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    • 2. 发明申请
    • Porous three dimensional nest scaffolding
    • 多孔三维巢脚手架
    • US20070168021A1
    • 2007-07-19
    • US11333054
    • 2006-01-17
    • David HolmesGurpreet SandhuRobert Simari
    • David HolmesGurpreet SandhuRobert Simari
    • A61F2/06A61F2/82A61F2/02
    • A61L27/38A61L27/54A61L31/005A61L31/16A61L2300/00
    • The invention provides porous three dimensional scaffold structures that may be used to deliver a bioactive agent, such as cells, into a location within the body. In one example form, the porous three dimensional structure may be a stent. In another example form, the porous three dimensional structure may be a microscale or nanoscale device for the delivery of the bioactive agent. The scaffold may include a substrate and one or more nests connected to the substrate. The nest(s) extend away from the substrate to define an enclosed volume on the substrate within each nest. The nests have openings that extend from an outer surface of the nest to the enclosed volume within each nest. The scaffold includes a bioactive agent disposed within the enclosed volume of at least one nest on the substrate. The bioactive agent is delivered to the patient when the scaffold is located within the patient.
    • 本发明提供了可用于将生物活性剂(例如细胞)输送到体内的位置的多孔三维支架结构。 在一个示例形式中,多孔三维结构可以是支架。 在另一个示例形式中,多孔三维结构可以是用于递送生物活性剂的微尺度或纳米级装置。 支架可以包括基底和连接到基底的一个或多个巢。 嵌套从衬底延伸离开,以在每个嵌套内的衬底上限定封闭的体积。 巢具有从巢的外表面延伸到每个窝内的封闭体积的开口。 支架包括设置在衬底上的至少一个嵌套的封闭体积内的生物活性剂。 当支架位于患者体内时,将生物活性剂递送至患者。