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1. 发明授权

US5443704A Electrophoresis gel container assemblies 失效
标题翻译：电泳凝胶容器组件
公开(公告)号：US5443704A
公开(公告)日：1995-08-22
申请号：US816448
申请日：1991-12-31
申请人： Francis H. Kirkpatrick , T. Chad Willis , William Watt , Henry A. Daum, III , Satyin Kaura , Pegram A. Johnson
发明人： Francis H. Kirkpatrick , T. Chad Willis , William Watt , Henry A. Daum, III , Satyin Kaura , Pegram A. Johnson
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44704
摘要： This invention provides electrophoresis gel container assemblies comprising at least a container element, a cover element, and means for releasably sealing the cover element to the container element; methods for fabricating and for using the container assemblies; and kits comprising the container assemblies with or without precast electrophoresis gels therein in combination with at least one electrophoresis auxiliary item.
摘要翻译：本发明提供了电泳凝胶容器组件，其包括至少一个容器元件，盖元件和用于将盖元件可释放地密封到容器元件的装置; 用于制造和使用容器组件的方法; 以及包括具有或不具有预先电泳凝胶的容器组件的试剂盒，其与至少一种电泳辅助物质组合。

2. 发明授权

US4983268A High gel strength low electroendosmosis agarose 失效
标题翻译：高凝胶强度低电沉积琼脂糖
公开(公告)号：US4983268A
公开(公告)日：1991-01-08
申请号：US389141
申请日：1989-08-03
申请人： Francis H. Kirkpatrick , Kenneth Guiseley , Richard Provonchee , Samuel Nochumson
发明人： Francis H. Kirkpatrick , Kenneth Guiseley , Richard Provonchee , Samuel Nochumson
IPC分类号： B01D57/02 , B01J13/00 , C07K1/24 , C07K1/26 , C08B37/00 , C08B37/12 , C12M1/00 , G01N27/447
CPC分类号： B01D57/02 , C07K1/24 , C07K1/26 , C08B37/0039 , G01N27/44752
摘要： Purified agarose suitable for rapid electrophoresis, characterized by a sulfate content of less than 0.2 wt % but greater than zero, a pyruvate content of 0-0.1 wt %, and a nitrogen content of 0-0.02 wt %. Gels prepared from the agarose exhibit a gel strength at 1.0 wt % concentration of at least 1200 g/cm.sup.2, substantial absence of DNA binding in 0.07 M or less tris acetate buffer, and an electroendosmosis (EEO) at 1.0 wt % concentration of 0.05 or less. Agaroses are purified to provide the low EEO material by dissolving agarose or alkali-modified agar in an aqueous medium buffered at a pH of 6.0 to 8.0 and containing no more than 2.0 nM salt as chloride, and precipitating the agarose by contact with a lower alkanol.
摘要翻译：适用于快速电泳的纯化琼脂糖，其特征在于硫酸盐含量小于0.2重量％但大于零，丙酮酸含量为0-0.1重量％，氮含量为0-0.02重量％。从琼脂糖制备的凝胶显示1.0重量％浓度至少为1200g / cm 2的凝胶强度，在0.07M或更少的三乙酸盐缓冲液中基本上不存在DNA结合，以及1.0wt％浓度为0.05的电沉积（EEO）或减。纯化Agaroses以通过将琼脂糖或碱改性琼脂溶解在pH 6.0至8.0的缓冲液中并含有不超过2.0nM的盐作为氯化物，并通过与低级链烷醇接触沉淀琼脂糖而提供低EEO材料。

3. 发明授权

US06197173B1 Methods and reagents for gel electrophoresis 失效
标题翻译：凝胶电泳方法和试剂
公开(公告)号：US06197173B1
公开(公告)日：2001-03-06
申请号：US09344906
申请日：1999-06-26
申请人： Francis H. Kirkpatrick
发明人： Francis H. Kirkpatrick
IPC分类号： C08F246
CPC分类号： G01N27/44747 , C08F220/56
摘要： Polymerization of gels for electrophoresis with improved photoinitiators results in gels which are suitable for electrophoresis. The new initiator systems are much faster than current systems for making such gels. Moreover, the polymerization reaction can be conducted in the presence of oxygen, which greatly simplifies gel casting. In particular, it is possible with the invention to cast and use gels of acrylic monomers in a “submarine” mode, which was not previously possible with acrylamide gels. Continuous casting of gels is facilitated.
摘要翻译：用改进的光引发剂进行电泳聚合，得到适合电泳的凝胶。新的启动器系统比用于制造这种凝胶的当前系统要快得多。此外，聚合反应可以在氧的存在下进行，这大大简化了凝胶浇铸。特别地，本发明可以以“潜艇”模式铸造和使用丙烯酸类单体的凝胶，丙烯酰胺凝胶以前不可能。连续铸造凝胶是有利的。

4. 发明授权

US5143646A Polysaccharide resolving gels and gel systems for stacking electrophoresis 失效
标题翻译：多糖分解凝胶和凝胶体系用于层叠电泳
公开(公告)号：US5143646A
公开(公告)日：1992-09-01
申请号：US691041
申请日：1991-06-20
申请人： Samuel Nochumson , Foner P. Curtis , Jonathan H. Morgan , Francis H. Kirkpatrick
发明人： Samuel Nochumson , Foner P. Curtis , Jonathan H. Morgan , Francis H. Kirkpatrick
IPC分类号： G01N27/447 , B01D57/02 , B01J13/00 , B01J13/02 , B01J19/08 , C08B37/12 , C08L5/12 , C25D13/06
CPC分类号： G01N27/44747 , B01J19/082 , C08L5/12 , Y10S436/806
摘要： Electrophoretic resolving gel compositions, discontinuous stacking gel systems containing these and other resolving gel compositions, and kits for preparing such gel systems, comprising one or more polysaccharide hydrogels of which agarose is typical wherein at least one of the gels in the resolving gel composition has been derivatized and at least one of the gels in the resolving gel composition has been depolymerized sufficiently to reduce its casting-effective viscosity.
摘要翻译： PCT No.PCT / US90 / 00184 Sec。 371日期1991年6月20日 102（e）1991年6月20日PCT PCT。1990年1月16日。电泳分辨凝胶组合物，含有这些和其它拆分凝胶组合物的不连续堆叠凝胶体系，以及用于制备这种凝胶体系的试剂盒，其包含一种或多种多糖水凝胶其中所述琼脂糖是典型的，其中拆分凝胶组合物中的至少一种凝胶已被衍生化，并且拆分凝胶组合物中的至少一种凝胶已被充分解聚以降低其铸造有效粘度。

5. 发明授权

US5277915A Gel-in-matrix containing a fractured hydrogel 失效
$Gel-in-matrix containing a fractured hydrogel$
标题翻译：含有裂缝水凝胶的凝胶基质
公开(公告)号：US5277915A
公开(公告)日：1994-01-11
申请号：US861155
申请日：1992-03-27
申请人： Richard B. Provonchee , Francis H. Kirkpatrick
发明人： Richard B. Provonchee , Francis H. Kirkpatrick
IPC分类号： B01D15/08 , B01J20/28 , B01J47/00 , C08J9/42 , A61K9/14 , C08J5/20 , C12N1/16
CPC分类号： B01J20/28026 , B01D15/08 , B01J20/28028 , B01J20/28033 , B01J20/28042 , B01J20/28045 , B01J20/28047 , B01J20/28069 , B01J20/28078 , B01J47/007 , C08J9/42 , B01D15/34 , C08J2205/02 , C08J2403/00 , Y10T428/249955 , Y10T428/249958 , Y10T428/249994 , Y10T428/2967 , Y10T428/2982 , Y10T442/2033
摘要： A three dimensional porous matrix, such as a reticulated open-cell foam, having within its matrix structure a mechanically-fractured hydrogel containing a network of fracture channels. The mechanically-fractured hydrogel may be a gel that has been partially dewatered by compression of the gel in situ.The porosity of the gel-in-matrix makes it useful for chromatographic applications and for immobilization of biologically-active components, where efficient, intimate contact of the hydrogel with a liquid medium is important.
摘要翻译：三维多孔基质，例如网状开孔泡沫，在其基质结构内具有包含断裂通道网络的机械断裂的水凝胶。机械断裂的水凝胶可以是通过原位压缩凝胶而部分脱水的凝胶。凝胶基质的孔隙度使其对于色谱应用和固定生物活性组分是有用的，其中水凝胶与液体介质的有效的紧密接触是重要的。

6. 发明授权

US5916427A Methods and reagents for gel electrophoresis 失效
标题翻译：凝胶电泳方法和试剂
公开(公告)号：US5916427A
公开(公告)日：1999-06-29
申请号：US746077
申请日：1996-11-06
申请人： Francis H Kirkpatrick
发明人： Francis H Kirkpatrick
IPC分类号： C08F2/46 , C08F220/56 , G01N27/447 , G01N27/26
CPC分类号： G01N27/44747 , C08F220/56
摘要： Polymerization of gels for electrophoresis with improved photoinitiators results in gels which are suitable for electrophoresis. The new initiator systems are much faster than current systems for making such gels. Moreover, the polymerization reaction can be conducted in the presence of oxygen, which greatly simplifies gel casting. In particular, it is possible with the invention to cast and use gels of acrylic monomers in a "submarine" mode, which was not previously possible with acrylamide gels. Continuous casting of gels is facilitated.
摘要翻译：用改进的光引发剂进行电泳聚合，得到适合电泳的凝胶。新的启动器系统比用于制造这种凝胶的当前系统要快得多。此外，聚合反应可以在氧的存在下进行，这大大简化了凝胶浇铸。特别地，本发明可以以“潜艇”模式铸造和使用丙烯酸类单体的凝胶，丙烯酰胺凝胶以前不可能。连续铸造凝胶是有利的。

7. 发明申请

US20100331067A1 Multidimensional crossword game and puzzle 审中-公开
标题翻译：多维填字游戏和拼图
公开(公告)号：US20100331067A1
公开(公告)日：2010-12-30
申请号：US12803379
申请日：2010-06-25
申请人： Francis H. Kirkpatrick
发明人： Francis H. Kirkpatrick
IPC分类号： A63F9/24
CPC分类号： A63F3/00643
摘要： A multidimensional crossword game or puzzle has three or four functional dimensions, two physical and one or two representational, laid out on a planar board. Rules of play are applied on a two dimensional array of boards to achieve this multidimensional effect. Completion of a legal word can occur in any one of the three or four dimensions. Rules of the game may require that after the first word is played, subsequent words must contain at least one letter from a previously played word. Crossword puzzle rules and conventions can be similar to existing puzzles. Vertical stacking of pieces on one or more cells can be used to create the effect of an additional dimension on these boards.
摘要翻译：多维填字游戏或拼图具有三个或四个功能尺寸，两个物理和一个或两个表示，布置在平面板上。游戏规则应用于二维阵列阵列以实现这种多维效果。法律词汇的完成可以在三个或四个维度中的任何一个中发生。游戏规则可能要求在播放第一个单词之后，后续单词必须至少包含一个来自以前播放的单词的字母。纵横字谜规则和约定可以与现有的谜题相似。可以在一个或多个单元上垂直堆叠碎片，以在这些板上产生附加尺寸的效果。

8. 发明授权

US06254098B1 Practical four-dimensional tic-tac-toe 有权
标题翻译：实用的四维tic-tac-toe
公开(公告)号：US06254098B1
公开(公告)日：2001-07-03
申请号：US09260165
申请日：1999-03-01
申请人： Francis H Kirkpatrick
发明人： Francis H Kirkpatrick
IPC分类号： A63F300
CPC分类号： A63F3/00643 , A63F3/00094 , A63F2003/0022 , A63F2009/2485
摘要： A layout which is practically useful for playing tic-tac-toe (TTT) in four dimensions is disclosed. The layout consists of an array of tiles, each tile containing a 5×5 array of substantially square cells, where the tiles are arrayed in a 5×5 pattern. For ease of visual interpretation, the tiles are preferably separated by approximately the width of a cell. The layout is implemented physically or as an electronic program coupled to a display. The rules are analogous to classical TTT; two variants are described.
摘要翻译：披露了一种在四维方面实现有趣的布局。布局由瓦片阵列组成，每个瓦片包含基本上为方形单元格的5x5阵列，其中瓦片以5x5格局排列。为了便于视觉解释，瓦片优选地分开大约单元格的宽度。该布局物理地或者作为耦合到显示器的电子程序来实现。规则类似于传统的TTT; 描述了两种变体。

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