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1. 发明申请

US20160256149A1 DEVICES AND METHODS OF VISUALIZING AND DETERMINING DEPTH OF PENETRATION IN CARDIAC TISSUE 审中-公开
标题翻译：可视化和确定心脏组织渗透深度的装置和方法
公开(公告)号：US20160256149A1
公开(公告)日：2016-09-08
申请号：US15061748
申请日：2016-03-04
申请人： Guided Delivery Systems Inc.
发明人： Russel SAMPSON , Charles ADAM , Son NGUYEN , David Scott BARON
IPC分类号： A61B17/04 , A61B90/00
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0493 , A61B90/06 , A61B2017/00247 , A61B2017/00336 , A61B2017/0409 , A61B2017/0441 , A61B2017/0464 , A61B2090/062 , A61B2090/0811 , A61B2090/3966
摘要： Disclosed herein are devices and methods for assessing the surface of a target cardiac tissue and for delivering a tissue anchor to cardiac tissue at a preselected depth within the myocardium in a beating heart procedure. In one variation, an anchor delivery device comprises an elongate body, a tissue anchor disposed within a first longitudinal lumen of the elongate body, and a tissue depth indicator slidable within a second longitudinal lumen of the elongate body. The tissue depth indicator has a first configuration that indicates the boundary of the surface of the target tissue and a second configuration that indicates when the distal tip of the elongate body has been advanced to a preselected depth into the target tissue. In some variations, a tissue depth indicator may also be configured to resist or limit the penetration of the delivery device into tissue after a preselected depth has been reached.
摘要翻译：本文公开了用于评估目标心脏组织的表面并且用于在搏动心脏程序中以心肌内的预选深度将组织锚定件递送至心脏组织的装置和方法。在一个变型中，锚定器传送装置包括细长主体，设置在细长主体的第一纵向内腔内的组织锚，以及可在细长主体的第二纵向内腔内滑动的组织深度指示器。组织深度指示器具有指示目标组织的表面的边界的第一构造和指示细长体的远侧末端何时已经前进到目标组织中的预选深度的第二构造。在一些变型中，组织深度指示器还可以被配置为在已经达到预选深度之后抵抗或限制输送装置进入组织的穿透。

2. 发明申请

US20140303649A1 MULTI-WINDOW GUIDE TUNNEL 有权
标题翻译：多窗口导轨
公开(公告)号：US20140303649A1
公开(公告)日：2014-10-09
申请号：US14309837
申请日：2014-06-19
申请人： GUIDED DELIVERY SYSTEMS INC.
发明人： Huu NGUYEN , Son NGUYEN , Eugene SERINA , Tammy Y. TAM
IPC分类号： A61F2/24 , A61B17/10
CPC分类号： A61B17/10 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/068 , A61B17/0682 , A61B17/0684 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0464 , A61F2/2445 , A61F2/2451
摘要： Described herein are devices and methods for delivering implants that comprise multiple coupled anchors. The anchors are secured to tissue using a multi-opening guide tunnel that is configured to releasably retain one or more portions of the implant located between two of the anchors. The releasable retention of one or more intervening portions of the implant maintains the position of the implant and the guide tunnel until the implant is secured to the tissue. The multi-opening guide tunnel permits securement of the multiple anchors without requiring repositioning of the guide tunnel for each anchor.
摘要翻译：这里描述了用于递送包括多个连接的锚的植入物的装置和方法。使用构造成可释放地保持位于两个锚定件之间的植入物的一个或多个部分的多开口引导隧道将锚固定到组织。植入物的一个或多个中间部分的可释放保留维持植入物和引导通道的位置，直到植入物固定到组织。多开口引导通道允许固定多个锚，而不需要为每个锚重新定位引导隧道。

3. 发明申请

US20150164639A1 DELIVERY DEVICES AND METHODS FOR HEART VALVE REPAIR 有权
标题翻译：输送装置和心脏瓣膜修复方法
公开(公告)号：US20150164639A1
公开(公告)日：2015-06-18
申请号：US14626826
申请日：2015-02-19
申请人： Guided Delivery Systems Inc.
发明人： Niel F. STARKSEN , John TO , Mariel FABRO , Michael F. WEI , Rodolfo A. MORALES
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61B2017/0496 , A61B2017/2905 , A61F2/2427 , A61F2/2442 , A61F2/2445 , A61F2/2454 , A61F2/2466
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.
摘要翻译：装置，系统和方法便于心脏瓣膜环空处理装置的定位，从而增强环空处理。方法通常包括将锚定器输送装置通过患者的脉管系统推进到心脏中的一个位置处理瓣膜环，使锚定器输送装置与一段长度的瓣膜环接触，将多个耦合的锚固件从锚定器输送装置输送到将锚固件固定到环形空间，并将锚固件拉紧在一起以周向地紧固阀环。装置通常包括具有至少一个张紧构件和至少一个张紧致动器的细长导管，用于使导管的远端部分变形以帮助其符合瓣膜环。导管装置可用于导航二尖瓣下方的子宫下空间，以便锚定器输送装置的定位。

4. 发明申请

US20140142619A1 ANCHOR DEPLOYMENT DEVICES AND RELATED METHODS 有权
标题翻译：锚固部署装置及相关方法
公开(公告)号：US20140142619A1
公开(公告)日：2014-05-22
申请号：US14052593
申请日：2013-10-11
申请人： GUIDED DELIVERY SYSTEMS INC.
发明人： Eugene SERINA , Stephen C. MEIER , Shih-Hsiung Albert YUAN , Mariel FABRO
IPC分类号： A61B17/00
CPC分类号： A61M25/0043 , A61B1/00078 , A61B1/3137 , A61B6/12 , A61B6/481 , A61B6/485 , A61B8/12 , A61B17/00234 , A61B17/0057 , A61B17/320016 , A61B17/7208 , A61B2017/00243 , A61M25/0041 , A61M25/04 , A61M2210/127
摘要： Described here are devices, methods, and kits for the deployment of tissue anchors. In some variations, the devices may comprise a shaft defining a lumen for housing at least one anchor therein and a mechanism for deploying the anchor distally from the lumen. In certain variations, the devices may comprise one or more stop elements. For example, a device may comprise a stop element that limits the advancement of the device through an opening in a wall portion or at the distal end of another device.
摘要翻译：这里描述了用于部署组织锚的装置，方法和试剂盒。在一些变型中，装置可以包括限定用于容纳至少一个锚固件的内腔的轴以及用于将锚固件从内腔远端展开的机构。在某些变型中，装置可以包括一个或多个停止元件。例如，装置可以包括限制装置通过壁部分中的开口或另一装置的远端的开口的止挡元件。

5. 发明申请

US20030233142A1 Devices and methods for heart valve repair 有权
标题翻译：心脏瓣膜修复的装置和方法
公开(公告)号：US20030233142A1
公开(公告)日：2003-12-18
申请号：US10461043
申请日：2003-06-13
申请人： GUIDED DELIVERY SYSTEMS, INC.
发明人： Rodolfo A. Morales , Niel F. Starksen
IPC分类号： A61F002/24
CPC分类号： A61B17/0487 , A61B1/00082 , A61B1/00096 , A61B1/04 , A61B8/12 , A61B17/00234 , A61B17/0401 , A61B17/0644 , A61B17/0684 , A61B17/083 , A61B17/10 , A61B17/1285 , A61B17/3421 , A61B17/3423 , A61B2017/00243 , A61B2017/0488 , A61B2017/0496 , A61B2017/06023 , A61B2017/3425 , A61B2017/3484 , A61B2017/3488 , A61F2/2445 , A61F2/2451
摘要： Methods and devices provide constriction of a heart valve annulus to treat cardiac valve regurgitation and other conditions. Embodiments typically include a device for attaching a cinching or tightening apparatus to a heart valve annulus to reduce the circumference of the annulus, thus reducing valve regurgitation. Tightening devices may include multiple tethered clips, multiple untethered crimping clips, stabilizing devices, visualization devices, and the like. In one embodiment, a plurality of tethered clips is secured circumferentially to a valve annulus, and the tether coupling the clips is cinched to reduce the circumference of at least a portion of the annulus. Methods and devices may be used in open heart surgical procedures, minimally invasive procedures, catheter-based procedures, and/or procedures on beating hearts or stopped hearts.
摘要翻译：方法和装置提供心脏瓣膜环的收缩以治疗心脏瓣膜反流和其他状况。实施例通常包括用于将收紧或紧固装置附接到心脏瓣膜环的装置以减小环的周长，从而减少瓣膜反流。紧固装置可以包括多个系绳夹，多个未卷绕的压接夹，稳定装置，可视化装置等。在一个实施例中，多个系留夹紧件被周向地固定到阀环上，并且联接夹子的系链被收紧以减小环空的至少一部分的圆周。方法和装置可用于开放心脏手术程序，微创手术，基于导管的手术和/或跳动心脏或停止的心脏的程序。

6. 发明申请

US20170224489A1 DEVICES AND METHODS FOR HEART VALVE REPAIR 审中-公开
公开(公告)号：US20170224489A1
公开(公告)日：2017-08-10
申请号：US15265781
申请日：2016-09-14
申请人： Guided Delivery Systems, Inc.
发明人： Niel F. STARKSEN , John TO
IPC分类号： A61F2/24 , A61B8/12 , A61B8/08 , A61B17/00 , A61B6/00
CPC分类号： A61F2/2466 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61F2/2445
摘要： Devices and methods provide enhanced treatment of a cardiac valve annulus. Methods generally involve contacting an anchor delivery device with the valve annulus and releasing a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus. Anchors, which in some embodiments are super-elastic or shape memory self-securing anchors, are then drawn together to tighten the annulus. Devices generally include an elongate catheter having a housing at or near the distal end for releasably housing a plurality of coupled anchors. The housing may be flexible, may conform to a valve annulus, and in some embodiments may be coupled with an expandable member to enhance contact of the housing with annular tissue. In one embodiment, self-securing anchors lie approximately flat within the delivery device housing, allowing anchors with relatively large deployed shapes to be housed in and deployed from a relatively narrow delivery device.

7. 发明申请

US20160220785A1 DIAGNOSTIC CATHETERS, GUIDE CATHETERS, VISUALIZATION DEVICES AND CHORD MANIPULATION DEVICES, AND RELATED KITS AND METHODS 审中-公开
公开(公告)号：US20160220785A1
公开(公告)日：2016-08-04
申请号：US14868290
申请日：2015-09-28
申请人： Guided Delivery Systems Inc.
发明人： Mariel FABRO
IPC分类号： A61M25/00 , A61B8/12 , A61B6/00 , A61B17/00 , A61B6/12
CPC分类号： A61M25/0043 , A61B1/00078 , A61B1/3137 , A61B6/12 , A61B6/481 , A61B6/485 , A61B8/12 , A61B17/00234 , A61B17/0057 , A61B17/320016 , A61B17/7208 , A61B2017/00243 , A61M25/0041 , A61M25/04 , A61M2210/127
摘要： Described herein are devices, methods and kits for assessing and/or enhancing the accessibility of a subvalvular space of a heart, accessing the subvalvular space of the heart (e.g., to provide access for one or more other devices), and/or positioning one or more devices in the subvalvular space of the heart. The devices described herein may, for example, comprise catheters that may be used to manipulate one or more chordae tendineae, diagnostic catheters having different sizes and/or shapes (e.g., different curvatures), guide catheters having different sizes and/or shapes (e.g., different curvatures), and visualization catheters. In some variations, the devices, methods, and/or kits may be used to visualize a target site, such as a subannular groove of a heart valve. In certain variations, the devices, methods, and/or kits may be used to manipulate chordae tendineae to provide additional space in a ventricle of a heart (e.g., enhancing the accessibility of the ventricle).

8. 发明申请

US20150182216A1 DEVICES AND METHODS FOR HEART VALVE REPAIR 有权
标题翻译：用于心脏瓣膜修复的装置和方法
公开(公告)号：US20150182216A1
公开(公告)日：2015-07-02
申请号：US14589855
申请日：2015-01-05
申请人： Guided Delivery Systems Inc.
发明人： Rodolfo A. MORALES , Niel F. STARKSEN
IPC分类号： A61B17/04 , A61B8/12 , A61B1/04 , A61B17/00 , A61F2/24
CPC分类号： A61B17/0487 , A61B1/00082 , A61B1/00096 , A61B1/04 , A61B8/12 , A61B17/00234 , A61B17/0401 , A61B17/0644 , A61B17/0684 , A61B17/083 , A61B17/10 , A61B17/1285 , A61B17/3421 , A61B17/3423 , A61B2017/00243 , A61B2017/0488 , A61B2017/0496 , A61B2017/06023 , A61B2017/3425 , A61B2017/3484 , A61B2017/3488 , A61F2/2445 , A61F2/2451
摘要： Methods and devices provide constriction of a heart valve annulus to treat cardiac valve regurgitation and other conditions. Embodiments typically include a device for attaching a cinching or tightening apparatus to a heart valve annulus to reduce the circumference of the annulus, thus reducing valve regurgitation. Tightening devices may include multiple tethered clips, multiple untethered crimping clips, stabilizing devices, visualization devices, and the like. In one embodiment, a plurality of tethered clips is secured circumferentially to a valve annulus, and the tether coupling the clips is cinched to reduce the circumference of at least a portion of the annulus. Methods and devices may be used in open heart surgical procedures, minimally invasive procedures, catheter-based procedures, and/or procedures on beating hearts or stopped hearts.
摘要翻译：方法和装置提供心脏瓣膜环的收缩以治疗心脏瓣膜反流和其他状况。实施例通常包括用于将收紧或紧固装置附接到心脏瓣膜环的装置以减小环的周长，从而减少瓣膜反流。紧固装置可以包括多个系绳夹，多个未卷绕的压接夹，稳定装置，可视化装置等。在一个实施例中，多个系留夹紧件被周向地固定到阀环上，并且联接夹子的系链被收紧以减小环空的至少一部分的圆周。方法和装置可用于开放心脏手术程序，微创手术，基于导管的手术和/或跳动心脏或停止的心脏的程序。

9. 发明申请

US20140194976A1 DEVICES AND METHODS FOR HEART VALVE REPAIR 有权
标题翻译：用于心脏瓣膜修复的装置和方法
公开(公告)号：US20140194976A1
公开(公告)日：2014-07-10
申请号：US14156347
申请日：2014-01-15
申请人： Guided Delivery Systems Inc.
发明人： Niel F. STARKSEN , John TO
IPC分类号： A61F2/24
CPC分类号： A61F2/2466 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61F2/2445
摘要： Devices and methods provide enhanced treatment of a cardiac valve annulus. Methods generally involve contacting an anchor delivery device with the valve annulus and releasing a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus. Anchors, which in some embodiments are super-elastic or shape memory self-securing anchors, are then drawn together to tighten the annulus. Devices generally include an elongate catheter having a housing at or near the distal end for releasably housing a plurality of coupled anchors. The housing may be flexible, may conform to a valve annulus, and in some embodiments may be coupled with an expandable member to enhance contact of the housing with annular tissue. In one embodiment, self-securing anchors lie approximately flat within the delivery device housing, allowing anchors with relatively large deployed shapes to be housed in and deployed from a relatively narrow delivery device.
摘要翻译：装置和方法提供对心脏瓣膜环的增强的治疗。方法通常包括使锚定器输送装置与阀环接触，并从锚定器输送装置释放多个联接的锚固件，以将锚固件固定到环形空间。然而，在一些实施例中，将超弹性或形状记忆自固定锚固件锚固在一起以紧固环。装置通常包括细长导管，其具有在远端处或附近的壳体，用于可释放地容纳多个联接的锚定件。壳体可以是柔性的，可以符合阀环，并且在一些实施例中可以与可扩张构件联接，以增强壳体与环形组织的接触。在一个实施例中，自固定锚定件大致平坦地位于输送装置壳体内，允许具有相对大的展开形状的锚定装置容纳在相对窄的输送装置中并从相对狭窄的输送装置展开。

10. 发明申请

US20140188140A1 TERMINATION DEVICES AND RELATED METHODS 有权
标题翻译：终止设备及相关方法
公开(公告)号：US20140188140A1
公开(公告)日：2014-07-03
申请号：US14033369
申请日：2013-09-20
申请人： GUIDED DELIVERY SYSTEMS INC.
发明人： Stephen C. MEIER , Eugene SERINA , Charles J. ADAM , Mariel FABRO , Tammy Y. TAM , John P. LUNSFORD , Tenny C. CALHOUN , Brian TANG , Stephen OLSON
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0485 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B17/10 , A61B2017/00243 , A61B2017/00783 , A61B2017/045 , A61B2017/0451 , A61B2017/0488 , A61B2017/0496 , A61B2017/320052
摘要： Devices and methods for locking and/or cutting tethers during a tissue modification procedure are described. In some variations, a tether may be used to tighten tissue by bringing two pieces or sections of the tissue together. The tether, which may be under tension, may be locked to maintain the tension, and excess tether may be severed, using one or more of the devices and/or methods. The devices and/or methods may be used, for example, in minimally invasive procedures.
摘要翻译：描述了在组织修改过程中锁定和/或切割系绳的装置和方法。在一些变型中，系绳可以用于通过将组织的两个或多个部分组合在一起来收紧组织。可能处于张力下的系绳可以被锁定以保持张力，并且可以使用一种或多种装置和/或方法来切断多余的系绳。装置和/或方法可以用于例如微创程序。

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