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1. 发明授权

US10814013B2 Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications 有权
公开(公告)号：US10814013B2
公开(公告)日：2020-10-27
申请号：US13562879
申请日：2012-07-31
申请人： David J. Yang , Dongfang Yu , Andrew S. Thompson , F. David Rollo
发明人： David J. Yang , Dongfang Yu , Andrew S. Thompson , F. David Rollo
IPC分类号： A61K49/00 , A61K51/04 , A61K49/06
摘要： Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

2. 发明申请

US20130039853A1 EFFICIENT SYNTHESIS OF CHELATORS FOR NUCLEAR IMAGING AND RADIOTHERAPY: COMPOSITIONS AND APPLICATIONS 审中-公开
标题翻译：核成像和放射治疗的有效合成：组合物和应用
公开(公告)号：US20130039853A1
公开(公告)日：2013-02-14
申请号：US13562879
申请日：2012-07-31
申请人： David J. Yang , Dongfang Yu , Andrew S. Thompson , F. David Rollo
发明人： David J. Yang , Dongfang Yu , Andrew S. Thompson , F. David Rollo
IPC分类号： A61K51/08 , A61K38/05 , A61P35/00 , A61P35/02 , A61K49/22 , A61K49/04 , A61P9/00 , A61P9/10 , A61K49/00 , A61K49/14
摘要： Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
摘要翻译：公开了合成螯合剂靶向配体缀合物的新方法，包含这种缀合物的组合物，以及这种缀合物的治疗和诊断应用。组合物包括任选地螯合到一种或多种金属离子的螯合剂靶向配体缀合物。还提出了高纯度合成这些组合物的方法。还公开了使用这些新型组合物成像，治疗和诊断受试者疾病的方法，例如对象内的肿瘤成像方法和诊断心肌缺血的方法。

3. 发明申请

US20110085969A1 CHELATOR-TARGETING LIGAND CONJUGATES FOR CARDIOVASCULAR IMAGING 审中-公开
标题翻译：用于心血管成像的针对性配对的配对
公开(公告)号：US20110085969A1
公开(公告)日：2011-04-14
申请号：US12900200
申请日：2010-10-07
申请人： F. David Rollo , Jerry L. Bryant
发明人： F. David Rollo , Jerry L. Bryant
IPC分类号： A61K51/04 , A61K51/08 , A61P43/00
CPC分类号： A61K51/0491
摘要： Disclosed are methods of imaging a site in a heart of a subject to detect cardiovascular disease that involve stressing a subject, administering to the stressed subject an effective amount of a radionuclide-labeled chelator-glucose analog conjugate, and imaging the heart of the subject by detecting a signal generated by the conjugate in the heart of the subject. Also disclosed are methods of imaging a peripheral blood vessel in a subject by using a detectable amount of a radionuclide-labeled chelator-glucose analog conjugate. Also disclosed are methods of distinguishing a false positive nuclear cardiology scan from a true positive nuclear cardiology scan, methods of diagnosing congestive heart failure or cardiac ischemia that involve imaging a subject that has been administered a radionuclide-labeled chelator-glucose analog conjugate, and methods to distinguish viable from nonviable myocardium.
摘要翻译：公开了对受试者心脏中的部位成像以检测涉及对受试者施加压力的心血管疾病的方法，向受压受试者施用有效量的放射性核素标记的螯合剂 - 葡萄糖类似物缀合物，并通过检测由对象的心脏中的缀合物产生的信号。还公开了通过使用可检测量的放射性核素标记的螯合剂 - 葡萄糖模拟缀合物对受试者中的外周血管进行成像的方法。还公开了区分假阳性核心脏病学扫描与真正的核心脏病学扫描的方法，诊断充血性心力衰竭或心脏缺血的方法，其涉及对已经施用放射性核素标记的螯合剂 - 葡萄糖模拟缀合物的受试者成像，以及方法以区分可行和不可行的心肌。

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