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1. 发明授权

US08712549B2 Method and system for monitoring and treating hemodynamic parameters 有权
标题翻译：监测和治疗血液动力学参数的方法和系统
公开(公告)号：US08712549B2
公开(公告)日：2014-04-29
申请号：US10734490
申请日：2003-12-11
申请人： Mark Zdeblick , George M. Savage
发明人： Mark Zdeblick , George M. Savage
IPC分类号： A61N1/00
CPC分类号： A61B5/036 , A61B5/0422 , A61B18/1492 , A61B18/22 , A61B2562/02 , A61N1/0529 , A61N1/0551 , A61N1/0553 , A61N1/056
摘要： A multiplexed medical carrier provides for sensing one or more patient parameters and/or delivering energy via separately identifiable effectors. The carrier includes a body and at least two electrical conductors coupled with at least two effectors. Effectors may be any combination of sensors, actuators or both. Sensors may measure such parameters as pressure, oxygen content, volume, conductivity, fluid flow rate, or any other chemical or physical parameters. Actuators may be used, for example, to pace a heart, stimulate muscle or neural tissue, broadcast ultrasonic energy, emit light, heat or other forms of radiation, or deliver any form of energy or substance. A method for collecting medical data from a patient includes interrogating a network of multiplexed sensors residing on parallel conductors in the patient, including addressing a first addressable sensor in the network to obtain data and addressing a second addressable sensor in the network to obtain data.
摘要翻译：复用的医疗载体提供用于感测一个或多个患者参数和/或通过单独识别的效应器递送能量。载体包括主体和与至少两个效应器耦合的至少两个电导体。效应器可以是传感器，致动器或两者的任何组合。传感器可以测量诸如压力，氧含量，体积，电导率，流体流速或任何其它化学或物理参数的参数。例如，可以使用致动器来调节心脏，刺激肌肉或神经组织，广播超声能量，发射光，热或其他形式的辐射，或递送任何形式的能量或物质。一种用于从患者收集医学数据的方法包括询问驻留在患者的并行导体上的复用传感器的网络，包括寻址网络中的第一可寻址传感器以获得数据并寻址网络中的第二可寻址传感器以获得数据。

2. 发明授权

US07925329B2 Implantable doppler tomography system 有权
标题翻译：可植入多普勒层析成像系统
公开(公告)号：US07925329B2
公开(公告)日：2011-04-12
申请号：US11249152
申请日：2005-10-11
申请人： Mark Zdeblick , George M. Savage
发明人： Mark Zdeblick , George M. Savage
IPC分类号： A61B5/05
CPC分类号： A61N1/36528 , A61B5/05 , A61B5/1107
摘要： The inventive implantable Doppler tomography system allows, for the first time, the use of Doppler shift for purposes of tracking cardiac wall motion. The present inventive Doppler tomography system methods and devices provide a critical new tool in the physician's armamentarium which provides accurate, real time monitoring of the mechanical performance of the heart.
摘要翻译：本发明的可植入多普勒层析成像系统首次允许使用多普勒频移来跟踪心脏壁运动。本发明的多普勒层析成像系统方法和装置在医师装置中提供关键的新工具，其提供对心脏的机械性能的准确的实时监测。

3. 发明申请

US20080255647A1 Implantable Addressable Segmented Electrodes 审中-公开
标题翻译：可植入可寻址分段电极
公开(公告)号：US20080255647A1
公开(公告)日：2008-10-16
申请号：US11793904
申请日：2005-12-22
申请人： Marc Jensen , Benedict J. Costello , Todd Thompson , Mark Zdeblick , Jeremy Frank , Dino Lei , Olivier Colliou , George M. Savage
发明人： Marc Jensen , Benedict J. Costello , Todd Thompson , Mark Zdeblick , Jeremy Frank , Dino Lei , Olivier Colliou , George M. Savage
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/375
摘要： Implantable addressable segmented electrode devices, as well as methods for making and using the same, are provided. The subject devices include segmented electrode structures made up of an integrated circuit electrically coupled to two or more electrodes, where each electrode can be individually activated. Also provided are implantable devices and systems, as well as kits containing such devices and systems or components thereof, which include the segmented electrode structures.
摘要翻译：提供了可植入可寻址的分段电极装置，以及制造和使用它们的方法。主题装置包括由电耦合到两个或更多个电极的集成电路构成的分段电极结构，其中每个电极可以被单独激活。还提供了可植入装置和系统，以及包含这种装置和系统或其组件的试剂盒，其包括分段的电极结构。

4. 发明申请

US20080242976A1 Electric field tomography 审中-公开
标题翻译：电场断层扫描
公开(公告)号：US20080242976A1
公开(公告)日：2008-10-02
申请号：US11664468
申请日：2007-03-30
申请人： Timothy L. Robertson , Olivier Colliou , Benedict J. Costello , George M. Savage , Todd Thompson , Mark J. Zdeblick
发明人： Timothy L. Robertson , Olivier Colliou , Benedict J. Costello , George M. Savage , Todd Thompson , Mark J. Zdeblick
IPC分类号： A61B5/04
CPC分类号： A61B5/1107 , A61B5/686 , A61B2562/046 , A61N1/056 , A61N1/3627 , A61N1/36514 , A61N1/36578 , A61N1/368 , A61N1/3684 , A61N1/375 , A61N1/3752 , A61N1/3756 , A61N2001/0585
摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via continuous field tomography are provided. In the subject methods, a continuous field (e.g., an electrical, mechanical, electromechanical, or other field) sensing element is stably associated with the tissue location. A property of the applied continuous field is detected with the sensing element to evaluate movement of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译：提供了通过连续场断层摄影评估诸如心脏位置（例如心脏壁）的组织运动的方法。在主题方法中，连续场（例如，电，机械，机电或其他场）感测元件与组织位置稳定地相关联。使用感测元件检测所施加的连续场的属性，以评估组织位置的运动。还提供了用于实践主题方法的系统，装置和相关组合物。主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

5. 发明申请

US20080208068A1 DYNAMIC POSITIONAL INFORMATION CONSTRAINED HEART MODEL 审中-公开
标题翻译：动态位置信息约束心脏模型
公开(公告)号：US20080208068A1
公开(公告)日：2008-08-28
申请号：US12037851
申请日：2008-02-26
申请人： Timothy Robertson , George M. Savage
发明人： Timothy Robertson , George M. Savage
IPC分类号： A61B5/00 , G06G7/48
CPC分类号： G16H50/50
摘要： Methods and systems for producing a computational model of the heart which is patient-specific are provided. Embodiments of the methods and systems include providing a computational model of a heart, obtaining dynamic positional information data from a patient and modifying the heart model with the dynamic positional information data to produce a patient-specific heart model. The invention finds use in a variety of different applications, including but not limited to diagnosis and treatment of heart conditions.
摘要翻译：提供了用于产生患者特异性的心脏计算模型的方法和系统。方法和系统的实施例包括提供心脏的计算模型，从患者获得动态位置信息数据，并用动态位置信息数据修改心脏模型以产生患者特异性心脏模型。本发明用于各种不同的应用，包括但不限于心脏病症的诊断和治疗。

6. 发明授权

US06306129B1 Cryosurgical system and method 有权
标题翻译：冷冻系统及方法
公开(公告)号：US06306129B1
公开(公告)日：2001-10-23
申请号：US09377377
申请日：1999-08-19
申请人： William A. Little , Igor Sapozhnikov , Todd Thompson , George M. Savage
发明人： William A. Little , Igor Sapozhnikov , Todd Thompson , George M. Savage
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2018/00041 , F25B9/006 , F25B40/00 , F25B47/022 , Y10S128/27
摘要： A cryosurgical system comprises a compressor unit and a probe assembly. A secondary refrigerant stream from the compressor unit pre-cools a heat exchanger within the probe assembly in a standby mode of operation. After the heat exchange is pre-cooled, a primary refrigerant stream can be passed through the cooled heat exchanger and thereafter expanded within a tissue-contacting portion of the probe assembly to achieve very low temperatures, typically minus 100° C. or lower. After cooling, the refrigerant stream may be passed through the probe assembly with no or partial expansion to warm the tissue-contacting surface of the probe. A probe sheath can be used to provide sterility.
摘要翻译：冷冻手术系统包括压缩机单元和探针组件。来自压缩机单元的二次制冷剂流在待机操作模式下预热冷却探针组件内的热交换器。在热交换预冷却之后，初级制冷剂流可以通过冷却的热交换器，然后在探针组件的组织接触部分内膨胀，以达到通常为零下100摄氏度以下的非常低的温度。在冷却之后，制冷剂流可以通过探针组件而没有或部分膨胀以加热探针的组织接触表面。探针护套可用于提供无菌性。

7. 发明授权

US5979453A Needle myolysis system for uterine fibriods 失效
标题翻译：针灸解剖系统子宫肌瘤
公开(公告)号：US5979453A
公开(公告)日：1999-11-09
申请号：US744610
申请日：1996-11-06
申请人： George M. Savage , Margaret Webber
发明人： George M. Savage , Margaret Webber
IPC分类号： A61B17/00 , A61B18/00 , A61B18/14 , A61M1/00 , A61N1/40 , A61B17/39
CPC分类号： A61B18/1477 , A61N1/403 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B2017/00084 , A61B2017/00106 , A61B2018/00196 , A61B2018/1253 , A61B2090/3782
摘要： The present invention provides electrosurgical needles, needle systems, and methods for their use which will allow the surgeon to target a tumor's blood supply. Generally, the invention facilities targeting the bloodflow of the tumor by incorporating a doppler ultrasound transducer into the needle or needle sheath. Preferably, the surgeon will also be able to control the temperature of the needle using an integral temperature sensor to effect maximum transfer of the RF energy into the tissue, thereby maximizing the volume of tissue destroyed. Furthermore, when used (for example) in the treatment of uterine fibroids, the present invention will reduce damage to the serosa by monitoring the uterine surface temperature during myolysis through a temperature sensor integrated into the sheath holding the myolysis needle.
摘要翻译：本发明提供电外科手术针，针系统及其使用方法，其将允许外科医生靶向肿瘤的血液供应。通常，本发明的设备通过将多普勒超声换能器并入针或针鞘中来靶向肿瘤的血流。优选地，外科医生还将能够使用一体式温度传感器来控制针的温度，以实现RF能量到组织中的最大转移，从而最大化破坏的组织的体积。此外，当使用（例如）用于治疗子宫肌瘤时，本发明通过通过集成到保持解肌细胞的鞘中的温度传感器来监测解肌肉中的子宫表面温度来减少对浆膜的损伤。

8. 发明授权

US08036743B2 Automated optimization of multi-electrode pacing for cardiac resynchronization 有权
标题翻译：自动优化用于心脏再同步的多电极起搏
公开(公告)号：US08036743B2
公开(公告)日：2011-10-11
申请号：US11909786
申请日：2006-03-31
申请人： George M. Savage , Todd Thompson , Mark J. Zdeblick , Lawrence W. Arne , Olivier Colliou , Benedict James Costello , Fataneh A. Omidvar
发明人： George M. Savage , Todd Thompson , Mark J. Zdeblick , Lawrence W. Arne , Olivier Colliou , Benedict James Costello , Fataneh A. Omidvar
IPC分类号： A61N1/39
CPC分类号： A61N1/3627 , A61N1/08 , A61N1/36185 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/3686 , A61N1/37247
摘要： One embodiment of the present invention provides a system for automatically optimizing CRT procedures using a multi-electrode pacing lead. During operation, the system performs a first set of iterations to select one or more satellites on one or more pacing leads inserted in a patient. A pacing lead includes a plurality of pacing satellites, and a pacing satellite includes a plurality of electrodes that can be individually addressed and used for transmitting or detecting electric signals. The system then performs a second set of iterations to select one or more electrodes on the selected satellites. The system further performs a third set of iterations to select one or more timing configurations for pacing signals transmitted through one or more of the selected electrodes.
摘要翻译：本发明的一个实施例提供一种用于使用多电极起搏引线自动优化CRT程序的系统。在操作期间，系统执行第一组迭代以在插入患者体内的一个或多个起搏引线上选择一个或多个卫星。起搏引线包括多个起搏卫星，并且起搏卫星包括多个电极，其可单独寻址并用于发送或检测电信号。然后，系统执行第二组迭代以选择所选卫星上的一个或多个电极。该系统进一步执行第三组迭代以选择一个或多个定时配置，用于通过一个或多个所选择的电极传输的起搏信号。

9. 发明授权

US4922423A Position and seal wear indicator for valves and blowout preventers 失效
标题翻译：阀门和防喷器的位置和密封磨损指示器
公开(公告)号：US4922423A
公开(公告)日：1990-05-01
申请号：US130938
申请日：1987-12-10
申请人： Paul C. Koomey , George M. Savage , James T. Stewart
发明人： Paul C. Koomey , George M. Savage , James T. Stewart
IPC分类号： E21B33/06 , E21B33/064 , E21B34/16 , E21B44/00 , G01S15/88
CPC分类号： E21B33/064 , E21B33/063 , E21B34/16 , E21B44/00 , G01S15/88
摘要： A position and seal or packing wear indicator for mechanical flow controlling devices such as valves and blowout preventers. For blowout preventers the system includes ultrasonic sensors for each ram and annular blowout preventer of a blowout preventer stack. Each of the ultrasonic sensors is positioned within the wall structure of the valve or blowout preventer and is recessed with respect to the inner wall surface such that a desired echo thereof occurs at the plane of the inner wall surface, thereby rendering the electronic signal processing system capable of accurately and positively sensing the precise positions of the flow controlling devices at all times. Electrical signals from the ultrasonic sensors are converted by an electronic signal conditioner to a usable interface format for transmission through a multi-conductor cable system to a remotely located computer. The computer includes software which generates on its CRT a graphical display of the respective positions of the flow controlling devices. The position detection capability provided by precision spacing of the ultrasonic sensors from the inner wall surface develops sufficient position indicating accuracy that detection of seal or packing wear can be identified. The computer also includes a printer for printing out data such as position indicating data or the graphical display of the CRT and also includes a data port for transmission of data to remote locations via microwave.
摘要翻译：用于机械流量控制装置（如阀门和防喷器）的位置和密封或包装磨损指示器。对于防喷器，该系统包括用于防喷器堆叠的每个压头和环形防喷器的超声波传感器。每个超声波传感器位于阀或防喷器的壁结构内，并且相对于内壁表面凹陷，使得其在内壁表面的平面处出现期望的回波，从而使电子信号处理系统能够始终精确地和肯定地感测流量控制装置的精确位置。来自超声波传感器的电信号通过电子信号调节器转换成可用的接口格式，以通过多导体电缆系统传输到位于远程的计算机。计算机包括在其CRT上产生流控制装置的相应位置的图形显示的软件。通过超声波传感器与内壁表面的精密间隔提供的位置检测能力发展出足够的位置，指示可以识别密封件或包装磨损的检测的精度。计算机还包括用于打印诸如位置指示数据或CRT的图形显示的数据的打印机，并且还包括用于经由微波将数据传输到远程位置的数据端口。

10. 发明申请

US20090076338A1 PATIENT CUSTOMIZED THERAPEUTIC REGIMENS 有权
标题翻译：患者自定义治疗方案
公开(公告)号：US20090076338A1
公开(公告)日：2009-03-19
申请号：US12299303
申请日：2007-05-02
申请人： Mark J. Zdeblick , Andrew Thompson , George M. Savage
发明人： Mark J. Zdeblick , Andrew Thompson , George M. Savage
IPC分类号： G06Q50/00 , A61B5/00
CPC分类号： G06F19/3456 , A61B5/0002 , A61B5/0028 , A61B5/073 , A61B5/4833 , A61B5/4848 , G06F19/00 , G06F19/34 , G06F19/3418 , G06F19/345 , G06F19/3475 , G06Q10/00 , G06Q50/22 , G16H50/20 , H01M8/02 , H01M2220/10 , H04B13/005 , Y10S128/903 , Y10S128/92
摘要： Methods, systems and compositions that allow for treating a patient according to a patient customized therapeutic regimen are provided. Embodiments of the invention include obtaining dosage administration information from a patient and using the same to tailor a therapeutic regimen for the patient. Embodiments of the invention further include preparing and forwarding to the patient physical pharmaceutical dosages based on the customized therapeutic regimen.
摘要翻译：提供了允许根据患者定制的治疗方案治疗患者的方法，系统和组合物。本发明的实施方案包括从患者获得剂量给药信息并使用它来定制患者的治疗方案。本发明的实施方案还包括基于定制的治疗方案制备并转发患者物理药物剂量。

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