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1. 发明授权

US5281519A Simple, rapid and reliable method for detecting thalassemia 失效
标题翻译：用于检测地中海贫血的简单，快速和可靠的方法
公开(公告)号：US5281519A
公开(公告)日：1994-01-25
申请号：US965513
申请日：1992-10-23
申请人： Alan N. Schechter , Shu-Zhen Huang , Griffin P. Rodgers
发明人： Alan N. Schechter , Shu-Zhen Huang , Griffin P. Rodgers
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： A simple, rapid and reliable method for diagnosis of thalassemia is described. The method comprises amplification of the cDNA by polymerase chain reaction and determining the ratio between .alpha. and .beta. hemoglobin chain mRNAs.
摘要翻译：描述了用于诊断地中海贫血的简单，快速和可靠的方法。该方法包括通过聚合酶链反应扩增cDNA并确定（α）和（β）血红蛋白链mRNA之间的比例。

2. 发明授权

US3716707A Pneumatic ratemeter and counter 失效
标题翻译：气动测速仪和计数器
公开(公告)号：US3716707A
公开(公告)日：1973-02-13
申请号：US3716707D
申请日：1971-12-29
申请人： GRIFFIN P , SHARKI M
发明人： SHARKI M , GRIFFIN P
IPC分类号： G06D1/00 , F15B21/00 , F15C1/00 , G01P3/28 , G06M1/12 , G06M1/18 , G06M1/00
CPC分类号： G06M1/183 , F15B21/00 , F15C1/003 , G01P3/28 , G06M1/123 , Y10T137/86445
摘要： A one-shot sensor valve receives a mechanical force from pump rod movement and operates to pressurize a one-shot air tank from a regulated air supply. When the pump rod moves back to its original position, the one-shot tank is discharged into fluidic logic circuitry which energizes a counter and passes the air signal to a ratemeter transfer valve and into a one-shot storage valve. The one-shot storage valve stores air pressure in a second one-shot air tank and a time air tank receives compressed air at a constant and predetermined rate from a flowrater through the ratemeter transfer valve. When the transfer valve is energized, the pressure in the time tank is transferred through a booster relay to a readout device. As the signals are coupled from the counter to the ratemeter, the second one-shot air tank is released into a dump pilot valve operator and a dump valve to discharge the time air tank. In the time between the dumping of the time tank and its transfer into the readout device, the time tank is building pressure at a set rate determined by the flowrater. The time between pulses is then represented by a pressure buildup in the time tank. In an alternative embodiment, the flowrater is replaced with a timing motor which drives a timing disc having a hole therethrough which causes air to be passed alternately through a pair of air switches which respectively cause an air volume tank to be pressured up and dumped at a rate commensurate with the rotation of the disc. Based upon the principal that when a given volume of air at a given pressure is allowed to expand into a second volume on a timed cycle, the resultant pressure at any time is a measure of the time from the first cycle to the time of measurement, the pressure in the air timing tank at any time is thus proportional to the rate of pulses generated by the one-shot sensor valve or by the mechanical force that causes the one-shot sensor valve to operate.

3. 发明授权

US731663A Baling-press. 失效
公开(公告)号：US731663A
公开(公告)日：1903-06-23
申请号：US1902135111
申请日：1902-12-13
申请人： A U WALKER , CARR WILLIAM T , CARR GRIFFIN P , WILLIAMS HENRY E
发明人： CARR WILLIAM T , CARR GRIFFIN P , WILLIAMS HENRY E
CPC分类号： B30B9/321

4. 发明授权

US07557196B2 hGC-1, a gene encoding a member of the olfactomedin-related protein family 有权
标题翻译： hGC-1是编码嗅蛋白多糖相关蛋白家族成员的基因
公开(公告)号：US07557196B2
公开(公告)日：2009-07-07
申请号：US10497890
申请日：2002-12-09
申请人： Griffin P. Rodgers , Wen-li Liu , Jiachang Zhang
发明人： Griffin P. Rodgers , Wen-li Liu , Jiachang Zhang
IPC分类号： C07H21/04
CPC分类号： C12Q1/6886 , A61K38/00 , C07K14/47 , C12Q2600/158
摘要： An isolated acid having the sequence of a) SEQ ID NO: 1; b) the sequence of SEQ ID NO: 2; c) the sequence of SEQ ID NO: 3; d) a sequence complementary to any of a), b), or c); or e) a sequence of at least 10 contiguous nucleotides specific for any of a)-d). The invention relates to the identification and characterization of a hitherto unidentified human gene, hGC-1. The protein encoded by hGC-1 appears to be a member of the olfactomedin-related proteins. The invention relates generally to the gene (hGC-1), nucleic acids, cDNA, vectors, polypeptides, protein, antibodies, cells, transgenic animal, and other compositions related to hGC-1. Additionally, primers are provided for identifying hGC-1. The invention further relates to methods of using these compositions, such as diagnosis and treatment of various cancers, and kits comprising these compositions.
摘要翻译：具有a）SEQ ID NO：1的序列的分离的酸; b）SEQ ID NO：2的序列; c）SEQ ID NO：3的序列; d）与a），b）或c）中任一个互补的序列; 或e）对于a）-d）中的任何一个特异的至少10个连续核苷酸的序列。本发明涉及迄今未知的人基因hGC-1的鉴定和表征。由hGC-1编码的蛋白质似乎是嗅蛋白多糖相关蛋白的成员。本发明一般涉及与hGC-1相关的基因（hGC-1），核酸，cDNA，载体，多肽，蛋白质，抗体，细胞，转基因动物和其它组合物。另外，提供了用于鉴定hGC-1的引物。本发明还涉及使用这些组合物的方法，例如各种癌症的诊断和治疗，以及包含这些组合物的试剂盒。

5. 发明授权

US06322981B1 Rapid method for diagnosing the various forms of alpha-thalassemia 失效
标题翻译：用于诊断各种形式的α-地中海贫血的快速方法
公开(公告)号：US06322981B1
公开(公告)日：2001-11-27
申请号：US09308796
申请日：1999-07-16
申请人： Griffin P. Rodgers , Delia C. Tang
发明人： Griffin P. Rodgers , Delia C. Tang
IPC分类号： C12Q168
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to the simultaneous and specific identification of the variant forms of &agr;-thalassemia. This invention utilizes simple and readily available equipment to rapidly identify, diagnose and differentiate the different forms of &agr;-thalassemia. Specifically, the present invention relates to a simple and rapid non-radioisotopic technique for the diagnosis and differentiation of the common forms of &agr;-thalassemia has been developed. This approach works on any biological tissue including blood, wherein the assay works equally well with fresh blood and dried blood samples stored on filter paper.
摘要翻译：本发明涉及α-地中海贫血的变体形式的同时和特异性鉴定。本发明利用简单易用的设备来快速鉴别，诊断和区分不同形式的α-地中海贫血。具体地说，本发明涉及用于诊断和分化常见形式的α-地中海贫血的简单且快速的非放射性同位素技术。这种方法适用于包括血液在内的任何生物组织，其中测定与储存在滤纸上的新鲜血液和干燥血液样品同样良好。

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