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    • 3. 发明申请
    • Pyrrolopyrimidine Derivatives
    • 吡咯并嘧啶衍生物
    • US20070270588A1
    • 2007-11-22
    • US10591765
    • 2005-03-04
    • Francois BischoffLudo KennisMirielle BraekenGaston DielsAtsuro Nakazato
    • Francois BischoffLudo KennisMirielle BraekenGaston DielsAtsuro Nakazato
    • C07D487/04
    • C07D487/04
    • According to the present invention, there is provided an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastro-intestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. A pyrrolopyrimidine derivative represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.
    • 根据本发明,提供了一种抗CRF受体的拮抗剂,其作为治疗或预防药物是有效的,其涉及CRF被认为涉及的疾病,例如抑郁症,焦虑症,阿尔茨海默氏病,帕金森病,亨廷顿氏舞蹈病,进食 疾病,高血压,胃肠疾病,药物依赖,脑梗塞,脑缺血,脑水肿,头部外伤,炎症,免疫相关疾病,特异性,肠易激综合征,睡眠障碍,癫痫,皮肤病,精神分裂症,疼痛等 由下式[I]表示的吡咯并嘧啶衍生物对CRF受体具有高亲和力,并且对于涉及CRF的疾病有效。