专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20040204478A1 Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake 审中-公开
标题翻译：具有作为回肠胆汁酸转运抑制剂和牛磺胆酸摄取的活性的新型苯并噻吖啶
公开(公告)号：US20040204478A1
公开(公告)日：2004-10-14
申请号：US10830125
申请日：2004-04-23
申请人： G.D. Searle & Company
发明人： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
IPC分类号： C07D337/16 , A61K031/38
CPC分类号： A61K31/38 , B24B5/18 , B24B21/12 , C07C319/14 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/65539 , C07K5/06086 , C08G65/329 , C07C323/12 , C07C323/18
摘要： Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
摘要翻译：提供了新的苯并噻庚因，衍生物和类似物; 含有它们的药物组合物; 以及在医学中使用这些化合物和组合物的方法，特别是用于预防和治疗哺乳动物中高脂血症的疾病，例如与动脉粥样硬化或高胆固醇血症有关的那些。

2. 发明申请

US20030055274A1 Processes for preparation of 9,11-epoxy steroids and intermediates useful therein 失效
标题翻译：制备9,11-环氧类固醇及其中有用的中间体的方法
公开(公告)号：US20030055274A1
公开(公告)日：2003-03-20
申请号：US10112355
申请日：2002-03-29
申请人： G.D. Searle & Company
发明人： John S. Ng , Chin Liu , Dennis K. Anderson , Jon P. Lawson , Joseph Wieczorek , Sastry A. Kunda , Leo J. Letendre , Mark J. Pozzo , Yuen-Lung L. Sing , Ping T. Wang , Edward E. Yonan , Richard M. Weier , Thomas B. Kowar , Julio A. Baez , Bernhard Erb
IPC分类号： C07J001/00
CPC分类号： C12P33/10 , C07D301/12 , C07J1/0059 , C07J21/00 , C07J21/003 , C07J31/006 , C07J41/0094 , C07J53/002 , C07J71/0005 , C07J71/0015 , C12P33/005
摘要： Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of formula (I) wherein: nullAnullAnull represents the group nullCHR4nullCHR5null or nullCR4nullCR5null, R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, aryloxy; R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical; nullBnullBnull represents the group nullCHR6nullCHR7null or an alpha- or beta-oriented group (III), where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy; and R8 and R9 are independently selected from the group consisting of hydrogen, hydroxy, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R6 or R7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring. 1
摘要翻译：提供了多种新的反应方案，新的工艺步骤和新的中间体，用于合成环氧麦芽糖酮和式（I）的其它化合物，其中：-AA-表示-CHR 4 -CHR 5 - 或-CR 4 = CR 5 - ，R 3，R 4和 R5独立地选自氢，卤素，羟基，低级烷基，低级烷氧基，羟基烷基，烷氧基烷基，羟基羰基，氰基，芳氧基; R1表示α-取代的低级烷氧基羰基或羟烷基; -BB-表示基团-CHR6-CHR7-或α取代或β-取代基团（III），其中R6和R7独立地选自氢，卤素，低级烷氧基，酰基，羟基烷基，烷氧基烷基，羟基羰基烷基，烷氧基羰基，酰氧基烷基，氰基和芳氧基; 并且R 8和R 9独立地选自氢，羟基，卤素，低级烷氧基，酰基，羟基烷基，烷氧基烷基，羟基羰基，烷基，烷氧基羰基，酰氧基烷基，氰基和芳氧基，或者R 8和R 9一起包含碳环或杂环结构或R8或R9与R6或R7一起包含与五环D环稠合的碳环或杂环结构。

3. 发明申请

US20040191874A1 Process for preparation of 9, 11-epoxy steroids and intermediates useful therein 失效
标题翻译：制备9,11-环氧类固醇及其中有用的中间体的方法
公开(公告)号：US20040191874A1
公开(公告)日：2004-09-30
申请号：US10608101
申请日：2003-06-27
申请人： G.D. Searle & Company
发明人： John S. Ng , Ping T. Wang , Julio A. Baez , Chin Liu , Dennis K. Anderson , Jon P. Lawson , Bernhard Erb , Joseph Wieczorek , Gennaro Mucciariello , Fortunato Vanzanella , Sastry A. Kunda , Leo J. Letendre , Mark J. Pozzo , Yuen-Lung L. Sing , Edward E. Yonan
IPC分类号： C12P019/02
CPC分类号： C07J71/00 , C07J21/00 , C07J21/003 , C07J31/006 , C07J53/00 , C07J53/002 , C07J71/0015 , C12P33/005 , C12P33/10 , C12Q1/02
摘要： Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I 1 wherein: -A-A- represents the group nullCHR4nullCHR5null or CR4nullCR5nullR3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, aryloxy, R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical, nullBnullBnull represents the group nullCHR6nullCHR7null or an alpha- or beta-oriented group: 2 where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, and R8 and R9 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R6 or R7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.
摘要翻译：提供了多种新的反应方案，新的方法步骤和新的中间体，用于合成环氧麦芽糖酮和式I的其它化合物，其中：-AA-表示基团-CHR 4 -CHR 5 - 或CR 4 = CR R 5，R 4和R 5独立地选自氢，卤素，羟基，低级烷基，低级烷氧基，羟烷基，烷氧基烷基，羟基羰基，氰基，芳氧基， 1>表示α-取代的低级烷氧基羰基或羟烷基，-BB-表示基团-CHR 6 -CHR 7 - 或α或β-取代基团：其中R 6和R 7 烷基，烷氧基羰基，酰氧基烷基，氰基，芳氧基，R 8和R 9独立地选自氢，卤代，低级烷氧基，酰基，羟基烷基，烷氧基烷基，羟基羰基，氢，卤素，低级烷氧基，酰基，羟基烷基，烷氧基烷基，羟基羰基，烷基，烷氧基羰基，酰氧基烷基，氰基，芳氧基或R 8 nd R 9一起包含碳环或杂环结构，或R 8或R 9与R 6或R 7一起包含与五环D环稠合的碳环或杂环结构。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式