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1. 发明申请

US20090137830A1 Process for the preparation of a metal-organic compound comprising a spectator ligand 失效
标题翻译：制备包含观察配体的金属 - 有机化合物的方法
公开(公告)号：US20090137830A1
公开(公告)日：2009-05-28
申请号：US12066468
申请日：2006-09-13
申请人： Edwin Gerard Ijpeij , Martin Alexander Zuideveld , Henricus Johannes Arts , Francis Van Der Burgt , Gerardus Henricus Josephus Van Doremaele
发明人： Edwin Gerard Ijpeij , Martin Alexander Zuideveld , Henricus Johannes Arts , Francis Van Der Burgt , Gerardus Henricus Josephus Van Doremaele
IPC分类号： C07F7/28
CPC分类号： C07F7/28 , C08F4/65912 , C08F10/00 , C08F210/18 , C08F4/6592 , C08F210/06 , C08F232/00 , C08F2500/03
摘要： The invention relates to a process for the production of an organometallic compound according to formula (1): MALjYrX(p·(n+v+r)Rn (formula 1) where: M is a metal of groups 3-13 or the lanthanide series, and p is the valency of the metal M, A represents an anionic spectator ligand whose valency v is 1 or 2, Y is a spectator ligand represented by formula (2): wherein the spectator ligand is covalently bonded to the metal M via the imine nitrogen atom, Sub1 is a substituent, which comprises a group 14 atom through which SUb1 is bonded to the imine carbon atom, Sub2 is a substituent, which comprises an atom of groups 15-16, through which Sub2 is bonded to the imine carbon atom, sub1 and sub2 might be connected to each other forming a ring system, r is an integer>0, L is an optional neutral Lewis basic ligand, j is an integer denoting the number of neutral ligands L, X is an halide, and R is an anionic ligand, wherein an organometallic reagent according to formula (3), MALjXp−v (formula 3), is contacted with an alkylating agent, thus forming a precursor in which at least one of the halide atoms is replaced by an anionic ligand R that may be independently selected from the group consisting of alkyl, arylalkyl, aryl, or a combination thereof, which precursor is subsequently contacted with an imine according to formula (2).
摘要翻译：本发明涉及一种制备根据式（1）的有机金属化合物的方法：MALjYrX（p。（n + v + r）Rn（式1）其中：M是3-13族金属或镧系元素并且p是金属M的化合价，A表示其价态v为1或2的阴离子观察配体，Y为由式（2）表示的旁观者配体：其中旁观者配体与金属M共价键合，通过亚胺氮原子，Sub1是一个取代基，它包括一个14族原子，SUb1通过该原子与亚胺碳原子键合，Sub2是一个取代基，它包含一个第15-16族的原子，Sub2通过它与亚胺键合碳原子，亚1和亚2可以彼此连接形成环系，r是> 0的整数，L是任选的中性路易斯碱性配体，j是表示中性配体L的数的整数，X是卤素，并且R是阴离子配体，其中根据式（3）的有机金属试剂，MALjXp-v（式3），与烷基化剂接触，从而形成其中至少一个卤素原子被可独立地选自烷基，芳烷基，芳基或其组合的阴离子配体R代替的前体，该前体随后与式（2）的亚胺接触。

2. 发明授权

US09035078B2 Preparation of nitrile compounds 有权
标题翻译：腈化合物的制备
公开(公告)号：US09035078B2
公开(公告)日：2015-05-19
申请号：US14131344
申请日：2012-07-06
申请人： Paulus Lambertus Alsters , Edwin Gerard Ijpeij
发明人： Paulus Lambertus Alsters , Edwin Gerard Ijpeij
IPC分类号： C07D301/03 , C07D303/08 , C07C255/16 , C07D301/12 , C07D303/38 , C07C253/30 , C07D303/46
CPC分类号： C07C255/16 , C07C253/30 , C07D301/12 , C07D303/38 , C07D303/46 , C07C255/12 , C07C255/14
摘要： The invention relates to novel nitrile compounds according to formula I and II: (I) Formula I wherein: X=—CH3 or —C≡N, (II) Formula II wherein: X=—CH3 or —C≡N, each Y is independently chosen from —OH or RC(0)0-, each R is independently chosen from a C1-21 alkyl group. The invention also relates to processes for the preparation of nitrile compounds according to formula I and II and to uses of the nitrile compounds.
摘要翻译：本发明涉及式I和II的新型腈化合物：其中：X = -CH 3或-C≡N，（II）式II其中：X = -CH 3或-C≡N，每个Y 独立地选自-OH或RC（O）O-，每个R独立地选自C 1-12烷基。本发明还涉及制备根据式I和II的腈化合物和腈化合物的用途的方法。

3. 发明申请

US20140200342A1 PROCESS FOR PREPARING 3'-THIOSUBSTITUTED CEPHALOSPORINS EMPLOYING A PENCILLIN G ACYLASE 审中-公开
标题翻译：制备三磷酸腺苷磷酸三钙的方法
公开(公告)号：US20140200342A1
公开(公告)日：2014-07-17
申请号：US14128736
申请日：2012-06-21
申请人： Harold Moody , Claudia Cusan , Gerard Ijpeij
发明人： Harold Moody , Claudia Cusan , Gerard Ijpeij
IPC分类号： C12P17/18 , C07D501/57
CPC分类号： C12P17/184 , C07D501/57 , C12P35/04
摘要： The present invention relates to a process for the preparation of 3′-thiosubstituted cephalosporins by enzymatic condensation of a nucleus with a phenylglycine derivative. Furthermore the present invention relates to a crystalline form of a compound of general formula (1) wherein R2 is OH and X is S and R1 is a radical of formula (2a) with R3 is CH3.
摘要翻译：本发明涉及通过细胞核与苯基甘氨酸衍生物的酶促缩合制备3'-取代的头孢菌素的方法。此外，本发明涉及通式（1）的化合物的结晶形式，其中R 2是OH，X是S，R 1是式（2a）的基团，其中R 3是CH 3。

4. 发明申请

US20150112057A1 NOVEL CRYSTALLINE CEFOPERAZONE INTERMEDIATE 审中-公开
标题翻译：新型水晶CEFOPERAZONE中间件
公开(公告)号：US20150112057A1
公开(公告)日：2015-04-23
申请号：US14128818
申请日：2012-06-21
申请人： Harold Monro Moody , Claudia Cusan , Edwin Gerard Ijpeij
发明人： Harold Monro Moody , Claudia Cusan , Edwin Gerard Ijpeij
IPC分类号： C07D501/57 , C12P35/00
CPC分类号： C07D501/57 , C12P35/00
摘要： The present invention relates to a crystalline form of an intermediate for cefoperazone of formula (1) and to a process for the preparation thereof by enzymatic condensation of a 3′-thiosubstituted β-lactam nucleus with a phenylglycine derivative.
摘要翻译：本发明涉及式（1）的头孢哌酮的中间体的结晶形式及其通过3'-取代的β-内酰胺核与苯基甘氨酸衍生物的酶促缩合制备的方法。

5. 发明授权

US07705172B2 Process for the preparation of a metal-organic compound comprising a spectator ligand 失效
标题翻译：制备包含观察配体的金属 - 有机化合物的方法
公开(公告)号：US07705172B2
公开(公告)日：2010-04-27
申请号：US12066468
申请日：2006-09-13
申请人： Edwin Gerard Ijpeij , Martin Alexander Zuideveld , Henricus Johannes Arts , Francis Van Der Burgt , Gerardus Henricus Josephus Van Doremaele
发明人： Edwin Gerard Ijpeij , Martin Alexander Zuideveld , Henricus Johannes Arts , Francis Van Der Burgt , Gerardus Henricus Josephus Van Doremaele
IPC分类号： C07F15/06
CPC分类号： C07F7/28 , C08F4/65912 , C08F10/00 , C08F210/18 , C08F4/6592 , C08F210/06 , C08F232/00 , C08F2500/03
摘要： The invention relates to a process for the production of an organometallic compound according to formula (1): MALjYrX(p.(n+v+r)Rn (formula 1) where: M is a metal of groups 3-13 or the lanthanide series, and p is the valency of the metal M, A represents an anionic spectator ligand whose valency v is 1 or 2, Y is a spectator ligand represented by formula (2): wherein the spectator ligand is covalently bonded to the metal M via the imine nitrogen atom, Sub1 is a substituent, which comprises a group 14 atom through which SUb1 is bonded to the imine carbon atom, Sub2 is a substituent, which comprises an atom of groups 15-16, through which Sub2 is bonded to the imine carbon atom, sub1 and sub2 might be connected to each other forming a ring system, r is an integer>0, L is an optional neutral Lewis basic ligand, j is an integer denoting the number of neutral ligands L, X is an halide, and R is an anionic ligand, wherein an organometallic reagent according to formula (3), MALjXp−v (formula 3), is contacted with an alkylating agent, thus forming a precursor in which at least one of the halide atoms is replaced by an anionic ligand R that may be independently selected from the group consisting of alkyl, arylalkyl, aryl, or a combination thereof, which precursor is subsequently contacted with an imine according to formula (2).
摘要翻译：本发明涉及一种制备根据式（1）的有机金属化合物的方法：MALjYrX（p。（n + v + r）Rn（式1）其中：M是3-13族金属或镧系元素并且p是金属M的化合价，A表示其价态v为1或2的阴离子观察配体，Y为由式（2）表示的旁观者配体：其中旁观者配体与金属M共价键合，通过亚胺氮原子，Sub1是一个取代基，它包含一个14族原子，SUb1通过它与亚胺碳原子键合，Sub2是一个取代基，它包含一个第15-16族的原子，Sub2通过它与亚胺键合碳原子，亚1和亚2可以彼此连接形成环系，r是> 0的整数，L是任选的中性路易斯碱性配体，j是表示中性配体L的数的整数，X是卤素，并且R是阴离子配体，其中根据式（3）的有机金属试剂，MALjXp-v（式3 ）与烷基化剂接触，从而形成其中至少一个卤化物原子被可以独立地选自烷基，芳基烷基，芳基或其组合的阴离子配体R代替的前体，该前体随后与式（2）的亚胺接触。

6. 发明申请

US20140213804A1 PREPARATION OF NITRILE COMPOUNDS 有权
标题翻译：化合物的制备
公开(公告)号：US20140213804A1
公开(公告)日：2014-07-31
申请号：US14131344
申请日：2012-07-06
申请人： Paulus Lambertus Alsters , Edwin Gerard Ijpeij
发明人： Paulus Lambertus Alsters , Edwin Gerard Ijpeij
IPC分类号： C07D303/46 , C07C255/16 , C07C253/30 , C07D301/12
CPC分类号： C07C255/16 , C07C253/30 , C07D301/12 , C07D303/38 , C07D303/46 , C07C255/12 , C07C255/14
摘要： The invention relates to novel nitrile compounds according to formula I and II: (I) Formula I wherein: X=—CH3 or —C≡N, (II) Formula II wherein: X=—CH3 or —C≡N, each Y is independently chosen from —OH or RC(O)O—, each R is independently chosen from a C1−21 alkyl group. The invention also relates to processes for the preparation of nitrile compounds according to formula I and II and to uses of the nitrile compounds.
摘要翻译：本发明涉及式I和II的新型腈化合物：其中：X = -CH 3或-C≡N，（II）式II其中：X = -CH 3或-C≡N，每个Y 独立地选自-OH或RC（O）O-，每个R独立地选自C 1-12烷基。本发明还涉及制备根据式I和II的腈化合物和腈化合物的用途的方法。

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