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1. 发明申请

US20110287454A1 METHODS FOR MONOCLONAL ANTIBODY PRODUCTION 审中-公开
标题翻译：单克隆抗体生产方法
公开(公告)号：US20110287454A1
公开(公告)日：2011-11-24
申请号：US13115282
申请日：2011-05-25
申请人： Bettina Wagner
发明人： Bettina Wagner
IPC分类号： C12P21/08 , C07K19/00 , G01N33/53 , C12N15/63
CPC分类号： C07K16/00 , C07K16/24 , C07K16/2809 , C07K16/2851
摘要： This invention provides improved methods for production of monoclonal antibodies against a protein of interest. The present methods are based on immunization of an animal with a fusion protein between a protein of interest and a Th2 cytokine such as IL-4, IL-5, IL-13 and IL-31.
摘要翻译：本发明提供了生产针对目的蛋白质的单克隆抗体的改进方法。本发明的方法是基于目标蛋白与Th2细胞因子如IL-4，IL-5，IL-13和IL-31之间的融合蛋白的动物免疫。

2. 发明申请

US20130273572A1 Methods for Diagnosing Lyme Disease 有权
标题翻译：诊断莱姆病的方法
公开(公告)号：US20130273572A1
公开(公告)日：2013-10-17
申请号：US13876077
申请日：2011-09-27
申请人： Bettina Wagner
发明人： Bettina Wagner
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , C07K14/20 , G01N33/56911 , G01N2333/20 , Y02A50/57
摘要： A method for diagnosing Lyme disease status in a mammal is provided. The method entails, in a biological sample obtained or derived from a mammal, determining antibodies to Borrelia burgdorferi (B. burgdorferi) outer surface proteins (Osp) OspA, OspC, and OspF. Based upon determining the OspA, OspC, and OspF antibodies, the mammal can be diagnosed as vaccinated, not vaccinated, infected or not infected with B. burgdorferi. Mammals that have early, intermediate or chronic B. burgdorferi infection can also be identified. The method is particularly suited for use with horses and dogs. Isolated or recombinant B. burgdorferi antigens and compositions that contain them are also provided.
摘要翻译：提供了一种用于诊断哺乳动物中莱姆病状况的方法。该方法需要在获得或衍生自哺乳动物的生物样品中测定布氏疏螺旋体（布氏疏螺旋体）外表面蛋白（Osp）OspA，OspC和OspF的抗体。基于确定OspA，OspC和OspF抗体，可以将哺乳动物诊断为接种疫苗，未接种疫苗，感染或不用布氏疏螺旋体感染。也可以鉴定具有早期，中度或慢性勃氏疏螺旋体感染的哺乳动物。该方法特别适用于马和狗。还提供了分离的或重组的布氏疏螺旋体抗原和含有它们的组合物。

3. 发明授权

US08946393B2 Methods for diagnosing lyme disease 有权
标题翻译：诊断淋巴结病的方法
公开(公告)号：US08946393B2
公开(公告)日：2015-02-03
申请号：US13876077
申请日：2011-09-27
申请人： Bettina Wagner
发明人： Bettina Wagner
IPC分类号： C07K14/20 , A61K38/00 , G01N33/68 , G01N33/569
CPC分类号： G01N33/6854 , C07K14/20 , G01N33/56911 , G01N2333/20 , Y02A50/57
摘要： A method for diagnosing Lyme disease status in a mammal is provided. The method entails, in a biological sample obtained or derived from a mammal, determining antibodies to Borrelia burgdorferi (B. burgdorferi) outer surface proteins (Osp) OspA, OspC, and OspF. Based upon determining the OspA, OspC, and OspF antibodies, the mammal can be diagnosed as vaccinated, not vaccinated, infected or not infected with B. burgdorferi. Mammals that have early, intermediate or chronic B. burgdorferi infection can also be identified. The method is particularly suited for use with horses and dogs. Isolated or recombinant B. burgdorferi antigens and compositions that contain them are also provided.
摘要翻译：提供了一种用于诊断哺乳动物中莱姆病状况的方法。该方法需要在获得或衍生自哺乳动物的生物样品中测定布氏疏螺旋体（布氏疏螺旋体）外表面蛋白（Osp）OspA，OspC和OspF的抗体。基于确定OspA，OspC和OspF抗体，可以将哺乳动物诊断为接种疫苗，未接种疫苗，感染或不用布氏疏螺旋体感染。也可以鉴定具有早期，中度或慢性勃氏疏螺旋体感染的哺乳动物。该方法特别适用于马和狗。还提供了分离的或重组的布氏疏螺旋体抗原和含有它们的组合物。

4. 发明授权

US08586319B2 Recombinant ACE2 polypeptide dimer 有权
标题翻译：重组ACE2多肽二聚体
公开(公告)号：US08586319B2
公开(公告)日：2013-11-19
申请号：US12664641
申请日：2008-06-12
申请人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
发明人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
IPC分类号： A61K38/48
CPC分类号： A61K38/4813 , A61K38/00 , C07K14/70596 , C12N9/48 , C12N9/64
摘要： The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.
摘要翻译：本发明涉及重组ACE2多肽，其中ACE2多肽作为二聚体存在。二聚体特异性地由糖基化单体形成，并用于生产延长半衰期的药物产品。

5. 发明申请

US20100310546A1 ACE2 Polypeptide 有权
标题翻译： ACE2多肽
公开(公告)号：US20100310546A1
公开(公告)日：2010-12-09
申请号：US12664641
申请日：2008-06-12
申请人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
发明人： Manfred Schuster , Hans Loibner , Evelyne Janzek-Hawlat , Bernhard Peball , Stefan Stranner , Bettina Wagner , Robert Weik
IPC分类号： A61K38/48 , C12N5/10 , C12N9/48
CPC分类号： A61K38/4813 , A61K38/00 , C07K14/70596 , C12N9/48 , C12N9/64
摘要： The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.
摘要翻译：本发明涉及重组ACE2多肽，其中ACE2多肽作为二聚体存在。二聚体特异性地由糖基化单体形成，并用于生产延长半衰期的药物产品。

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