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1. 发明授权

US4473649A Antibiotic producing streptomyces 失效
标题翻译：抗生素生产链霉菌
公开(公告)号：US4473649A
公开(公告)日：1984-09-25
申请号：US414239
申请日：1982-09-02
申请人： Lester A. Dolak , Fritz Reusser , Thomas M. Castle , Betty R. Hannon , Alice L. Laborde , Charles K. Marschke
发明人： Lester A. Dolak , Fritz Reusser , Thomas M. Castle , Betty R. Hannon , Alice L. Laborde , Charles K. Marschke
IPC分类号： C12P1/06 , C12N1/20 , C12R1/465
CPC分类号： C12P1/06 , Y10S435/886
摘要： Novel antibiotic U-64,864 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces braegensis Dietz sp.n., NRRL 12567. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Thus, antibiotic U-64,864 can be used in various environments to eradicate or control such bacteria.
摘要翻译：新颖的抗生素U-64,864可在受控条件下使用微生物Streptomyces braegensis Dietz sp.n.，NRRL 12567的生物学纯培养物在发酵过程中生产。该抗生素对各种革兰氏阳性菌如金黄色葡萄球菌，化脓性链球菌和肺炎链球菌。因此，抗生素U-64,864可用于各种环境以消除或控制这些细菌。

2. 发明授权

US4343906A Hybrid plasmid of pBR322 and Streptomyces plasmid and E. coli containing same 失效
标题翻译： pBR322和Streptomyces质粒的杂交质粒和含有其的大肠杆菌
公开(公告)号：US4343906A
公开(公告)日：1982-08-10
申请号：US068418
申请日：1979-08-21
申请人： Fritz Reusser , Vedpal S. Malik
发明人： Fritz Reusser , Vedpal S. Malik
IPC分类号： C12N15/76 , C12N1/20
CPC分类号： C12N15/76
摘要： A process for cloning DNA into a suitable host, which comprises fragmenting said DNA to obtain fragmented DNA, ligating said fragmented DNA into a suitable vector to obtain chimeric (hybrid) DNA, and transforming said chimeric DNA into said ultimate host. By this process, the useful chemical plasmid pUC3, which is obtainable from a biologically pure culture of the microorganism Streptomyces sp. 3022a, NRRL 11441, is cloned into the well-known bacterium E. coli HB101. This cloning of pUC3 into E. coli HB101 enables the production of large amounts of plasmid pUC3 DNA. pUC3 is useful as a cloning vehicle in recombinant DNA work. For example, using recombinant DNA methodology, a desired gene, for example, the insulin gene, can be inserted into pUC3 and the resulting plasmid can then be transformed into a suitable host microbe which, upon culturing, produces the desired insulin.
摘要翻译：将DNA克隆到合适的宿主中的方法，其包括将所述DNA片段化以获得片段化的DNA，将所述片段化DNA连接到合适的载体中以获得嵌合（杂交）DNA，并将所述嵌合DNA转化到所述最终宿主中。通过这个过程，可以从微生物链霉菌Streptomyces sp。的生物纯培养物获得的有用的化学质粒pUC3。 3022a，NRRL 11441克隆到公知的大肠杆菌HB101中。将pUC3克隆到大肠杆菌HB101中能够产生大量的质粒pUC3DNA。 pUC3可用作重组DNA工作中的克隆载体。例如，使用重组DNA方法，将期望的基因，例如胰岛素基因插入到pUC3中，然后将得到的质粒转化成合适的宿主微生物，培养后产生所需的胰岛素。

3. 发明授权

US4259450A Antibiotic acanthomycin and process for preparing 失效
标题翻译：抗生素棘皮瘤及其制备方法
公开(公告)号：US4259450A
公开(公告)日：1981-03-31
申请号：US772552
申请日：1977-02-28
申请人： Alexander D. Argoudelis , Thomas F. Brodasky , Fritz Reusser
发明人： Alexander D. Argoudelis , Thomas F. Brodasky , Fritz Reusser
IPC分类号： C07G11/00 , A01N63/02 , A61K35/74 , A61P31/04 , C12P1/06 , C12N1/20 , A61K35/00
CPC分类号： A01N63/02
摘要： Antibiotic acanthomycin (U-53,827) produced by the controlled fermentation of the microorganism Streptomyces espinosus subsp. acanthus, NRRL 11081. This antibiotic and its base addition salts are active against Gram-positive bacteria. Accordingly, they can be used in various environments to eradicate or control such bacteria.
摘要翻译：通过微生物链霉菌Streptomyces espinosus subsp。的控制发酵产生的抗生素棘皮瘤霉素（U-53,827）鳄梨，NRRL 11081.该抗生素及其碱加成盐对革兰氏阳性菌具有活性。因此，它们可以用于各种环境中以消除或控制这些细菌。

4. 发明授权

US4404190A Composition of matter and process 失效
标题翻译：物质和过程的组成
公开(公告)号：US4404190A
公开(公告)日：1983-09-13
申请号：US341437
申请日：1982-01-22
申请人： Lester A. Dolak , Fritz Reusser , Thomas M. Castle , Betty R. Hannon , Alice L. Laborde , Charles K. Marschke
发明人： Lester A. Dolak , Fritz Reusser , Thomas M. Castle , Betty R. Hannon , Alice L. Laborde , Charles K. Marschke
IPC分类号： C12P1/06 , A61K35/00
CPC分类号： C12P1/06
摘要： Novel antibiotic U-64,864 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces braegensis Dietz sp.n., NRRL 12567. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Thus, antibiotic U-64,864 can be used in various environments to eradicate or control such bacteria.
摘要翻译：新颖的抗生素U-64,864可在受控条件下使用微生物Streptomyces braegensis Dietz sp.n.，NRRL 12567的生物学纯培养物在发酵过程中生产。该抗生素对各种革兰氏阳性菌如金黄色葡萄球菌，化脓性链球菌和肺炎链球菌。因此，抗生素U-64,864可用于各种环境以消除或控制这些细菌。

5. 发明授权

US4332898A Hybrid plasmid and process of making same 失效
标题翻译：杂交质粒及其制备方法
公开(公告)号：US4332898A
公开(公告)日：1982-06-01
申请号：US159852
申请日：1980-06-16
申请人： Fritz Reusser
发明人： Fritz Reusser
IPC分类号： C12N15/70 , C12N15/75 , C12N15/00
CPC分类号： C12N15/70 , C12N15/75 , C12R1/19 , Y10S435/849
摘要： A novel chemical compound, plasmid pUC1021, which was constructed from Bacillus megaterium chromosomal DNA and plasmid pBR322. Hybrid plasmid pUC1021 contains a functional tet gene promoter, and, thus, is useful as a cloning vehicle in recombinant DNA work. For example, using well known DNA methodology, a desired gene, for example, the insulin gene, can be inserted into pUC1021 and the resulting plasmid can then be transformed into a suitable host microbe which, upon culturing, produces the desired insulin.
摘要翻译：一种新型化合物，质粒pUC1021，其由巨大芽孢杆菌染色体DNA和质粒pBR322构建。杂交质粒pUC1021含有功能性的tet基因启动子，因此可用作重组DNA工作中的克隆载体。例如，使用众所周知的DNA方法，可以将期望的基因，例如胰岛素基因插入到pUC1021中，然后将得到的质粒转化成合适的宿主微生物，培养后产生所需的胰岛素。

6. 发明授权

US5981537A Pyrimidine-thioalkyl and alkylether compounds 失效
标题翻译：嘧啶硫代烷基和烷基醚化合物
公开(公告)号：US5981537A
公开(公告)日：1999-11-09
申请号：US640898
申请日：1996-05-09
申请人： Richard A. Nugent , Stephen T. Schlachter , Michael J. Murphy , Joel Morris , Richard C. Thomas , Donn G. Wishka , Fritz Reusser , Gary J. Cleek , Irene W. Althaus
发明人： Richard A. Nugent , Stephen T. Schlachter , Michael J. Murphy , Joel Morris , Richard C. Thomas , Donn G. Wishka , Fritz Reusser , Gary J. Cleek , Irene W. Althaus
IPC分类号： C07D239/34 , A61K31/505 , A61P31/12 , A61P31/18 , C07D239/38 , C07D239/46 , C07D239/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04 , A61K31/535 , C07D239/02 , C07D413/00
CPC分类号： C07D239/47 , A61K31/505 , C07D239/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04
摘要： The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R.sup.4 is selected from the group consisting of --H or --NR.sub.15 R.sub.16 where R.sub.15 is --H and R.sub.16 is --H, C.sub.1 -C.sub.6 alkyl, --NH.sub.2 or R.sub.15 and R.sub.16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R.sub.6 is selected from the group consisting of --H, or halo (preferably --Cl); with the overall proviso that R.sub.4 and R.sub.6 are not both --H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive.
摘要翻译： PCT No.PCT / US94 / 12713 Sec。 371日期：1996年5月9日 102（e）日期1996年5月9日PCT 1994年11月9日PCT公布。公开号WO95 / 13267 日期1995年5月18日本发明涉及式（I）的嘧啶 - 硫代烷基和烷基醚化合物和式（IA）的嘧啶 - 硫烷基和烷基醚，即式（I）的化合物，其中R 4选自 - H或-NR 15 R 16，其中R 15是-H，R 16是-H，C 1 -C 6烷基，-NH 2或R 15和R 16与1-形式的1-吡咯烷子基，1-吗啉代或1-哌啶子基一起; 并且R 6选自-H或卤素（优选-Cl）; 其总体条件是R4和R6不是-H。式（IA）的化合物可用于治疗HIV阳性的个体。

7. 发明授权

US4397950A Process for production of antibiotic U-64,767 using Streptomyces macronensis NRRL 12566 失效
标题翻译：使用Streptomyces macronensis NRRL 12566生产抗生素U-64,767的方法
公开(公告)号：US4397950A
公开(公告)日：1983-08-09
申请号：US324246
申请日：1981-11-23
申请人： Lester A. Dolak , Fritz Reusser , Thomas M. Castle , Betty R. Hannon , Alice L. Laborde , Charles K. Marschke
发明人： Lester A. Dolak , Fritz Reusser , Thomas M. Castle , Betty R. Hannon , Alice L. Laborde , Charles K. Marschke
IPC分类号： C12P1/06 , C12P17/06 , C12N1/20 , C12R1/465
CPC分类号： C12P1/06 , Y10S435/886
摘要： Novel antibiotic U-64,767 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces macronensis Dietz sp.n., NRRL 12566. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus and Streptococcus pyogenes. It is also active against the Gram-negative bacterium Streptococcus pneumoniae. Thus, antibiotic U-64,767 can be used in various environments to eradicate or control such bacteria.
摘要翻译：新型抗生素U-64,767可在受控条件下使用微生物链霉菌（Streptomyces macronensis Dietz sp.n.，NRRL 12566）的生物学纯培养物在发酵过程中生产。该抗生素对各种革兰氏阳性菌如金黄色葡萄球菌和化脓链球菌有活性。它也对革兰氏阴性菌肺炎链球菌有活性。因此，抗生素U-64,767可用于各种环境中以消除或控制这些细菌。

8. 发明授权

US4362817A Hybrid plasmid and process of making same 失效
标题翻译：杂交质粒及其制备方法
公开(公告)号：US4362817A
公开(公告)日：1982-12-07
申请号：US239258
申请日：1981-03-02
申请人： Fritz Reusser
发明人： Fritz Reusser
IPC分类号： C12N15/70 , C12N15/76 , C12N15/00 , C12N1/00 , C12N1/20 , C12R1/19
CPC分类号： C12N15/76 , C12N15/70 , Y10S435/849
摘要： A novel chemical compound, plasmid pUC1060, which was constructed from Streptomyces sp. 3022a chromosomal DNA and plasmid pBR322. Hybrid plasmid pUC1060 contains a functional tet gene promoter composed of streptomycete and E. coli DNA, and, thus, is useful as a cloning vehicle in recombinant DNA work. For example, using well known DNA methodology, a desired gene, for example, the insulin gene, can be inserted into pUC1060 and the resulting plasmid can then be transformed into a suitable host microbe which, upon culturing, produces the desired insulin.
摘要翻译：一种新型化合物，质粒pUC1060，由Streptomyces sp。 3022a染色体DNA和质粒pBR322。杂交质粒pUC1060含有由链霉菌和大肠杆菌DNA组成的功能性tet基因启动子，因此可用作重组DNA工作中的克隆载体。例如，使用众所周知的DNA方法，可将所需基因，例如胰岛素基因插入到pUC1060中，然后将得到的质粒转化成合适的宿主微生物，培养后产生所需的胰岛素。

9. 发明授权

US3689639A Antibiotic berninamycin and process for making same 失效
标题翻译：抗生素BERNINAMYCIN及其制备方法
公开(公告)号：US3689639A
公开(公告)日：1972-09-05
申请号：US3689639D
申请日：1969-01-23
申请人： MALCOLM E BERGY , JOHN H COATS , FRITZ REUSSER
发明人： BERGY MALCOLM E , COATS JOHN H , REUSSER FRITZ
IPC分类号： A61K21/00
CPC分类号： C12P1/06 , Y10S435/886
摘要： Antibiotic berninamycin producible by culturing Streptomyces bernensis Dietz, sp. nov., in an aqueous nutrient medium. Berninamycin inhibits the growth of Bacillus subtilis and can be used to control slime and corrosion in petroleum products caused by this bacterium.
摘要翻译：通过培养链霉菌（Streptomyces bernensis Dietz）生产的抗生素贝尔霉素 nov。，在含水营养培养基中。贝尼霉素抑制枯草芽孢杆菌的生长，可用于控制由该细菌引起的石油产品中的粘液和腐蚀。

10. 发明授权

US3998698A Process for producing antibiotic U-51,640 失效
标题翻译：生产抗生素U-51,640的方法
公开(公告)号：US3998698A
公开(公告)日：1976-12-21
申请号：US674860
申请日：1976-04-08
申请人： Alexander D. Argoudelis , Fritz Reusser
发明人： Alexander D. Argoudelis , Fritz Reusser
IPC分类号： C07H5/04 , C12D9/00
CPC分类号： C07H5/04 , Y10S435/886
摘要： Antibiotic U-51,640 produced by the controlled fermentation of the microorganism Streptomyces ficellus Dietz, sp. n., NRRL 8067. This antibiotic and its acid addition salts are active against Gram-positive and Gram-negative bacteria. Accordingly, they can be used in various environments to eradicate or control such bacteria.
摘要翻译：通过微生物链霉菌（Streptomyces ficellus Dietz）的受控发酵产生的抗生素U-51,640。这种抗生素及其酸加成盐对革兰氏阳性和革兰氏阴性菌具有活性。因此，它们可以用于各种环境中以消除或控制这些细菌。

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