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1. 发明申请

US20080175878A1 Protease for activating clotting factor VII 有权
标题翻译：用于激活凝血因子VII的蛋白酶
公开(公告)号：US20080175878A1
公开(公告)日：2008-07-24
申请号：US11984058
申请日：2007-11-13
申请人： Jurgen Romisch , Annette Feussner , Hans-Arnold Stohr
发明人： Jurgen Romisch , Annette Feussner , Hans-Arnold Stohr
IPC分类号： A61K9/00 , C12Q1/56 , A61P7/00 , A61K38/48
CPC分类号： A61L15/38 , A61K38/00 , A61K38/57 , C07K14/745 , C12N9/6424 , C12Q1/56 , G01N33/86 , G01N2333/96447
摘要： A protease for activating the blood clotting factor VII is described, which (a) is inhibited by the presence of aprotinin, (b) is increased in its activity by calcium ions and/or heparin or heparin-related substances, and (c) in SDS-PAGE, on subsequent staining in the non-reduced state, comprises one or more bands in the molecular weight range from 50 to 75 kDa; and in SDS-PAGE, on subsequent staining in the reduced state, comprises a band at 40 to 55 kDa, one or more bands in the molecular weight range from 10 to 35 kDa, and a band, which corresponds to a proenzyme, in the molecular weight range between 60 and 65 kDa.
摘要翻译：描述了用于激活凝血因子VII的蛋白酶，其中（a）被抑肽酶抑制，（b）钙离子和/或肝素或肝素相关物质的活性增加，（c）在随后在非还原状态下染色的SDS-PAGE包含分子量范围为50至75kDa的一个或多个条带; 并且在SDS-PAGE中，在还原状态下的随后染色中，包含在40至55kDa的条带，分子量范围为10至35kDa的一个或多个条带和对应于酶原的条带分子量范围在60和65kDa之间。

2. 发明授权

US5068106A t-PA solution of high concentration and use of the solution in human and veterinary medicine 失效
标题翻译： t-PA高浓度溶液，并在人兽药中使用该溶液
公开(公告)号：US5068106A
公开(公告)日：1991-11-26
申请号：US201880
申请日：1988-06-03
申请人： Eric P. Paques , Hans-Arnold Stohr
发明人： Eric P. Paques , Hans-Arnold Stohr
IPC分类号： C12N9/64 , A61K38/46 , A61K38/49 , A61K47/18 , A61L2/00 , A61P7/02 , C12N9/96
CPC分类号： C12N9/96 , A61K38/49 , A61K47/183 , A61K9/0019 , A61L2/0023
摘要： In the preparation of parenteral solutions for the therapy and prophylaxis of thromboses and embolisms, because of the poor solubility of t-PA hitherto either the infusion of very large volumes has been necessary, or else a solution with a low volume and a high t-PA concentration has been prepared at the expense of setting up a non-physiologically low pH of 2 to 5.Hence, the present invention relates to a process for the preparation of a solution of high concentration of a protein having plasminogen activator activity, where an increase in stability and solubility is achieved by adding at least two substances from the group of D- and/or L-amino acids, their salts, derivatives or homologs. This invention also relates to a process for the pasteurization of a protein solution having t-PA activity, and to a t-PA-containing solution prepared by the claimed process, and to the use of this solution as a fibrinolytic in human and veterinary medicine.
摘要翻译：在制备用于治疗和预防血栓栓塞和肠栓塞的肠胃外溶液中，由于t-PA的溶解性差，所以必须输入非常大的体积，或者是具有低体积和高t- 已经以建立2至5的非生理学低pH为代价制备了PA浓度。因此，本发明涉及一种制备高浓度具有纤溶酶原激活剂活性的蛋白质的溶液的方法，其中通过从D-和/或L-氨基酸，其盐，衍生物或同系物组中加入至少两种物质来实现稳定性和溶解度的增加。本发明还涉及一种用于将具有t-PA活性的蛋白质溶液巴氏杀菌的方法以及通过所要求保护的方法制备的含有t-PA的溶液的方法，以及该溶液在人和兽医学中作为纤维蛋白溶解剂的用途。

3. 发明申请

US20050202002A1 Protease for activating clotting factor VII 审中-公开
标题翻译：用于激活凝血因子VII的蛋白酶
公开(公告)号：US20050202002A1
公开(公告)日：2005-09-15
申请号：US11118396
申请日：2005-05-02
申请人： Jurgen Romisch , Annette Feussner , Hans-Arnold Stohr
发明人： Jurgen Romisch , Annette Feussner , Hans-Arnold Stohr
IPC分类号： A61K38/46 , A61K38/00 , A61K38/48 , A61L15/38 , C07K14/745 , C12N9/64 , C12Q1/56 , G01N33/53 , G01N33/86
CPC分类号： A61L15/38 , A61K38/00 , A61K38/57 , C07K14/745 , C12N9/6424 , C12Q1/56 , G01N33/86 , G01N2333/96447
摘要： A protease for activating the blood clotting factor VII is described, which (a) is inhibited by the presence of aprotinin, (b) is increased in its activity by calcium ions and/or heparin or heparin-related substances, and (c) in SDS-PAGE, on subsequent staining in the non-reduced state, has one or more brands in the molecular weight range from 50 to 75 kDa and kDa in the reduced state has a band at 40 to 55 kDa and one or more bands in the molecular weight range from 10 to 35 kDa. The proenzyme of this protease is also characterized. Further, a process for obtaining this protease and its use in hemorrhage prophylaxis or hemostasis is described. Moreover, a test system for the qualitative and quantitative detection of a protease which activates the blood clotting factor VII is described.
摘要翻译：描述了用于激活凝血因子VII的蛋白酶，其中（a）被抑肽酶抑制，（b）钙离子和/或肝素或肝素相关物质的活性增加，（c）在未还原状态下随后染色的SDS-PAGE在50至75kDa的分子量范围内具有一个或多个品牌，还原状态下的kDa具有40至55kDa的条带和分子量范围为10至35kDa。该蛋白酶的酶还具有特征。此外，描述了获得该蛋白酶的方法及其在出血预防或止血中的用途。此外，描述了用于定性和定量检测激活凝血因子VII的蛋白酶的测试系统。

4. 发明授权

US5968759A Method for the quantification of activated coagulation factor VII (FVIIa) 失效
标题翻译：定量活化凝血因子VII（FVIIa）的方法
公开(公告)号：US5968759A
公开(公告)日：1999-10-19
申请号：US731580
申请日：1996-10-16
申请人： Jurgen Romisch , Hans-Arnold Stohr
发明人： Jurgen Romisch , Hans-Arnold Stohr
IPC分类号： C12Q1/56 , C07K14/745 , G01N33/86 , C12Q1/00 , C12Q1/37
CPC分类号： G01N33/86 , G01N2333/8128 , G01N2333/96447 , G01N2333/96463 , G01N2400/40
摘要： The invention relates to a method for the quantification of coagulation factor VIIa (F VIIa) in FVIIa- or FVII/FVIIa-containing solutions by means of selective binding to immobilized soluble thromboplastin.
摘要翻译：本发明涉及通过选择性结合固定的可溶性凝血激酶原定量FVII-或FVII / FVIIa溶液中凝血因子VIIa（F VIIa）的方法。

5. 发明授权

US4650678A Readily dissolvable lyophilized fibrinogen formulation 失效
标题翻译：易溶解的冻干纤维蛋白原制剂
公开(公告)号：US4650678A
公开(公告)日：1987-03-17
申请号：US639617
申请日：1984-08-10
申请人： Peter Fuhge , Norbert Heimburger , Hans-Arnold Stohr , Wolfgang Burk
发明人： Peter Fuhge , Norbert Heimburger , Hans-Arnold Stohr , Wolfgang Burk
IPC分类号： A61K35/14 , A61K38/00 , A61K38/16 , A61K38/43 , A61K47/16 , A61L24/10 , C07K14/75 , A61K31/155 , A61K31/17 , A61K31/195
CPC分类号： A61L24/106 , C07K14/75 , A61K38/00
摘要： A solid fibrinogen formulation is described, which formulation contains, in addition to fibrinogen, a substance containing the urea or guanidine radical, and a process for its preparation. This formulation is used for the preparation of a fibrinogen solution which is suitable as an adhesive for human and animal tissue and as a fibrinogen concentrate for intravenous administration.
摘要翻译：描述了一种固体纤维蛋白原制剂，该制剂除纤维蛋白原外还含有含有尿素或胍基的物质及其制备方法。该制剂用于制备纤维蛋白原溶液，其适合作为人和动物组织的粘合剂以及用于静脉内施用的纤维蛋白原浓缩物。

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