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1. 发明申请

US20090269279A1 Toxicology and Cellular Effect of Manufactured Nanomaterials 有权
标题翻译：制造纳米材料的毒理学和细胞效应
公开(公告)号：US20090269279A1
公开(公告)日：2009-10-29
申请号：US12111026
申请日：2008-04-28
申请人： Fanqing Chen
发明人： Fanqing Chen
IPC分类号： A61K49/00 , C12Q1/68 , C12Q1/02 , C40B30/00 , A61K9/14
CPC分类号： C12Q1/6883 , A61K47/6855 , A61K47/6925 , B82Y5/00 , C12Q2600/106 , C12Q2600/142 , C12Q2600/158 , G01N33/5014
摘要： The increasing use of nanotechnology in consumer products and medical applications underlies the importance of understanding its potential toxic effects to people and the environment. Herein are described methods and assays to predict and evaluate the cellular effects of nanomaterial exposure. Exposing cells to nanomaterials at cytotoxic doses induces cell cycle arrest and increases apoptosis/necrosis, activates genes involved in cellular transport, metabolism, cell cycle regulation, and stress response. Certain nanomaterials induce genes indicative of a strong immune and inflammatory response within skin fibroblasts. Furthermore, the described multiwall carbon nanoonions (MWCNOs) can be used as a therapeutic in the treatment of cancer due to its cytotoxicity.
摘要翻译：在消费品和医疗应用中越来越多地使用纳米技术是了解其对人类和环境的潜在毒性作用的重要性的基础。本文描述了预测和评估纳米材料暴露的细胞效应的方法和测定法。以细胞毒性剂量将细胞暴露于纳米材料诱导细胞周期停滞并增加凋亡/坏死，激活参与细胞运输，代谢，细胞周期调节和应激反应的基因。某些纳米材料诱导表达皮肤成纤维细胞中强烈的免疫和炎症反应的基因。此外，由于其细胞毒性，所述多壁碳纳米管（MWCNO）可用作治疗癌症的治疗剂。

2. 发明申请

US20080118941A1 Signal Peptide-Semiconductor Nanocrystal Conjugates 审中-公开
标题翻译：信号肽 - 半导体纳米晶体共轭体
公开(公告)号：US20080118941A1
公开(公告)日：2008-05-22
申请号：US11661946
申请日：2005-09-02
申请人： Fanqing Chen , Daniele Gerion
发明人： Fanqing Chen , Daniele Gerion
IPC分类号： C12Q1/02 , C07K7/00 , C07K14/00 , G01N33/58 , C12N5/06 , C07K2/00 , C07K7/08
CPC分类号： B82Y15/00 , A61K47/6923 , A61K47/6929 , A61K49/0056 , A61K49/0067 , B82Y5/00 , G01N33/588
摘要： The present invention provides signal peptide-semiconductor nanocrystal-peptide conjugates and methods for using the conjugates in methods for imaging live cells and subcellular trafficking processes.
摘要翻译：本发明提供了信号肽半导体纳米晶体 - 肽缀合物以及在用于成像活细胞和亚细胞运输过程的方法中使用缀合物的方法。

3. 发明授权

US09037214B2 Multi-modality nanoparticles having optically responsive shape 有权
标题翻译：具有光学响应形状的多模态纳米颗粒
公开(公告)号：US09037214B2
公开(公告)日：2015-05-19
申请号：US13202976
申请日：2010-02-23
申请人： Fanqing Chen , Louis-Serge Bouchard
发明人： Fanqing Chen , Louis-Serge Bouchard
IPC分类号： B82Y15/00 , A61K49/00 , A61K49/18 , A61K49/22 , B22F1/00 , B22F1/02 , B82Y30/00 , A61K51/12 , B82Y5/00
CPC分类号： A61K49/0002 , A61K49/183 , A61K49/1857 , A61K49/1866 , A61K49/1875 , A61K49/225 , A61K51/1244 , B22F1/0018 , B22F1/025 , B22F2998/00 , B82Y5/00 , B82Y30/00 , Y10S977/712 , Y10S977/888 , Y10S977/89 , Y10S977/902 , Y10T428/2991 , B22F1/0025
摘要： In certain embodiments novel nanoparticles (nanowontons) are provided that are suitable for multimodal imaging and/or therapy. In one embodiment, the nanoparticles include a first biocompatible (e.g., gold) layer, an inner core layer (e.g., a non-biocompatible material), and a biocompatible (e.g., gold) layer. The first gold layer includes a concave surface that forms a first outer surface of the layered nanoparticle. The second gold layer includes a convex surface that forms a second outer surface of the layered nanoparticle. The first and second gold layers encapsulate the inner core material layer. Methods of fabricating such nanoparticles are also provided.
摘要翻译：在某些实施方案中，提供适用于多模式成像和/或治疗的新型纳米颗粒（纳米酮）。在一个实施方案中，纳米颗粒包括第一生物相容性（例如金）层，内芯层（例如，非生物相容性材料）和生物相容性（例如金）层。第一金层包括形成层状纳米颗粒的第一外表面的凹面。第二金层包括形成层状纳米颗粒的第二外表面的凸表面。第一和第二金层封装内芯材料层。还提供了制造这种纳米颗粒的方法。

4. 发明申请

US20120136241A1 Multi-Modality Nanoparticles Having Optically Responsive Shape 有权
标题翻译：具有光学响应形状的多模式纳米粒子
公开(公告)号：US20120136241A1
公开(公告)日：2012-05-31
申请号：US13202976
申请日：2010-02-23
申请人： Fanqing Chen , Louis-Serge Bouchard
发明人： Fanqing Chen , Louis-Serge Bouchard
IPC分类号： A61B5/055 , B05D5/00 , B29C41/42 , B29C41/38 , B32B5/16 , B29C41/22 , B82Y40/00 , B82Y5/00
CPC分类号： A61K49/0002 , A61K49/183 , A61K49/1857 , A61K49/1866 , A61K49/1875 , A61K49/225 , A61K51/1244 , B22F1/0018 , B22F1/025 , B22F2998/00 , B82Y5/00 , B82Y30/00 , Y10S977/712 , Y10S977/888 , Y10S977/89 , Y10S977/902 , Y10T428/2991 , B22F1/0025
摘要： In certain embodiments novel nanoparticles (nanowontons) are provided that are suitable for multimodal imaging and/or therapy. In one embodiment, the nanoparticles include a first biocompatible (e.g., gold) layer, an inner core layer (e.g., a non-biocompatible material), and a biocompatible (e.g., gold) layer. The first gold layer includes a concave surface that forms a first outer surface of the layered nanoparticle. The second gold layer includes a convex surface that forms a second outer surface of the layered nanoparticle. The first and second gold layers encapsulate the inner core material layer. Methods of fabricating such nanoparticles are also provided.
摘要翻译：在某些实施方案中，提供适用于多模式成像和/或治疗的新型纳米颗粒（纳米酮）。在一个实施方案中，纳米颗粒包括第一生物相容性（例如金）层，内芯层（例如，非生物相容性材料）和生物相容性（例如金）层。第一金层包括形成层状纳米颗粒的第一外表面的凹面。第二金层包括形成层状纳米颗粒的第二外表面的凸表面。第一和第二金层包封内芯材料层。还提供了制造这种纳米颗粒的方法。

5. 发明授权

US08440423B2 Bioremediation of nanomaterials 有权
标题翻译：纳米材料的生物修复
公开(公告)号：US08440423B2
公开(公告)日：2013-05-14
申请号：US12525875
申请日：2008-02-05
申请人： Frank Fanqing Chen , Jay D. Keasling , Yinjie J. Tang
发明人： Frank Fanqing Chen , Jay D. Keasling , Yinjie J. Tang
IPC分类号： C12Q1/02
CPC分类号： C12N1/20 , B82Y5/00 , C02F3/34 , C02F2103/36 , C12P3/00 , C12P7/02 , C12P13/001 , C12Q1/025
摘要： The present invention provides a method comprising the use of microorganisms for nanotoxicity study and bioremediation. In some embodiment, the microorganisms are bacterial organisms such as Gram negative bacteria, which are used as model organisms to study the nanotoxicity of the fullerene compounds: E. coli W3110, a human related enterobacterium and Shewanella oneidensis MR-1, an environmentally important bacterium with versatile metabolism.
摘要翻译：本发明提供一种包括使用微生物进行纳米毒性研究和生物修复的方法。在一些实施方案中，微生物是诸如革兰氏阴性细菌的细菌生物，其用作模型生物体以研究富勒烯化合物的纳米毒性：大肠杆菌W3110，人相关肠杆菌和一种环境重要的细菌具有多才多艺的新陈代谢。

6. 发明申请

US20120315218A9 Toxicology and Cellular Effect of Manufactured Nanomaterials 有权
标题翻译：制造纳米材料的毒理学和细胞效应
公开(公告)号：US20120315218A9
公开(公告)日：2012-12-13
申请号：US12111026
申请日：2008-04-28
申请人： Fanqing Chen
发明人： Fanqing Chen
IPC分类号： A61K49/00 , A61K9/14 , C40B30/00 , C12Q1/68 , C12Q1/02
CPC分类号： C12Q1/6883 , A61K47/6855 , A61K47/6925 , B82Y5/00 , C12Q2600/106 , C12Q2600/142 , C12Q2600/158 , G01N33/5014
摘要： The increasing use of nanotechnology in consumer products and medical applications underlies the importance of understanding its potential toxic effects to people and the environment. Herein are described methods and assays to predict and evaluate the cellular effects of nanomaterial exposure. Exposing cells to nanomaterials at cytotoxic doses induces cell cycle arrest and increases apoptosis/necrosis, activates genes involved in cellular transport, metabolism, cell cycle regulation, and stress response. Certain nanomaterials induce genes indicative of a strong immune and inflammatory response within skin fibroblasts. Furthermore, the described multiwall carbon nanoonions (MWCNOs) can be used as a therapeutic in the treatment of cancer due to its cytotoxicity.
摘要翻译：在消费品和医疗应用中越来越多地使用纳米技术是了解其对人类和环境的潜在毒性作用的重要性的基础。本文描述了预测和评估纳米材料暴露的细胞效应的方法和测定法。以细胞毒性剂量将细胞暴露于纳米材料诱导细胞周期停滞并增加凋亡/坏死，激活参与细胞运输，代谢，细胞周期调节和应激反应的基因。某些纳米材料诱导表达皮肤成纤维细胞中强烈的免疫和炎症反应的基因。此外，由于其细胞毒性，所述多壁碳纳米管（MWCNO）可用作治疗癌症的治疗剂。

7. 发明申请

US20180015470A1 MICROFLUIDICS BASED FETAL CELL DETECTION AND ISOLATION FOR NON-INVASIVE PRENATAL TESTING 审中-公开
公开(公告)号：US20180015470A1
公开(公告)日：2018-01-18
申请号：US15545604
申请日：2016-01-19
申请人： Fanqing Chen , Unimed Biotech (Shanghai) Co., Ltd.
发明人： Fanqing Chen , Tania Chakrabarty
IPC分类号： B01L3/00 , C12Q1/68
CPC分类号： B01L3/502753 , B01L2200/0647 , B01L2200/0668 , B01L2300/0681 , C12N5/0641 , C12N2501/599 , C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , G01N33/5302 , G01N33/56966 , G01N33/80
摘要： Embodiments disclosed herein provides methods for isolation of fetal cells for non-invasive prenatal diagnosis, comprising: providing a maternal blood sample; applying the maternal blood sample to a filter integrated on a microfluidic device to thereby enrich the nucleated blood cells from the maternal blood sample; labeling the enriched nucleated blood cells, within the microfluidic device, with a fluorescent binding moiety or affinity molecule that specifically binds to a fetal cell-specific antigen or a non-fetal cell-specific antigen; and isolating the fetal cells. Embodiments disclosed herein provide integrated microfluidic devices for non-invasive isolation of fetal cells, comprising: a filter; a binding moiety or affinity molecule that specifically binds to a fetal cell-specific antigen or a non-fetal cell-specific antigen; and a microscopy-visualizable chamber.

8. 发明授权

US08785505B2 Toxicology and cellular effect of manufactured nanomaterials 有权
标题翻译：制造纳米材料的毒理学和细胞效应
公开(公告)号：US08785505B2
公开(公告)日：2014-07-22
申请号：US12111026
申请日：2008-04-28
申请人： Fanqing Chen
发明人： Fanqing Chen
IPC分类号： A61K31/015
CPC分类号： C12Q1/6883 , A61K47/6855 , A61K47/6925 , B82Y5/00 , C12Q2600/106 , C12Q2600/142 , C12Q2600/158 , G01N33/5014
摘要： The increasing use of nanotechnology in consumer products and medical applications underlies the importance of understanding its potential toxic effects to people and the environment. Herein are described methods and assays to predict and evaluate the cellular effects of nanomaterial exposure. Exposing cells to nanomaterials at cytotoxic doses induces cell cycle arrest and increases apoptosis/necrosis, activates genes involved in cellular transport, metabolism, cell cycle regulation, and stress response. Certain nanomaterials induce genes indicative of a strong immune and inflammatory response within skin fibroblasts. Furthermore, the described multiwall carbon nanoonions (MWCNOs) can be used as a therapeutic in the treatment of cancer due to its cytotoxicity.
摘要翻译：在消费品和医疗应用中越来越多地使用纳米技术是了解其对人类和环境的潜在毒性作用的重要性的基础。本文描述了预测和评估纳米材料暴露的细胞效应的方法和测定法。以细胞毒性剂量将细胞暴露于纳米材料诱导细胞周期停滞并增加凋亡/坏死，激活参与细胞运输，代谢，细胞周期调节和应激反应的基因。某些纳米材料诱导表达皮肤成纤维细胞中强烈的免疫和炎症反应的基因。此外，由于其细胞毒性，所述多壁碳纳米管（MWCNO）可用作治疗癌症的治疗剂。

9. 发明申请

US20110039291A1 Bioremediation of Nanomaterials 有权
标题翻译：纳米材料的生物修复
公开(公告)号：US20110039291A1
公开(公告)日：2011-02-17
申请号：US12525875
申请日：2008-02-05
申请人： Frank Fanqing Chen , Jay D. Keasling , Yinjie J. Tang
发明人： Frank Fanqing Chen , Jay D. Keasling , Yinjie J. Tang
IPC分类号： C12Q1/02 , C02F3/34 , B82Y99/00
CPC分类号： C12N1/20 , B82Y5/00 , C02F3/34 , C02F2103/36 , C12P3/00 , C12P7/02 , C12P13/001 , C12Q1/025
摘要： The present invention provides a method comprising the use of microorganisms for nanotoxicity study and bioremediation. In some embodiment, the microorganisms are bacterial organisms such as Gram negative bacteria, which are used as model organisms to study the nanotoxicity of the fullerene compounds: E. coli W3110, a human related enterobacterium and Shewanella oneidensis MR-1, an environmentally important bacterium with versatile metabolism.
摘要翻译：本发明提供一种包括使用微生物进行纳米毒性研究和生物修复的方法。在一些实施方案中，微生物是诸如革兰氏阴性细菌的细菌生物，其用作模型生物体以研究富勒烯化合物的纳米毒性：大肠杆菌W3110，人相关肠杆菌和一种环境重要的细菌具有多才多艺的新陈代谢。

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