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1. 发明申请

US20090117596A1 Antibody-Sensitized Latex 审中-公开
标题翻译：抗体敏化乳胶
公开(公告)号：US20090117596A1
公开(公告)日：2009-05-07
申请号：US11989183
申请日：2005-07-28
申请人： Toshikazu Hashimoto , Fumio Mishina , Takekazu Okumura , Fumiko Nagai , Shuta Yamamoto , Haruji Sawada
发明人： Toshikazu Hashimoto , Fumio Mishina , Takekazu Okumura , Fumiko Nagai , Shuta Yamamoto , Haruji Sawada
IPC分类号： G01N33/569
CPC分类号： G01N33/56911 , G01N33/54313
摘要： Antibody-sensitized latex for use in determination of a bacterium belonging to the genus Nitrospira, the latex comprising latex particles each having a specific gravity of about 1.5 g/mL and an average particle diameter in the range of 1.0-1.5 μm and an antibody adsorbed thereon. The antibody is specific to a bacterium belonging to the genus Nitrospira having an activity of nitrite oxidization. The latex is mixed with a sample, allowed to stand for a predetermined period of time, and observed on the presence or absence of agglutination of the latex particles in the mixture. This latex permits detection and determination of a bacterium belonging to the genus Nitrospira which is found in biological sewage treatment systems, such as streams and activated sludge, as well as in water of rivers, lakes and seashore, and in soil habitats, in a simple and easy manner.
摘要翻译：用于测定属于硝基螺菌属的细菌的抗体敏化胶乳，所述胶乳包含各自具有约1.5g / mL的比重和平均粒径在1.0-1.5μm范围内的胶乳颗粒和吸附的抗体上。该抗体对具有亚硝酸盐氧化活性的属于硝基螺旋菌属的细菌是特异性的。将胶乳与样品混合，静置预定时间，并且在混合物中胶乳颗粒的凝集存在或不存在时观察。该乳胶允许检测和测定属于硝基螺旋菌属的细菌，其在生物污水处理系统中发现，例如溪流和活性污泥，以及在河流，湖泊和海滨的水中以及在土壤栖息地中，以简单的和方便。

2. 发明申请

US20060068047A1 Adsorbent for endocrine disruptors and foods and drinks containing the same 审中-公开
公开(公告)号：US20060068047A1
公开(公告)日：2006-03-30
申请号：US11246129
申请日：2005-10-11
申请人： Kenji Ohishi , Haruji Sawada , Wakae Yokoi , Yasuto Yoshida , Tsunekazu Watanabe
发明人： Kenji Ohishi , Haruji Sawada , Wakae Yokoi , Yasuto Yoshida , Tsunekazu Watanabe
IPC分类号： A61K35/74
CPC分类号： A23L2/52 , A23L2/02 , A23L5/28 , A23L29/065 , A23L33/135 , A23P10/28
摘要： An adsorbent for endocrine disruptors which contains as the active ingredient viable or dead cells of intestinal microorganisms or constituents thereof. When the adsorbent for endocrine disruptors and foods and drinks containing the same are orally taken either daily or simultaneously with endocrine disruptors typified by bisphenols, alkylphenols and triazines and foods and drinks contaminated therewith, the absorption of these endocrine disruptors into the body can be inhibited and the discharge from the body of the endocrine disruptors, which have been once incorporated into the body, can be promoted.

3. 发明申请

US20050244426A1 Cholesterol-lowering agents, secondary bile acid production inhibitors and foods and drinks 失效
标题翻译：胆固醇降低剂，二级胆汁酸生产抑制剂和食品和饮料
公开(公告)号：US20050244426A1
公开(公告)日：2005-11-03
申请号：US11176398
申请日：2005-07-08
申请人： Haruji Sawada , Yasuto Yoshida , Yasue Wada , Kenji Ohishi , Masahiko Itoh , Wakae Yokoi , Tunekazu Watanabe
发明人： Haruji Sawada , Yasuto Yoshida , Yasue Wada , Kenji Ohishi , Masahiko Itoh , Wakae Yokoi , Tunekazu Watanabe
IPC分类号： A23L1/28 , A23L1/30 , A23L2/52 , A61K36/064 , A61P3/06 , A61K35/72
CPC分类号： A23L2/52 , A23L5/00 , A23L31/00 , A23L31/10 , A23L33/10 , A23L33/14 , A23V2002/00 , A61K36/064 , A23V2250/218
摘要： Secondary bile acid production inhibitors and cholesterol-lowering agents containing a yeast as the active ingredient.
摘要翻译：二级胆汁酸生成抑制剂和含有酵母作为活性成分的降胆固醇剂。

4. 发明申请

US20080260709A1 CHOLESTEROL-LOWERING AGENTS, SECONDARY BILE ACID PRODUCTION INHIBITORS AND FOODS AND DRINKS 失效
标题翻译：胆固醇降低剂，二级酸生产抑制剂和食品和饮料
公开(公告)号：US20080260709A1
公开(公告)日：2008-10-23
申请号：US12125545
申请日：2008-05-22
申请人： Haruji SAWADA , Yasuto Yoshida , Yasue Wada , Kenji Ohishi , Masahiko Itoh , Wakae Yokoi , Tunekazu Watanabe
发明人： Haruji SAWADA , Yasuto Yoshida , Yasue Wada , Kenji Ohishi , Masahiko Itoh , Wakae Yokoi , Tunekazu Watanabe
IPC分类号： A61K36/06 , A61P9/00 , A61P35/04 , A61P3/00
CPC分类号： A23L2/52 , A23L5/00 , A23L31/00 , A23L31/10 , A23L33/10 , A23L33/14 , A23V2002/00 , A61K36/064 , A23V2250/218
摘要： Secondary bile acid production inhibitors and cholesterol-lowering agents containing a yeast as the active ingredient.
摘要翻译：二级胆汁酸生产抑制剂和含有酵母作为活性成分的降胆固醇剂。

5. 发明授权

US5234904A Antihypertensives containing polysaccharide peptidoglycan complexes extracted from the cell wall of lactic acid bacteria 失效
标题翻译：含有从酸性细菌细胞壁提取的多糖肽肽复合物的抗生素
公开(公告)号：US5234904A
公开(公告)日：1993-08-10
申请号：US542734
申请日：1990-06-22
申请人： Haruji Sawada , Masayoshi Furusiro , Kouichi Hirai , Mahoko Motoike , Tunekazu Watanabe , Teruo Yokokura , Masaaki Watanuki , Seizaburo Kobayashi
发明人： Haruji Sawada , Masayoshi Furusiro , Kouichi Hirai , Mahoko Motoike , Tunekazu Watanabe , Teruo Yokokura , Masaaki Watanuki , Seizaburo Kobayashi
IPC分类号： A23L1/30 , A61K31/00 , A61K35/74 , A61K38/00 , A61P9/00 , A61P9/12 , C07K9/00
CPC分类号： C07K9/005 , A23C9/123 , A23L2/382 , A23L33/18 , A61K31/715 , A61K38/164 , A23V2002/00
摘要： The present invention relates to antihypertensives and food and drinks, containing as effective component polysaccharideglycopeptide complexes derived from cell wall of Gram positive bacteria (also referred to as peptidoglycan). The present invention provides extremely strong and safe antihypertensives and food and drinks, which may exert hypotensive effects if administered orally to spontaneous hypertensive rats and renal hypertensive rats at a single dose as low as 1 mg/kg.

6. 发明授权

US4604353A Method for producing conjugated ursodeoxycholic acids by means of microbial transformation 失效
标题翻译：通过微生物转化制备复合型熊去氧胆酸的方法
公开(公告)号：US4604353A
公开(公告)日：1986-08-05
申请号：US583426
申请日：1984-02-24
申请人： Haruji Sawada , Masaaki Watanuki
发明人： Haruji Sawada , Masaaki Watanuki
IPC分类号： C07J9/00 , C07J41/00 , C12P33/06 , C12R1/645
CPC分类号： C12P33/06 , C07J41/0061 , C07J9/005 , Y10S435/911
摘要： A one step method of producing conjugated ursodeoxycholic acids from conjugated lithocholic acids by means of microbial transformation which comprises subjecting the conjugated lithocholic acids to the action of microorganisms which belong to Mortierella and which are capable of producing conjugated ursodeoxycholic acids from conjugated lithocholic acids.
摘要翻译：通过微生物转化从缀合的石胆酸中生产共轭熊去氧胆酸的一步法，其包括使缀合的石胆酸受到属于被孢霉属的微生物的作用，并且能够从共轭的石胆酸产生缀合的熊去氧胆酸。

7. 发明授权

US07754204B2 Cholesterol-lowering agents, secondary bile acid production inhibitors and foods and drinks 失效
标题翻译：胆固醇降低剂，二级胆汁酸生产抑制剂和食品和饮料
公开(公告)号：US07754204B2
公开(公告)日：2010-07-13
申请号：US12125545
申请日：2008-05-22
申请人： Haruji Sawada , Yasuto Yoshida , Yasue Wada , Kenji Ohishi , Masahiko Itoh , Wakae Yokoi , Tsunekazu Watanabe
发明人： Haruji Sawada , Yasuto Yoshida , Yasue Wada , Kenji Ohishi , Masahiko Itoh , Wakae Yokoi , Tsunekazu Watanabe
IPC分类号： A01N63/04 , A23L1/28
CPC分类号： A23L2/52 , A23L5/00 , A23L31/00 , A23L31/10 , A23L33/10 , A23L33/14 , A23V2002/00 , A61K36/064 , A23V2250/218
摘要： Secondary bile acid production inhibitors and cholesterol-lowering agents containing a yeast as the active ingredient.
摘要翻译：二级胆汁酸生成抑制剂和含有酵母作为活性成分的降胆固醇剂。

8. 发明授权

US07413740B2 Cholesterol-lowering agents, secondary bile acid production inhibitors and foods and drinks 失效
标题翻译：胆固醇降低剂，二级胆汁酸生产抑制剂和食品和饮料
公开(公告)号：US07413740B2
公开(公告)日：2008-08-19
申请号：US11176398
申请日：2005-07-08
申请人： Haruji Sawada , Yasuto Yoshida , Yasue Wada , Kenji Ohishi , Masahiko Itoh , Wakae Yokoi , Tunekazu Watanabe
发明人： Haruji Sawada , Yasuto Yoshida , Yasue Wada , Kenji Ohishi , Masahiko Itoh , Wakae Yokoi , Tunekazu Watanabe
IPC分类号： A61K36/06
CPC分类号： A23L2/52 , A23L5/00 , A23L31/00 , A23L31/10 , A23L33/10 , A23L33/14 , A23V2002/00 , A61K36/064 , A23V2250/218
摘要： Secondary bile acid production inhibitors and cholesterol-lowering agents containing a yeast as the active ingredient.
摘要翻译：二级胆汁酸生成抑制剂和含有酵母作为活性成分的降胆固醇剂。

9. 发明授权

US07101544B1 Cholesterol-lowering agents, secondary bile acid production inhibitors, and foods and drinks 失效
标题翻译：胆固醇降低剂，二级胆汁酸生产抑制剂，食品和饮料
公开(公告)号：US07101544B1
公开(公告)日：2006-09-05
申请号：US10031569
申请日：2000-07-19
申请人： Haruji Sawada , Yasuto Yoshida , Yasue Wada , Kenji Ohishi , Masahiko Itoh , Wakae Yokoi , Tunekazu Watanabe
发明人： Haruji Sawada , Yasuto Yoshida , Yasue Wada , Kenji Ohishi , Masahiko Itoh , Wakae Yokoi , Tunekazu Watanabe
IPC分类号： A13C9/12 , A23L1/28
CPC分类号： A23L2/52 , A23L5/00 , A23L31/00 , A23L31/10 , A23L33/10 , A23L33/14 , A23V2002/00 , A61K36/064 , A23V2250/218
摘要： Secondary bile acid production inhibitors and cholesterol-lowering agents containing a yeast as the active ingredient.
摘要翻译：二级胆汁酸生成抑制剂和含有酵母作为活性成分的降胆固醇剂。

10. 发明授权

US4579819A Method for production of ursodeoxycholic acid by means of microbial transformation 失效
标题翻译：通过微生物转化生产熊去氧胆酸的方法
公开(公告)号：US4579819A
公开(公告)日：1986-04-01
申请号：US471460
申请日：1983-03-02
申请人： Haruji Sawada , Hisaharu Taguchi
发明人： Haruji Sawada , Hisaharu Taguchi
IPC分类号： C07J9/00 , C12N1/14 , C12P33/06 , C12R1/77
CPC分类号： C07J9/005 , C12P33/06 , Y10S435/929
摘要： A one-step method of producing ursodeoxycholic acid by means of microbial transformation which comprises subjecting lithocholic acid to the action of a ursodeoxycholic acid producing microorganism.
摘要翻译：通过微生物转化产生熊去氧胆酸的一步法，其包括使石胆酸产生产生熊去氧胆酸的微生物的作用。

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