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1. 发明申请

US20150139942A1 Method for Tretaing a GD2 Positive Cancer 有权
标题翻译： GD2阳性癌症的治疗方法
公开(公告)号：US20150139942A1
公开(公告)日：2015-05-21
申请号：US14409161
申请日：2012-07-31
申请人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat , Susanne Wiederkum , Bernhard Peball , Stefan Stranner , Oliver Mutschlechner , Franz Groiss , Ruth Ladenstein , Holger Lode
发明人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat , Susanne Wiederkum , Bernhard Peball , Stefan Stranner , Oliver Mutschlechner , Franz Groiss , Ruth Ladenstein , Holger Lode
IPC分类号： C07K16/30 , A61K31/485 , A61K39/395 , A61K45/06
CPC分类号： C07K16/3084 , A61K31/485 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/734 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a method for treating a GD2 positive cancer by administering a preparation comprising an anti-GD2 antibody to a patient as a continuous intravenous infusion over 24 hours per day.
摘要翻译：本发明涉及一种治疗GD2阳性癌症的方法，其通过以每天24小时连续静脉内输注给患者施用包含抗GD2抗体的制剂。

2. 发明授权

US08586319B2 Recombinant ACE2 polypeptide dimer 有权
标题翻译：重组ACE2多肽二聚体
公开(公告)号：US08586319B2
公开(公告)日：2013-11-19
申请号：US12664641
申请日：2008-06-12
申请人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
发明人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
IPC分类号： A61K38/48
CPC分类号： A61K38/4813 , A61K38/00 , C07K14/70596 , C12N9/48 , C12N9/64
摘要： The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.
摘要翻译：本发明涉及重组ACE2多肽，其中ACE2多肽作为二聚体存在。二聚体特异性地由糖基化单体形成，并用于生产延长半衰期的药物产品。

3. 发明申请

US20100310546A1 ACE2 Polypeptide 有权
标题翻译： ACE2多肽
公开(公告)号：US20100310546A1
公开(公告)日：2010-12-09
申请号：US12664641
申请日：2008-06-12
申请人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
发明人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
IPC分类号： A61K38/48 , C12N5/10 , C12N9/48
CPC分类号： A61K38/4813 , A61K38/00 , C07K14/70596 , C12N9/48 , C12N9/64
摘要： The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.
摘要翻译：本发明涉及重组ACE2多肽，其中ACE2多肽作为二聚体存在。二聚体特异性地由糖基化单体形成，并用于生产延长半衰期的药物产品。

4. 发明申请

US20110033524A1 TREATMENT OF TUMORS 有权
标题翻译：治疗肿瘤
公开(公告)号：US20110033524A1
公开(公告)日：2011-02-10
申请号：US12937029
申请日：2009-04-07
申请人： Evelyne Janzek-hawlat , Hans Loibner , Manfred Schuster , Bernhard Peball
发明人： Evelyne Janzek-hawlat , Hans Loibner , Manfred Schuster , Bernhard Peball
IPC分类号： A61K38/48 , A61K9/127 , A61K39/395 , A61P35/00 , A61P35/04
CPC分类号： A61K38/4813 , A61K9/0019 , C12Y304/17023
摘要： The invention provides for innovative improvements in tumour therapy, particularly therapies which are conducted using endogenous substances and which have no or only mild side-effects. Accordingly the present invention relates to methods of treating or preventing tumor diseases other than lung cancer comprising administering a polypeptide with an angiotensin-converting-enzyme-2 (ACE2) activity.
摘要翻译：本发明提供了在肿瘤治疗方面的创新改进，特别是使用内源性物质进行治疗并且没有或仅有轻微的副作用的疗法。因此，本发明涉及治疗或预防除肺癌以外的肿瘤疾病的方法，包括给予具有血管紧张素转化酶-2（ACE2）活性的多肽。

5. 发明申请

US20100261214A1 Method for Determining ACE2 Activity 有权
标题翻译：确定ACE2活性的方法
公开(公告)号：US20100261214A1
公开(公告)日：2010-10-14
申请号：US12445906
申请日：2007-10-19
申请人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat
发明人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat
IPC分类号： C12Q1/37
CPC分类号： G01N33/573 , C12Q1/37
摘要： The present invention relates to a method of determining ACE2 activity, comprising the following steps: providing ACE2-binding units immobilized on a solid carrier and specific for a part of ACE2 which is not involved in the catalytic activity of ACE2; contacting the immobilized ACE2-binding units with a sample which potentially includes the ACE2, wherein the ACE2 is bound by the ACE2-binding unit; removing the non-binding portions of the sample from the ACE2 bound to the ACE2-binding units; adding a substrate of the ACE2 which is reacted by the ACE2 activity, with the reaction providing a signal; and measuring the change in the signal during a specific period of time, wherein the change can be correlated with the ACE2 activity.
摘要翻译：本发明涉及一种测定ACE2活性的方法，包括以下步骤：提供固定在固体载体上且对ACE2的不参与ACE2催化活性的一部分ACE2特异的ACE2结合单元; 使固定化的ACE2结合单元与潜在地包含ACE2的样品接触，其中ACE2被ACE2结合单元结合; 从与ACE2结合单元结合的ACE2中除去样品的非结合部分; 加入由ACE2活性反应的ACE2底物，反应提供信号; 并测量特定时间段内信号的变化，其中变化可以与ACE2活性相关。

6. 发明授权

US09777068B2 Method for treating a GD2 positive cancer 有权
公开(公告)号：US09777068B2
公开(公告)日：2017-10-03
申请号：US14409161
申请日：2012-07-31
申请人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat , Susanne Wiederkum , Bernhard Peball , Stefan Stranner , Oliver Mutschlechner , Franz Groiss , Ruth Ladenstein , Holger Lode
发明人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat , Susanne Wiederkum , Bernhard Peball , Stefan Stranner , Oliver Mutschlechner , Franz Groiss , Ruth Ladenstein , Holger Lode
IPC分类号： C07K16/30 , A61K39/395 , A61K31/485 , A61K45/06 , A61K39/00
CPC分类号： C07K16/3084 , A61K31/485 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/734 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a method for treating a GD2 positive cancer by administering a preparation comprising an anti-GD2 antibody to a patient as a continuous intravenous infusion over 24 hours per day.

7. 发明授权

US08946162B2 Treatment of tumors 有权
标题翻译：治疗肿瘤
公开(公告)号：US08946162B2
公开(公告)日：2015-02-03
申请号：US12937029
申请日：2009-04-07
申请人： Evelyne Janzek-Hawlat , Hans Loibner , Manfred Schuster , Bernhard Peball
发明人： Evelyne Janzek-Hawlat , Hans Loibner , Manfred Schuster , Bernhard Peball
IPC分类号： A61K38/48 , A61K9/00
CPC分类号： A61K38/4813 , A61K9/0019 , C12Y304/17023
摘要： The invention provides for innovative improvements in tumor therapy, particularly therapies which are conducted using endogenous substances and which have no or only mild side-effects. Accordingly the present invention relates to methods of treating or preventing tumor diseases other than lung cancer comprising administering a polypeptide with an angiotensin-converting-enzyme-2 (ACE2) activity.
摘要翻译：本发明提供了在肿瘤治疗方面的创新改进，特别是使用内源性物质进行治疗并且没有或仅有轻微的副作用的疗法。因此，本发明涉及治疗或预防除肺癌以外的肿瘤疾病的方法，包括给予具有血管紧张素转化酶-2（ACE2）活性的多肽。

8. 发明授权

US08241864B2 Method for determining ACE2 activity 有权
标题翻译：确定ACE2活性的方法
公开(公告)号：US08241864B2
公开(公告)日：2012-08-14
申请号：US12445906
申请日：2007-10-19
申请人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat
发明人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat
IPC分类号： C12Q1/37
CPC分类号： G01N33/573 , C12Q1/37
摘要： Methods of determining ACE2 activity in a sample by reacting the sample with ACE2-binding units immobilized on a solid carrier and specific for a part of ACE2 not involved in the catalytic activity of ACE2. The reaction provides a signal that can be correlated with the ACE2 activity. These methods allow for ACE2 activity in complex solutions, such as bodily liquids or culture supernatants, to be quantitatively determined using the endogenous activity of the enzyme to be quantified by converting a signal-providing substrate.
摘要翻译：通过使样品与固定在固体载体上的ACE2结合单元反应并且对ACE2的一部分ACE2没有参与ACE2的催化活性而特异性地测定样品中ACE2活性的方法。该反应提供了可以与ACE2活性相关的信号。这些方法允许复杂溶液中的ACE2活性，例如体液或培养物上清液，使用通过转化提供信号的底物量化的酶的内源活性进行定量测定。

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