专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080050771A1 Process for the Synthesis of Cefaclor 有权
标题翻译：头孢克洛合成方法
公开(公告)号：US20080050771A1
公开(公告)日：2008-02-28
申请号：US11794119
申请日：2005-12-23
申请人： Harold Moody , Theodorus Johannes Goldfried Maria Dooren
发明人： Harold Moody , Theodorus Johannes Goldfried Maria Dooren
IPC分类号： C12P35/00 , C07D501/02
CPC分类号： C12P35/04 , C07D501/58 , C12P35/00
摘要： The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with D-phenylglycine in activated form (PGa) in the presence of an enzyme in a reaction mixture to form cefaclor, wherein at least part of 7-ACCA and/or PGa are added to the reaction mixture during the course of the reaction. The invention also relates to an aqueous mixture comprising an amount of cefaclor of >10 (w/w) %, an amount of 7-amino-3-chloro cephalosporanic acid of
摘要翻译：本发明涉及一种头孢克洛的合成方法，该方法包括使7-氨基-3-氯头孢菌酸（7-ACCA）与活性形式的D-苯基甘氨酸（PGa）在酶的存在下反应混合物以形成头孢克洛，其中在反应过程中将7-ACCA和/或PGa的至少一部分加入到反应混合物中。本发明还涉及包含一定量的头孢克洛> 10（w / w）％，7-氨基-3-氯头孢菌酸的量<2（w / w）％和D量（w / w）％的苯基甘氨酸和从该水性混合物中回收头孢克洛的方法。本发明还涉及具有小于0.250的在400nm（A≤400）的吸光度的晶体形式的头孢克洛。

2. 发明申请

US20140200342A1 PROCESS FOR PREPARING 3'-THIOSUBSTITUTED CEPHALOSPORINS EMPLOYING A PENCILLIN G ACYLASE 审中-公开
标题翻译：制备三磷酸腺苷磷酸三钙的方法
公开(公告)号：US20140200342A1
公开(公告)日：2014-07-17
申请号：US14128736
申请日：2012-06-21
申请人： Harold Moody , Claudia Cusan , Gerard Ijpeij
发明人： Harold Moody , Claudia Cusan , Gerard Ijpeij
IPC分类号： C12P17/18 , C07D501/57
CPC分类号： C12P17/184 , C07D501/57 , C12P35/04
摘要： The present invention relates to a process for the preparation of 3′-thiosubstituted cephalosporins by enzymatic condensation of a nucleus with a phenylglycine derivative. Furthermore the present invention relates to a crystalline form of a compound of general formula (1) wherein R2 is OH and X is S and R1 is a radical of formula (2a) with R3 is CH3.
摘要翻译：本发明涉及通过细胞核与苯基甘氨酸衍生物的酶促缩合制备3'-取代的头孢菌素的方法。此外，本发明涉及通式（1）的化合物的结晶形式，其中R 2是OH，X是S，R 1是式（2a）的基团，其中R 3是CH 3。

3. 发明申请

US20050124029A1 Process for the preparation of a betha- lactam antibiotic with mutated penicillin acylase 审中-公开
标题翻译：用突变型青霉素酰基转移酶制备贝那内酰胺抗生素的方法
公开(公告)号：US20050124029A1
公开(公告)日：2005-06-09
申请号：US10499662
申请日：2002-12-18
申请人： Wynand Alkema , Harold Moody , Jan Van Der Laan , Theodorus Johannes Van Dooren , Wilhelmus Hubertus Boesten
发明人： Wynand Alkema , Harold Moody , Jan Van Der Laan , Theodorus Johannes Van Dooren , Wilhelmus Hubertus Boesten
IPC分类号： C12N1/21 , C12N9/84 , C12N15/55 , C12P35/04 , C07D501/14 , C12N9/10
CPC分类号： C12N9/84
摘要： The invention relates to mutated penicillin acylases having a high synthesis/hydrolysis ratio in comparison with wild-type penicillin acylases and at least 1% of the activity. The invention also relates to a process for the enzymatic preparation of a β-lactam antibiotic from a β-lactam nucleus and an activated side chain with the aid of mutated penicillin acylases.
摘要翻译：本发明涉及与野生型青霉素酰基转移酶相比具有高合成/水解比的突变青霉素酰基转移酶和至少1％的活性。本发明还涉及借助于突变的青霉素酰基转移酶从β-内酰胺核和活化的侧链酶制备β-内酰胺抗生素的方法。

4. 发明申请

US20060189802A1 Process for the preparation of cephradine 有权
标题翻译：制备头孢拉定的方法
公开(公告)号：US20060189802A1
公开(公告)日：2006-08-24
申请号：US10562345
申请日：2004-07-01
申请人： Dennis Heemskerk , Anja Gerarda Hogenboom , Carlos Lenhardt , Harold Moody , Theodorus Johannes Godfried Maria Dooren
发明人： Dennis Heemskerk , Anja Gerarda Hogenboom , Carlos Lenhardt , Harold Moody , Theodorus Johannes Godfried Maria Dooren
IPC分类号： C07D501/14
CPC分类号： C07D501/00 , C12P35/04
摘要： The present invention describes a process for preparing cephradine, said process comprising reacting 7-aminodesacetoxy cephalosporanic acid (7-ADCA) with D-dihydrophenylglycine in activated form (DHa) in the presence of an enzyme in a reaction mixture to form cephradine, resulting in a conversion of 7-ADCA into cephradine of at least 70%, wherein the concentration D-dihydrophenylglycine (DH) in the reaction mixture is below 2 wt.%, wherein the conversion of 7-ADCA into cephradine & equals; (nCEF/n7-ADCA)*100%, wherein nCEF=quantity of cephradine formed (in mole); and n7-ADCA=total quantity of 7-ADCA added to reaction mixture (in mole). The invention also describes a process for the preparation of cephradine hydrate characterised in that the process comprises: —reacting 7-amino acid desacetoxy cephalosporanic acid (7-ADCA) with DHa in the presence of an enzyme in a reaction mixture to form cephradine; —preparing an aqueous solution comprising at least part of the cephradine; and crystallising the cephradine from said aqueous solution. The invention further describes cephradine hydrate obtainable by a process according to invention. The invention also describes cephradine hydrate with an absorbance at 450 nm of below 0.050.
摘要翻译：本发明描述了一种制备头孢拉定的方法，所述方法包括使7-氨基二乙酰氧基头孢菌酸（7-ADCA）与活化形式的二氢苯基甘氨酸（DHa）在酶的存在下在反应混合物中反应形成头孢拉定，得到将7-ADCA转化为至少70％的头孢拉定，其中反应混合物中D-二氢苯基甘氨酸（DH）的浓度低于2重量％，其中7-ADCA转化成头孢拉定等于; （％CEF / n 7-ADCA）* 100％，其中n CEF =形成的头孢拉定量（以摩尔计）; 和n 7-ADCA =加入到反应混合物中的7-ADCA的总量（以摩尔计）。本发明还描述了一种制备头孢拉定水合物的方法，其特征在于该方法包括：在反应混合物中，在酶的存在下，用7-氨基酸脱乙酰氧基头孢菌酸（7-ADCA）与DHa反应形成头孢拉定; - 制备包含至少一部分头孢拉定的水溶液; 并从所述水溶液中结晶头孢拉定。本发明还描述了通过根据本发明的方法获得的头孢拉定水合物。本发明还描述了在450nm处的吸光度低于0.050的头孢拉定水合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式