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1. 发明申请

US20180356397A1 MIMICRY OF NEUROINFLAMMATORY MICROENVIRONMENTS AND METHODS OF USE AND MANUFACTURING THEREOF 审中-公开
公开(公告)号：US20180356397A1
公开(公告)日：2018-12-13
申请号：US15670354
申请日：2017-08-07
申请人： Hansang Cho
发明人： Hansang Cho
IPC分类号： G01N33/50
CPC分类号： G01N33/5029 , C12M23/16 , C12N5/0618 , C12N5/0634 , G01N33/5088
摘要： A method for simulating the neuroinflammatory response in brains comprising the steps of providing a microfluidic device for regulating microgliosis comprising a base, a central chamber located on the base, a size-exclusive barrier surrounding the central chamber, an annular chamber outside the barrier, a plurality of selective cellular migration channels connecting the annular chamber to the central chamber, a central reservoir in fluid communication with the central chamber and side reservoirs in fluid communication with the annular chamber; providing a camera to record the microfluidic device and cells, culturing a plurality of microglial cells within the central or annular chamber, culturing a plurality of a second cell type within the annular or central chamber, adding a chemoattractant to the central chamber and recording the microfluidic device for a period of time to record the morphogenesis of activated cells in the annular chamber and migration across the barrier.

2. 发明申请

US20080056589A1 Spatial-temporal regulation method for robust model estimation 有权
标题翻译：鲁棒模型估计的时空调节方法
公开(公告)号：US20080056589A1
公开(公告)日：2008-03-06
申请号：US11516351
申请日：2006-09-05
申请人： Shih-Jong J. Lee , Seho Oh , Hansang Cho
发明人： Shih-Jong J. Lee , Seho Oh , Hansang Cho
IPC分类号： G06K9/36 , G06K9/46
CPC分类号： G06K9/036 , G06K9/0014 , G06K9/40
摘要： A computerized spatial-temporal regulation method for accurate spatial-temporal model estimation receives a spatial temporal sequence containing object confidence mask. A spatial-temporal weight regulation is performed to generate weight sequence output. A weighted model estimation is performed using the spatial temporal sequence and the weight sequence to generate at least one model parameter output. An iterative weight update is performed to generate weight sequence output. A weighted model estimation is performed to generate estimation result output. A stopping criteria is checked and the next iteration iterative weight update and weighted model estimation is performed until the stopping criteria is met. A model estimation is performed to generate model parameter output. An outlier data identification is performed to generate outlier data output. A spatial-temporal data integrity check is performed and the outlier data is disqualified.
摘要翻译：用于精确空间 - 时间模型估计的计算机空间 - 时间调节方法接收包含对象置信掩模的空间时间序列。执行空间 - 时间权重调节以产生权重序列输出。使用空间时间序列和权重序列来执行加权模型估计，以生成至少一个模型参数输出。执行迭代权重更新以产生权重序列输出。执行加权模型估计以产生估计结果输出。检查停止标准，并执行下一次迭代迭代权重更新和加权模型估计，直到满足停止标准。执行模型估计以产生模型参数输出。执行异常值数据识别以产生离群数据输出。执行空间 - 时间数据完整性检查，异常值数据被取消资格。

3. 发明授权

US07974456B2 Spatial-temporal regulation method for robust model estimation 有权
标题翻译：鲁棒模型估计的时空调节方法
公开(公告)号：US07974456B2
公开(公告)日：2011-07-05
申请号：US11516351
申请日：2006-09-05
申请人： Shih-Jong J. Lee , Seho Oh , Hansang Cho
发明人： Shih-Jong J. Lee , Seho Oh , Hansang Cho
IPC分类号： G06K9/00
CPC分类号： G06K9/036 , G06K9/0014 , G06K9/40
摘要： A computerized spatial-temporal regulation method for accurate spatial-temporal model estimation receives a spatial temporal sequence containing object confidence mask. A spatial-temporal weight regulation is performed to generate weight sequence output. A weighted model estimation is performed using the spatial temporal sequence and the weight sequence to generate at least one model parameter output. An iterative weight update is performed to generate weight sequence output. A weighted model estimation is performed to generate estimation result output. A stopping criteria is checked and the next iteration iterative weight update and weighted model estimation is performed until the stopping criteria is met. A model estimation is performed to generate model parameter output. An outlier data identification is performed to generate outlier data output. A spatial-temporal data integrity check is performed and the outlier data is disqualified.
摘要翻译：用于精确空间 - 时间模型估计的计算机空间 - 时间调节方法接收包含对象置信掩模的空间时间序列。执行空间 - 时间权重调节以产生权重序列输出。使用空间时间序列和权重序列来执行加权模型估计，以生成至少一个模型参数输出。执行迭代权重更新以产生权重序列输出。执行加权模型估计以产生估计结果输出。检查停止标准，并执行下一次迭代迭代权重更新和加权模型估计，直到满足停止标准。执行模型估计以产生模型参数输出。执行异常值数据识别以产生离群数据输出。执行空间 - 时间数据完整性检查，异常值数据被取消资格。

4. 发明申请

US20100105053A1 APTAMER BASED SENSORS AND RELATED METHODS AND SYSTEMS 审中-公开
标题翻译：基于APTAMER的传感器及相关方法和系统
公开(公告)号：US20100105053A1
公开(公告)日：2010-04-29
申请号：US12576206
申请日：2009-10-08
申请人： Hansang CHO , Stephen M. LANE , Brian R. BAKER , Sebastian WACHSMANN-HOGIU , Cynthia V. PAGBA , Jeffrey B.H. TOK , Ted Alfred LAURENCE , Luke P. LEE
发明人： Hansang CHO , Stephen M. LANE , Brian R. BAKER , Sebastian WACHSMANN-HOGIU , Cynthia V. PAGBA , Jeffrey B.H. TOK , Ted Alfred LAURENCE , Luke P. LEE
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： G01N33/54373 , C12Q1/6825 , C12Q1/6837 , Y10T156/10 , C12Q2565/632 , C12Q2525/205
摘要： An aptamer based-sensor comprising: a target binding aptamer attaching a Raman probe and a metal coated surface; and related methods and systems
摘要翻译：一种适体基传感器，包括：连接拉曼探针和金属涂覆表面的靶结合适体; 以及相关的方法和系统

5. 发明申请

US20100136551A1 MICROFLUIDIC PLATFORM AND RELATED METHODS AND SYSTEMS 审中-公开
标题翻译：微流平台及相关方法和系统
公开(公告)号：US20100136551A1
公开(公告)日：2010-06-03
申请号：US12576209
申请日：2009-10-08
申请人： Hansang CHO , Brian R. BAKER , Luke P. LEE , Jane BEARINGER
发明人： Hansang CHO , Brian R. BAKER , Luke P. LEE , Jane BEARINGER
IPC分类号： C12Q1/68 , C12M1/34 , B29C65/00 , B32B37/00
CPC分类号： G01N33/54373 , C12Q1/6825 , C12Q1/6837 , Y10T156/10 , C12Q2565/632 , C12Q2525/205
摘要： A microfluidic platform comprising one or more chambers connectable through microfluidic channels, and comprising a substrate presenting aptamer sensors detectable through Raman active molecules, and related methods and systems.
摘要翻译：一种微流体平台，包括可通过微流体通道连接的一个或多个腔室，并且包括呈现通过拉曼活性分子可检测的适体传感器的基底以及相关的方法和系统。

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