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1. 发明公开

US20240218304A1 THERAPEUTIC ALCOHOLIC BEVERAGE COMPRISING NATURAL HERBAL DERIVATIVES AND METHOD OF MAKING THEREOF 审中-公开
公开(公告)号：US20240218304A1
公开(公告)日：2024-07-04
申请号：US18148480
申请日：2022-12-30
申请人： Mark DeCaro , Guobao Wei
发明人： Mark DeCaro , Guobao Wei
IPC分类号： C12G3/055 , C12G3/07
CPC分类号： C12G3/055 , C12G3/07
摘要： Therapeutic alcoholic beverage compositions and the methods of making are disclosed. In particular, the invention relates to a therapeutic alcoholic beverage composition comprising one or more therapeutic compounds derived from natural herb materials. The natural herb materials are selected from Cannabis materials, psilocybin mushrooms, the combination of those, and others. The therapeutic compounds comprising psychoactive compounds Δ9-tetrahydrocannabinol (THC), supporting non-psychoactive cannabidiol (CBD) and terpenes derived from Cannabis materials, and/or psychedelic compounds including psilocybin, psilocin, baeocystin, norbaeocystin, and norpsilocin derived from psilocybin mushrooms. The therapeutic compounds have a concentration varying from 0.00001% to 10% in the alcoholic beverage. The therapeutic alcoholic beverage can be further enhanced by aroma and flavor substances derived from wood materials. The methods of making comprising treating alcoholic beverage with natural herb materials and wood materials in presence of subcritical, critical, or supercritical carbon dioxide.

2. 发明授权

US09101475B2 Segmented delivery system 有权
标题翻译：分段交货系统
公开(公告)号：US09101475B2
公开(公告)日：2015-08-11
申请号：US12705369
申请日：2010-02-12
申请人： Guobao Wei , Todd M. Boyce , Robert Cohen , Cristy Richards , Lawrence A. Shimp
发明人： Guobao Wei , Todd M. Boyce , Robert Cohen , Cristy Richards , Lawrence A. Shimp
IPC分类号： A61F2/28 , A61F2/30 , A61F2/46 , A61B17/82 , A61F2/00
CPC分类号： A61B17/8819 , A61B17/823 , A61B17/8825 , A61B2017/8813 , A61F2/30 , A61F2/4603 , A61F2002/0086 , A61F2002/2825 , A61F2002/2835 , A61F2002/30059 , A61F2002/30064 , A61F2002/3007 , A61F2002/30072 , A61F2002/30588 , A61F2002/30677 , A61F2002/3068 , A61F2002/3093 , A61F2002/30971 , A61F2002/4623 , A61F2002/4627 , A61F2250/0068 , A61F2310/00592 , A61F2310/00958 , A61F2310/0097
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.
摘要翻译：提供了将物质或材料输送到手术部位的覆盖物。其中提供的物质的覆盖物可以被称为递送系统。通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多室结构，直到覆盖物被放置在手术部位。放置时，覆盖物可以促进物质或周围材料的转移。例如，物质可以被主动地或被动地释放到手术部位。覆盖物可以参与，控制或以其他方式调节物质的释放。在各种实施方案中，覆盖物可以由胶原材料形成，并且适用于各种程序特异性用途。

3. 发明授权

US08916185B2 Immobilizing particles onto surfaces 有权
标题翻译：将颗粒固定在表面上
公开(公告)号：US08916185B2
公开(公告)日：2014-12-23
申请号：US12038783
申请日：2008-02-27
申请人： Peter X. Ma , Guobao Wei
发明人： Peter X. Ma , Guobao Wei
IPC分类号： A61F2/00 , A61F13/00 , A61K9/70 , A61K9/14 , B01D67/00
CPC分类号： B01D67/0004 , B01D67/0083 , B01D2323/22 , Y10T428/25 , Y10T428/254
摘要： A method for immobilizing micro-particles, nano-particles or combinations thereof onto a surface is disclosed. The method includes distributing the micro-particles, nano-particles or combinations thereof onto the surface. The surface and the particles are exposed to thermal treatment, vapor treatment or combinations thereof, thereby adhering at least some of the micro-particles, nano-particles or combinations thereof to the surface. Materials including such immobilized micro-particles, nano-particles or combinations thereof are also disclosed herein.
摘要翻译：公开了将微粒，纳米颗粒或其组合固定在表面上的方法。该方法包括将微粒，纳米颗粒或其组合分布到表面上。表面和颗粒暴露于热处理，蒸汽处理或其组合，从而将至少一些微粒，纳米颗粒或其组合粘附到表面上。包括这种固定化微粒，纳米颗粒或其组合的材料也在本文中公开。

4. 发明授权

US08758806B2 Human lubrication gel 有权
标题翻译：人体润滑凝胶
公开(公告)号：US08758806B2
公开(公告)日：2014-06-24
申请号：US13355712
申请日：2012-01-23
申请人： Susan J. Drapeau , Guobao Wei
发明人： Susan J. Drapeau , Guobao Wei
IPC分类号： A61K38/39 , A61K9/14 , A61K9/50 , A61K9/70 , A61P29/00 , A61P19/08 , A61P21/02 , A61P19/02 , B82Y5/00
CPC分类号： A61K47/42 , A61K9/0024 , A61K9/06 , A61K31/573 , A61K38/00 , A61K38/1875 , A61K38/2066 , B82Y5/00 , C07K16/241 , C07K16/245
摘要： Human lubricating gels, methods and kits for delivering a therapeutic agent to a target tissue site beneath the skin of a patient utilizing human lubricating gel are provided, the human lubricating gel being capable of adhering to the target tissue site and comprising one or more biodegradable formulations containing an effective amount of the therapeutic agent. In various embodiments, the human lubricating gel is sprayable and hardens after contacting the target tissue site.
摘要翻译：提供人体润滑凝胶，用于使用人体润滑凝胶将治疗剂递送到患者皮肤下面的靶组织部位的方法和试剂盒，所述人润滑凝胶能够粘附到靶组织部位并且包含一种或多种可生物降解制剂含有有效量的治疗剂。在各种实施方案中，人体润滑凝胶在与靶组织部位接触后是可喷雾的和硬化的。

5. 发明授权

US08357384B2 Bone matrix compositions and methods 有权
标题翻译：骨基质组成和方法
公开(公告)号：US08357384B2
公开(公告)日：2013-01-22
申请号：US12140044
申请日：2008-06-16
申请人： Keyvan Behnam , Guobao Wei , Nanette Forsyth , Todd M. Boyce , Lawrence A. Shimp
发明人： Keyvan Behnam , Guobao Wei , Nanette Forsyth , Todd M. Boyce , Lawrence A. Shimp
IPC分类号： A61K35/00 , A61K35/32
CPC分类号： A61K35/00 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3695 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
摘要翻译：提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及胞吐作用或内吞诱导活性。在一个实施方案中，用于产生骨诱导性组合物的方法包括提供部分去矿物质的骨，处理部分去矿物质的骨以破坏骨的胶原结构，以及任选地提供组织衍生的提取物，并将组织衍生的提取物加入到部分去矿物质骨。在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。

6. 发明申请

US20090234277A1 DELIVERY SYSTEM 有权
公开(公告)号：US20090234277A1
公开(公告)日：2009-09-17
申请号：US12171168
申请日：2008-07-10
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Sigurd H. Berven , Randal R. Betz , Michael F. O'Brien , Alexis P. Shelokov
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Sigurd H. Berven , Randal R. Betz , Michael F. O'Brien , Alexis P. Shelokov
IPC分类号： A61B17/70
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

7. 发明申请

US20090157087A1 DELIVERY SYSTEM ATTACHMENT 有权
标题翻译：交付系统附件
公开(公告)号：US20090157087A1
公开(公告)日：2009-06-18
申请号：US12205539
申请日：2008-09-05
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
IPC分类号： A61B17/58 , A61B17/10 , A61B17/08 , A61F2/28 , A61M29/00
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译：提供了将物质或材料输送到手术部位的覆盖物。其中提供的物质的覆盖物可以被称为递送系统。通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。放置时，覆盖物可以促进物质或周围材料的转移。例如，物质可以被主动地或被动地释放到手术部位。覆盖物可以参与，控制或以其他方式调节物质的释放。

8. 发明授权

US09492278B2 Delivery system 有权
标题翻译：输送系统
公开(公告)号：US09492278B2
公开(公告)日：2016-11-15
申请号：US12171168
申请日：2008-07-10
申请人： Guobao Wei , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Sigurd H. Berven , Randal R. Betz , Michael F. O'Brien , Alexis P. Shelokov
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Sigurd H. Berven , Randal R. Betz , Michael F. O'Brien , Alexis P. Shelokov
IPC分类号： A61F2/28 , A61B17/70 , A61F2/30 , A61F2/00 , A61F2/44 , A61F2/46
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译：提供了将物质或材料输送到手术部位的覆盖物。其中提供的物质的覆盖物可以被称为递送系统。通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多室结构，直到覆盖物被放置在手术部位。放置时，覆盖物可以促进物质或周围材料的转移。例如，物质可以被主动地或被动地释放到手术部位。覆盖物可以参与，控制或以其他方式调节物质的释放。

9. 发明授权

US09265830B2 Implantable compositions and methods for preparing the same 有权
标题翻译：可植入组合物及其制备方法
公开(公告)号：US09265830B2
公开(公告)日：2016-02-23
申请号：US13090745
申请日：2011-04-20
申请人： Christina Mossaad , Lawrence A. Shimp , Guobao Wei , John Winterbottom
发明人： Christina Mossaad , Lawrence A. Shimp , Guobao Wei , John Winterbottom
IPC分类号： A61K47/10 , A61K38/18 , A61K9/00 , A61K47/36 , A61K9/06 , A61K35/32 , A61L27/36 , A61L27/54
CPC分类号： A61L27/3608 , A61K9/0024 , A61K9/06 , A61K35/32 , A61K38/1875 , A61K47/10 , A61K47/36 , A61L27/26 , A61L27/54 , A61L2300/412 , A61L2300/414 , A61L2430/02
摘要： Methods for forming implantable compositions are provided. In some embodiments, the methods include (i) providing a gel base, (ii) adding water and a hydrating agent to the gel base to form a mixture, (iii) reducing the water content of the mixture; and (iv) adding a delivered material before, during, and/or after step (ii) or (iii). The water content is reduced to about 5% or less by weight of the implantable composition.
摘要翻译：提供了可植入组合物的形成方法。在一些实施方案中，所述方法包括（i）提供凝胶基质，（ii）向凝胶基质中加入水和水合剂以形成混合物，（iii）降低混合物的水含量; 和（iv）在步骤（ii）或（iii）之前，期间和/或之后加入递送的材料。含水量降低至可植入组合物重量的约5％或更少。

10. 发明授权

US08568769B2 Particle-containing complex porous materials 有权
标题翻译：含颗粒的复合多孔材料
公开(公告)号：US08568769B2
公开(公告)日：2013-10-29
申请号：US13564874
申请日：2012-08-02
申请人： Peter X. Ma , Guobao Wei
发明人： Peter X. Ma , Guobao Wei
IPC分类号： A61K9/70
CPC分类号： A61K9/0024 , A61K9/1647 , A61K9/1652 , A61K9/1658 , A61K9/1694 , A61K9/5153 , A61K9/5161 , A61K9/5169 , A61K9/70 , A61K48/0008 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/258 , A61L2300/43 , A61L2300/602 , A61L2300/622 , A61L2300/624
摘要： Porous materials and methods for forming them are disclosed. One method for immobilizing micro-particles and/or nano-particles onto internal pore surfaces and/or external pore surfaces of porous materials includes suspending the micro-particles and/or nano-particles in a liquid adapted to swell, soften, and/or deform either the porous materials and/or the particles, thereby forming a liquid-particle suspension. The method further includes adding the suspension to the porous materials; and removing the liquid, thereby forming the porous materials having the micro-particles and/or nano-particles immobilized on the internal pore surfaces and/or the external pore surfaces.
摘要翻译：公开了用于形成它们的多孔材料和方法。将微粒和/或纳米颗粒固定在多孔材料的内孔表面和/或外孔表面上的一种方法包括将微粒和/或纳米颗粒悬浮在适于膨胀，软化和/或使多孔材料和/或颗粒变形，从而形成液体 - 颗粒悬浮液。该方法还包括将悬浮液加入到多孔材料中; 并除去液体，由此形成具有固定在内孔表面和/或外孔表面上的微粒和/或纳米颗粒的多孔材料。

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