用于治疗青光眼或降低眼内压的治疗组合物，其包含药物有效量的药物的组合，其包含（i）Rho - （+） - N-（1H-吡咯并[2,3-b] 吡啶-4-基）-4-（1-氨基乙基）苯甲酰胺或其板条，和（ii）作为异丙基异佛石或其盐的前列腺素，和（iii）任选的药学上可接受的载体。

3. 发明授权

US08111375B2 Exposure apparatus and method for manufacturing device 有权
标题翻译：曝光装置及其制造方法
公开(公告)号：US08111375B2
公开(公告)日：2012-02-07
申请号：US11600763
申请日：2006-11-17
申请人： Hideaki Hara
发明人： Hideaki Hara
IPC分类号： G03B27/42 , G03B27/52
CPC分类号： G03F7/70341 , G03B27/42
摘要： An exposure apparatus wherein an image of a pattern is projected onto a substrate via a projection optical system to expose the substrate, includes: a substrate moving device that is movable while holding the substrate above the projection optical system; and a liquid immersion unit that fills at least a portion of the space between the projection optical system and the substrate with a liquid, wherein the image of the pattern is projected onto the substrate via the projection optical system and the liquid.
摘要翻译：一种曝光装置，其中图案的图像通过投影光学系统投射到基板上以露出基板，包括：基板移动装置，其可在保持基板在投影光学系统之上的同时移动; 以及液体浸渍单元，其用液体填充投影光学系统和基板之间的空间的至少一部分，其中图案的图像经由投影光学系统和液体投射到基板上。

4. 发明申请

US20120029088A1 ANTI-ANXIETY COMPOSITION 审中-公开
标题翻译：抗坏血酸组合物
公开(公告)号：US20120029088A1
公开(公告)日：2012-02-02
申请号：US13188328
申请日：2011-07-21
申请人： Hideaki HARA , Atsushi OOYAGI , Takashi ISHIBASHI
发明人： Hideaki HARA , Atsushi OOYAGI , Takashi ISHIBASHI
IPC分类号： A61K31/122 , C07C49/647 , A61P25/22 , C07C49/743
CPC分类号： A61K31/122 , A23L2/52 , A23L33/105 , A61K2300/00
摘要： This invention provides a highly safe anti-anxiety composition that can be used for treatment or prevention of anxiety disorders. Such anti-anxiety composition comprises, as an active ingredient, a carotenoid.
摘要翻译：本发明提供了可用于治疗或预防焦虑症的高度安全的抗焦虑组合物。这种抗焦虑组合物包含类胡萝卜素作为活性成分。

5. 发明授权

US07972612B2 Remedy for glaucoma comprising Rho kinase inhibitor and β-blocker 有权
标题翻译：治疗包括Rho激酶抑制剂和β-阻断剂的青光眼
公开(公告)号：US07972612B2
公开(公告)日：2011-07-05
申请号：US10535000
申请日：2003-11-17
申请人： Masakazu Hatano , Tadashi Nakajima , Takeshi Matsugi , Hideaki Hara
发明人： Masakazu Hatano , Tadashi Nakajima , Takeshi Matsugi , Hideaki Hara
IPC分类号： A61K9/00 , A61K31/535 , A61K31/44
CPC分类号： A61K45/06 , A61K31/138 , A61K31/343 , A61K31/353 , A61K31/437 , A61K31/4409 , A61K31/4412 , A61K31/496 , A61K31/5377 , A61K31/551 , Y10S514/913 , A61K2300/00
摘要： A subject of the present invention is to find utility of a combination of a Rho kinase inhibitor having a novel action and a β-blocker as a therapeutic agent for glaucoma. Actions of reducing intraocular pressure are complemented and/or enhanced each other by combining the Rho kinase inhibitor with the β-blocker. For the administration mode, each drug can be administered in combination or in mixture.
摘要翻译：本发明的主题是发现具有新作用的Rho激酶抑制剂与抑制剂组合作为青光眼治疗剂的用途。通过将Rho激酶抑制剂与抑制剂结合来补充和/或增强眼内压降低的作用。对于给药模式，每种药物可以组合或混合施用。

6. 发明授权

US07826031B2 Liquid recovery apparatus, exposure apparatus, exposure method, and device manufacturing method 有权
公开(公告)号：US07826031B2
公开(公告)日：2010-11-02
申请号：US11606935
申请日：2006-12-01
申请人： Hideaki Hara , Hiroaki Takaiwa , Dai Arai
发明人： Hideaki Hara , Hiroaki Takaiwa , Dai Arai
IPC分类号： G03B27/52 , G03B27/42 , G03B27/58 , G03B27/32
CPC分类号： G03F7/70341 , G03F7/2041 , G03F7/70533 , G03F7/70866 , G03F7/70933 , G03F7/70991
摘要： An exposure apparatus exposes a substrate by projecting an image of a pattern onto the substrate via a projection optical system and a liquid that fills a gap between the projection optical system and the substrate. The exposure apparatus has a liquid recovery mechanism with a drive section powered by electric power supplied from a commercial power source and an uninterruptible power source separate from the commercial power source. When the commercial power source has a failure, the supply of electric power to the drive section is switched to the uninterruptible power source.

7. 发明申请

US20080291410A1 Exposure apparatus and method for manufacturing device 有权
标题翻译：曝光装置及其制造方法
公开(公告)号：US20080291410A1
公开(公告)日：2008-11-27
申请号：US12219835
申请日：2008-07-29
申请人： Hideaki Hara
发明人： Hideaki Hara
IPC分类号： G03B27/42 , G03B27/52
CPC分类号： G03F7/70341 , G03B27/42
摘要： An immersion exposure apparatus includes an optical member, a supply outlet that supplies a liquid to a space between an upper surface of the optical member and a movable object, and an annular member at least a portion of which is arranged around the optical member, the space between the upper surface of the optical member and the object being filled with the liquid.
摘要翻译：浸没式曝光装置包括光学构件，供应出口，其将液体供应到光学构件的上表面与可移动物体之间的空间，以及环形构件，其至少一部分布置在光学构件周围，光学构件的上表面与被充满液体的物体之间的空间。

8. 发明授权

US06212942B1 Leakage inspection method and apparatus 有权
标题翻译：泄漏检查方法和装置
公开(公告)号：US06212942B1
公开(公告)日：2001-04-10
申请号：US09172891
申请日：1998-10-15
申请人： Hideaki Hara , Shoji Iriyama
发明人： Hideaki Hara , Shoji Iriyama
IPC分类号： G01M308
CPC分类号： G01M3/24
摘要： A leakage inspection method and apparatus having a pressure wave generating means, including an air supply source, a regulator, and a solenoid valve. A pressure wave of a fluid is applied to a normal flow path of an measurement object by the pressure wave generating means to detect internal leakage by measuring, by means of a microphone, a difference between the transfer time during which the pressure wave passes through the normal flow path and the transfer time during which the pressure wave passes through the leakage flow path. Accordingly, the internal leakage of the fluid, flowing in the leakage flow path bypassing the normal flow path of an equipment having a partition and the normal flow path separated by the partition, is detected, if any.
摘要翻译：一种具有压力波产生装置的泄漏检查方法和装置，包括空气供应源，调节器和电磁阀。通过压力波产生装置将流体的压力波施加到测量对象的正常流动路径，以通过麦克风测量压力波通过的传递时间之间的差异来检测内部泄漏正常流路和压力波通过泄漏流路的传送时间。因此，如果有的话，检测到流过旁路通过具有分隔件的设备的正常流路的泄漏流路内的流体的内部泄漏和由隔板分开的正常流路。

9. 发明授权

US6158298A Stage apparatus and exposure apparatus provided with the stage apparatus 失效
标题翻译：设置有舞台装置的舞台装置和曝光装置
公开(公告)号：US6158298A
公开(公告)日：2000-12-12
申请号：US166192
申请日：1998-10-05
申请人： Hideaki Hara
发明人： Hideaki Hara
IPC分类号： G12B5/00 , G03F7/20 , H01L21/027 , H01L21/68 , H01L21/683
CPC分类号： G03F7/70691 , H01L21/68 , H01L21/6838 , Y10T74/20201 , Y10T74/20354
摘要： A stage apparatus comprises a pedestal, an X axis guide bar which is fixed on the pedestal, an X stage which is movable along an upper surface of the pedestal and the guide bar, and a Y stage which is placed over the X state and movable along the pedestal in a direction of the Y axis. Vacuum-pre-loadable static pressure air bearings, in which pressures of vacuum ports are independently controllable, are provided on a surface of the X stage opposing to the pedestal and on another surface of the X stage opposing to the X axis guide bar. By using the stage apparatus, the electric power consumption of driving means for movable units can be reduced, the amount of heat generation can be reduced, and the bearing gap can be adjusted highly accurately after assembling.
摘要翻译：舞台装置包括基座，固定在基座上的X轴导杆，可以沿着底座和导杆的上表面移动的X平台，以及设置在X状态上并可移动的Y平台沿Y轴的方向沿基座。真空预加载的静压空气轴承，其中真空端口的压力是可独立控制的，设置在与基座相对的X台的表面上，在与X轴导杆相对的X台的另一个表面上。通过使用平台装置，能够减少可动部的驱动装置的电力消耗，能够减少发热量，能够在组装后高精度地调整轴承间隙。

10. 发明申请

US20220401377A1 COMPOSITION FOR PREVENTING AND/OR TREATING NEURODEGENERATIVE DISORDERS 有权
公开(公告)号：US20220401377A1
公开(公告)日：2022-12-22
申请号：US17772139
申请日：2020-10-20
申请人： Hideaki HARA , ICHIMARU PHARCOS CO., LTD.
发明人： Hideaki HARA , Masashi MIKAMI , Hiroyuki KOJIMA , Tatsuji TAKAHASHI , Kenichi ITO , Iddamalgoda ARUNASIRI
IPC分类号： A61K31/047 , A61K36/23 , A61K31/192 , A61P25/28
摘要： Provided is a composition useful for preventing and/or treating neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. The composition is for preventing and/or treating a neurodegenerative disorder, and contains, as an active ingredient, a compound represented by the following formula (I): or an isomer thereof, or a salt thereof.

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