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1. 发明申请

US20110085969A1 CHELATOR-TARGETING LIGAND CONJUGATES FOR CARDIOVASCULAR IMAGING 审中-公开
标题翻译：用于心血管成像的针对性配对的配对
公开(公告)号：US20110085969A1
公开(公告)日：2011-04-14
申请号：US12900200
申请日：2010-10-07
申请人： F. David Rollo , Jerry L. Bryant
发明人： F. David Rollo , Jerry L. Bryant
IPC分类号： A61K51/04 , A61K51/08 , A61P43/00
CPC分类号： A61K51/0491
摘要： Disclosed are methods of imaging a site in a heart of a subject to detect cardiovascular disease that involve stressing a subject, administering to the stressed subject an effective amount of a radionuclide-labeled chelator-glucose analog conjugate, and imaging the heart of the subject by detecting a signal generated by the conjugate in the heart of the subject. Also disclosed are methods of imaging a peripheral blood vessel in a subject by using a detectable amount of a radionuclide-labeled chelator-glucose analog conjugate. Also disclosed are methods of distinguishing a false positive nuclear cardiology scan from a true positive nuclear cardiology scan, methods of diagnosing congestive heart failure or cardiac ischemia that involve imaging a subject that has been administered a radionuclide-labeled chelator-glucose analog conjugate, and methods to distinguish viable from nonviable myocardium.
摘要翻译：公开了对受试者心脏中的部位成像以检测涉及对受试者施加压力的心血管疾病的方法，向受压受试者施用有效量的放射性核素标记的螯合剂 - 葡萄糖类似物缀合物，并通过检测由对象的心脏中的缀合物产生的信号。还公开了通过使用可检测量的放射性核素标记的螯合剂 - 葡萄糖模拟缀合物对受试者中的外周血管进行成像的方法。还公开了区分假阳性核心脏病学扫描与真正的核心脏病学扫描的方法，诊断充血性心力衰竭或心脏缺血的方法，其涉及对已经施用放射性核素标记的螯合剂 - 葡萄糖模拟缀合物的受试者成像，以及方法以区分可行和不可行的心肌。

2. 发明授权

US09632069B2 Integrated systems and methods of evaluating cannabis and cannabinoid products for public safety, quality control and quality assurance purposes 有权
公开(公告)号：US09632069B2
公开(公告)日：2017-04-25
申请号：US14312051
申请日：2014-06-23
申请人： Elias Bernard Jackson, Jr. , Jerry L. Bryant, Jr.
发明人： Elias Bernard Jackson, Jr. , Jerry L. Bryant, Jr.
IPC分类号： G06F17/30 , G01N33/00 , G01N33/15 , G01N33/94
CPC分类号： G01N33/0098 , G01N33/15 , G01N33/948
摘要： Embodiments of the invention include integrated systems and methods of evaluating cannabis and cannabinoid products for public safety, quality control and quality assurance purposes for research and public use purposes. Embodiments of the invention facilitate suppliers and consumers of a cannabis and/or cannabinoid product to evaluate the origin, efficacy, potency, and quality of the product. Embodiments of the invention also include cannabis processing center where samples of the products are analyzed for research studies to test and set parameters for third parties. Embodiments of the invention include, for example, analyzing cannabis products to determine quality and quantity of desired components and undesired components, determining concentrations of cannabinoids in the product, and comparing measures of components in the product against regulations. Embodiments of the invention further include, for example, an online testing facility for determine whether cannabis products meet a plurality of regulations or guidelines.

3. 发明申请

US20150219610A1 Integrated Systems and Methods of Evaluating Cannabis and Cannabinoid Products for Public Safety, Quality Control and Quality Assurance Purposes 有权
标题翻译：用于公共安全，质量控制和质量保证目的的大麻和大麻素产品评估的综合系统和方法
公开(公告)号：US20150219610A1
公开(公告)日：2015-08-06
申请号：US14312051
申请日：2014-06-23
申请人： Elias Bernard Jackson, JR. , Jerry L. Bryant, JR.
发明人： Elias Bernard Jackson, JR. , Jerry L. Bryant, JR.
IPC分类号： G01N33/00 , G01N33/15 , C12Q1/10 , G06F17/30 , C12Q1/04 , C12Q1/14
CPC分类号： G01N33/0098 , G01N33/15 , G01N33/948
摘要： Embodiments of the invention include integrated systems and methods of evaluating cannabis and cannabinoid products for public safety, quality control and quality assurance purposes for research and public use purposes. Embodiments of the invention facilitate suppliers and consumers of a cannabis and/or cannabinoid product to evaluate the origin, efficacy, potency, and quality of the product. Embodiments of the invention also include cannabis processing center where samples of the products are analyzed for research studies to test and set parameters for third parties. Embodiments of the invention include, for example, analyzing cannabis products to determine quality and quantity of desired components and undesired components, determining concentrations of cannabinoids in the product, and comparing measures of components in the product against regulations. Embodiments of the invention further include, for example, an online testing facility for determine whether cannabis products meet a plurality of regulations or guidelines.
摘要翻译：本发明的实施例包括用于公共安全，质量控制和用于研究和公共使用目的的质量保证目的的大麻和大麻素产品的综合系统和方法。本发明的实施例有助于大麻和/或大麻素产品的供应商和消费者评估产品的起源，功效，效力和质量。本发明的实施例还包括大麻加工中心，其中分析产品样品用于研究研究以测试和设定第三方的参数。本发明的实施方案包括例如分析大麻产品以确定所需组分和不需要的组分的质量和数量，确定产品中大麻素的浓度，以及比较产品中组分与规定的测量。本发明的实施例还包括例如用于确定大麻产品是否符合多个规则或指南的在线测试设备。

4. 发明授权

US09050378B2 N2S2 chelate-targeting ligand conjugates 有权
标题翻译： N2S2螯合靶向配体缀合物
公开(公告)号：US09050378B2
公开(公告)日：2015-06-09
申请号：US10732919
申请日：2003-12-10
申请人： David J. Yang , Dong-Fang Yu , Chang-Sok Oh , Jerry L. Bryant, Jr.
发明人： David J. Yang , Dong-Fang Yu , Chang-Sok Oh , Jerry L. Bryant, Jr.
IPC分类号： A61K51/10 , A61K51/04 , A61K51/08
CPC分类号： A61K51/1093 , A61K51/0497 , A61K51/088
摘要： The invention provides, in a general sense, a new labeling strategy employing compounds that are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor angiogenesis targeting ligand, a tumor apoptosis targeting ligand, a disease receptor targeting ligand, amifostine, angiostatin, monoclonal antibody C225, monoclonal antibody CD31, monoclonal antibody CD40, capecitabine, a COX-2 inhibitor, deoxycytidine, fullerene, herceptin, human serum albumin, lactose, leuteinizing hormone, pyridoxal, quinazoline, thalidomide, transferrin, or trimethyl lysine. The present invention also pertains to kits employing the compounds of interest, and methods of assessing the pharmacology of an agent of interest using the present compounds.
摘要翻译：本发明在一般意义上提供了使用与靶向配体缀合的N 2 S 2螯合物的化合物的新标记策略，其中靶向配体是疾病细胞周期靶向化合物，肿瘤血管生成靶向配体，肿瘤凋亡靶向配体，疾病受体靶向配体，氨磷汀，血管抑素，单克隆抗体C225，单克隆抗体CD31，单克隆抗体CD40，卡培他滨，COX-2抑制剂，脱氧胞苷，富勒烯，赫赛汀，人血清白蛋白，乳糖，促黄体激素，吡哆醛，喹唑啉，沙利度胺，转铁蛋白或三甲基赖氨酸。本发明还涉及使用目的化合物的试剂盒，以及使用本发明化合物评价感兴趣剂的药理学的方法。

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