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1. 发明申请

US20120315679A1 SYNTHESIS OF (6S)-5,6,7,8-TETRAHYDROFOLIC ACID 有权
标题翻译：（6S）-5,6,7,8-四氢叶酸的合成
公开(公告)号：US20120315679A1
公开(公告)日：2012-12-13
申请号：US13523431
申请日：2012-06-14
申请人： Gerald S. Jones, JR. , Joseph P. St. Laurent , Scott A. Goodrich , George Maguire
发明人： Gerald S. Jones, JR. , Joseph P. St. Laurent , Scott A. Goodrich , George Maguire
IPC分类号： C12P17/18
CPC分类号： C12P17/182 , C07D475/04
摘要： A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methlTHFA; and (4) isolating (6S)-5-methylTHFA,
摘要翻译：（6S）-5-甲基-5,6,7,8-四氢叶酸（也称为（6S）-5-甲基THFA）的大规模化学酶制备方法，该方法包括以下步骤：（1）降低叶酸（FA）以产生二氢叶酸（DHFA）; （2）在NADP / NADPH，葡萄糖和GluDH存在下，用二氢叶酸还原酶（DHFR）立体选择性还原DHFA，得到（6S）-THFA; （3）将（6S）-THFA转化为（6S）-5-甲基-THFA; 和（4）分离（6S）-5-甲基THFA，

2. 发明授权

US06503256B2 Microderm abrasion device and method 有权
公开(公告)号：US06503256B2
公开(公告)日：2003-01-07
申请号：US09805700
申请日：2001-03-13
申请人： Roger Parkin , George Maguire , Young Cho
发明人： Roger Parkin , George Maguire , Young Cho
IPC分类号： A61B1750
CPC分类号： A61B17/545 , A61B2017/320004
摘要： A micro-dermabrasion system and method in which a handpiece includes an axially aligned treatment orifice and laterally offset particle supply and waste removal channels. At least a portion of the particle supply channel is angularly offset relative to the waste removal channel so the particle stream impinges substantially on the center of the treatment orifice. The handpiece employs tapered couplers to permit easy attachment and detachment of particle supply and waste removal lines in a handpiece having a small diameter. The particle supply container is designed to be pre-filled by a supplier, and disposed of when empty without disassembly. The supply container is also constructed to permit controlled aeration of the particles before delivery to the handpiece to reduce clogging of the particle lines and to facilitate continuous adjustment of particle flow rate.

3. 发明授权

US06432113B1 Skin abrasion device 有权
标题翻译：皮肤磨损装置
公开(公告)号：US06432113B1
公开(公告)日：2002-08-13
申请号：US09255954
申请日：1999-02-23
申请人： Roger C. Parkin , George Maguire
发明人： Roger C. Parkin , George Maguire
IPC分类号： A61B1750
CPC分类号： A61M1/0047 , A61B17/545 , A61B2017/320004 , A61M1/0094
摘要： A novel handpiece and system for abrasion of skin is disclosed. A short handpiece with a threadably movable tip is used. The opening in the tip is centered on the handpiece axis and a small diameter particle input channel and diameter larger output channel are both offset from the handpiece axis. A vacuum control opening is formed in the tip for easy control by the operator. Abrasive particles and removed tissue are applied to the interior of a cylindrical filter supported within a support can. The annular area between the can and filter is connected through a secondary emergency filter to a vacuum pump. The cylindrical filter can be a flexible filter bag. A large source of abrasive particles is coupled to the handpiece inlet and the filter is coupled to the handpiece outlet.
摘要翻译：公开了一种用于皮肤磨损的新型手持件和系统。使用具有可螺纹移动的尖端的短手机。尖端中的开口以手机轴为中心，小直径的颗粒输入通道和直径较大的输出通道都与手机轴线偏移。在顶端形成真空控制开口，以便操作者方便控制。研磨颗粒和去除的组织被施加到支撑在支撑罐内的圆柱形过滤器的内部。罐和过滤器之间的环形区域通过二次应急过滤器连接到真空泵。圆柱形过滤器可以是柔性过滤袋。磨料颗粒的大量来源连接到手持件入口，并且过滤器联接到手持件出口。

4. 发明授权

US1446737A Treatment of raw rubber and the like plastic substances 失效
标题翻译：处理生橡胶等塑料物质
公开(公告)号：US1446737A
公开(公告)日：1923-02-27
申请号：US52748622
申请日：1922-01-06
申请人： FREDERICK GEORGE MAGUIRE
IPC分类号： B29B15/02
CPC分类号： B29B15/02 , Y10S528/931

5. 发明申请

US20190308138A1 Simple application of surface coating based on a formulation containing additive to remove air pollutants. 审中-公开
公开(公告)号：US20190308138A1
公开(公告)日：2019-10-10
申请号：US16373108
申请日：2019-04-02
申请人： George Maguire
发明人： George Maguire
IPC分类号： B01D53/88 , B01D53/86 , B01D53/02 , C04B41/50
摘要： Simple application of surface coating based on a formulation containing additive to remove air pollutants is disclosed. This improved surface wash, surface coating, windscreen wash, windscreen coating, is applied as a surface coating, wash or treatment to automotive vehicles, during regular periodic intervals, wherein vehicle is washed, and surface coating applied and also applied as window wash as needed. And as such method is very well distributed geographically. This invention avoids complexities involved in operation of existing methods, where heavy, expensive equipment and complex operation is prevalent. The invention is simple enough such that human error is effectively avoided.

6. 发明授权

US09090925B2 Synthesis of (6S)-5,6,7,8-tetrahydrofolic acid 有权
标题翻译：（6S）-5,6,7,8-四氢叶酸的合成
公开(公告)号：US09090925B2
公开(公告)日：2015-07-28
申请号：US13523431
申请日：2012-06-14
申请人： Gerald S. Jones, Jr. , Joseph P. St. Laurent , Scott A. Goodrich , George Maguire
发明人： Gerald S. Jones, Jr. , Joseph P. St. Laurent , Scott A. Goodrich , George Maguire
IPC分类号： C12P17/18 , C07D475/04
CPC分类号： C12P17/182 , C07D475/04
摘要： A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methlTHFA; and (4) isolating (6S)-5-methylTHFA.
摘要翻译：（6S）-5-甲基-5,6,7,8-四氢叶酸（也称为（6S）-5-甲基THFA）的大规模化学酶制备方法，该方法包括以下步骤：（1）降低叶酸（FA）以产生二氢叶酸（DHFA）; （2）在NADP / NADPH，葡萄糖和GluDH存在下，用二氢叶酸还原酶（DHFR）立体选择性还原DHFA，得到（6S）-THFA; （3）将（6S）-THFA转化为（6S）-5-甲基-THFA; 和（4）分离（6S）-5-甲基THFA。

7. 发明授权

US1447930A Preparation of preservative substances for rubber latex 失效
标题翻译：橡胶胶乳防腐剂的制备
公开(公告)号：US1447930A
公开(公告)日：1923-03-06
申请号：US52834422
申请日：1922-01-10
申请人： FREDERICK GEORGE MAGUIRE , HUGH TAYLOR COULTER
IPC分类号： C08K5/138
CPC分类号： C08K5/138 , C08L7/02

8. 发明申请

US20100151533A1 Synthesis of (6S)-5methyl-5,6,7,8-tetrahydrofolic acid 审中-公开
标题翻译：（6S）-5-甲基-5,6,7,8-四氢叶酸的合成
公开(公告)号：US20100151533A1
公开(公告)日：2010-06-17
申请号：US12592770
申请日：2009-12-02
申请人： Gerald S. Jones, JR. , Joseph P. St. Laurent , Scott A. Goodrich , George Maguire
发明人： Gerald S. Jones, JR. , Joseph P. St. Laurent , Scott A. Goodrich , George Maguire
IPC分类号： C12P17/18
CPC分类号： C12P17/182 , C07D475/04
摘要： A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methylTHFA; and (4) isolating (6S)-5-methylTHFA.
摘要翻译：（6S）-5-甲基-5,6,7,8-四氢叶酸（也称为（6S）-5-甲基THFA）的大规模化学酶制备方法，该方法包括以下步骤：（1）降低叶酸（FA）以产生二氢叶酸（DHFA）; （2）在NADP / NADPH，葡萄糖和GluDH存在下，用二氢叶酸还原酶（DHFR）立体选择性还原DHFA，得到（6S）-THFA; （3）将（6S）-THFA转化为（6S）-5-甲基THFA; 和（4）分离（6S）-5-甲基THFA。

9. 发明申请

US20070190596A1 Synthesis of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid 审中-公开
标题翻译：（6S）-5-甲基-5,6,7,8-四氢叶酸的合成
公开(公告)号：US20070190596A1
公开(公告)日：2007-08-16
申请号：US11656084
申请日：2007-01-22
申请人： Gerald Jones , Joseph Laurent , Scott Goodrich , George Maguire
发明人： Gerald Jones , Joseph Laurent , Scott Goodrich , George Maguire
IPC分类号： C12P1/00
CPC分类号： C12P17/182 , C07D475/04
摘要： A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methylTHFA; and (4) isolating (6S)-5-methylTHFA.
摘要翻译：（6S）-5-甲基-5,6,7,8-四氢叶酸（也称为（6S）-5-甲基THFA）的大规模化学酶制备方法，该方法包括以下步骤：（1）降低叶酸（FA）以产生二氢叶酸（DHFA）; （2）在NADP / NADPH，葡萄糖和GluDH存在下，用二氢叶酸还原酶（DHFR）立体选择性还原DHFA，得到（6S）-THFA; （3）将（6S）-THFA转化为（6S）-5-甲基THFA; 和（4）分离（6S）-5-甲基THFA。

10. 发明授权

US06235039B1 Skin abrasion device 有权
标题翻译：皮肤磨损装置
公开(公告)号：US06235039B1
公开(公告)日：2001-05-22
申请号：US09496394
申请日：2000-02-02
申请人： Roger C. Parkin , George Maguire
发明人： Roger C. Parkin , George Maguire
IPC分类号： A61B1750
CPC分类号： A61B17/545 , A61B2017/320004 , A61M1/0047
摘要： A novel handpiece and system for abrasion of skin is disclosed. A short handpiece with a threadably removable tip is used. The opening in the tip is centered on the handpiece axis and a small diameter particle inlet channel and larger diameter outlet channel are both offset from the handpiece axis. A central blade or barrier within the tip divides the tip into two volumes which each communicate with the opening and respective ones of the inlet and outlet passages. A vacuum control opening is formed in the tip for easy control by the operator. Abrasive particles and removed tissue are applied to the interior of a cylindrical filter supported within a supporting container. The annular area between the container and this filter is connected through a secondary emergency filter to a vacuum pump. The cylindrical filter can be a flexible filter bag. A large source of abrasive particles is coupled to the handpiece inlet and the filter is coupled to the handpiece outlet.
摘要翻译：公开了一种用于皮肤磨损的新型手持件和系统。使用具有可螺纹移除的尖端的短手机。尖端中的开口位于手机轴线上，小直径颗粒入口通道和较大直径的出口通道都与手机轴线偏移。尖端内部的中心叶片或障碍物将尖端分成两个体积，每个体积与开口和相应的入口通道和出口通道连通。在顶端形成真空控制开口，以便操作者方便控制。研磨颗粒和去除的组织被施加到支撑在支撑容器内的圆柱形过滤器的内部。容器和该过滤器之间的环形区域通过二次应急过滤器连接到真空泵。圆柱形过滤器可以是柔性过滤袋。磨料颗粒的大量来源连接到手持件入口，并且过滤器联接到手持件出口。

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