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1. 发明授权

US07557196B2 hGC-1, a gene encoding a member of the olfactomedin-related protein family 有权
标题翻译： hGC-1是编码嗅蛋白多糖相关蛋白家族成员的基因
公开(公告)号：US07557196B2
公开(公告)日：2009-07-07
申请号：US10497890
申请日：2002-12-09
申请人： Griffin P. Rodgers , Wen-li Liu , Jiachang Zhang
发明人： Griffin P. Rodgers , Wen-li Liu , Jiachang Zhang
IPC分类号： C07H21/04
CPC分类号： C12Q1/6886 , A61K38/00 , C07K14/47 , C12Q2600/158
摘要： An isolated acid having the sequence of a) SEQ ID NO: 1; b) the sequence of SEQ ID NO: 2; c) the sequence of SEQ ID NO: 3; d) a sequence complementary to any of a), b), or c); or e) a sequence of at least 10 contiguous nucleotides specific for any of a)-d). The invention relates to the identification and characterization of a hitherto unidentified human gene, hGC-1. The protein encoded by hGC-1 appears to be a member of the olfactomedin-related proteins. The invention relates generally to the gene (hGC-1), nucleic acids, cDNA, vectors, polypeptides, protein, antibodies, cells, transgenic animal, and other compositions related to hGC-1. Additionally, primers are provided for identifying hGC-1. The invention further relates to methods of using these compositions, such as diagnosis and treatment of various cancers, and kits comprising these compositions.
摘要翻译：具有a）SEQ ID NO：1的序列的分离的酸; b）SEQ ID NO：2的序列; c）SEQ ID NO：3的序列; d）与a），b）或c）中任一个互补的序列; 或e）对于a）-d）中的任何一个特异的至少10个连续核苷酸的序列。本发明涉及迄今未知的人基因hGC-1的鉴定和表征。由hGC-1编码的蛋白质似乎是嗅蛋白多糖相关蛋白的成员。本发明一般涉及与hGC-1相关的基因（hGC-1），核酸，cDNA，载体，多肽，蛋白质，抗体，细胞，转基因动物和其它组合物。另外，提供了用于鉴定hGC-1的引物。本发明还涉及使用这些组合物的方法，例如各种癌症的诊断和治疗，以及包含这些组合物的试剂盒。

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