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1. 发明申请

US20070053980A1 Extended release tiagabine formulations with reduced side-effects 审中-公开
标题翻译：延长释放的噻加滨配方，减少副作用
公开(公告)号：US20070053980A1
公开(公告)日：2007-03-08
申请号：US11592694
申请日：2006-11-03
申请人： Francisco Alvarez , Kathleen Apfelbaum , David Brown , Linda Gustavson , Russell Slade
发明人： Francisco Alvarez , Kathleen Apfelbaum , David Brown , Linda Gustavson , Russell Slade
IPC分类号： A61K9/22
CPC分类号： A61K9/1617 , A61K9/2031 , A61K9/2054 , A61K31/4535
摘要： Extended release tiagabine formulations that demonstrate fewer side-effects when administered to a patient.
摘要翻译：延长释放的噻加滨制剂，在给予患者时表现出较少的副作用。

2. 发明授权

US06357337B1 Spring brake actuator with sealed chamber and method for sealing 有权
标题翻译：带密封腔的弹簧制动执行器和密封方法
公开(公告)号：US06357337B1
公开(公告)日：2002-03-19
申请号：US09549188
申请日：2000-04-14
申请人： Francisco Alvarez , Mark A. Davis
发明人： Francisco Alvarez , Mark A. Davis
IPC分类号： F01B1900
CPC分类号： B60T17/083
摘要： A sealed vehicle brake actuator having a housing divided into a first chamber and a second chamber by a movable member such as a diaphragm. The housing comprises a first and second portion joined with the diaphragm therebetween to seal the portions to one another and mount the diaphragm. The joint is formed by deforming at least a part of the first portion into a groove formed in the second portion with the diaphragm pinched between first and second housing portions. The deforming of a part of the first portion into the groove can be accomplished by deforming the wall edge of the first portion, continuously or discretely, into the groove, preferably by rolling. Alternatively, the sidewall of the first portion overlying the groove can be deformed into the groove by rolling the first portion, continuously or discretely, or by discretely punching the sidewall.
摘要翻译：一种密封的车辆制动器致动器，其具有通过诸如隔膜的可动构件分成第一室和第二室的壳体。壳体包括与其间的隔膜连接的第一和第二部分，以将部分彼此密封并安装隔膜。接头是通过将第一部分的至少一部分变形成形成在第二部分中的槽而形成的，其中隔膜夹在第一和第二壳体部分之间。第一部分的一部分变形成凹槽可以通过使第一部分的壁边缘连续或离散地优选地通过轧制而变形成凹槽来实现。或者，覆盖凹槽的第一部分的侧壁可以通过连续或离散地滚动第一部分或通过离散地冲压侧壁而变形成凹槽。

3. 发明授权

US5921311A Installation for eliminating impurities during casting of metals 失效
标题翻译：金属铸造时消除杂质的安装
公开(公告)号：US5921311A
公开(公告)日：1999-07-13
申请号：US721009
申请日：1996-09-26
申请人： Fernando Sitges Menendez , Francisco Alvarez Tamargo , Francisco Tamargo Garcia , Jose M. Matinez Valdes
发明人： Fernando Sitges Menendez , Francisco Alvarez Tamargo , Francisco Tamargo Garcia , Jose M. Matinez Valdes
IPC分类号： B22D11/10 , B22D35/00 , B22D41/05 , B22D41/06 , B22D43/00 , C22B9/02 , B22D44/00
CPC分类号： B22D43/004 , B22D41/05
摘要： An installation for eliminating impurities during casting of metals, comprising at least one casting ladle (2) which forms an outlet siphon (3) and can tilt around a transverse axis (14). Starting from the siphon (3), the casting ladle (2) is prolonged by a conduit (4) which ends at a scum-retaining pan (5), wherein the conduit forms a single piece with the ladle and the pan. The pan (5) has outlet orifices (7) at the bottom and is externally lined with a ceramic cloth (10) which acts as a filter for retention of impurities.
摘要翻译：一种用于在金属铸造期间消除杂质的装置，包括至少一个形成出口虹吸（3）并能够围绕横向轴线（14）倾斜的铸钢包（2）。从虹吸（3）开始，铸钢包（2）由导管（4）延伸，导管（4）终止于浮渣盘（5），其中导管与钢包和锅组成单件。锅（5）在底部有出口孔（7），外部衬有陶瓷布（10），其用作保留杂质的过滤器。

4. 发明授权

US5567285A Facility for removing electro-deposited layers from cathodes 失效
标题翻译：从阴极去除电沉积层的工具
公开(公告)号：US5567285A
公开(公告)日：1996-10-22
申请号：US455703
申请日：1995-05-31
申请人： Francisco J. Sitges Menendez , Fernando Sitges Menendez , Francisco Alvarez Tamargo , Francisco Tamargo Garcia , Jose M. Quiroga Alvarez , Ives Lefevre , Carlos Gonzalez Gonzalez
发明人： Francisco J. Sitges Menendez , Fernando Sitges Menendez , Francisco Alvarez Tamargo , Francisco Tamargo Garcia , Jose M. Quiroga Alvarez , Ives Lefevre , Carlos Gonzalez Gonzalez
IPC分类号： C25C7/08 , C25D17/00
CPC分类号： C25C7/08
摘要： A facility for removing electro-deposited layers from cathodes, including a cathode reception area, a cathode treatment area with a cathode washing apparatus and an extraction apparatus, and a storage area to store cathodes which have had electro-deposited layers removed. The extraction apparatus includes vertical claws and two parallel rollers mounted so that they are capable of turning freely upon two horizontal parallel bars. The bars are fixed between pairs of arms that are mounted so that they may tilt on a bracket. The bracket also carries upper separating rollers.
摘要翻译：用于从阴极除去电沉积层的设备，包括阴极接收区域，具有阴极清洗设备的阴极处理区域和提取设备，以及存储已经去除了电沉积层的阴极的存储区域。提取装置包括垂直爪和两个平行的辊，其安装成使得它们能够在两个水平的平行杆上自由转动。杆被固定在成对的臂之间，以便它们可以在支架上倾斜。支架还带有上分离辊。

5. 发明授权

US4261986A 4-Halo etianic acids and derivatives thereof 失效
标题翻译： 4-卤代亚氨酸及其衍生物
公开(公告)号：US4261986A
公开(公告)日：1981-04-14
申请号：US95762
申请日：1979-11-19
申请人： Francisco Alvarez
发明人： Francisco Alvarez
IPC分类号： C07J3/00 , C07J71/00 , A61K31/56
CPC分类号： C07J3/005 , Y10S514/887
摘要： Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17.beta.-carboxylic acids and esters substituted at the 4-position with a fluoro or chloro and optionally substituted at the six position with fluoro or chloro are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 9.alpha.-position with fluoro, chloro or bromo; substituted at the 11 with a keto, a .beta.-hydroxy or a .beta.-chloro (the latter only when there is a 9.alpha.-chloro); substituted at 16.alpha. (or 16.beta.) with methyl or hydrogen, and at 17.alpha. with hydroxy or an ester.
摘要翻译：某些3-氧代雄甾-4-烯和3-氧代雄甾-1,4-二烯17β-羧酸和在4-位被氟或氯取代并任选在六位被氟或氯取代的酯可用作抗炎类固醇。这些化合物任选在9位上被氟，氯或溴取代; 在11处用酮，β-羟基或β-氯代替（后者仅当存在9α-氯代时）; 在16α（或16β）与甲基或氢取代，在17α与羟基或酯取代。

6. 发明授权

US5543020A Cleaning system for electrolytic tanks 失效
标题翻译：电解槽清洗系统
公开(公告)号：US5543020A
公开(公告)日：1996-08-06
申请号：US261640
申请日：1994-06-17
申请人： Francisco J. Sitges Menendez , Fernando Sitges Menendez , Francisco Alvarez Tamargo , Ives Lefevre
发明人： Francisco J. Sitges Menendez , Fernando Sitges Menendez , Francisco Alvarez Tamargo , Ives Lefevre
IPC分类号： C25C7/00 , C25C7/06 , C25B15/00
CPC分类号： C25C7/06
摘要： A cleaning system for electrolytic tanks consisting of a cell with a preferably rectangular layout, very long relative to its width, and which is provided with at least one conduit with perforated walls, and preferably two, which run over the bottom of the cell, along its length, and ascend alongside the shorter walls until they reach, approximately, the level of liquid of the tank, said cell being provided below with surfaces which are inclined towards the perforated conduits, said conduits having sufficient cross-sectional area to act as guides through which are inserted a suction head and pipe for sludge extraction.
摘要翻译：一种用于电解池的清洁系统，其由具有优选矩形布局的电池构成，其相对于其宽度非常长，并且设置有至少一个具有穿孔壁的导管，并且优选地在电池底部延伸两个其长度，并沿着较短的墙壁上升，直到它们大致达到罐的液体水平，所述单元在下方设置有朝向穿孔的导管倾斜的表面，所述导管具有足够的横截面积以用作导轨通过它们插入用于污泥提取的吸头和管道。

7. 发明授权

US3975432A Process for preparing 2-(6-methoxy-2-naphthyl)propionic acid 失效
标题翻译：制备2-（6-甲氧基-2-萘基）丙酸的方法
公开(公告)号：US3975432A
公开(公告)日：1976-08-17
申请号：US444671
申请日：1974-02-21
申请人： Francisco Alvarez
发明人： Francisco Alvarez
IPC分类号： C07F3/06 , C07C51/09 , C07C67/00
CPC分类号： C07F3/06
摘要： 2-(6-Methoxy-2-naphthyl)propionic acid is prepared by reacting di(6-methoxy-2-naphthyl)-zinc or 6-methoxy-2-naphthylzinc halide with a lower alkyl 2-halopropionate in a suitable solvent to form a lower alkyl 2-(6-methoxy-2-naphthyl)propionate and hydrolyzing the ester group thereof. The product has anti-inflammatory, analgesic and anti-pyretic activities.
摘要翻译： 2-（6-甲氧基-2-萘基）丙酸通过二（6-甲氧基-2-萘基）锌或6-甲氧基-2-萘基锌卤化物与2-卤代丙酸低级烷基酯在合适的溶剂中反应而制备成形成2-（6-甲氧基-2-萘基）丙酸低级烷基酯并水解其酯基。该产品具有抗炎，止痛和抗焦虑活性。

8. 发明授权

US07308840B2 Torsional damper for a transmission output shaft 有权
标题翻译：传动输出轴的扭转阻尼器
公开(公告)号：US07308840B2
公开(公告)日：2007-12-18
申请号：US11160986
申请日：2005-07-19
申请人： Francisco Alvarez , Charles Poon , David Pariseau , Matthew Vance , Craig Smith
发明人： Francisco Alvarez , Charles Poon , David Pariseau , Matthew Vance , Craig Smith
IPC分类号： F16F15/12
CPC分类号： F16D3/76 , F16F15/1442 , F16H57/0006 , Y10T74/19633 , Y10T74/2131
摘要： A torsionally tuned damper assembly for a geared power transmission is disclosed. The damper assembly, at a power output end of a transmission power output shaft, has an inertia ring with a calibrated natural torsional frequency that reduces the resonance energy developed by gear rattle forces at a transmission gear mesh.
摘要翻译：公开了一种用于齿轮传动的扭转调节的阻尼器组件。在传动动力输出轴的动力输出端处的阻尼器组件具有具有校准的自然扭转频率的惯性环，其减小了传动齿轮啮合处的齿轮拨浪力产生的共振能量。

9. 发明申请

US20070017768A1 TORSIONAL DAMPER FOR A TRANSMISSION OUTPUT SHAFT 有权
标题翻译：变速箱输出轴扭矩阻尼器
公开(公告)号：US20070017768A1
公开(公告)日：2007-01-25
申请号：US11160986
申请日：2005-07-19
申请人： Francisco Alvarez , Charles Poon , David Pariseau , Matthew Vance , Craig Smith
发明人： Francisco Alvarez , Charles Poon , David Pariseau , Matthew Vance , Craig Smith
IPC分类号： F16H57/00 , F16D3/12 , F16D3/76
CPC分类号： F16D3/76 , F16F15/1442 , F16H57/0006 , Y10T74/19633 , Y10T74/2131
摘要： A torsionally tuned damper assembly for a geared power transmission is disclosed. The damper assembly, at a power output end of a transmission power output shaft, has an inertia ring with a calibrated natural torsional frequency that reduces the resonance energy developed by gear rattle forces at a transmission gear mesh.
摘要翻译：公开了一种用于齿轮传动的扭转调节的阻尼器组件。在传动动力输出轴的动力输出端处的阻尼器组件具有具有校准的自然扭转频率的惯性环，其减小了传动齿轮啮合处的齿轮拨浪力产生的共振能量。

10. 发明申请

US20050147669A1 Rapid dissolution formulation of a calcium receptor-active compound 有权
标题翻译：钙受体活性化合物的快速溶解制剂
公开(公告)号：US20050147669A1
公开(公告)日：2005-07-07
申请号：US10937870
申请日：2004-09-10
申请人： Glen Lawrence , Francisco Alvarez , Hung-Ren Lin , Tzuchi Ju
发明人： Glen Lawrence , Francisco Alvarez , Hung-Ren Lin , Tzuchi Ju
IPC分类号： A61K9/20 , A61K31/00 , A61K31/135 , A61K31/137 , A61P5/18
CPC分类号： A61K31/135 , A61K9/2077 , A61K9/2866 , A61K31/00 , A61K31/137
摘要： The present invention relates to a pharmaceutical composition comprising a therapeutically effective amount of a calcium receptor-active compound and at least one pharmaceutically acceptable excipient, wherein the composition has a controlled dissolution profile. The present invention further relates to a method of manufacturing the pharmaceutical composition, as well as a method of treating a disease using the pharmaceutical composition.
摘要翻译：本发明涉及包含治疗有效量的钙受体活性化合物和至少一种药学上可接受的赋形剂的药物组合物，其中所述组合物具有受控的溶出曲线。本发明还涉及一种制备药物组合物的方法，以及使用该药物组合物治疗疾病的方法。

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