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1. 发明授权

US07795388B2 Versatile platform for nanotechnology based on circular permutations of chaperonin protein 有权
标题翻译：基于伴侣蛋白的循环排列的纳米技术多功能平台
公开(公告)号：US07795388B2
公开(公告)日：2010-09-14
申请号：US11194991
申请日：2005-08-01
申请人： Chad D. Paavola , Jonathan D. Trent , Suzanne L. Chan , Yi-Fen Li , R. Andrew McMillan , Hiromi Kagawa
发明人： Chad D. Paavola , Jonathan D. Trent , Suzanne L. Chan , Yi-Fen Li , R. Andrew McMillan , Hiromi Kagawa
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： C07K14/47 , B82Y30/00
摘要： The present invention provides chaperonin polypeptides which are modified to include N-terminal and C-terminal ends that are relocated from the central pore region to various different positions in the polypeptide which are located on the exterior of the folded modified chaperonin polypeptide. In the modified chaperonin polypeptide, the naturally-occurring N-terminal and C-terminal ends are joined together directly or with an intervening linker peptide sequence. The relocated N-terminal or C-terminal ends can be covalently joined to, or bound with another molecule such as a nucleic acid molecule, a lipid, a carbohydrate, a second polypeptide, or a nanoparticle. The modified chaperonin polypeptides can assemble into double-ringed chaperonin structures. Further, the chaperonin structures can organize into higher order structures such as nanofilaments or nanoarrays which can be used to produce nanodevices and nanocoatings.
摘要翻译：本发明提供了伴侣伴侣多肽，其被修饰为包括从位于折叠的修饰的伴侣蛋白多肽的外部的多肽中的中心孔区域重新定位到各种不同位置的N末端和C末端。在修饰的伴侣蛋白多肽中，天然存在的N-末端和C-末端直接连接在一起或与插入的接头肽序列连接在一起。重新定位的N-末端或C-末端可共价连接至另一分子例如核酸分子，脂质，碳水化合物，第二多肽或纳米颗粒。修饰的伴侣蛋白多肽可以组装成双环伴侣蛋白结构。此外，伴侣蛋白结构可以组织成更高级的结构，例如可用于制备纳米装置和纳米涂层的纳米丝或纳米阵列。

2. 发明申请

US20100026505A1 DIGITAL PHOTO FRAME WITH BATTERY INDICATOR 审中-公开
标题翻译：带电池指示器的数码相框
公开(公告)号：US20100026505A1
公开(公告)日：2010-02-04
申请号：US12475580
申请日：2009-05-31
申请人： HAN-CHE WANG , XIAO-GUANG LI , YUNG-YI WANG , FENG ZHU , FEN LI
发明人： HAN-CHE WANG , XIAO-GUANG LI , YUNG-YI WANG , FENG ZHU , FEN LI
IPC分类号： G08B21/00
CPC分类号： G01R31/3646
摘要： A digital photo frame (DPF) capable of indicating battery is provided. The DPF includes a light-emitting diode (LED) unit, a battery, a battery detection unit, a processing unit, and a display control unit. The battery detection unit is connected to the battery and is configured to detect the charge of the battery and output a low battery alarm signal when the charge of the battery is below a predetermined value. The processing unit is connected to the battery detection unit, and is configured to producing a control signal when receiving the low battery alarm signal. The display control unit is connected to the processing unit and the LED unit, and is configured to control the LED unit to change its display state when receiving the control signal.
摘要翻译：提供能够指示电池的数码相框（DPF）。 DPF包括发光二极管（LED）单元，电池，电池检测单元，处理单元和显示控制单元。电池检测单元连接到电池，并且被配置为当电池的电量低于预定值时检测电池的电量并输出低电量警报信号。处理单元连接到电池检测单元，并且被配置为在接收到低电量警报信号时产生控制信号。显示控制单元连接到处理单元和LED单元，并且被配置为在接收到控制信号时控制LED单元改变其显示状态。

3. 发明申请

US20100013810A1 INTELLIGENT DIGITAL PHOTO FRAME 失效
标题翻译：智能数码相框
公开(公告)号：US20100013810A1
公开(公告)日：2010-01-21
申请号：US12475579
申请日：2009-05-31
申请人： SHIN-HONG CHUNG , XIAO-GUANG LI , HAN-CHE WANG , FEN LI , KUAN-HONG HSIEH , FENG ZHU
发明人： SHIN-HONG CHUNG , XIAO-GUANG LI , HAN-CHE WANG , FEN LI , KUAN-HONG HSIEH , FENG ZHU
IPC分类号： G09G5/00 , H04N5/64
CPC分类号： G09G3/20 , G09G2330/021 , G09G2330/022 , G09G2360/144
摘要： A digital photo frame (DPF) includes a power source, a display panel, a light detector, a motion detector, a processing unit, and a power management unit. The light detector is configured to detect the ambient brightness. The motion detection unit is configured to detect whether anyone is around. The processing unit is connected to the light detector and the motion detector. If the motion detector detects someone is around the DPF and the light detector detects the ambient brightness is below a predetermined value, the processing unit controls the power management unit to provide power to the display panel.
摘要翻译：数字相框（DPF）包括电源，显示面板，光检测器，运动检测器，处理单元和电源管理单元。光检测器被配置为检测环境亮度。运动检测单元被配置为检测是否有人在附近。处理单元连接到光检测器和运动检测器。如果运动检测器检测到有人在DPF周围，并且光检测器检测到环境亮度低于预定值，则处理单元控制电力管理单元向显示面板提供电力。

4. 发明申请

US20090265159A1 SPEECH RECOGNITION METHOD FOR BOTH ENGLISH AND CHINESE 失效
标题翻译：两种英语和中文的语音识别方法
公开(公告)号：US20090265159A1
公开(公告)日：2009-10-22
申请号：US12248924
申请日：2008-10-10
申请人： Tze-Fen LI , Tai-Jan Lee Li , Shih-Tzung Li , Shih-Hon Li , Li-Chuan Liao
发明人： Tze-Fen LI , Tai-Jan Lee Li , Shih-Tzung Li , Shih-Hon Li , Li-Chuan Liao
IPC分类号： G06F17/20
CPC分类号： G10L15/02
摘要： The present invention can recognize both English and Chinese at the same time. The most important skill is that the features of all English words (without samples) are entirely extracted from the features of Chinese syllables. The invention normalizes the signal waveforms of variable lengths for English words (Chinese syllables) such that the same words (syllables) can have the same features at the same time position. Hence the Bayesian classifier can recognize both the fast and slow utterance of sentences. The invention can improve the feature such that the speech recognition of the unknown English (Chinese) is guaranteed to be correct. Furthermore, since the invention can create the features of English words from the features of Chinese syllables, it can also create the features of other languages from the features of Chinese syllables and hence it can also recognize other languages, such as German, French, Japanese, Korean, Russian, etc.
摘要翻译：本发明可同时识别英文和中文。最重要的技能是所有英文单词（不含样本）的特征完全从中文音节的特征中提取出来。本发明使英文单词（中文音节）的可变长度的信号波形标准化，使得相同的单词（音节）可以在同一时间位置具有相同的特征。因此，贝叶斯分类器可以识别句子的快速和慢速发音。本发明可以改善特征，使得未知英语（中文）的语音识别被保证是正确的。此外，由于本发明可以从中文音节的特征中产生英文单词的特征，还可以从中文音节的特点创建其他语言的特征，因此也可以识别其他语言，如德语，法语，日语，韩语，俄语等

5. 发明申请

US20090160823A1 Optical Contact Controlled Medium Display 审中-公开
标题翻译：光学接触控制中等显示
公开(公告)号：US20090160823A1
公开(公告)日：2009-06-25
申请号：US12037160
申请日：2008-02-26
申请人： Shu-Fen Li
发明人： Shu-Fen Li
IPC分类号： G06F3/042
CPC分类号： G06F3/0421
摘要： An optical contact controlled medium display includes a computing device containing at least one information, an indication device connected to the computing device via a video signal unit to indicate the at least one information of the computing device, and an optical position detection device mounted on the indication device and electrically connected to the computing device. Thus, when the indication device is provided with a touch points the optical position detection device detects a position signal of the touch point from the indication device and transmits the position signal of the touch point to the computing device so that the computing device can compute a position of the touch point.
摘要翻译：光接触控制介质显示器包括包含至少一个信息的计算设备，经由视频信号单元连接到所述计算设备的指示设备，以指示所述计算设备的所述至少一个信息，以及安装在所述计算设备上的光学位置检测设备指示装置并且电连接到计算装置。因此，当指示装置设置有触摸点时，光学位置检测装置从指示装置检测触摸点的位置信号，并将触摸点的位置信号发送到计算装置，使得计算装置可以计算出触摸点的位置。

6. 外观设计

USD589751S1 Electric travel mug 有权
标题翻译：电动旅行杯
公开(公告)号：USD589751S1
公开(公告)日：2009-04-07
申请号：US29298336
申请日：2007-12-03
申请人： Chih-Hsiang Liu , Shu-Fen Li
设计人： Chih-Hsiang Liu , Shu-Fen Li

7. 外观设计

USD589750S1 Electric travel mug 有权
公开(公告)号：USD589750S1
公开(公告)日：2009-04-07
申请号：US29298335
申请日：2007-12-03
申请人： Chih-Hsiang Liu , Shu-Fen Li
设计人： Chih-Hsiang Liu , Shu-Fen Li

8. 发明申请

US20110300536A1 GENE MARKER AND METHOD FOR DETECTION OF ORAL CANCER 审中-公开
标题翻译：基因标记和检测口腔癌的方法
公开(公告)号：US20110300536A1
公开(公告)日：2011-12-08
申请号：US12901219
申请日：2010-10-08
申请人： Yu-Fen Li , Chien-Kuo Tai
发明人： Yu-Fen Li , Chien-Kuo Tai
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156
摘要： A gene marker for the detection of oral cancer, comprising methylated CpG sites in target genes, is provided. The CpG sites in the target genes are selected from a group consisting of the following CpG sites: FLT4_E206_F, ASCL1_E24_F, KDR_E79_F, TFPI2_P9_F, TERT_E20_F, ADCYAP1_P455_R, MT1A_P49_R, and combinations thereof. A method for the detection of oral cancer, comprising the following steps is also provided: a) providing a sample to be examined from an individual; b) detecting a methylation state of at least one CpG site in a target gene on the genomic DNA from cells of the sample, wherein the CpG site in the target gene is selected from a group consisting of the following CpG sites: FLT4_E206_F, ASCL1_E24_F, KDR_E79_F, TFPI2_P9_F, TERT_E20_F, ADCYAP1_P455_R, and MT1A_P49_R; and c) determining if the individual has oral cancer based on the methylation state of the selected CpG site in the target gene.
摘要翻译：提供了用于检测靶基因中的甲基化CpG位点的口腔癌检测的基因标记。靶基因中的CpG位点选自以下CpG位点：FLT4_E206_F，ASCL1_E24_F，KDR_E79_F，TFPI2_P9_F，TERT_E20_F，ADCYAP1_P455_R，MT1A_P49_R及其组合。还提供了一种用于检测口腔癌的方法，包括以下步骤：a）从个体提供待检查的样品; b）检测来自样品细胞的基因组DNA中靶基因中至少一个CpG位点的甲基化状态，其中靶基因中的CpG位点选自以下CpG位点：FLT4_E206_F，ASCL1_E24_F， KDR_E79_F，TFPI2_P9_F，TERT_E20_F，ADCYAP1_P455_R和MT1A_P49_R; 以及c）基于靶基因中所选择的CpG位点的甲基化状态来确定个体是否具有口腔癌。

9. 发明申请

US20100026914A1 DIGITAL PHOTO FRAME CAPABLE OF AUTOMATICALLY CHANGING DISPLAY MODE 审中-公开
标题翻译：数码相框可自动更改显示模式
公开(公告)号：US20100026914A1
公开(公告)日：2010-02-04
申请号：US12475578
申请日：2009-05-31
申请人： SHIN-HONG CHUNG , XIAO-GUANG LI , HAN-CHE WANG , FENG ZHU , KUAN-HONG HSIEH , FEN LI
发明人： SHIN-HONG CHUNG , XIAO-GUANG LI , HAN-CHE WANG , FENG ZHU , KUAN-HONG HSIEH , FEN LI
IPC分类号： H04N5/64
CPC分类号： G11B19/08
摘要： A digital photo frame (DPF) capable of automatically changing display mode is provided. The DPF includes a display unit, a motion detector, a processing unit, and a storage unit. The motion detector is configured to detect whether there is someone around the DPF, and produce a display switching signal if someone is around the DPF. The processing unit detects current display mode when it receives the display switching signal and change the display mode of the DPF to a slide show mode if current display mode is a still mode. The motion detector also produce a stop signal when it detects nobody around the DPF, the processing unit controls the display unit to display the pictures in the still mode when it receives the stop signal and detects current display mode is the slide show mode.
摘要翻译：提供能够自动改变显示模式的数码相框（DPF）。 DPF包括显示单元，运动检测器，处理单元和存储单元。运动检测器被配置为检测DPF周围是否有人，并且如果有人在DPF周围，则产生显示切换信号。处理单元在接收到显示切换信号时检测当前显示模式，并且如果当前显示模式是静止模式，则将DPF的显示模式改变为幻灯片放映模式。当运动检测器检测到DPF周围没有人时，运动检测器也产生停止信号，当接收到停止信号并且检测当前显示模式是幻灯片放映模式时，处理单元控制显示单元在静止模式下显示图像。

10. 发明申请

US20060084792A1 Versatile platform for nanotechnology based on circular permutations of chaperonin protein 有权
标题翻译：基于伴侣蛋白的循环排列的纳米技术多功能平台
公开(公告)号：US20060084792A1
公开(公告)日：2006-04-20
申请号：US11194991
申请日：2005-08-01
申请人： Chad Paavola , Jonathan Trent , Suzanne Chan , Yi-Fen Li , R. McMillan , Hiromi Kagawa
发明人： Chad Paavola , Jonathan Trent , Suzanne Chan , Yi-Fen Li , R. McMillan , Hiromi Kagawa
IPC分类号： C07K14/195 , C07H21/04 , C12P21/06 , C12N15/74 , C12N1/21
CPC分类号： C07K14/47 , B82Y30/00
摘要： The present invention provides chaperonin polypeptides which are modified to include N-terminal and C-terminal ends that are relocated from the central pore region to various different positions in the polypeptide which are located on the exterior of the folded modified chaperonin polypeptide. In the modified chaperonin polypeptide, the naturally-occurring N-terminal and C-terminal ends are joined together directly or with an intervening linker peptide sequence. The relocated N-terminal or C-terminal ends can be covalently joined to, or bound with another molecule such as a nucleic acid molecule, a lipid, a carbohydrate, a second polypeptide, or a nanoparticle. The modified chaperonin polypeptides can assemble into double-ringed chaperonin structures. Further, the chaperonin structures can organize into higher order structures such as nanofilaments or nanoarrays which can be used to produce nanodevices and nanocoatings.
摘要翻译：本发明提供了伴侣伴侣多肽，其被修饰为包括从位于折叠的修饰的伴侣蛋白多肽的外部的多肽中的中心孔区域重新定位到各种不同位置的N末端和C末端。在修饰的伴侣蛋白多肽中，天然存在的N-末端和C-末端直接连接在一起或与插入的接头肽序列连接在一起。重新定位的N-末端或C-末端可共价连接至另一分子例如核酸分子，脂质，碳水化合物，第二多肽或纳米颗粒。修饰的伴侣蛋白多肽可以组装成双环伴侣蛋白结构。此外，伴侣蛋白结构可以组织成更高级的结构，例如可用于制备纳米装置和纳米涂层的纳米丝或纳米阵列。

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