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1. 发明申请

US20070153954A1 Radium target and method for producing it 有权
标题翻译：镭目标及其生产方法
公开(公告)号：US20070153954A1
公开(公告)日：2007-07-05
申请号：US11589551
申请日：2006-10-30
申请人： Mark Harfensteller , Ernst Huenges , Michael Schilp , Josue Bermudez
发明人： Mark Harfensteller , Ernst Huenges , Michael Schilp , Josue Bermudez
IPC分类号： G21G1/10
CPC分类号： H05H6/00 , A61K51/1282 , G21G1/10
摘要： The present invention refers to a method for producing a radium target for the production of radionuclides by means of accelerated protons, whereby at least one radium containing material out of an aqueous-organic solution or suspension of such a material is applied by means of a dispersing device on a surface in such a way that the dispersing device and the surface are moving relatively towards each other and that the solvent is removed substantially spontaneously. Further, the invention refers to a radium target that is created in such a way that it may exhibit an activity of up to 1.5 curie. The radium targets according to the present invention serve for the production of the radionuclide 225Ac, which may be used in nuclear medicine in the treatment of cancer, particularly in form of its daughter nuclide 213Bi.
摘要翻译：本发明涉及通过加速质子制造用于生产放射性核素的镭靶的方法，其中通过分散剂施加至少一种含有有机溶液或这种材料的悬浮液的含镭射材料，装置以使分散装置和表面相对朝向彼此移动并且基本上自发地去除溶剂的方式。此外，本发明涉及一种镭目标，其以这样一种方式产生，其可以表现出高达1.5居里的活性。根据本发明的镭靶标用于生产放射性核素225A，其可用于治疗癌症的核医学，特别是其子核素的形式， / SUP> Bi。

2. 发明授权

US08349391B2 Radium target and method for producing it 有权
标题翻译：镭目标及其生产方法
公开(公告)号：US08349391B2
公开(公告)日：2013-01-08
申请号：US11589551
申请日：2006-10-30
申请人： Mark Harfensteller , Ernst Huenges , Michael Schilp , Josue Manuel Moreno Bermudez
发明人： Mark Harfensteller , Ernst Huenges , Michael Schilp , Josue Manuel Moreno Bermudez
IPC分类号： A61M36/14
CPC分类号： H05H6/00 , A61K51/1282 , G21G1/10
摘要： The present invention refers to a method for producing a radium target for the production of radionuclides by means of accelerated protons, whereby at least one radium containing material out of an aqueous-organic solution or suspension of such a material is applied by means of a dispersing device on a surface in such a way that the dispersing device and the surface are moving relatively towards each other and that the solvent is removed substantially spontaneously. Further, the invention refers to a radium target that is created in such a way that it may exhibit an activity of up to 1.5 curie. The radium targets according to the present invention serve for the production of the radionuclide 225Ac, which may be used in nuclear medicine in the treatment of cancer, particularly in form of its daughter nuclide 213Bi.
摘要翻译：本发明涉及通过加速质子制造用于生产放射性核素的镭靶的方法，其中通过分散剂施加至少一种含有有机溶液或这种材料的悬浮液的含镭射材料，装置以使分散装置和表面相对朝向彼此移动并且基本上自发地去除溶剂的方式。此外，本发明涉及一种镭目标，其以这样的方式产生，其可以表现出高达1.5居里的活性。根据本发明的镭目标用于生产放射性核素225Ac，其可用于治疗癌症的核医学，特别是其子核素213Bi的形式。

3. 发明申请

US20070076834A1 Radium Target and method for producing it 审中-公开
标题翻译：镭靶及其生产方法
公开(公告)号：US20070076834A1
公开(公告)日：2007-04-05
申请号：US11402143
申请日：2006-04-11
申请人： Josue Moreno Bermudez , Andreas Turler , Richard Henklemann , Mark Harfensteller , Ernst Huenges , Michael Schilp , Oliver Buck , Mauritius Geerlings
发明人： Josue Moreno Bermudez , Andreas Turler , Richard Henklemann , Mark Harfensteller , Ernst Huenges , Michael Schilp , Oliver Buck , Mauritius Geerlings
IPC分类号： G21G1/10
CPC分类号： C25D3/54 , A61K51/1282
摘要： The present invention relates to a radium target as well as to a method for producing it for the production of radionuclides by means of accelerated protons, wherein an electrodeposition of radium out of at least one aqueous organic solution containing 226Ra ions is carried out on at least one aluminium surface, wherein the aluminium surface is connected as cathode. With the 226Ra target according to the present invention, 225Ac/213Bi, which can be used, for example, for radioimmunotherapy for cancer treatment, can be produced continuously and in sufficient quantities at a reasonable price.
摘要翻译：本发明涉及一种镭靶及其生产用于通过加速质子制备放射性核素的方法，其中，将至少一种含有有机溶液的含镉电沉积在含有在至少一个铝表面上进行Ra离子，其中铝表面作为阴极连接。使用根据本发明的＆lt; 226＆gt;＆lt; 226＆gt;目标，可以使用例如用于癌症的放射免疫治疗的Bi2B2 Bi2B2 Bi 处理，可以以合理的价格连续生产和数量充足。

4. 发明申请

US20090191122A1 METHOD FOR PURIFICATION OF 225AC FROM IRRADIATED 226RA-TARGETS 审中-公开
标题翻译：从IRRADIATED 226RA-TARGETS中纯化225AC的方法
公开(公告)号：US20090191122A1
公开(公告)日：2009-07-30
申请号：US12280079
申请日：2007-02-19
申请人： Josue Manuel Moreno Bermudez , Andreas Turler , Richard Henklemann , Eva Kabai , Ernst Huenges
发明人： Josue Manuel Moreno Bermudez , Andreas Turler , Richard Henklemann , Eva Kabai , Ernst Huenges
IPC分类号： A61K51/00 , C22B60/00
CPC分类号： C22B60/0295 , A61K51/00 , B01D15/206 , B01D15/26 , C22B7/005 , C22B7/007 , C22B7/009 , G21G1/001 , G21G4/08 , G21G2001/0089
摘要： The present invention describes a method for purification of 225Ac from irradiated 226Ra-targets provided on a support, comprising a leaching treatment of the 226Ra-targets for leaching essentially the entirety of 225Ac and 226Ra with nitric or hydrochloric acid, followed by a first extraction chromatography for separating 225Ac from 226Ra and other Ra-isotopes and a second extraction chromatography for separating 225Ac from 210Po and 210Pb. The finally purified 225Ac can be used to prepare compositions useful for pharmaceutical purposes.
摘要翻译：本发明描述了一种用于从设置在载体上的辐照的226Rα-靶标纯化225Ac的方法，其包括用硝酸或盐酸浸提基本上整个225Ac和226Ra的226Ra-靶标的浸出处理，然后进行第一提取色谱用于从226Ra和其他Ra同位素分离225Ac，以及用于从210Po和210Pb分离225Ac的第二提取色谱。最终纯化的225Ac可用于制备用于制药目的的组合物。

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