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1. 发明申请

US20100003674A1 Adult stem cells, molecular signatures, and applications in the evaluation, diagnosis, and therapy of mammalian conditions 审中-公开
标题翻译：成人干细胞，分子标记和哺乳动物条件的评估，诊断和治疗中的应用
公开(公告)号：US20100003674A1
公开(公告)日：2010-01-07
申请号：US12217426
申请日：2008-07-03
申请人： Frederick O. Cope , Michael S. Blue
发明人： Frederick O. Cope , Michael S. Blue
IPC分类号： C12Q1/68 , C12N5/08
CPC分类号： C12Q1/6888 , C12Q1/6881 , C12Q2600/158
摘要： MicroRNA genes are associated with regulatory elements of living cells of all species. The perturbations of the expression of these genes and their gene products in the cell or genomic structure or chromosomal architecture of a cell provide specific signatures on the condition of the cell and even the organism. Evaluation of miR gene expression can therefore be used to indicate the presence and state of specific cell types and/or their state of differentiation relative to their surrounding tissue. The present invention relates to the identification of a stem cell-specific signature or signatures composed of protein and/or nucleic acid markers expressed by virtue of the position of a cell or cells in the time line of its/their development and the impact of the cells' environment on this signature as it relates to the cells' stem cell potential. The composition and combination of these signatures provides a means of identifying, manipulating and differentiating said adult stem cells and thus, their acquisition and utilization in research, diagnosis, and therapy of normal and pathological conditions.
摘要翻译： MicroRNA基因与所有物种的活细胞调节元件相关。这些基因及其基因产物在细胞或基因组结构或染色体结构中的表达的扰动在细胞甚至生物体的条件下提供特异性的特征。因此，miR基因表达的评估可用于指示特异性细胞类型的存在和状态和/或其相对于其周围组织的分化状态。本发明涉及鉴定由其在其发育的时间线中的细胞或细胞的位置所表达的蛋白质和/或核酸标志物组成的干细胞特异性特征或特征，以及细胞的这种特征的环境与细胞的干细胞潜能有关。这些标记的组合和组合提供了鉴定，操纵和区分所述成体干细胞并因此获得和利用其在正常和病理状况的研究，诊断和治疗中的手段。

2. 发明授权

US5514656A Method of providing enteral nutritional support for patients undergoing radiation therapy and/or chemotherapy 失效
标题翻译：为进行放射治疗和/或化疗的患者提供肠内营养支持的方法
公开(公告)号：US5514656A
公开(公告)日：1996-05-07
申请号：US68450
申请日：1993-05-28
申请人： Frederick O. Cope , Normanella T. DeWille , Ernest W. Richards , Terrence B. Mazer , Bonnie C. Abbruzzese , Gregory A. Snowden , Nickki L. Parlet , Laura A. Pease
发明人： Frederick O. Cope , Normanella T. DeWille , Ernest W. Richards , Terrence B. Mazer , Bonnie C. Abbruzzese , Gregory A. Snowden , Nickki L. Parlet , Laura A. Pease
IPC分类号： A23J3/14 , A23J3/34 , A23L1/29 , A23L1/30 , A23L1/305 , A61K38/01 , A61K38/16 , A61K38/17 , A23J3/16 , A23L1/052 , A61K47/42
CPC分类号： A61K38/01 , A23J3/14 , A23J3/346 , A23L33/12 , A23L33/18 , A23L33/185 , A23L33/19 , A23L33/40 , A61K38/168 , A61K38/17 , A23V2002/00
摘要： A method of providing enteral nutritional support to a person who is currently undergoing chemotherapy and/or radiation therapy involves including in the person's diet an enteral nutritional product having a protein system which includes a soy protein hydrolysate. The nutritional product is very low in folic acid, contains .beta.-carotene, and has a ratio of n-6 to n-3 fatty acids that is in the range of about 1.3:1 to 2.5:1.
摘要翻译：向正在进行化疗和/或放射治疗的人提供肠内营养支持的方法包括在该人的饮食中包括具有包含大豆蛋白水解物的蛋白质系统的肠内营养产品。营养产品叶酸非常低，含有β-胡萝卜素，并且n-6至n-3脂肪酸的比例在约1.3:1至2.5:1的范围内。

3. 发明授权

US5480872A Method of providing enternal nutritional support to persons infected with human immunodeficiency virus 失效
标题翻译：向感染人类免疫缺陷病毒的人提供内在营养支持的方法
公开(公告)号：US5480872A
公开(公告)日：1996-01-02
申请号：US069066
申请日：1993-05-28
申请人： Frederick O. Cope , Normanella T. DeWille , Ernest W. Richards , Terrence B. Mazer , Bonnie C. Abbruzzese , Gregory A. Snowden , Michael A. Chandler
发明人： Frederick O. Cope , Normanella T. DeWille , Ernest W. Richards , Terrence B. Mazer , Bonnie C. Abbruzzese , Gregory A. Snowden , Michael A. Chandler
IPC分类号： A23L1/29 , A23L1/305 , A61K38/01 , A23J3/16 , A23L1/052 , A61K38/17 , A61K47/42
CPC分类号： A61K38/011 , A23L33/18 , A23L33/40
摘要： Enteral nutritional support for a person infected with human immunodeficiency virus is provided by including in the diet a nutritional product which contains a soy protein hydrolysate having a degree of hydrolysis in the range of about 14 to 17 and a molecular weight partition, as determined by size exclusion chromatography, wherein 30-60% of the particles have a molecular weight in the range of 1500-5000 Daltons. The nutritional product also contains a source of intact protein. The nutritional product has a ratio, by weight, of n-6 to n-3 fatty acids of about 1.3:1 to 2.5:1. The nutritional product also contains a source of dietary fiber.
摘要翻译：通过在饮食中包括含有水解度在约14至17范围内的大豆蛋白水解产物和分子量分配的营养产品来提供对人体免疫缺陷病毒感染的人的肠内营养支持，由尺寸确定排阻层析，其中30-60％的颗粒具有1500-5000道尔顿范围内的分子量。营养产品还含有完整蛋白质的来源。营养产品的重量比为约1.3:1至2.5:1的n-6至n-3脂肪酸。营养产品还含有膳食纤维来源。

4. 发明申请

US20120270826A1 ADULT STEM CELLS, MOLECULAR SIGNATURES, AND APPLICATIONS IN THE EVALUATION, DIAGNOSIS, AND THERAPY OF MAMMALIAN CONDITIONS 审中-公开
标题翻译：成年干细胞，分子标记和应用在评估，诊断和治疗中的应用马马里兰条件
公开(公告)号：US20120270826A1
公开(公告)日：2012-10-25
申请号：US13458070
申请日：2012-04-27
申请人： Frederick O. Cope , Michael S. Blue
发明人： Frederick O. Cope , Michael S. Blue
IPC分类号： C40B30/04 , A61K31/7105 , A61P35/00 , C12N5/10
CPC分类号： C12Q1/6888 , C12Q1/6881 , C12Q2600/158
摘要： The present invention relates to the identification of a stem cell-specific signature or signatures composed of protein and/or nucleic acid markers expressed by virtue of the position of a cell or cells in the time line of its/their development and the impact of the cells' environment on this signature as it relates to the cells' stem cell potential. The composition and combination of these signatures provides a means of identifying, manipulating and differentiating said adult stem cells and thus, their acquisition and utilization in research, diagnosis, and therapy of normal and pathological conditions.
摘要翻译：本发明涉及鉴定由其在其发育的时间线中的细胞或细胞的位置所表达的蛋白质和/或核酸标志物组成的干细胞特异性特征或特征，以及细胞的这种特征的环境与细胞的干细胞潜能有关。这些标记的组合和组合提供了鉴定，操纵和区分所述成体干细胞并因此获得和利用其在正常和病理状况的研究，诊断和治疗中的手段。

5. 发明授权

US5547927A Enteral nutritional product for patients undergoing radiation therapy and/or chemotherapy 失效
标题翻译：进行放射治疗和/或化疗的患者的肠内营养产品
公开(公告)号：US5547927A
公开(公告)日：1996-08-20
申请号：US068919
申请日：1993-05-28
申请人： Frederick O. Cope , Normanella T. DeWille , Ernest W. Richards , Terrence B. Mazer , Bonnie C. Abbruzzese , Gregory A. Snowden , Nickki L. Parlet , Laura A. Pease
发明人： Frederick O. Cope , Normanella T. DeWille , Ernest W. Richards , Terrence B. Mazer , Bonnie C. Abbruzzese , Gregory A. Snowden , Nickki L. Parlet , Laura A. Pease
IPC分类号： A23J3/14 , A23J3/34 , A23L1/29 , A23L1/30 , A23L1/305 , A61K38/01 , A61K38/16 , A61K38/17 , A23J3/16 , A23J1/14 , A23J1/20
CPC分类号： A61K38/01 , A23J3/14 , A23J3/346 , A23L33/12 , A23L33/18 , A23L33/185 , A23L33/19 , A23L33/40 , A61K38/168 , A61K38/17 , A23V2002/00
摘要： An enteral nutritional product has been formulated for persons who are currently undergoing radiation therapy and/or chemotherapy. The nutritional product has a protein system which includes a soy protein hydrolysate. The nutritional product is very low in folic acid, contains .beta.-carotene, and has a ratio of n-6 to n-3 fatty acids that is in the range of about 1.3:1 to 2.5:1.
摘要翻译：目前正在接受放射治疗和/或化疗的人员已经制定了肠内营养产品。营养产品具有包括大豆蛋白水解产物的蛋白质系统。营养产品叶酸非常低，含有β-胡萝卜素，并且n-6至n-3脂肪酸的比例在约1.3:1至2.5:1的范围内。

6. 发明授权

US5403826A Nutritional product for persons infected with human immunodeficiency virus 失效
标题翻译：人类免疫缺陷病毒感染者的营养产品
公开(公告)号：US5403826A
公开(公告)日：1995-04-04
申请号：US69269
申请日：1993-05-28
申请人： Frederick O. Cope , Normanella T. DeWille , Ernest W. Richards , Terrence B. Mazer , Bonnie C. Abbruzzese , Gregory A. Snowden , Michael A. Chandler
发明人： Frederick O. Cope , Normanella T. DeWille , Ernest W. Richards , Terrence B. Mazer , Bonnie C. Abbruzzese , Gregory A. Snowden , Michael A. Chandler
IPC分类号： A23L1/29 , A23L1/305 , A61K38/01 , A16K37/02 , A16K31/70 , A16K35/60
CPC分类号： A61K38/011 , A23L33/18 , A23L33/40 , Y10S426/80
摘要： An enteral nutritional product for persons infected with human immunodeficiency virus contains a soy protein hydrolysate having a degree of hydrolysis in the range of about 14 to 17 and a molecular weight partition, as determined by size exclusion chromatography, wherein 30-60% of the particles have a molecular weight in the range of 1500-5000 Daltons. The nutritional product also contains a source of intact protein. The nutritional product has a ratio, by weight, of n-6 to n-3 fatty acids of about 1.3:1 to 2.5:1. The nutritional product also contains a source of dietary fiber.
摘要翻译：针对感染人类免疫缺陷病毒的人的肠内营养产品含有水解度在约14至17范围内的大豆蛋白水解产物和通过尺寸排阻色谱法测定的分子量分配，其中30-60％的颗粒分子量范围在1500-5000道尔顿。营养产品还含有完整蛋白质的来源。营养产品的重量比为约1.3:1至2.5:1的n-6至n-3脂肪酸。营养产品还含有膳食纤维来源。

7. 发明授权

US10806803B2 Compositions for targeting macrophages and other CD206 high expressing cells and methods of treating and diagnosis 有权
公开(公告)号：US10806803B2
公开(公告)日：2020-10-20
申请号：US15326985
申请日：2015-07-17
申请人： OHIO STATE INNOVATION FOUNDATION , CARDINAL HEALTH 414, LLC , Frederick O. Cope
发明人： Larry Schlesinger , Eric Bachelder , Frederick O. Cope
IPC分类号： A61K49/00 , A61K47/40 , A61K31/44 , A61K31/704 , A61K31/4409 , A61K47/61 , C08B37/02
摘要： Provided are compounds and compositions for targeting macrophages and other CD206 high expressing cells.

8. 发明授权

US5330972A Method of impeding apoptosis of CD4 cells in persons infected with human immunodeficiency virus 失效
标题翻译：阻止人类免疫缺陷病毒感染者CD4细胞凋亡的方法
公开(公告)号：US5330972A
公开(公告)日：1994-07-19
申请号：US69264
申请日：1993-05-28
申请人： Frederick O. Cope
发明人： Frederick O. Cope
IPC分类号： A23L33/00 , A61K31/19 , A61K38/01 , A61K45/06 , A61K37/02
CPC分类号： A61K45/06 , A23L33/40 , A61K31/19 , A61K38/011 , Y10S426/80
摘要： The apoptosis of CD4 cells in a person infected with the human immunodeficiency virus may be impeded by enterally feeding to the infected person a nutritional product which contains soy protein hydrolysate having a degree of hydrolysis in the range of about 14 to 17 and a molecular weight partition, as determined by size exclusion chromatography, wherein 30%-60% of the particles have a molecular weight in the range of 1500-5000 Daltons. The nutritional product also contains a source of intact protein. The nutritional product has a ratio, by weight, of n-6 to n-3 fatty acids of about 1.3:1 to 2.5:1. The nutritional product also contains a source of dietary fiber.
摘要翻译：感染人类免疫缺陷病毒的人中的CD4细胞的凋亡可能通过向感染者进行肠内给药而阻止含有水解度在约14至17范围内的大豆蛋白水解产物和分子量分配，通过尺寸排阻色谱法测定，其中30％-60％的颗粒具有在1500-5000道尔顿范围内的分子量。营养产品还含有完整蛋白质的来源。营养产品的重量比为约1.3:1至2.5:1的n-6至n-3脂肪酸。营养产品还含有膳食纤维来源。

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