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1. 发明申请

US20160258910A1 Standard Analyte Generator 有权
公开(公告)号：US20160258910A1
公开(公告)日：2016-09-08
申请号：US14638544
申请日：2015-03-04
申请人： Jonathan James Grandy , German Augusto Gomez-Rios , Janusz Boleslaw Pawliszyn
发明人： Jonathan James Grandy , German Augusto Gomez-Rios , Janusz Boleslaw Pawliszyn
IPC分类号： G01N30/04 , B01J20/281 , G01N1/40
CPC分类号： G01N30/04 , B01L2300/069 , G01N1/405 , G01N30/08 , G01N30/48 , G01N2001/2893 , G01N2030/009 , G01N2030/045 , G01N2030/062 , G01N2030/488
摘要： The invention describes the process by which a standard mixture of organic compounds are spiked and retained onto a composite sorbent matrix for the controlled generation of a standard in fluid above the spiked matrix either in gas (headspace) or aqueous phase which is contained in portable vials. The novelty of the aforementioned composite matrix stems from the combination of an immobilizing liquid phase such as silicone oil or a polyacrylonitrile solution, and solid, porous particles such as polystyrene-co-divinylbenzene (PS-DVB) or Hydrophilic/Lipophilic Balance (HLB) particles to strongly retain the spiked standards facilitating high capacity which translates into prolonged use as a source of calibrant. These novel composite mixtures exhibit sorptive capabilities greater than the sum of their individual components producing a standard analyte generator far superior to those described in the prior art. In addition swelling of the particles with the liquid phase facilitates immobilization of the composite sorbent matrix in the vial. Immobilization of said particles has also been achieved by cross-linking of a liquid polymeric solution such as polydimethylsiloxane (PDMS), allowing the composite sorbent matrix to be uniformly distributed on the vessel wall. With thermodynamic equilibrium strongly favoring the sorbent phase for a wide range of chemical compounds, this invention allows for the reproducible generation of an ultra-low concentration standard analyte mixture in fluid. If the fluid is gaseous, extractions from this headspace can be performed via solid phase microextraction (SPME), needle trap devices (NTD), or direct headspace extraction for injection onto various hyphenated gas chromatography (GC) systems. If the fluid is aqueous, extractions may be performed directly from the standard water for injection onto hyphenated GC or liquid chromatography (LC) systems. The invention can be used for a variety of applications ranging from integrated GC-MS or LC-MS tuning, automated instrument quality control (QC), preparation of reusable external calibration mixtures and, addition of internal standards wherein the method provides long-term stability, inter-batch reproducibility, repeatable analyte loading of the fluid, and quantifiable low concentrations at given temperatures.

2. 发明申请

US20150318158A1 PROBE FOR EXTRACTION OF MOLECULES OF INTEREST FROM A SAMPLE 有权
标题翻译：从样品中提取分子感兴趣的探索
公开(公告)号：US20150318158A1
公开(公告)日：2015-11-05
申请号：US14738678
申请日：2015-06-12
申请人： Janusz B. PAWLISZYN , German Augusto GOMEZ RIOS
发明人： Janusz B. PAWLISZYN , German Augusto GOMEZ RIOS
IPC分类号： H01J49/10 , H01J49/00 , H01J49/26
CPC分类号： H01J49/10 , A61B10/0045 , A61B10/02 , B01J20/286 , B01J20/287 , G01N1/405 , G01N33/50 , G01N2030/009 , G01N2030/062 , G01N2560/00 , H01J49/0031 , H01J49/26 , Y10T428/2933
摘要： The present disclosure describes a device for generating ionized molecules for analysis in a mass spectrometer. The device includes: a mesh substrate coated with an extraction phase, the extraction phase comprising a polymer that absorbs a molecule of interest from a matrix, or a polymer and solid phase microextraction (SPME) particles having pores dimensioned to absorb a molecule of interest from a matrix, where the mesh substrate has a sufficiently open structure to allow fluid to flow through the mesh substrate; and a solid substrate connected to the mesh substrate to provide stability to the coated mesh substrate. Mass spectrometry systems that include such a device are also described. Methods of analyzing an analyte previously extracted from a matrix onto the device are also described.
摘要翻译：本公开描述了用于在质谱仪中产生用于分析的离子化分子的装置。所述装置包括：涂覆有萃取相的网状基材，所述萃取相包含从基质中吸收目的分子的聚合物，或具有尺寸以吸收目的分子的孔的聚合物和固相微萃取（SPME）其中网状基底具有足够开放的结构以允许流体流过网状基底; 以及连接到网状基底的固体基底，以提供对被覆网状基底的稳定性。还描述了包括这种装置的质谱系统。还描述了将先前从基质提取的分析物分析到装置上的方法。

3. 发明授权

US09733234B2 Probe for extraction of molecules of interest from a sample 有权
公开(公告)号：US09733234B2
公开(公告)日：2017-08-15
申请号：US14738688
申请日：2015-06-12
申请人： Janusz B. Pawliszyn , German Augusto Gomez Rios
发明人： Janusz B. Pawliszyn , German Augusto Gomez Rios
IPC分类号： G01N1/02 , G01N30/00 , H01J49/16 , G01N33/50 , G01N1/40 , H01J49/04 , B01J20/286 , A61B10/00 , G01N30/06 , G01N30/72
CPC分类号： G01N33/50 , A61B10/0045 , B01J20/286 , G01N1/405 , G01N30/7233 , G01N2030/009 , G01N2030/062 , G01N2560/00 , H01J49/0409 , H01J49/168 , Y10T428/2933
摘要： A device is described for generating ionized molecules for analysis in a mass spectrometer. The device includes: a solid substrate having one or more edges and a coated area that is coated with an extraction phase comprising an extraction polymer. The solid substrate may have at least two edges that meet at an angle from about 8° to about 180°. Mass spectrometry systems that include such a device are also described. Methods of analyzing a molecule previously extracted from a sample onto the device are also described.

4. 发明申请

US20150318160A1 PROBE FOR EXTRACTION OF MOLECULES OF INTEREST FROM A SAMPLE 有权
标题翻译：从样品中提取分子感兴趣的探索
公开(公告)号：US20150318160A1
公开(公告)日：2015-11-05
申请号：US14738688
申请日：2015-06-12
申请人： Janusz B. PAWLISZYN , German Augusto GOMEZ RIOS
发明人： Janusz B. PAWLISZYN , German Augusto GOMEZ RIOS
IPC分类号： H01J49/16 , H01J49/00
CPC分类号： G01N33/50 , A61B10/0045 , B01J20/286 , G01N1/405 , G01N30/7233 , G01N2030/009 , G01N2030/062 , G01N2560/00 , H01J49/0409 , H01J49/168 , Y10T428/2933
摘要： A device is described for generating ionized molecules for analysis in a mass spectrometer. The device includes: a solid substrate having one or more edges and a coated area that is coated with an extraction phase comprising an extraction polymer. The solid substrate may have at least two edges that meet at an angle from about 8° to about 180°. Mass spectrometry systems that include such a device are also described. Methods of analyzing a molecule previously extracted from a sample onto the device are also described.
摘要翻译：描述了用于在质谱仪中产生用于分析的离子化分子的装置。该装置包括：具有一个或多个边缘的固体基底和涂覆有包含提取聚合物的萃取相的涂覆区域。固体基材可以具有至少两个边缘，其以约8°至约180°的角度相遇。还描述了包括这种装置的质谱系统。还描述了将先前从样品中提取的分子分析到装置上的方法。

5. 发明授权

US10103015B2 Sampling interface for mass spectrometry systems and methods 有权
公开(公告)号：US10103015B2
公开(公告)日：2018-10-16
申请号：US15581172
申请日：2017-04-28
申请人： DH Technologies Development PTE Ltd. , German Augusto Gomez Rios , Janusz B. Pawliszyn
发明人： Don W. Arnold , Thomas R. Covey , German Augusto Gomez Rios , Chang Liu , Janusz B. Pawliszyn
IPC分类号： H01J49/00 , H01J49/04
摘要： Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which a desorption solvent utilized in a sampling interface to desorb one or more analyte species from an SPME device is fluidly coupled to an ion source for ionizing the one or more analyte species desorbed into the desorption solvent for subsequent mass spectrometric analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In accordance with various aspects of the methods and systems described herein, the configuration the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.

6. 发明申请

US20170316926A1 Sampling Interface for Mass Spectrometry Systems and Methods 审中-公开
公开(公告)号：US20170316926A1
公开(公告)日：2017-11-02
申请号：US15581172
申请日：2017-04-28
申请人： German Augusto Gomez Rios , Janusz B. Pawliszyn , DH Technologies Development PTE Ltd.
发明人： Don W. Arnold , Thomas R. Covey , German Augusto Gomez Rios , Chang Liu , Janusz B. Pawliszyn
IPC分类号： H01J49/04 , H01J49/00
CPC分类号： H01J49/0404 , G01N1/405 , H01J49/0031 , H01J49/0459
摘要： Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which a desorption solvent utilized in a sampling interface to desorb one or more analyte species from an SPME device is fluidly coupled to an ion source for ionizing the one or more analyte species desorbed into the desorption solvent for subsequent mass spectrometric analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In accordance with various aspects of the methods and systems described herein, the configuration the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.

7. 发明授权

US09625426B2 Standard analyte generator 有权
公开(公告)号：US09625426B2
公开(公告)日：2017-04-18
申请号：US14638544
申请日：2015-03-04
申请人： Janusz Boleslaw Pawliszyn , Jonathan James Grandy , German Augusto Gomez Rios
发明人： Janusz Boleslaw Pawliszyn , Jonathan James Grandy , German Augusto Gomez Rios
IPC分类号： B01J20/281 , G01N1/40 , G01N30/04 , B01D15/10 , G01N30/00 , G01N30/06 , G01N1/28
CPC分类号： G01N30/04 , B01L2300/069 , G01N1/405 , G01N30/08 , G01N30/48 , G01N2001/2893 , G01N2030/009 , G01N2030/045 , G01N2030/062 , G01N2030/488
摘要： The invention describes the process by which a standard mixture of organic compounds are spiked and retained onto a composite sorbent matrix for the controlled generation of a standard in fluid above the spiked matrix either in a gaseous or aqueous phase. The novelty of the aforementioned composite matrix stems from the combination of an immobilizing liquid phase such as silicone oil or a polyacrylonitrile solution, and solid, porous particles such as polystyrene-co-divinylbenzene (PS-DVB) or hydrophilic/Lipophilic Balance (HLB) particles to strongly retain the spiked standards. These novel composite mixtures exhibit sorptive capabilities greater than the sum of their individual components. In addition swelling of the particles with the liquid phase facilitates immobilization of the composite sorbent matrix in the vial. With thermodynamic equilibrium strongly favoring the sorbent phase for a wide range of chemical compounds, this invention allows for the reproducible generation of an ultra-low concentration standard analyte mixture in fluid.

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