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1. 发明授权

US09590802B2 Navigation signal transmitter and method for generating navigation signal 有权
标题翻译：导航信号发射机和产生导航信号的方法
公开(公告)号：US09590802B2
公开(公告)日：2017-03-07
申请号：US14009338
申请日：2011-04-26
申请人： Hideyuki Torimoto , Makoto Ishii , Masahiro Asako , Hiroaki Maeda
发明人： Hideyuki Torimoto , Makoto Ishii , Masahiro Asako , Hiroaki Maeda
IPC分类号： G01S1/08 , G01S13/00 , H04L7/00 , G01S1/20 , G01S19/10 , G01S19/11 , G01S5/02
CPC分类号： H04L7/0091 , G01S1/20 , G01S5/021 , G01S5/0226 , G01S19/10 , G01S19/11
摘要： Provided is a navigation signal transmitter capable of ensuring reduction in frequency deviation of a terrestrially transmitted navigation signal at low cost. The navigation signal transmitter is operable to receive a transmission wave, generate a synchronization pulse in synchronization with a predetermined data frame, generate an internal clock fundamental oscillation by a reference signal synchronizing section (550) using the synchronization pulse as a reference signal, generate an IMES signal based on the internal clock fundamental oscillation, and transmit the IMES signal. The reference signal synchronizing section (550) comprises a counter circuit (551), a comparator (553), a low-pass control filter (554), a D/A converter (555) and a voltage controlled oscillator (556). The reference signal synchronizing section (550) is configured to, when a magnitude relationship between the number of clock pulses generated in the voltage controlled oscillator (556) using the synchronization pulse as the reference signal and a reference value falls within a predetermined value and continues a predetermined number of times in one direction, adjust a level of control voltage of the voltage controlled oscillator (556).
摘要翻译：提供能够以低成本确保地面传输的导航信号的频率偏差的导航信号发射机。导航信号发射器可操作以接收发射波，与预定数据帧同步产生同步脉冲，使用同步脉冲作为参考信号，通过参考信号同步部分（550）产生内部时钟基本振荡，生成 IMES信号基于内部时钟基波振荡，并传输IMES信号。参考信号同步部分（550）包括计数器电路（551），比较器（553），低通控制滤波器（554），D / A转换器（555）和压控振荡器（556）。参考信号同步部分（550）被配置为当使用作为参考信号的同步脉冲的压控振荡器（556）中产生的时钟脉冲数与基准值之间的幅度关系落在预定值内并继续在一个方向上预定次数，调节压控振荡器（556）的控制电压电平。

2. 发明授权

US09421299B2 Medical adhesive 有权
标题翻译：医用胶
公开(公告)号：US09421299B2
公开(公告)日：2016-08-23
申请号：US14005906
申请日：2012-03-09
申请人： Naoaki Kawakami , Hiroaki Maeda
发明人： Naoaki Kawakami , Hiroaki Maeda
IPC分类号： A61L24/04 , C09J175/04 , C09J175/08 , C08G18/48 , C08G18/77
CPC分类号： A61L24/046 , C08G18/4837 , C08G18/4845 , C08G18/773 , C09J175/04 , C09J175/08 , C08L75/04
摘要： The present invention is directed to providing a safe medical adhesive, a cured body of which is hard to be degraded and decomposed and thus stable and the cured body generates less amount of acid, aldehyde, etc. due to degradation/decomposition. The medical adhesive includes a hydrophilic urethane prepolymer (UP) obtained by reacting a polyisocyanate component (A) containing a fluorine-containing non-aromatic polyisocyanate compound (A1) as an essential ingredient and a polyol component (B) containing a hydrophilic polyol (B1) as an essential ingredient, wherein a chlorine content in a chlorine-containing organic compound based on the weight of the hydrophilic urethane prepolymer (UP) is 0.005 wt % or less.
摘要翻译：本发明旨在提供一种安全的医用粘合剂，其固化体难以降解和分解，因此稳定，固化体由于降解/分解而产生较少量的酸，醛等。医用胶粘剂包括通过使含有含氟非芳香族多异氰酸酯化合物（A1）作为必需成分的多异氰酸酯成分（A）与含有亲水性多元醇（B1）的多元醇成分（B）反应而得到的亲水性氨基甲酸酯预聚物（UP））作为必要成分，其中，基于亲水性氨基甲酸酯预聚物（UP）的重量，含氯有机化合物中的氯含量为0.005重量％以下。

3. 发明授权

US09091969B2 Electrophotographic image forming apparatus 有权
标题翻译：电子照相成像设备
公开(公告)号：US09091969B2
公开(公告)日：2015-07-28
申请号：US14173044
申请日：2014-02-05
申请人： Ryuji Yoshida , Hideki Zemba , Yusuke Mitani , Shotaro Hoshi , Masahiko Shakuto , Hiroaki Maeda
发明人： Ryuji Yoshida , Hideki Zemba , Yusuke Mitani , Shotaro Hoshi , Masahiko Shakuto , Hiroaki Maeda
IPC分类号： G03G15/16 , G03G15/02 , G03G15/06
CPC分类号： G03G15/1675 , G03G15/0266 , G03G15/065
摘要： An image forming apparatus includes a charging bias output device, a developing bias output device, a transfer bias output device, and a controller. The controller controls the transfer bias output device to supply a transfer bias from a time at which a first position of a photosensitive member arrives at a transfer position after the charging bias output device starts supplying a charging bias. An initial value of the transfer bias is controlled to be smaller than a normal set value for a predetermined time period which is a time after the transfer bias starts to be supplied and within a time corresponding to a rise time during which a surface potential of the photosensitive member reaches a predetermined potential after the charging bias starts to be output. The first position of the photosensitive member is a position at which the charging device starts charging the photosensitive member.
摘要翻译：图像形成装置包括充电偏压输出装置，显影偏压输出装置，转印偏压输出装置和控制器。控制器控制转印偏压输出装置，以在充电偏压输出装置开始提供充电偏压之后从感光元件的第一位置到达转印位置的时间提供转印偏压。转移偏压的初始值被控制为小于正常设定值，该预定时间段是在转印偏差开始被提供之后的时间内，并且在与上述时间相对应的时间内，感光元件在充电偏压开始输出之后达到预定电位。感光构件的第一位置是充电装置开始对感光构件充电的位置。

4. 发明授权

US08748132B2 Process for preparing inclusion body-forming protein 有权
标题翻译：制备包涵体形成蛋白的方法
公开(公告)号：US08748132B2
公开(公告)日：2014-06-10
申请号：US13125328
申请日：2009-10-21
申请人： Hiroshi Nakatake , Akihiro Meta , Kiyotaka Suenaga , Masaki Hirashima , Hiroaki Maeda
发明人： Hiroshi Nakatake , Akihiro Meta , Kiyotaka Suenaga , Masaki Hirashima , Hiroaki Maeda
IPC分类号： C12P21/04
CPC分类号： C12N9/6491 , C07K2319/02 , C12P21/02
摘要： A process for preparing an inclusion body-forming protein is provided. A nucleic acid fragment having a nucleotide sequence coding for a modified alkaline phosphatase signal peptide (modified APSP) where leucine at the 13th position in the amino acid sequence shown in SEQ ID NO: 1 is substituted with proline and/or alanine at the 21st position is substituted with the other amino acid, downstream of which nucleotide sequence is bound a nucleotide sequence of a gene of a protein of interest is also provided.
摘要翻译：提供了一种制备包涵体形成蛋白的方法。具有编码改变的碱性磷酸酶信号肽（修饰的APSP）的核苷酸序列的核酸片段，其中在SEQ ID NO：1所示的氨基酸序列中的第13位的亮氨酸被第21位的脯氨酸和/或丙氨酸取代还提供了另一个氨基酸，其下游的核苷酸序列与目的蛋白质的基因的核苷酸序列结合。

5. 发明申请

US20140016722A1 NAVIGATION SIGNAL TRANSMITTER AND METHOD FOR GENERATING NAVIGATION SIGNAL 有权
标题翻译：导航信号发射器和导航信号的生成方法
公开(公告)号：US20140016722A1
公开(公告)日：2014-01-16
申请号：US14009338
申请日：2011-04-26
申请人： Hideyuki Torimoto , Makoto Ishii , Masahiro Asako , Hiroaki Maeda
发明人： Hideyuki Torimoto , Makoto Ishii , Masahiro Asako , Hiroaki Maeda
IPC分类号： H04L7/00
CPC分类号： H04L7/0091 , G01S1/20 , G01S5/021 , G01S5/0226 , G01S19/10 , G01S19/11
摘要： Provided is a navigation signal transmitter capable of ensuring reduction in frequency deviation of a terrestrially transmitted navigation signal at low cost. The navigation signal transmitter is operable to receive a transmission wave, generate a synchronization pulse in synchronization with a predetermined data frame, generate an internal clock fundamental oscillation by a reference signal synchronizing section (550) using the synchronization pulse as a reference signal, generate an IMES signal based on the internal clock fundamental oscillation, and transmit the IMES signal. The reference signal synchronizing section (550) comprises a counter circuit (551), a comparator (553), a low-pass control filter (554), a D/A converter (555) and a voltage controlled oscillator (556). The reference signal synchronizing section (550) is configured to, when a magnitude relationship between the number of clock pulses generated in the voltage controlled oscillator (556) using the synchronization pulse as the reference signal and a reference value falls within a predetermined value and continues a predetermined number of times in one direction, adjust a level of control voltage of the voltage controlled oscillator (556).
摘要翻译：提供能够以低成本确保地面传输的导航信号的频率偏差的导航信号发射机。导航信号发射器可操作以接收发射波，与预定数据帧同步产生同步脉冲，使用同步脉冲作为参考信号，通过参考信号同步部分（550）产生内部时钟基本振荡，生成 IMES信号基于内部时钟基波振荡，并传输IMES信号。参考信号同步部分（550）包括计数器电路（551），比较器（553），低通控制滤波器（554），D / A转换器（555）和压控振荡器（556）。参考信号同步部分（550）被配置为当使用作为参考信号的同步脉冲的压控振荡器（556）中产生的时钟脉冲数与基准值之间的幅度关系落在预定值内并继续在一个方向上预定次数，调节压控振荡器（556）的控制电压的电平。

6. 发明授权

US08364101B2 Amplifying device and transmitter apparatus 有权
标题翻译：放大装置和发射机装置
公开(公告)号：US08364101B2
公开(公告)日：2013-01-29
申请号：US12721064
申请日：2010-03-10
申请人： Yoshinobu Shizawa , Hiroaki Maeda , Yousuke Okazaki , Hirotake Honda
发明人： Yoshinobu Shizawa , Hiroaki Maeda , Yousuke Okazaki , Hirotake Honda
IPC分类号： H04B1/04 , H01Q11/12
CPC分类号： H03F1/0288 , H03F1/0222 , H03F1/3247 , H03F2201/3233
摘要： An amplifying device includes an amplifier including a first amplifying element with a drain voltage thereof being controlled, and a second amplifying element, the amplifier amplifying a transmission signal with the first and second amplifying elements, synthesizing the transmission signals amplified by the first and second amplifying elements, and outputting the synthesized transmission signal; a distortion compensator part which performs distortion compensation on the input signal in accordance with a compensation coefficient derived from a difference between a input signal and a feedback signal generated from a portion of a signal output from the amplifier; and a controller part which controls the drain voltage of the first amplifying element in response to a result of a comparison between a power level of the input signal prior to the distortion compensation operation by the distortion compensator part and a threshold value.
摘要翻译：一种放大装置，包括：放大器，包括其漏极电压被控制的第一放大元件;以及第二放大元件，放大器利用第一和第二放大元件放大发送信号，合成由第一和第二放大元件放大的发送信号并输出合成的发送信号; 失真补偿部，其根据从输入信号和从放大器输出的信号的一部分产生的反馈信号之间的差导出的补偿系数，对输入信号进行失真补偿; 以及控制器部分，其响应于在失真补偿器部分的失真补偿操作之前的输入信号的功率电平与阈值之间的比较的结果来控制第一放大元件的漏极电压。

7. 发明授权

US08283137B2 Process for producing recombinant fibrinogen highly producing cell and highly producing cell 有权
标题翻译：用于生产重组纤维蛋白原高产细胞和高产细胞的方法
公开(公告)号：US08283137B2
公开(公告)日：2012-10-09
申请号：US10566266
申请日：2004-07-28
申请人： Reiko Matsuyama , Hiroaki Maeda
发明人： Reiko Matsuyama , Hiroaki Maeda
IPC分类号： C12N1/00 , C12N5/10 , C12N5/16 , C12P21/00
CPC分类号： C07K14/75
摘要： When genes encoding three kinds of proteins constituting fibrinogen, an α chain (or variant of α chain), a β chain and a γ chain (or variant of γ chain) are incorporated into an animal cell, a constitutional ratio of respective genes is such that a α chain (and/or variant of γ chain) gene is an equal amount to a 1000-fold amount relative to an α chain (and/or variant of α chain) gene and a β chain gene and, further, by using a baculovirus P35 gene, a recombinant fibrinogen highly producing cell is prepared.
摘要翻译：当编码构成纤维蛋白原的三种蛋白质的基因，α链（或α链的变体），a＆bgr; 链和γ链（或γ链的变体）并入动物细胞中，各基因的构成比例使得α链（和/或γ链的变体）基因等于1000倍相对于α链（和/或α链的变体）基因和bgr的量; 链基因，并且通过使用杆状病毒P35基因，制备重组纤维蛋白原高产细胞。

8. 发明申请

US20120225818A1 PLASMA PROTEIN EFFECTIVE FOR SUPPRESSING COUGH 审中-公开
标题翻译：有效抑制咳嗽的等离子体蛋白质
公开(公告)号：US20120225818A1
公开(公告)日：2012-09-06
申请号：US13389215
申请日：2010-08-05
申请人： Shintaro Kamei , Asami Shindome , Takayoshi Hamamoto , Hiroaki Maeda , Masaki Hirashima , Sachio Okuda , Misako Umehashi , Sachie Ogawa , Megumi Imuta , Norio Akaike , Kazuo Takahama , Ryoko Wada
发明人： Shintaro Kamei , Asami Shindome , Takayoshi Hamamoto , Hiroaki Maeda , Masaki Hirashima , Sachio Okuda , Misako Umehashi , Sachie Ogawa , Megumi Imuta , Norio Akaike , Kazuo Takahama , Ryoko Wada
IPC分类号： A61K38/36 , A61P11/14
CPC分类号： C12N9/6443 , A61K38/4846
摘要： The activated Factor XI is provided as an antitussive for cough caused by the stimulation at the tracheal bifurcation such as chronic cough. A pharmaceutical composition for prevention, treatment and/or symptom amelioration of cough, comprising a polypeptide chain as an active ingredient and a pharmaceutically acceptable carrier, wherein the polypeptide chain consists of a full length amino acid sequence constituting activated Factor XI (hereinafter also referred to as “FXIa”), the amino acid sequence with one or several amino acids therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences.
摘要翻译：提供活化因子XI作为由气管分叉如慢性咳嗽引起的咳嗽的镇咳药。一种用于预防，治疗和/或症状改善咳嗽的药物组合物，其包含多肽链作为活性成分和药学上可接受的载体，其中所述多肽链由构成活化因子XI的全长氨基酸序列组成（以下也称为作为“FXIa”），其中具有一个或几个氨基酸的氨基酸序列被缺失，取代或加入，或任一上述氨基酸序列的部分序列，或包含上述任何一种的氨基酸序列氨基酸序列。

9. 发明授权

US07972835B2 Blood-viscosity reducing agent 有权
公开(公告)号：US07972835B2
公开(公告)日：2011-07-05
申请号：US12369329
申请日：2009-02-11
申请人： Masahito Hitosugi , Hiroaki Maeda , Kazunobu Omura
发明人： Masahito Hitosugi , Hiroaki Maeda , Kazunobu Omura
IPC分类号： C12N1/20 , C12N9/56 , A01N1/02 , A61K9/36
CPC分类号： C12N9/54
摘要： A blood-viscosity reducing agent contains a protein derived from Bacillus subtilis natto and including, sequentially from an amino group terminal, a first structural amino acid sequence having alanine, threonine, aspartic acid, glycine, valine, glutamic acid, tryptophan, asparagine, valine, aspartic acid, glutamine, isoleucine, aspartic acid, alanine, proline, lysine, alanine, tryptophan, alanine, leucine, glycine, tyrosine aspartic, acid, glycine, threonine, glycine, threonine, valine, valine, alanine, serine, isoleucine, aspartic acid, threonine, glycine, valine, glutamic acid, tryptophan, asparagine, histidine, proline, alanine, leucine, lysine, glutamic acid, lysine, tyrosine, arginine, glycine, tyrosine, asparagine, proline, glutamic acid, asparagine, proline, asparagine, glutamic acid, proline, glutamic acid, asparagine, glutamic acid, methionine, asparagine, tryptophan, tyrosine, aspartic acid, alanine, valine, alanine, glycine, glutamic acid, alanine, serine, proline, tyrosine, aspartic acid, aspartic acid, leucine, alanine, histidine, glycine, threonine, histidine, valine, and threonine, a second structural amino acid sequence having alanine, phenylalanine, serine, glutamic acid, aspartic acid, glycine, glycine, threonine, aspartic acid, alanine, aspartic acid, isoleucine, leucine, glutamic acid, alanine, glycine, glutamic acid, tryptophan, valine, and leucine, a third structural amino acid sequence having aspartic acid, alanine, glutamic acid, glycine, asparagine, proline, histidine, proline, glutamic acid, methionine, alanine, proline, aspartic acid, and valine, and a fourth structural amino acid sequence having valine, proline, glycine, glutamine, alanine, tyrosine, glutamic acid, aspartic acid, glycine, tryptophan, and aspartic acid, thereby reducing the viscosity of whole blood.

10. 发明授权

US07960508B2 Peptide having cytotoxicity inhibitory activity and method of screening these peptide having cytotoxicity inhibitory activity 失效
标题翻译：具有细胞毒性抑制活性的肽和筛选具有细胞毒性抑制活性的肽的方法
公开(公告)号：US07960508B2
公开(公告)日：2011-06-14
申请号：US10477101
申请日：2002-05-10
申请人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
发明人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
IPC分类号： A61K38/00 , A61K38/04 , A61K38/16 , A61K38/10 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/4747 , C07K14/47 , G01N33/5014
摘要： A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.
摘要翻译：含有一种或多种硒代半胱氨酸的肽片段或一系列肽片段，其毒性低于硒代胱氨酸并且具有细胞毒性抑制活性。根据本发明的肽片段或一系列肽片段优选具有来自硒蛋白P的C末端的第260至第362位氨基酸残基的氨基酸序列，或其中具有一个或几个氨基酸残基的所述氨基酸序列是缺失，取代或添加，或上述氨基酸序列中的任一个的部分序列，或包含作为上述氨基酸序列之一的氨基酸序列。还提供了具有细胞毒性抑制活性的肽片段的筛选方法。

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